[go: up one dir, main page]

BR9709444A - Derivados de indazol 1,3,5-trissubstituidos com açao antiasmática antialérgica inibidora de inflamação e imunomoduladora - Google Patents

Derivados de indazol 1,3,5-trissubstituidos com açao antiasmática antialérgica inibidora de inflamação e imunomoduladora

Info

Publication number
BR9709444A
BR9709444A BR9709444A BR9709444A BR9709444A BR 9709444 A BR9709444 A BR 9709444A BR 9709444 A BR9709444 A BR 9709444A BR 9709444 A BR9709444 A BR 9709444A BR 9709444 A BR9709444 A BR 9709444A
Authority
BR
Brazil
Prior art keywords
allergic
tri
inhibiting
indazole derivatives
substituted indazole
Prior art date
Application number
BR9709444A
Other languages
English (en)
Inventor
Rudolf Schindler
Ilona Fleischhauer
Istvan Szelenyi
Original Assignee
Dresden Arzneimittel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dresden Arzneimittel filed Critical Dresden Arzneimittel
Publication of BR9709444A publication Critical patent/BR9709444A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BR9709444A 1996-03-20 1997-03-07 Derivados de indazol 1,3,5-trissubstituidos com açao antiasmática antialérgica inibidora de inflamação e imunomoduladora BR9709444A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19610882A DE19610882A1 (de) 1996-03-20 1996-03-20 Neue 1,3,5-trisubstituierte Indazol-Derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
PCT/EP1997/001166 WO1997034874A1 (de) 1996-03-20 1997-03-07 1,3,5-trisubstituierte indazol-derivate mit antiasthmatischer, antiallergischer, entzündungshemmender und immunmodulierender wirkung

Publications (1)

Publication Number Publication Date
BR9709444A true BR9709444A (pt) 1999-08-10

Family

ID=7788810

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9709444A BR9709444A (pt) 1996-03-20 1997-03-07 Derivados de indazol 1,3,5-trissubstituidos com açao antiasmática antialérgica inibidora de inflamação e imunomoduladora

Country Status (10)

Country Link
US (1) US5776932A (pt)
EP (1) EP0888307A1 (pt)
JP (1) JP2000506874A (pt)
AR (1) AR006283A1 (pt)
AU (1) AU2025697A (pt)
BR (1) BR9709444A (pt)
CA (1) CA2200385A1 (pt)
DE (1) DE19610882A1 (pt)
WO (1) WO1997034874A1 (pt)
ZA (1) ZA971883B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69709493T2 (de) * 1996-06-27 2002-10-31 Pfizer Inc., New York Substituierte Indazolderivate
DE19821003A1 (de) 1998-05-11 1999-11-18 Dresden Arzneimittel Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19821002A1 (de) * 1998-05-11 1999-11-18 Dresden Arzneimittel Neue 1,5- und 3-O-substituierte 1H-Indazole mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US6169185B1 (en) 1999-02-25 2001-01-02 Day-Glo Color Corp. Ink jet printing inks
DE10007203A1 (de) * 2000-02-17 2001-08-23 Asta Medica Ag Neue Kombination nichtsedierender Antihistaminika mit Substanzen, die die Leukotrienwirkung beeinflussen, zur Behandlung der Rhinitis/Konjunktivitis
EP1448557A4 (en) * 2001-10-26 2005-02-02 Univ Connecticut HETEROINDANE: A NEW CLASS OF HIGH-ACTIVITY CANNABIMIMETIC LIGANDS
TW200505913A (en) 2003-03-28 2005-02-16 Hoffmann La Roche Novel oxazole derivatives, their manufacture and use as pharmaceutical agents
US7582631B2 (en) * 2004-01-14 2009-09-01 Amgen Inc. Substituted heterocyclic compounds and methods of use
US8034940B2 (en) 2006-08-09 2011-10-11 Bristol-Myers Squibb Company Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
WO2009071483A1 (en) * 2007-12-07 2009-06-11 Via Pharmaceuticals, Inc. 1- (indaz0l-5-yl) -ureas as diacylglycerol acyltransferase inhibitors
US10500178B2 (en) 2015-03-13 2019-12-10 The Board Of Trustees Of The Leland Stanford Junior University LTB4 inhibition to prevent and treat human lymphedema
CN115197117B (zh) * 2022-05-17 2023-09-15 沈阳化工大学 抑制金黄色葡萄球菌胱硫醚-γ-裂解酶的吲哚类衍生物
WO2024178219A1 (en) * 2023-02-23 2024-08-29 Brian Shoichet 1-acyl-3-aminoindazoles for treating cystic fibrosis

