[go: up one dir, main page]

WO1997039120A3 - Antisense inhibitors of vascular endothelial growth factor (vefg/vpf) expression - Google Patents

Antisense inhibitors of vascular endothelial growth factor (vefg/vpf) expression Download PDF

Info

Publication number
WO1997039120A3
WO1997039120A3 PCT/US1997/006412 US9706412W WO9739120A3 WO 1997039120 A3 WO1997039120 A3 WO 1997039120A3 US 9706412 W US9706412 W US 9706412W WO 9739120 A3 WO9739120 A3 WO 9739120A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligonucleotides
expression
growth factor
vascular endothelial
endothelial growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1997/006412
Other languages
French (fr)
Other versions
WO1997039120A2 (en
Inventor
Nilabh Chaudhary
T Sudhakar Rao
Ganapathi R Revankar
Paul A Cossum
Robert F Rando
Anusch Peyman
Eugen Uhlmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aronex Pharmaceuticals Inc
Original Assignee
Aronex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aronex Pharmaceuticals Inc filed Critical Aronex Pharmaceuticals Inc
Priority to BR9708701-7A priority Critical patent/BR9708701A/en
Priority to JP9537367A priority patent/JP2000509259A/en
Priority to AU27336/97A priority patent/AU2733697A/en
Priority to EP97921238A priority patent/EP0910634A2/en
Publication of WO1997039120A2 publication Critical patent/WO1997039120A2/en
Publication of WO1997039120A3 publication Critical patent/WO1997039120A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to the inhibition of vascular endothelial growth factor expression with oligonucleotides. The oligonucleotides of the present invention are thought to bind to target nRNA in a sequence specific manner and prevent expression of the encoded gene. Chemical modifications of the oligonucleotides for increasing their stability and binding efficiency are disclosed. These modifications increase the stability and the efficiency of the oligonucleotides contemplated in this invention. Oligonucleotides compositions can be used in ex vivo therapies for the treatment of macrophages or in vivo therapies by injection, inhalation, topical treatment or other routes of administration.
PCT/US1997/006412 1996-04-17 1997-04-17 Antisense inhibitors of vascular endothelial growth factor (vefg/vpf) expression Ceased WO1997039120A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BR9708701-7A BR9708701A (en) 1996-04-17 1997-04-17 Anti-sense inhibitors of vascular endothelial growth factor expression.
JP9537367A JP2000509259A (en) 1996-04-17 1997-04-17 Antisense inhibitor of vascular endothelial growth factor (VEgF / VPF) expression
AU27336/97A AU2733697A (en) 1996-04-17 1997-04-17 Antisense inhibitors of vascular endothelial growth factor (vegf/vpf) expression
EP97921238A EP0910634A2 (en) 1996-04-17 1997-04-17 ANTISENSE INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEgF/VPF) EXPRESSION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1575296P 1996-04-17 1996-04-17
US60/015,752 1996-04-17

Publications (2)

Publication Number Publication Date
WO1997039120A2 WO1997039120A2 (en) 1997-10-23
WO1997039120A3 true WO1997039120A3 (en) 1998-02-19

Family

ID=21773402

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/006412 Ceased WO1997039120A2 (en) 1996-04-17 1997-04-17 Antisense inhibitors of vascular endothelial growth factor (vefg/vpf) expression

Country Status (7)

