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BR9708701A - Inibidores anti-sense de expressão do fator de crescimento endotelial vascular. - Google Patents

Inibidores anti-sense de expressão do fator de crescimento endotelial vascular.

Info

Publication number
BR9708701A
BR9708701A BR9708701-7A BR9708701A BR9708701A BR 9708701 A BR9708701 A BR 9708701A BR 9708701 A BR9708701 A BR 9708701A BR 9708701 A BR9708701 A BR 9708701A
Authority
BR
Brazil
Prior art keywords
growth factor
vascular endothelial
endothelial growth
oligonucleotides
expression
Prior art date
Application number
BR9708701-7A
Other languages
English (en)
Inventor
Nilabh Chaudhary
T Sudhakar Rao
Ganapathi R Revankar
Paul A Cossum
Robert F Rando
Anusch Peyman
Eugen Uhlmann
Original Assignee
Hoechst Marion Roussel De Gmbh
Aronex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel De Gmbh, Aronex Pharmaceuticals Inc filed Critical Hoechst Marion Roussel De Gmbh
Publication of BR9708701A publication Critical patent/BR9708701A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Patente de Invenção: <B>"INIBIDORES ANTI-SENSE DE EXPRESSãO DO FATOR DE CRESCIMENTO ENDOTELIAL VASCULAR"<D>. A presente invenção refere-se à inibição da expressão do fator de crescimento endotelial vascular com oligonucleotídeos. Acredita-se que os oligonucleotídeos da presente invenção se ligam ao mRNA alvo de forma seq³encia-específica e impede a expressão do gene codificado. São apresentadas modificações químicas dos oligonucleotídeos para aumentar sua estabilidade e eficácia de ligação. Essas modificações aumentam a estabilidade e eficácia dos oligonucleotídeos contemplados nesta invenção. Composições de oligonucleotídeos podem ser usadas em terapias ex vivo para o tratamento de macrófagos ou terapias in vivo por tratamento por injeção, inalação, tópico ou outras vias de administração.
BR9708701-7A 1996-04-17 1997-04-17 Inibidores anti-sense de expressão do fator de crescimento endotelial vascular. BR9708701A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1575296P 1996-04-17 1996-04-17
PCT/US1997/006412 WO1997039120A2 (en) 1996-04-17 1997-04-17 Antisense inhibitors of vascular endothelial growth factor (vefg/vpf) expression

Publications (1)

Publication Number Publication Date
BR9708701A true BR9708701A (pt) 2000-01-04

Family

ID=21773402

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9708701-7A BR9708701A (pt) 1996-04-17 1997-04-17 Inibidores anti-sense de expressão do fator de crescimento endotelial vascular.

Country Status (7)

Country Link
EP (1) EP0910634A2 (pt)
JP (1) JP2000509259A (pt)
KR (1) KR20000005561A (pt)
AU (1) AU2733697A (pt)
BR (1) BR9708701A (pt)
CA (1) CA2251945A1 (pt)
WO (1) WO1997039120A2 (pt)

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Also Published As

Publication number Publication date
JP2000509259A (ja) 2000-07-25
WO1997039120A3 (en) 1998-02-19
CA2251945A1 (en) 1997-10-23
AU2733697A (en) 1997-11-07
EP0910634A2 (en) 1999-04-28
KR20000005561A (ko) 2000-01-25
WO1997039120A2 (en) 1997-10-23

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