BR9709844A - Preparação aquosa de insulina formulação farmacêutica parenteral usos de um carboidrato n o-redutor ou reduzido e de manitol sorbitol xilitol inositol trealose sacarose ou qualquer sua mistura e processo de fabricação de uma preparação de insulina - Google Patents

Preparação aquosa de insulina formulação farmacêutica parenteral usos de um carboidrato n o-redutor ou reduzido e de manitol sorbitol xilitol inositol trealose sacarose ou qualquer sua mistura e processo de fabricação de uma preparação de insulina

Info

Publication number: BR9709844A
Authority: BR; Brazil
Prior art keywords: insulin; preparation; reducing; inositol; mixture
Prior art date: 1996-06-20

Application number

BR9709844A

Other languages

English (en)

Inventor

Lone Logstrup Kimer

Per Balschmidt

Steen Jensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-20

Filing date

1997-06-19

Publication date

1999-08-10

1997-06-19 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1999-08-10 Publication of BR9709844A publication Critical patent/BR9709844A/pt

Links

150000001720 carbohydrates Chemical class 0.000 title abstract 6
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 6
102000004877 Insulin Human genes 0.000 title abstract 3
108090001061 Insulin Proteins 0.000 title abstract 3
229940125396 insulin Drugs 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 3
239000000203 mixture Substances 0.000 title abstract 2
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 title 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 title 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 title 1
SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 title 1
229930195725 Mannitol Natural products 0.000 title 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 title 1
229930006000 Sucrose Natural products 0.000 title 1
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 title 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 title 1
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 title 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 title 1
229960000367 inositol Drugs 0.000 title 1
239000000594 mannitol Substances 0.000 title 1
235000010355 mannitol Nutrition 0.000 title 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title 1
239000000600 sorbitol Substances 0.000 title 1
239000005720 sucrose Substances 0.000 title 1
239000000811 xylitol Substances 0.000 title 1
235000010447 xylitol Nutrition 0.000 title 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 title 1
229960002675 xylitol Drugs 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 2
101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000002170 ethers Chemical class 0.000 abstract 1
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biochemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Molecular Biology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Hematology (AREA)
Dermatology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Medicinal Preparation (AREA)

BR9709844A 1996-06-20 1997-06-19 Preparação aquosa de insulina formulação farmacêutica parenteral usos de um carboidrato n o-redutor ou reduzido e de manitol sorbitol xilitol inositol trealose sacarose ou qualquer sua mistura e processo de fabricação de uma preparação de insulina BR9709844A (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK68496		1996-06-20
DK89996		1996-08-27
PCT/DK1997/000267 WO1997048413A1 (en)	1996-06-20	1997-06-19	Insulin preparations containing carbohydrates

Publications (1)

Publication Number	Publication Date
BR9709844A true BR9709844A (pt)	1999-08-10

Family

ID=26064448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9709844A BR9709844A (pt)	1996-06-20	1997-06-19	Preparação aquosa de insulina formulação farmacêutica parenteral usos de um carboidrato n o-redutor ou reduzido e de manitol sorbitol xilitol inositol trealose sacarose ou qualquer sua mistura e processo de fabricação de uma preparação de insulina

Country Status (16)

Country	Link
EP (1)	EP0910402B1 (pt)
JP (2)	JP4472027B2 (pt)
KR (1)	KR20000022030A (pt)
CN (1)	CN1198643C (pt)
AT (1)	ATE369146T1 (pt)
AU (1)	AU719361B2 (pt)
BR (1)	BR9709844A (pt)
CA (1)	CA2258099A1 (pt)
CZ (1)	CZ297682B6 (pt)
DE (1)	DE69737995T2 (pt)
ES (1)	ES2292189T3 (pt)
HU (1)	HUP9904156A3 (pt)
IL (1)	IL127365A0 (pt)
NO (1)	NO324276B1 (pt)
PL (1)	PL188736B1 (pt)
WO (1)	WO1997048413A1 (pt)

Families Citing this family (33)

