BR9709078A - Composto de inibição de metalproteases de matriz composição farmacêutica e processo para tratar um mamífero - Google Patents
Composto de inibição de metalproteases de matriz composição farmacêutica e processo para tratar um mamíferoInfo
- Publication number
- BR9709078A BR9709078A BR9709078A BR9709078A BR9709078A BR 9709078 A BR9709078 A BR 9709078A BR 9709078 A BR9709078 A BR 9709078A BR 9709078 A BR9709078 A BR 9709078A BR 9709078 A BR9709078 A BR 9709078A
- Authority
- BR
- Brazil
- Prior art keywords
- mammal
- treating
- pharmaceutical composition
- inhibition compound
- compound pharmaceutical
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 239000011159 matrix material Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/88—Unsaturated compounds containing keto groups containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64502996A | 1996-05-15 | 1996-05-15 | |
| PCT/US1997/008608 WO1997043240A1 (en) | 1996-05-15 | 1997-05-12 | INHIBITION OF MATRIX METALLOPROTEASES BY 2-(φ-AROYLALKYL)-4-BIARYL-OXOBUTYRIC ACIDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9709078A true BR9709078A (pt) | 1999-08-03 |
Family
ID=24587374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9709078A BR9709078A (pt) | 1996-05-15 | 1997-05-12 | Composto de inibição de metalproteases de matriz composição farmacêutica e processo para tratar um mamífero |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0904260B1 (pt) |
| JP (1) | JP3524556B2 (pt) |
| CN (1) | CN1119313C (pt) |
| AR (1) | AR007099A1 (pt) |
| AT (1) | ATE224350T1 (pt) |
| AU (1) | AU715877B2 (pt) |
| BR (1) | BR9709078A (pt) |
| CA (1) | CA2254750C (pt) |
| CO (1) | CO5011071A1 (pt) |
| DE (1) | DE69715619T2 (pt) |
| ES (1) | ES2184092T3 (pt) |
| HN (1) | HN1997000070A (pt) |
| HR (1) | HRP970242A2 (pt) |
| ID (1) | ID17938A (pt) |
| PA (1) | PA8429601A1 (pt) |
| PE (1) | PE66198A1 (pt) |
| SV (1) | SV1997000038A (pt) |
| TN (1) | TNSN97081A1 (pt) |
| TW (1) | TW457231B (pt) |
| WO (1) | WO1997043240A1 (pt) |
| YU (1) | YU18397A (pt) |
| ZA (1) | ZA974028B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HRP970246B1 (en) | 1996-05-15 | 2002-04-30 | Bayer Ag | Substituted oxobutric acids as matrix metalloprotease inhibitors |
| ZA974033B (en) | 1996-05-15 | 1998-02-19 | Bayer Ag | Substituted 4-arylbutyric acid derivatives as matrix metalloprotease inhibitors. |
| CO5070565A1 (es) | 1996-05-15 | 2001-08-28 | Bayer Corp | Inhibicion de las metaloproteasas de matriz por compuestos de fenetilo sustituido y sus composiciones farmaceuticas |
| MY132463A (en) | 1996-05-15 | 2007-10-31 | Bayer Corp | Inhibition of matrix metalloproteases by substituted biaryl oxobutyric acids |
| US6288063B1 (en) | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
| EP1031349A1 (en) * | 1999-02-25 | 2000-08-30 | Bayer Aktiengesellschaft | Use of substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives for the treatment of cerebral diseases |
| JP2017509665A (ja) | 2014-04-03 | 2017-04-06 | バイエル ファーマ アクチエンゲゼルシャフト | 気道疾患治療のための2,5−ジ置換されたシクロペンタンカルボン酸類 |
| US20170022171A1 (en) | 2014-04-03 | 2017-01-26 | Bayer Pharma Aktiengesellschaft | 2,5-disubstituted cyclopentanecarboxylic acids and their use |
