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BR9709748A - Método de inalação de pó seco - Google Patents

Método de inalação de pó seco

Info

Publication number
BR9709748A
BR9709748A BR9709748-9A BR9709748A BR9709748A BR 9709748 A BR9709748 A BR 9709748A BR 9709748 A BR9709748 A BR 9709748A BR 9709748 A BR9709748 A BR 9709748A
Authority
BR
Brazil
Prior art keywords
dry powder
inhaler
composition
microns
flow rate
Prior art date
Application number
BR9709748-9A
Other languages
English (en)
Inventor
Robert Schultz
Clyde Witham
Malcolm Hill
Original Assignee
Dura Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21777075&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9709748(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dura Pharma Inc filed Critical Dura Pharma Inc
Publication of BR9709748A publication Critical patent/BR9709748A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Flow Control (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Patente de Invenção: <B>"MéTODO DE INALAçãO DE Pó SECO"<D>. Um método para a inalação de uma droga em pó seco inclui as etapas de prover uma composição de droga em pó seco tendo um tamanho de partícula de droga de a partir de cerca de 1-7 mícrons e um diâmetro aerodinâmico médio de massa do aerossol dispersado de a patir de cerca de 3,5 a 5,5 mícrons. Esta composição é carregada para um inalador que é em geral independente da velocidade de fluxo, e com o inalador tendo uma resistência ao fluxo de inspiração de cerca de 0,12 a 0,21 (cm H~ 2~O)^ ¢^) acima da faixa de cerca de 15-60 L/min. O paciente inala a composição de droga do inalador com uma velocidade de fluxo de inspiração de cerca de 15-60 L/min, resultando em uma eficiência de liberação medida pela fração respirável maior do que 20%.
BR9709748-9A 1996-04-29 1997-04-21 Método de inalação de pó seco BR9709748A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1642896P 1996-04-29 1996-04-29
PCT/US1997/006621 WO1997040819A1 (en) 1996-04-29 1997-04-21 Methods of dry powder inhalation

Publications (1)

Publication Number Publication Date
BR9709748A true BR9709748A (pt) 2000-01-11

Family

ID=21777075

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9709748-9A BR9709748A (pt) 1996-04-29 1997-04-21 Método de inalação de pó seco

Country Status (16)

Country Link
US (1) US6116237A (pt)
EP (1) EP0896525B1 (pt)
JP (2) JP2000510109A (pt)
AT (1) ATE247948T1 (pt)
AU (1) AU724503B2 (pt)
BR (1) BR9709748A (pt)
CA (1) CA2252814A1 (pt)
CZ (1) CZ343798A3 (pt)
DE (1) DE69724420T2 (pt)
DK (1) DK0896525T3 (pt)
ES (1) ES2205210T3 (pt)
HU (1) HUP9901575A3 (pt)
IL (1) IL126701A (pt)
NO (1) NO984999D0 (pt)
NZ (1) NZ332669A (pt)
WO (1) WO1997040819A1 (pt)