Country Link
EP (1) EP0910634A2 (en)
JP (1) JP2000509259A (en)
KR (1) KR20000005561A (en)
AU (1) AU2733697A (en)
BR (1) BR9708701A (en)
CA (1) CA2251945A1 (en)
WO (1) WO1997039120A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858711B2 (en) 1996-01-23 2005-02-22 Affymetrix, Inc. Labeling reagents
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010018514A1 (en) 1998-07-31 2001-08-30 Mcgall Glenn H. Nucleic acid labeling compounds
US6965020B2 (en) 1996-01-23 2005-11-15 Affymetrix, Inc. Nucleic acid labeling compounds
US7423143B2 (en) 1996-01-23 2008-09-09 Affymetrix. Inc. Nucleic acid labeling compounds
US5837283A (en) 1997-03-12 1998-11-17 The Regents Of The University Of California Cationic lipid compositions targeting angiogenic endothelial cells
US7112338B2 (en) 1997-03-12 2006-09-26 The Regents Of The University Of California Cationic liposome delivery of taxanes to angiogenic blood vessels
CA2334960C (en) 1998-06-10 2012-01-03 Biognostik Gesellschaft Fur Biomolekulare Diagnostik Mbh Combination of tgf-.beta. inhibition and immune stimulation to treat hyperproliferative diseases
EP0978561A1 (en) * 1998-08-07 2000-02-09 Hoechst Marion Roussel Deutschland GmbH Antisense oligonucleotides for the inhibition of VEGF expression
EP1564292A1 (en) * 2000-01-19 2005-08-17 Parkash S. Gill Pharmaceutical compositions and methods of treatment based on VEGF antisense oligonucleotides
PT1309726E (en) 2000-03-30 2010-03-08 Whitehead Biomedical Inst RNA INTERFERENCE-SPECIFIC RNA INTERFERENCE MEDIATORS
DE60130583T3 (en) 2000-12-01 2018-03-22 Europäisches Laboratorium für Molekularbiologie SMALL RNA MOLECULES TRANSFERRING RNA INTERFERENCE
EP1385829A4 (en) 2001-03-12 2005-10-19 Affymetrix Inc Nucleic acid labeling compounds
EP1560931B1 (en) * 2002-11-14 2011-07-27 Dharmacon, Inc. Functional and hyperfunctional sirna
WO2006006948A2 (en) 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
CN100371444C (en) * 2005-12-12 2008-02-27 清华大学深圳研究生院 VEGF expression-inhibiting siRNA and application thereof
CN101437933B (en) 2005-12-28 2013-11-06 斯克里普斯研究所 Natural antisense and non-coding RNA transcripts as drug targets
EP2370579B1 (en) 2008-12-04 2017-03-29 CuRNA, Inc. Treatment of erythropoietin (epo) related diseases by inhibition of natural antisense transcript to epo
CN107338251A (en) 2008-12-04 2017-11-10 库尔纳公司 It is diseases related that natural antisense transcript by suppressing tumor suppressor gene treats tumor suppressor gene
PL2396038T3 (en) 2009-02-12 2016-05-31 Curna Inc Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
ES2656290T3 (en) 2009-03-16 2018-02-26 Curna, Inc. Treatment of diseases related to nuclear factor (derived from erythroid 2) similar to 2 (NRF2) by inhibition of natural antisense transcript to NRF2
EP2408920B1 (en) 2009-03-17 2017-03-08 CuRNA, Inc. Treatment of delta-like 1 homolog (dlk1) related diseases by inhibition of natural antisense transcript to dlk1
ES2609655T3 (en) 2009-05-06 2017-04-21 Curna, Inc. Treatment of diseases related to tristetraproline (TTP) by inhibition of natural antisense transcript for TTP
KR101835889B1 (en) 2009-05-06 2018-03-08 큐알엔에이, 인크. Treatment of lipid transport and metabolism gene related diseases by inhibition of natural antisense transcript to a lipid transport and metabolism gene
KR101749356B1 (en) 2009-05-18 2017-07-06 큐알엔에이, 인크. Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor
CA2762987A1 (en) 2009-05-22 2010-11-25 Joseph Collard Treatment of transcription factor e3 (tfe3) and insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to tfe3
ES2629339T3 (en) 2009-06-16 2017-08-08 Curna, Inc. Treatment of diseases related to paraoxonase 1 (pon1) by inhibition of natural antisense transcript to pon1
ES2620960T3 (en) 2009-06-16 2017-06-30 Curna, Inc. Treatment of diseases related to a collagen gene by inhibiting a natural antisense transcript to a collagen gene
KR101807323B1 (en) 2009-06-24 2017-12-08 큐알엔에이, 인크. Ttreatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
KR101807324B1 (en) 2009-06-26 2017-12-08 큐알엔에이, 인크. Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene
CN102712925B (en) 2009-07-24 2017-10-27 库尔纳公司 Treatment of SIRTUIN (SIRT)-associated diseases by inhibiting the natural antisense transcript of SIRTUIN (SIRT)
JP6189594B2 (en) 2009-08-11 2017-08-30 クルナ・インコーポレーテッド Treatment of adiponectin (ADIPOQ) -related diseases by suppression of natural antisense transcripts against adiponectin (ADIPOQ)
CN102482670B (en) 2009-08-21 2018-06-15 库尔纳公司 Treatment of CHIP-associated diseases by inhibiting the natural antisense transcript of 'C-terminus of HSP70-interacting protein' (CHIP)