| US20170119776A1 (en) | 2014-04-03 | 2017-05-04 | Bayer Pharma Aktiengesellschaft | Chiral 2,5-disubstituted cyclopentanecarboxylic acid derivatives and use thereof |
| CN116687925B (zh) * | 2022-11-04 | 2024-10-22 | 中国科学院遗传与发育生物学研究所 | 一种侵蚀性蛋白酶抑制剂及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS243570B1 (en) * | 1984-08-31 | 1986-06-12 | Miroslav Kuchar | Omega-aryloxoalkane acids |
| GB9101468D0 (en) * | 1991-01-23 | 1991-03-06 | Ciba Geigy | Coating compositions |
| US5789434A (en) * | 1994-11-15 | 1998-08-04 | Bayer Corporation | Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors |
-
1997
- 1997-05-09 CO CO97025187A patent/CO5011071A1/es unknown
- 1997-05-09 TN TNTNSN97081A patent/TNSN97081A1/fr unknown
- 1997-05-09 ZA ZA9704028A patent/ZA974028B/xx unknown
- 1997-05-09 HR HR08/645,029A patent/HRP970242A2/xx not_active Application Discontinuation
- 1997-05-12 YU YU18397A patent/YU18397A/sr unknown
- 1997-05-12 DE DE69715619T patent/DE69715619T2/de not_active Expired - Fee Related
- 1997-05-12 AT AT97924788T patent/ATE224350T1/de not_active IP Right Cessation
- 1997-05-12 PE PE1997000364A patent/PE66198A1/es not_active Application Discontinuation
- 1997-05-12 CN CN97196453A patent/CN1119313C/zh not_active Expired - Fee Related
- 1997-05-12 WO PCT/US1997/008608 patent/WO1997043240A1/en not_active Ceased
- 1997-05-12 HN HN1997000070A patent/HN1997000070A/es unknown
- 1997-05-12 BR BR9709078A patent/BR9709078A/pt not_active IP Right Cessation
- 1997-05-12 JP JP54119597A patent/JP3524556B2/ja not_active Expired - Fee Related
- 1997-05-12 ES ES97924788T patent/ES2184092T3/es not_active Expired - Lifetime
- 1997-05-12 TW TW086106287A patent/TW457231B/zh not_active IP Right Cessation
- 1997-05-12 EP EP97924788A patent/EP0904260B1/en not_active Expired - Lifetime
- 1997-05-12 CA CA002254750A patent/CA2254750C/en not_active Expired - Fee Related
- 1997-05-12 SV SV1997000038A patent/SV1997000038A/es not_active Application Discontinuation
- 1997-05-12 PA PA19978429601A patent/PA8429601A1/es unknown
- 1997-05-12 AR ARP970101979A patent/AR007099A1/es unknown
- 1997-05-12 AU AU30104/97A patent/AU715877B2/en not_active Ceased
- 1997-05-14 ID IDP971608A patent/ID17938A/id unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE224350T1 (de) | 2002-10-15 |
| WO1997043240A1 (en) | 1997-11-20 |
| AU715877B2 (en) | 2000-02-10 |
| TW457231B (en) | 2001-10-01 |
| ES2184092T3 (es) | 2003-04-01 |
| HN1997000070A (es) | 1997-09-08 |
| HRP970242A2 (en) | 1998-04-30 |
| PE66198A1 (es) | 1998-10-23 |
| ID17938A (id) | 1998-02-12 |
| TNSN97081A1 (fr) | 2005-03-15 |
| SV1997000038A (es) | 1998-09-01 |
| JP2001509783A (ja) | 2001-07-24 |
| DE69715619D1 (de) | 2002-10-24 |
| EP0904260A1 (en) | 1999-03-31 |
| CO5011071A1 (es) | 2001-02-28 |
| JP3524556B2 (ja) | 2004-05-10 |
| ZA974028B (en) | 1998-02-19 |
| YU18397A (en) | 1999-11-22 |
| CA2254750C (en) | 2003-09-30 |
| CN1234791A (zh) | 1999-11-10 |
| AU3010497A (en) | 1997-12-05 |
| CN1119313C (zh) | 2003-08-27 |
| AR007099A1 (es) | 1999-10-13 |
| PA8429601A1 (es) | 2000-05-24 |
| EP0904260B1 (en) | 2002-09-18 |
| CA2254750A1 (en) | 1997-11-20 |
| DE69715619T2 (de) | 2003-01-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1838 DE 28/03/2006. |