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1054833A (pt) * 1963-08-09
GB1152885A (en) * 1966-08-29 1969-05-21 Acraf Indazole-3-yl-Oxyalkanoic Acids and process for the preparation thereof
IL28032A (en) * 1966-08-29 1971-08-25 Acraf Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof
US3625970A (en) * 1968-04-17 1971-12-07 Cutter Lab 1-(disubstituted phenyl or benzyl)-1h-indazol-3-yloxyacetic acid
GB1435943A (en) * 1973-02-07 1976-05-19 Delmar Chem Indazole-derived tertiary amines
US4537966A (en) * 1983-12-22 1985-08-27 Pennwalt Corporation 1-(Aminobenzoyl)-1H-indazol-3-ols
EP0191520B1 (en) * 1985-02-12 1989-06-21 AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (1-phenylmethyl-5-hydroxy-1h-indazol-3-yl)-oxyacetic acid and salts thereof for use as a medicament, and pharmaceutical compositions containing them
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
IE910278A1 (en) * 1990-02-16 1991-08-28 Ici Plc Heterocyclic compounds
US5334597A (en) * 1991-10-17 1994-08-02 Merck Frosst Canada, Inc. Indole carbamates as leukotriene antagonists
DE4224363A1 (de) * 1992-07-23 1994-01-27 Henkel Kgaa Nitroindazolinone als Färbemittel für Fasern natürlichen Ursprungs und synthetische Fasern
KR100224135B1 (ko) * 1993-01-28 1999-10-15 다께다 구니오 퀴놀린 또는 퀴나졸린 유도체, 그 제조 및 용도

Also Published As

Publication number Publication date
AR006283A1 (es) 1999-08-11
ZA971883B (en) 1997-11-10
WO1997034874A1 (de) 1997-09-25
DE19610882A1 (de) 1997-09-25
CA2200385A1 (en) 1997-09-20
US5776932A (en) 1998-07-07
EP0888307A1 (de) 1999-01-07
AU2025697A (en) 1997-10-10
JP2000506874A (ja) 2000-06-06

Similar Documents

Publication Publication Date Title
NO970412D0 (no) Indol-, indazol-, pyridopyrrol- og pyridopyrazol-derivater med antiastmatisk, antiallergisk, anti-inflammatorisk og immunomodulerende virkning
NO984354D0 (no) Avisingsmiddel og anvendelse av dette
PT915846E (pt) Fenilcetoenois 2-substituidos e 2,5-substituidos
TR199501463A2 (tr) Triazolil türevleri.
LT97145A (lt) Pirazol-4-il-benzoilo dariniai ir herbicidinė priemonė
ZA964646B (en) Substituted N-(indole-2-Carbonyl)-ß-alanimamides and derivatives as antidiabetic agents.
DE69525418D1 (de) Benzimidazol-derivate
BR9709051A (pt) Derivados de indazol substituidos e compostos relacionados
IS4970A (is) Setnar 6,6-heteró-bísýklískar afleiður
DE69839392D1 (de) In 1-stellung substituierte 4-carbamoyl-1,2,4-triazol-5-on-derivate und herbizide
DE69816946D1 (de) Druckkompensationvorrichtung und Druckkompensationverfahren
PH31175A (en) Indole and benzimi-dazole-substituted imidazole and benzimidazole derivatives.
BR9709444A (pt) Derivados de indazol 1,3,5-trissubstituidos com açao antiasmática antialérgica inibidora de inflamação e imunomoduladora
NL1007057A1 (nl) Scharnierconstructie en daarbij gebruikte onderdelen.
EE9800378A (et) Alküülaminobensotiasooli ja -bensoksasooli derivaadid
IS5942A (is) 3,3-bíarýlpíperidín og 2,2-bíarýlmorfólín afleiður
ATE227282T1 (de) 2,4-diaminopyrimidin-derivate
ATE199147T1 (de) Benzisoxazol- und indazol- derivate als antipsychotika
DE69727047D1 (de) Entpaketierer und rahmenausgleicher damit
PT811593E (pt) Agentes insecticidas e acaricidas 1,4-diaril-2-fluor-2-buteno
DE69714358D1 (de) 9,10-disubstituierte campothecinderivate mit antitumoraktivität
FI954031A7 (fi) Taipumaltaan ohjattu tela
FI955603L (fi) Tela
DE69527501D1 (de) Vorrichtung mit lautsprechereinheit, lautsprechereinheit und gehäuse dafür
DE69722064D1 (de) 1,25-Dihydroxy-16,22,23-trisdehydro-Cholecalciferol-Derivate

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]