Families Citing this family (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6060069A (en) * 1991-05-20 2000-05-09 Dura Pharmaceuticals, Inc. Pulmonary delivery of pharmaceuticals
ES2284226T3 (es) * 1991-07-02 2007-11-01 Nektar Therapeutics Dispositivo para proporcionar medicamentos en aerosol.
US6681767B1 (en) * 1991-07-02 2004-01-27 Nektar Therapeutics Method and device for delivering aerosolized medicaments
CA2200727C (en) 1994-09-21 2006-11-28 Adrian E. Smith Apparatus and methods for dispersing dry powder medicaments
JP2000510109A (ja) * 1996-04-29 2000-08-08 デュラ・ファーマシューティカルズ・インコーポレイテッド 乾燥粉末の吸入方法
US6946117B1 (en) 1997-09-29 2005-09-20 Nektar Therapeutics Stabilized preparations for use in nebulizers
US6309623B1 (en) 1997-09-29 2001-10-30 Inhale Therapeutic Systems, Inc. Stabilized preparations for use in metered dose inhalers
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US20060165606A1 (en) 1997-09-29 2006-07-27 Nektar Therapeutics Pulmonary delivery particles comprising water insoluble or crystalline active agents
US6433040B1 (en) 1997-09-29 2002-08-13 Inhale Therapeutic Systems, Inc. Stabilized bioactive preparations and methods of use
GEP20043260B (en) 1998-03-16 2004-06-25 Nectar Therapeutics Aerosolized Active Agent Delivery and Device for Realization Thereof
US6257233B1 (en) 1998-06-04 2001-07-10 Inhale Therapeutic Systems Dry powder dispersing apparatus and methods for their use
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
UA73924C2 (en) 1998-10-09 2005-10-17 Nektar Therapeutics Device for delivering active agent formulation to lungs of human patient
JP2000217917A (ja) * 1999-01-27 2000-08-08 Unisia Jecs Corp 吸入式投薬器
EP1190364A2 (en) 1999-04-23 2002-03-27 Massachusetts Institute Of Technology System and method for polymer notation
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
US6606992B1 (en) 1999-06-30 2003-08-19 Nektar Therapeutics Systems and methods for aerosolizing pharmaceutical formulations
US7464706B2 (en) * 1999-07-23 2008-12-16 Mannkind Corporation Unit dose cartridge and dry powder inhaler
US7305986B1 (en) 1999-07-23 2007-12-11 Mannkind Corporation Unit dose capsules for use in a dry powder inhaler
EP1266013B1 (en) * 2000-03-08 2014-10-15 Massachusetts Institute Of Technology Heparinase iii and uses thereof
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
DK1280520T4 (en) 2000-05-10 2018-06-25 Novartis Ag Phospholipid based powders for drug delivery
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
WO2002013897A2 (en) 2000-08-14 2002-02-21 Advanced Inhalation Research, Inc. Inhalation device and method
ATE426805T1 (de) 2000-09-12 2009-04-15 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
EP1328260A2 (en) 2000-10-18 2003-07-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
EP1370318B1 (en) * 2001-03-15 2005-07-20 The Government of the United States of America, as represented by the Secretary, Department of Health &amp; Human Services Systems and methods for aerosol delivery of agents
US6766799B2 (en) * 2001-04-16 2004-07-27 Advanced Inhalation Research, Inc. Inhalation device
CA2446904A1 (en) * 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
US20070122353A1 (en) 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7766013B2 (en) 2001-06-05 2010-08-03 Alexza Pharmaceuticals, Inc. Aerosol generating method and device
US7458374B2 (en) 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
CA2460904C (en) 2001-09-19 2011-03-22 Advent Pharmaceuticals Pty Ltd An inhaler for delivering metered doses of powdered medicament
SI1458360T1 (sl) 2001-12-19 2011-08-31 Novartis Ag Pulmonalno dajanje aminoglikozidov
GB0217199D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
GB0201677D0 (en) 2002-01-25 2002-03-13 Glaxo Group Ltd Medicament dispenser
US6705316B2 (en) 2002-03-11 2004-03-16 Battelle Pulmonary Therapeutics, Inc. Pulmonary dosing system and method
PT1494732E (pt) 2002-03-20 2008-03-20 Mannkind Corp Aparelho de inalação
JP4897198B2 (ja) * 2002-03-20 2012-03-14 アルカームズ，インコーポレイテッド 吸入装置で使用する穿孔手段
US7185651B2 (en) 2002-06-18 2007-03-06 Nektar Therapeutics Flow regulator for aerosol drug delivery and methods
GB0217196D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
JP2005533582A (ja) * 2002-07-25 2005-11-10 グラクソ　グループ　リミテッド 薬剤ディスペンサ
GB0217198D0 (en) * 2002-07-25 2002-09-04 Glaxo Group Ltd Medicament dispenser
JP2005533581A (ja) * 2002-07-25 2005-11-10 グラクソ　グループ　リミテッド 薬剤ディスペンサ
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
GB0308771D0 (en) * 2003-04-16 2003-05-21 Univ Loughborough Pulmonary drug delivery
CN100381083C (zh) 2003-04-29 2008-04-16 韩力 一种非可燃性电子喷雾香烟
WO2004104493A2 (en) 2003-05-21 2004-12-02 Alexza Pharmaceuticals, Inc. Methods of controlling uniformity of substrate temperature and self-contained heating unit and drug-supply unit employing same
GB0313604D0 (en) * 2003-06-12 2003-07-16 Britannia Pharmaceuticals Ltd Delivery device for powdered medicament
GB0317374D0 (en) * 2003-07-24 2003-08-27 Glaxo Group Ltd Medicament dispenser
DK1699434T3 (da) * 2003-09-02 2011-05-30 Norton Healthcare Ltd Fremgangsmåde til fremstilling af et lægemiddel
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