EP2480669B1 (en) 2009-09-25 2017-11-08 CuRNA, Inc. Treatment of filaggrin (flg) related diseases by modulation of flg expression and activity
ES2661813T3 (en) 2009-12-16 2018-04-04 Curna, Inc. Treatment of diseases related to membrane transcription factor peptidase, site 1 (mbtps1) by inhibition of the natural antisense transcript to the mbtps1 gene
WO2011079263A2 (en) 2009-12-23 2011-06-30 Curna, Inc. Treatment of uncoupling protein 2 (ucp2) related diseases by inhibition of natural antisense transcript to ucp2
DK2516648T3 (en) 2009-12-23 2018-02-12 Curna Inc TREATMENT OF HEPATOCYTE GROWTH FACTOR (HGF) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT AGAINST HGF
JP5993744B2 (en) 2009-12-29 2016-09-14 カッパーアールエヌエー，インコーポレイテッド Treatment of nuclear respiratory factor 1 related diseases by inhibition of natural antisense transcripts against nuclear respiratory factor 1 (NRF1)
WO2011090741A2 (en) 2009-12-29 2011-07-28 Opko Curna, Llc TREATMENT OF TUMOR PROTEIN 63 (p63) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO p63
KR101853511B1 (en) 2009-12-31 2018-06-20 큐알엔에이, 인크. Treatment of insulin receptor substrate 2 (irs2) related diseases by inhibition of natural antisense transcript to irs2 and transcription factor e3 (tfe3)
WO2011082409A2 (en) 2010-01-04 2011-07-07 Curna, Inc. Treatment of interferon regulatory factor 8 (irf8) related diseases by inhibition of natural antisense transcript to irf8
ES2671877T3 (en) 2010-01-25 2018-06-11 Curna, Inc. Treatment of diseases related to RNASA (H1) by inhibition of the natural antisense transcript to RNASA H1
KR101838308B1 (en) 2010-02-22 2018-03-13 큐알엔에이, 인크. Treatment of pyrroline-5-carboxylate reductase 1 (pycr1) related diseases by inhibition of natural antisense transcript to pycr1
ES2657969T3 (en) 2010-04-02 2018-03-07 Curna, Inc. Treatment of diseases related to Colony Stimulating Factor 3 (CSF3) by inhibition of the natural antisense transcript to CSF3
JP5978203B2 (en) 2010-04-09 2016-08-24 カッパーアールエヌエー，インコーポレイテッド Treatment of fibroblast growth factor (FGF21) fibroblast growth factor FGF21) related diseases by inhibition of natural antisense transcripts against FGF21
RU2018110642A (en) 2010-05-03 2019-02-27 Курна, Инк. TREATMENT OF DISEASES ASSOCIATED WITH SIRTUIN (SIRT) BY INHIBITING A NATURAL ANTISENSE TRANSCRIPT TO SIRTUIN (SIRT)
TWI586356B (en) 2010-05-14 2017-06-11 可娜公司 Treatment of par4 related diseases by inhibition of natural antisense transcript to par4
ES2664585T3 (en) 2010-05-26 2018-04-20 Curna, Inc. Treatment of diseases related to methionine sulfoxide reductase (MSRA) by inhibiting the natural antisense transcript to MSRA
WO2011150005A2 (en) 2010-05-26 2011-12-01 Opko Curna Llc Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1
CN103025873B (en) 2010-06-23 2018-05-08 库尔纳公司 Treatment of SCNA-associated diseases by inhibiting natural antisense transcripts of voltage-gated sodium channel alpha subunit (SCNA)
CN103068982B (en) 2010-07-14 2017-06-09 库尔纳公司 DLG relevant diseases are treated by suppressing the natural antisense transcript of the big homologue of plate-like (DLG)
JP2013539456A (en) 2010-07-28 2013-10-24 アルコン リサーチ，リミテッド SiRNA Targeting VEGFA and Methods for In Vivo Treatment
JP6049623B2 (en) 2010-10-22 2016-12-21 カッパーアールエヌエー，インコーポレイテッド Treatment of IDUA-related diseases by inhibition of natural antisense transcripts to α-L-iduronidase (IDUA)
US10000752B2 (en) 2010-11-18 2018-06-19 Curna, Inc. Antagonat compositions and methods of use
EP2643463B1 (en) 2010-11-23 2017-09-27 CuRNA, Inc. Treatment of nanog related diseases by inhibition of natural antisense transcript to nanog
ES2653247T3 (en) 2011-06-09 2018-02-06 Curna, Inc. Treatment of frataxin-related diseases (FXN) by inhibiting the natural antisense transcript to the FXN gene
EP2753317B1 (en) 2011-09-06 2020-02-26 CuRNA, Inc. TREATMENT OF DISEASES RELATED TO ALPHA SUBUNITS OF SODIUM CHANNELS, VOLTAGE-GATED (SCNxA) WITH SMALL MOLECULES
JP2015511494A (en) 2012-03-15 2015-04-20 キュアナ，インク． Treatment of BDNF-related diseases by inhibition of natural antisense transcripts against brain-derived neurotrophic factor (BDNF)
US9758786B2 (en) 2016-02-09 2017-09-12 Autotelic, Llc Compositions and methods for treating pancreatic cancer
WO2020109344A1 (en) 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Occular administration device for antisense oligonucleotides
US20240189243A1 (en) * 2022-11-14 2024-06-13 Industrial Technology Research Institute Lipid compound or a derivative thereof and pharmaceutical composition employing the same

