[go: up one dir, main page]

BR9709205A - Polipeptìdeos processados com arividade de il-16, processos para a sua produção e seu uso - Google Patents

Polipeptìdeos processados com arividade de il-16, processos para a sua produção e seu uso

Info

Publication number
BR9709205A
BR9709205A BR9709205-3A BR9709205A BR9709205A BR 9709205 A BR9709205 A BR 9709205A BR 9709205 A BR9709205 A BR 9709205A BR 9709205 A BR9709205 A BR 9709205A
Authority
BR
Brazil
Prior art keywords
activity
production
processes
polypeptide
polypeptides
Prior art date
Application number
BR9709205-3A
Other languages
English (en)
Inventor
Boehringer Mannheim Gmgh
Michael Baier
Norbert Bannert
Albrecht Werner
Kurt Lang
Original Assignee
Bundesrep Deutschland
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19617202A external-priority patent/DE19617202A1/de
Priority claimed from DE1996117203 external-priority patent/DE19617203A1/de
Application filed by Bundesrep Deutschland, Boehringer Mannheim Gmbh filed Critical Bundesrep Deutschland
Publication of BR9709205A publication Critical patent/BR9709205A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5446—IL-16
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)

Abstract

Patente de Invenção:<B>"POLIPEPTìDEOS PROCESSADOS COM ATIVIDADE DE IL-16, PROCESSOS PARA A SUA PRODUçãO E SEU USO"<D>. Um ácido nucléico que pode ser usado para expressar um polipeptídeo com atividade de interleucina-16 em uma célula de hospedeiro procariótica ou eucariótica, sendo que o dito ácido nucléico codifica um polipeptídeo com a seq³ência de aminoácidos SEQ ID NO:2 ou uma SEQ ID NO:2 alongada N-terminalmente por um resíduo de ácido aspártico ou uma forma encurtada no terminal C em até 8 aminoácidos é adequado para a produção de um polipeptídeo de IL-16 ativo.
BR9709205-3A 1996-04-30 1997-04-30 Polipeptìdeos processados com arividade de il-16, processos para a sua produção e seu uso BR9709205A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19617202A DE19617202A1 (de) 1996-04-30 1996-04-30 Prozessierte Polypeptide mit IL-16-Aktivität, Verfahren zu ihrer Herstellung und Verwendung
DE1996117203 DE19617203A1 (de) 1996-04-30 1996-04-30 Prozessierte Polypeptide mit IL-16-Aktivität, Verfahren zu ihrer Herstellung und Verwendung
PCT/EP1997/002216 WO1997041231A1 (de) 1996-04-30 1997-04-30 Prozessierte polypeptide mit il-16-aktivität, verfahren zu ihrer herstellung und verwendung

Publications (1)

Publication Number Publication Date
BR9709205A true BR9709205A (pt) 2000-01-11

Family

ID=26025242

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9709205-3A BR9709205A (pt) 1996-04-30 1997-04-30 Polipeptìdeos processados com arividade de il-16, processos para a sua produção e seu uso

Country Status (11)

Country Link
US (1) US6506582B1 (pt)
EP (1) EP0904374A1 (pt)
JP (1) JP3251592B2 (pt)
KR (1) KR100308441B1 (pt)
CN (1) CN1217025A (pt)
AU (1) AU712122B2 (pt)
BR (1) BR9709205A (pt)
CA (1) CA2253259A1 (pt)
DE (1) DE19780377D2 (pt)
TR (1) TR199802168T2 (pt)
WO (1) WO1997041231A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19614099A1 (de) * 1996-04-10 1997-10-16 Bundesrep Deutschland Genomische Nukleinsäuren, die für Polypeptide mit IL-16-Aktivität codieren, Verfahren zu ihrer Herstellung und Verwendung
WO2008039716A2 (en) * 2006-09-28 2008-04-03 Centocor Ortho Biotech Inc. Method for detecting il-16 activity and modulation of il-16 activity based on phosphorylated stat-6 proxy levels
US7754207B2 (en) * 2006-10-27 2010-07-13 Centocor Ortho Biotech Inc. Methods of treating pulmonary fibrosis
US20110217259A1 (en) * 2010-03-03 2011-09-08 Djordje Atanackovic IL-16 as a target for diagnosis and therapy of hematological malignancies and solid tumors
CN114984189B (zh) * 2022-05-27 2024-06-04 昆明理工大学 一种白细胞介素16蛋白的新用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
GB9214857D0 (en) * 1992-07-13 1992-08-26 Medical Res Council Human nucleic acid fragments and their use
ATE419356T1 (de) * 1993-05-21 2009-01-15 Univ Boston Chemoattraktion-auslösender faktor aus lymphozyten und dessen verwendung
DE19513152A1 (de) 1995-04-07 1996-10-10 Bundesrep Deutschland Verwendung eines "Immundefizienzvirus-supprimierenden Lymphokins (ISL)" zur Hemmung der Virusvermehrung, insbesondere von Retroviren