CA2555390C (en) 2004-02-19 2014-08-05 Coley Pharmaceutical Group, Inc. Immunostimulatory viral rna oligonucleotides
EP2258428B1 (en) * 2004-04-02 2019-11-27 The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services Aerosol delivery systems
JP2007533387A (ja) 2004-04-21 2007-11-22 イノベータ バイオメド リミテッド 吸入器
GB0409197D0 (en) 2004-04-24 2004-05-26 Innovata Biomed Ltd Device
US7540286B2 (en) 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
CA2576961A1 (en) 2004-08-12 2006-03-02 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
GB0418278D0 (en) * 2004-08-16 2004-09-15 Glaxo Group Ltd Medicament dispenser
MX2007001903A (es) 2004-08-20 2007-08-02 Mannkind Corp Catalisis de sintesis de dicetopiperazina.
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
WO2006030459A1 (en) * 2004-09-16 2006-03-23 Giampiero Cossi Disposable monodose inhaler for powdered medicaments
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
GB0515584D0 (en) * 2005-07-28 2005-09-07 Glaxo Group Ltd Medicament dispenser
KR101486397B1 (ko) 2005-09-14 2015-01-28 맨카인드 코포레이션 활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
ES2526879T3 (es) 2006-02-15 2015-01-16 Adiutide Pharmaceuticals Gmbh Composiciones y procedimientos para formulaciones de oligonucleótidos
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
GB0622827D0 (en) * 2006-11-15 2006-12-27 Glaxo Group Ltd Sheet driver for use in a drug dispenser
EP2121088B1 (en) 2007-03-09 2016-07-13 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
WO2008156586A2 (en) * 2007-06-12 2008-12-24 Alkermes, Inc. Inhalation device for powdered substances
WO2008151796A2 (en) * 2007-06-15 2008-12-18 Boehringer Ingelheim International Gmbh Inhaler
EP2082762A1 (en) 2008-01-24 2009-07-29 Boehringer Ingelheim International Gmbh Inhaler
KR101541209B1 (ko) * 2008-03-27 2015-07-31 맨카인드 코포레이션 건조 분말 흡입 시스템
US9358352B2 (en) 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
RU2608439C2 (ru) 2008-06-13 2017-01-18 Маннкайнд Корпорейшн Ингалятор для сухого порошка и система для доставки лекарственных средств
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
EP2609954B1 (en) 2008-06-20 2021-12-29 MannKind Corporation An interactive apparatus for real-time profiling of inhalation efforts
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
CN102159270B (zh) 2008-09-26 2014-07-02 奥里尔治疗公司 一种带有具有气道盘沟槽的气道盘的吸入器和相关的气道盘和方法
JP5470393B2 (ja) * 2008-09-26 2014-04-16 オリエル・セラピューティクス，インコーポレイテッド ドライパウダー吸入器
CA2732827C (en) * 2008-10-01 2016-10-11 Oriel Therapeutics, Inc. Dry powder inhalers with rotating piercing mechanisms and related devices and methods
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2399637B1 (en) 2009-02-23 2014-10-22 Japan Tobacco, Inc. Non-heating tobacco flavor suction device
EP2676695A3 (en) * 2009-03-11 2017-03-01 MannKind Corporation Apparatus, system and method for measuring resistance of an inhaler
CN102647979B (zh) 2009-06-12 2015-03-04 曼金德公司 具有确定比表面积的二酮哌嗪颗粒
WO2011039646A2 (en) 2009-09-30 2011-04-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Papilloma virus -like particles for targeted gene delivery
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
EP2694402B1 (en) 2011-04-01 2017-03-22 MannKind Corporation Blister package for pharmaceutical cartridges
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
WO2013063160A1 (en) 2011-10-24 2013-05-02 Mannkind Corporation Methods and compositions for treating pain
CA2878457C (en) 2012-07-12 2021-01-19 Mannkind Corporation Dry powder drug delivery systems and methods
KR101466616B1 (ko) * 2012-10-11 2014-11-28 한미약품 주식회사 건조분말 흡입장치
WO2014066856A1 (en) 2012-10-26 2014-05-01 Mannkind Corporation Inhalable influenza vaccine compositions and methods
US8545878B1 (en) 2012-11-09 2013-10-01 Civitas Therapeutics, Inc. Capsules containing high doses of levodopa for pulmonary use
WO2014074797A1 (en) * 2012-11-09 2014-05-15 Civitas Therapeutics, Inc. Ultra low density pulmonary powders
US10034988B2 (en) * 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
EP3587404B1 (en) 2013-03-15 2022-07-13 MannKind Corporation Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
CA2918369C (en) 2013-07-18 2021-06-29 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
EP3030294B1 (en) 2013-08-05 2020-10-07 MannKind Corporation Insufflation apparatus
WO2015042412A1 (en) 2013-09-20 2015-03-26 E-Nicotine Technology. Inc. Devices and methods for modifying delivery devices
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10898660B2 (en) 2014-09-10 2021-01-26 Fontem Holdings 1 B.V. Methods and devices for modulating air flow in delivery devices
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
WO2016067252A1 (en) 2014-10-31 2016-05-06 Glaxosmithkline Intellectual Property Development Limited Powder formulation
PL3247235T3 (pl) 2015-01-22 2021-04-06 Fontem Holdings 1 B.V. Elektroniczne urządzenia odparowujące
IT201600093878A1 (it) 2016-09-19 2018-03-19 Hollycon Italy Pte Ltd S R L Inalatore monodose a perdere per medicinali in polvere
WO2018071435A1 (en) 2016-10-11 2018-04-19 Microdose Therapeutx, Inc. Inhaler and methods of use thereof
WO2019152873A1 (en) 2018-02-02 2019-08-08 Alexza Pharmaceuticals, Inc. Electrical condensation aerosol device