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002258A1 (en) * 1990-07-27 1992-02-20 Isis Pharmaceuticals, Inc. Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
WO1993010820A1 (en) * 1991-11-26 1993-06-10 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
WO1995004142A2 (en) * 1993-07-27 1995-02-09 Hybridon, Inc. Antisense oligonucleotide inhibition of vascular endothelial growth factor expression
WO1996000286A1 (en) * 1994-06-27 1996-01-04 Toagosei Co., Ltd. Antisense nucleic acid compound
US5484908A (en) * 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
DE19502912A1 (en) * 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilized Oligonucleotides
WO1996023065A2 (en) * 1995-01-26 1996-08-01 Hybridon, Inc. Inhibition of neovascularization using vegf-specific oligonucleotides

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002258A1 (en) * 1990-07-27 1992-02-20 Isis Pharmaceuticals, Inc. Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
WO1993010820A1 (en) * 1991-11-26 1993-06-10 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5484908A (en) * 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
WO1995004142A2 (en) * 1993-07-27 1995-02-09 Hybridon, Inc. Antisense oligonucleotide inhibition of vascular endothelial growth factor expression
WO1996000286A1 (en) * 1994-06-27 1996-01-04 Toagosei Co., Ltd. Antisense nucleic acid compound
EP0769552A1 (en) * 1994-06-27 1997-04-23 Toagosei Co., Ltd. Antisense nucleic acid compound
WO1996023065A2 (en) * 1995-01-26 1996-08-01 Hybridon, Inc. Inhibition of neovascularization using vegf-specific oligonucleotides
DE19502912A1 (en) * 1995-01-31 1996-08-01 Hoechst Ag G-Cap Stabilized Oligonucleotides

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHAUDHARY, N. ET AL.: "POTENT ANTISENSE INHIBITION OF VEGF EXPRESSION USING CHEMICAL REDESIGNED OLIGONUCLEOTIDES", MOLECULAR BIOLOGY OF THE CELL, vol. 7, December 1996 (1996-12-01), pages 352A, XP000670185 *
GUY-CAFFEY J K ET AL: "NOVEL POLYAMINOLIPIDS ENHANCE THE CELLULAR UPTAKE OF OLIGONUCLEOTIDES", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 270, no. 52, 29 December 1995 (1995-12-29), pages 31391 - 31396, XP002029823 *
LEWIS, J. ET AL.: "A serum-resistant cytofectin for cellular delivery of antisense oligodeoxynucleotides and plasmid DNA", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, 16 April 1996 (1996-04-16), WASHINGTON US, pages 3176 - 3181, XP002038489 *
SANGHVI, Y. ET AL.: "Antisense oligodeoxynucleotides: synthesis, biophysical and biological evaluation of oligodeoxynucleotides containing modified pyrimidines.", NUCLEIC ACIDS RESEARCH., vol. 21, 1993, OXFORD GB, pages 3197 - 3203, XP002049543 *
THIERRY, A. ET AL.: "In vitro and in vivo inhibition of tumorigenicity of neoplastic Kaposi's sarcoma cell line (KS Y-1) by liposomal IL-6, IL-8 and VEGF antisense oligodeoxynucleotides", PROCEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 36, March 1995 (1995-03-01), pages 413, XP002038488 *
TISCHER E ET AL: "THE HUMAN GENE FOR VASCULAR ENDOTHELIAL GROWTH FACTOR MULTIPLE PROTEIN FORMS ARE ENCODED THROUGH ALTERNATIVE EXON SPLICING", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 266, no. 18, 25 June 1991 (1991-06-25), pages 11947 - 11954, XP002007151 *
UCHIDA, K. ET AL.: "SELECTION OF ANTISENSE OLIGODEOXYRIBONUCLEOTIDES THAT INHIBIT VEGF/VPF EXPRESSION IN A CELL-FREE SYSTEM", ANTISENSE RESEARCH AND DEVELOPMENT, vol. 5, 21 March 1995 (1995-03-21), pages 87 - 8, XP002006442 *
WAGNER, R. ET AL.: "Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines.", SCIENCE, (1993 JUN 4) 260 (5113) 1510-3, XP002038487 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858711B2 (en) 1996-01-23 2005-02-22 Affymetrix, Inc. Labeling reagents
US7291463B2 (en) 1996-01-23 2007-11-06 Affymetrix, Inc. Nucleic acid labeling compounds