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ZA989644B (en) *	1997-10-24	2000-04-25	Lilly Co Eli	Insoluble insulen compositions.
PE123799A1 (es)	1997-10-24	1999-12-13	Lilly Co Eli	Composiciones insolubles de insulina
CO4970787A1 (es)	1997-12-23	2000-11-07	Lilly Co Eli	Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
EP1396272A1 (en) *	1997-12-23	2004-03-10	Eli Lilly & Company	Insoluble Insulin Compositions for Controlling Blood Glucose
WO1999048520A1 (en) *	1998-03-24	1999-09-30	Joergensen Klavs Holger	Novel preparation of protracted acting human insulin
GB9806462D0 (en) *	1998-03-26	1998-05-27	Glaxo Group Ltd	Improved compositions for inhalation
IL142002A0 (en) *	1998-10-16	2002-03-10	Novo Nordisk As	Insulin preparation for pulmonary delivery containing menthol
US6211144B1 (en)	1998-10-16	2001-04-03	Novo Nordisk A/S	Stable concentrated insulin preparations for pulmonary delivery
HUP0104111A3 (en) *	1998-10-16	2002-05-28	Novo Nordisk As	Stable concentrated insulin preparations for pulmonary delivery
US6635617B1 (en)	1998-10-16	2003-10-21	Novo Nordisk A/S	Insulin preparations for pulmonary delivery containing menthol
US7642230B2 (en) *	2003-05-01	2010-01-05	Ltt Bio-Pharma Co., Ltd.	Zinc-containing sustained-release composition, its preparation, and method for producing the same
ES2544329T3 (es) *	2004-10-05	2015-08-28	Novo Nordisk A/S	Una formulación farmacéutica que contiene insulina cristalina e insulina disuelta
WO2006053906A1 (en) *	2004-11-22	2006-05-26	Novo Nordisk A/S	Soluble, stable insulin-containing formulations with a protamine salt
CN1931360B (zh) *	2006-09-22	2013-02-13	江苏万邦生化医药股份有限公司	双时相精蛋白锌胰岛素注射液(30%)及其制备方法
DK2229407T3 (en)	2008-01-09	2017-02-27	Sanofi Aventis Deutschland	NEW INSULIN DERIVATIVES WITH EXTREMELY DELAYED TIME / EFFECTS PROFILE
CN103736082A (zh)	2008-10-17	2014-04-23	赛诺菲-安万特德国有限公司	胰岛素和glp-1激动剂的组合
AU2010317995B2 (en)	2009-11-13	2014-04-17	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical composition comprising a GLP-1 agonist, an insulin, and methionine
CN102711804B (zh)	2009-11-13	2015-09-16	赛诺菲-安万特德国有限公司	包含glp-1激动剂和甲硫氨酸的药物组合物
PT2611458T (pt)	2010-08-30	2016-12-16	Sanofi Aventis Deutschland	Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
ES2550357T3 (es)	2011-08-29	2015-11-06	Sanofi-Aventis Deutschland Gmbh	Combinación farmacéutica para su uso en el control glucémico en pacientes de diabetes de tipo 2
AR087744A1 (es)	2011-09-01	2014-04-16	Sanofi Aventis Deutschland	Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa
TWI641381B (zh)	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
JP6735674B2 (ja) *	2014-01-09	2020-08-05	サノフイＳａｎｏｆｉ	インスリンアスパルトの安定化された医薬製剤
KR20160104726A (ko) *	2014-01-09	2016-09-05	사노피	인슐린 유사체 및/또는 인슐린 유도체의 안정화된 무글리세롤 약제학적 제형
JP2020114861A (ja) *	2014-01-09	2020-07-30	サノフイＳａｎｏｆｉ	インスリンアナログおよび／またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤
RU2016132342A (ru)	2014-01-09	2018-02-14	Санофи	Стабилизированные фармацевтические составы на основе инсулиновых аналогов и/или инсулиновых производных
JP2020143105A (ja) *	2014-01-09	2020-09-10	サノフイＳａｎｏｆｉ	インスリンアスパルトの安定化された医薬製剤
JP7173953B2 (ja) *	2014-01-09	2022-11-16	サノフイ	インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
KR102578030B1 (ko)	2014-12-12	2023-09-14	사노피-아벤티스 도이칠란트 게엠베하	인슐린 글라진／릭시세나티드 고정비 제형
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
WO2017163159A1 (en) *	2016-03-21	2017-09-28	Wockhardt Limited	Biphasic pharmaceutical composition of insulin human