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB248400A (pt) * 1925-02-28 1926-11-18 Societe Francaise Des Films Herault
US3831606A (en) * 1971-02-19 1974-08-27 Alza Corp Auto inhaler
IT1220979B (it) * 1981-06-04 1990-06-21 Lofarma Farma Lab Capsule contenenti un allergene e procedimento per la loro preparazione
GB8432063D0 (en) * 1984-12-19 1985-01-30 Riker Laboratories Inc Physically modified steroids
EP0470154B1 (en) * 1989-04-28 1996-06-05 Riker Laboratories, Inc. Dry powder inhalation device
US5176132A (en) * 1989-05-31 1993-01-05 Fisons Plc Medicament inhalation device and formulation
US5492112A (en) * 1991-05-20 1996-02-20 Dura Pharmaceuticals, Inc. Dry powder inhaler
US5327883A (en) * 1991-05-20 1994-07-12 Dura Pharmaceuticals, Inc. Apparatus for aerosolizing powdered medicine and process and using
US5469843A (en) * 1991-11-12 1995-11-28 Minnesota Mining And Manufacturing Company Inhalation device
WO1994008552A2 (en) * 1992-10-19 1994-04-28 Dura Pharmaceuticals, Inc. Dry powder inhaler
SE9203743D0 (sv) * 1992-12-11 1992-12-11 Astra Ab Efficient use
US5354934A (en) * 1993-02-04 1994-10-11 Amgen Inc. Pulmonary administration of erythropoietin
US5792057A (en) * 1993-05-21 1998-08-11 Aradigm Corporation Ventilation imaging using a fine particle aerosol generator
US5388574A (en) * 1993-07-29 1995-02-14 Ingebrethsen; Bradley J. Aerosol delivery article
JPH0753358A (ja) * 1993-08-17 1995-02-28 Teijin Ltd 吸入剤
US5524613A (en) * 1993-08-25 1996-06-11 Habley Medical Technology Corporation Controlled multi-pharmaceutical inhaler
US5522385A (en) * 1994-09-27 1996-06-04 Aradigm Corporation Dynamic particle size control for aerosolized drug delivery
US5503869A (en) * 1994-10-21 1996-04-02 Glaxo Wellcome Inc. Process for forming medicament carrier for dry powder inhalator
US5645051A (en) * 1995-04-21 1997-07-08 Dura Pharmaceuticals, Inc. Unit dose dry powder inhaler
US5622166A (en) * 1995-04-24 1997-04-22 Dura Pharmaceuticals, Inc. Dry powder inhaler delivery system
JP2000510109A (ja) * 1996-04-29 2000-08-08 デュラ・ファーマシューティカルズ・インコーポレイテッド 乾燥粉末の吸入方法

Also Published As

Publication number Publication date
NZ332669A (en) 1999-02-25
HUP9901575A2 (hu) 1999-08-30
NO984999L (no) 1998-10-27
AU724503B2 (en) 2000-09-21
DK0896525T3 (da) 2003-12-01
ATE247948T1 (de) 2003-09-15
EP0896525A4 (en) 2001-01-10
JP2009148586A (ja) 2009-07-09
EP0896525B1 (en) 2003-08-27
IL126701A0 (en) 1999-08-17
ES2205210T3 (es) 2004-05-01
DE69724420T2 (de) 2004-06-09
AU2737197A (en) 1997-11-19
NO984999D0 (no) 1998-10-27
DE69724420D1 (de) 2003-10-02
IL126701A (en) 2001-08-08
EP0896525A1 (en) 1999-02-17
JP2000510109A (ja) 2000-08-08
US6116237A (en) 2000-09-12
CZ343798A3 (cs) 1999-02-17
CA2252814A1 (en) 1997-11-06
HUP9901575A3 (en) 1999-11-29
WO1997040819A1 (en) 1997-11-06

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