Also Published As

Publication number Publication date
JP2000509259A (en) 2000-07-25
CA2251945A1 (en) 1997-10-23
AU2733697A (en) 1997-11-07
EP0910634A2 (en) 1999-04-28
BR9708701A (en) 2000-01-04
KR20000005561A (en) 2000-01-25
WO1997039120A2 (en) 1997-10-23

Similar Documents

Publication Publication Date Title
WO1997039120A3 (en) Antisense inhibitors of vascular endothelial growth factor (vefg/vpf) expression
Zellweger et al. Antitumor activity of antisense clusterin oligonucleotides is improved in vitro and in vivo by incorporation of 2′-O-(2-methoxy) ethyl chemistry
WO1995004142A3 (en) Antisense oligonucleotide inhibition of vascular endothelial growth factor expression
WO2005117954A3 (en) Compositions and methods for treatment of neovascular diseases
ATE202140T1 (en) INHIBITION OF NEOVASCULASIZATION BY VEGF-SPECIFIC OLIGONUCLEOTIDES
WO2000059899A8 (en) Novel lipoic acid derivatives, their preparation, and pharmaceutical compositions containing them
WO2003022227A3 (en) Antisense modulation of vascular endothelial growth factor receptor-1 expression
EP1165594A4 (en) MODULATION OF STAT3 EXPRESSION USING ANTISENSE OLIGONUCLEOTIDES
WO2002042295A3 (en) Peptides as met-ap2 inhibitors
WO2000006133A3 (en) Compositions for treating diseases associated with glycosaminoglycan-associated molecular interactions
WO2006035434A3 (en) Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
WO2001080843A3 (en) Inhibition of abnormal cell proliferation with camptothecin and combinations including the same
WO2001052833A8 (en) Compositions for delivery of a cortisol antagonist
WO2003070283A3 (en) Agent for inhibiting development or progress of proliferative diseases and especially cancer diseases and pharmaceutical composition containing said agent
WO2004046345A3 (en) Use of hmgb fragments as anti-inflammatory agents
WO2001074376A3 (en) Cathepsin inhibitors in cancer treatment
WO2000071703A3 (en) Inhibition of histone deacetylase
WO2007029249A3 (en) Oligoribonucleotides and methods of use thereof for treatment of cardiovascular diseases
WO2006091862A3 (en) Cytokine inhibitors and their use in therapy
WO2001032832A3 (en) Antisense inhibition of nucleolin expression
WO2004030660A3 (en) Compositions for treatment of prostate and other cancers
Zavvar et al. Gene therapy in rheumatoid arthritis: Strategies to select therapeutic genes
WO2001054706A3 (en) Method for treating kidney disorders
WO2002009679A3 (en) Use of 13-cis retinoic acid for the treatment of emphysema
WO2001074807A1 (en) Indolylpyrrole derivatives and cell death inhibitors

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 97194721.X

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AL AM AT AU AZ BA BB BG BR BY CA CH CN CU CZ DE DK EE ES FI GB GE GH HU IL IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK TJ TM TR TT UA UG US UZ VN YU AM AZ BY KG KZ MD RU TJ TM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH KE LS MW SD SZ UG AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: PA/a/1998/008578

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 1019980708435

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2251945

Country of ref document: CA

Ref document number: 2251945

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1997921238

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1997921238

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1019980708435

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1997921238

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1019980708435

Country of ref document: KR