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US4439181A (en) *	1981-01-26	1984-03-27	Regents Of The University Of Minnesota	Polyol-hormone mixture for use in chronic parenteral hormone administration
US4839341A (en) *	1984-05-29	1989-06-13	Eli Lilly And Company	Stabilized insulin formulations
US4876241A (en) *	1987-05-22	1989-10-24	Armour Pharmaceutical Company	Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
EP0705275B1 (en) *	1993-06-21	1999-02-03	Novo Nordisk A/S	Asp-b28 insulin crystals

1997
- 1997-06-19 EP EP97927018A patent/EP0910402B1/en not_active Expired - Lifetime
- 1997-06-19 HU HU9904156A patent/HUP9904156A3/hu unknown
- 1997-06-19 IL IL12736597A patent/IL127365A0/xx active IP Right Grant
- 1997-06-19 PL PL97330828A patent/PL188736B1/pl not_active IP Right Cessation
- 1997-06-19 CN CNB971956642A patent/CN1198643C/zh not_active Expired - Fee Related
- 1997-06-19 KR KR1019980710428A patent/KR20000022030A/ko not_active Ceased
- 1997-06-19 AT AT97927018T patent/ATE369146T1/de not_active IP Right Cessation
- 1997-06-19 WO PCT/DK1997/000267 patent/WO1997048413A1/en not_active Ceased
- 1997-06-19 BR BR9709844A patent/BR9709844A/pt not_active IP Right Cessation
- 1997-06-19 DE DE69737995T patent/DE69737995T2/de not_active Expired - Lifetime
- 1997-06-19 AU AU31665/97A patent/AU719361B2/en not_active Ceased
- 1997-06-19 ES ES97927018T patent/ES2292189T3/es not_active Expired - Lifetime
- 1997-06-19 JP JP50212898A patent/JP4472027B2/ja not_active Expired - Lifetime
- 1997-06-19 CZ CZ0395798A patent/CZ297682B6/cs not_active IP Right Cessation
- 1997-06-19 CA CA002258099A patent/CA2258099A1/en not_active Abandoned
1998
- 1998-12-18 NO NO19985978A patent/NO324276B1/no unknown
2009
- 2009-05-07 JP JP2009112968A patent/JP2009242400A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
KR20000022030A (ko)	2000-04-25
PL188736B1 (pl)	2005-04-29
PL330828A1 (en)	1999-06-07
JP4472027B2 (ja)	2010-06-02
IL127365A0 (en)	1999-10-28
DE69737995D1 (de)	2007-09-20
WO1997048413A1 (en)	1997-12-24
ES2292189T3 (es)	2008-03-01
DE69737995T2 (de)	2008-04-24
CZ297682B6 (cs)	2007-03-07
ATE369146T1 (de)	2007-08-15
JP2000513343A (ja)	2000-10-10
CN1198643C (zh)	2005-04-27
NO985978L (no)	1999-02-19
CZ395798A3 (cs)	1999-05-12
AU719361B2 (en)	2000-05-04
HUP9904156A2 (hu)	2000-06-28
EP0910402B1 (en)	2007-08-08
CA2258099A1 (en)	1997-12-24
NO985978D0 (no)	1998-12-18
CN1222084A (zh)	1999-07-07
NO324276B1 (no)	2007-09-17
AU3166597A (en)	1998-01-07
JP2009242400A (ja)	2009-10-22
EP0910402A1 (en)	1999-04-28
HUP9904156A3 (en)	2000-07-28

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BR9709845A (pt)	1999-08-10	Preparação aquosa de insulina formulação farmacêutica parenteral e processo para aumentar a estabilidade química de uma preparação de insulina
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