Also Published As

Publication number Publication date
KR100308441B1 (ko) 2001-11-02
JPH11508453A (ja) 1999-07-27
EP0904374A1 (de) 1999-03-31
AU712122B2 (en) 1999-10-28
CN1217025A (zh) 1999-05-19
CA2253259A1 (en) 1997-11-06
JP3251592B2 (ja) 2002-01-28
US6506582B1 (en) 2003-01-14
AU2775297A (en) 1997-11-19
WO1997041231A1 (de) 1997-11-06
KR20000065005A (ko) 2000-11-06
TR199802168T2 (xx) 1999-02-22
DE19780377D2 (de) 1999-08-05

Similar Documents

Publication Publication Date Title
BR9713108A (pt) Colagenase recombinante do tipo i de clostridium histolytucum e o uso da mesma para o isolamento de células e de grupos de células
NZ597685A (en) Proteins and nucleic acids from meningitis/sepsis-associated escherichia coli
DE60033138D1 (de) Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
ATE110414T1 (de) System zur bearbeitung von hefe, welches eine zur bearbeitungsstelle benachbarte negativ geladene aminosäure beeinhaltet.
DE3587840D1 (de) Für das Polypeptid des T-Zellantigenreceptors kodierende Nukleinsäure.
ATE169678T1 (de) Stabilisierte enzyme
YU218690A (sh) Postupak za pripremanje protein kompleksa u kojima deluje faktor viii:c
ES2421720T3 (es) Homólogos del factor de necrosis tumoral y ácidos nucleicos que los codifican
BR9709205A (pt) Polipeptìdeos processados com arividade de il-16, processos para a sua produção e seu uso
BR9809416A (pt) Processo para clivagem de proteìnas de fusão
ATE317443T1 (de) N-terminal verlängerte proteine exprimiert in hefe
ES2525317T3 (es) Producción recombinante de inhibidores de la fusión antivirales peptídicos
DK1196560T3 (da) Neurotrofisk faktor receptor GFR-alfa-4
NO20012232L (no) Enzymatisk amidering av peptider
ZA874430B (en) New polypeptides,their preparation and use
DE69737561D1 (de) Klonierte rezeptoren des glukagon-ähnlichen peptids-2
CO5090903A1 (es) Nuevos peptidos para ser usados en una terapia de tolerancia inducida para impedir las alteraciones autoinmunes, en particular, artritis reumatoidea
BR9907216A (pt) Mutantes de il-16, processos para sua produção e utilização dos mesmos
DE60043664D1 (de) Dungen davon
ATE427355T1 (de) Menschliche alpha2-delta4-calciumkanal- untereinheit codierende cdna
WO2001098355A3 (en) Cgi-69 compositions and methods of use
WO2024251939A3 (en) Ccr1 modulators and methods of use
ATE426663T1 (de) Neue isoform der menschlichen camp-abhangigen protein kinase, c alpha-s, mit lokalisation im spermazellen-mittelteil und deren anwendung
ATE511516T1 (de) Gpr-146-rezeptor
BRPI0621280A8 (pt) Polipeptídeo tendo atividade esterase e esterase recombinante e seus usos

Legal Events

Date Code Title Description
TC Change of name
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: IMDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO - DE ACORDO COM O ART. 8O DA LPI.