BR9708655A - Derivados de isatina como inibidores de acetilcolinesterase e analgésicos - Google Patents

Derivados de isatina como inibidores de acetilcolinesterase e analgésicos

Info

Publication number: BR9708655A
Authority: BR; Brazil
Prior art keywords: analgesics; acetylcholinesterase inhibitors; isatin derivatives; isatin; derivatives
Prior art date: 1996-04-12

Application number

BR9708655A

Other languages

English (en)

Inventor

Stephen J Shimshock

Abdul E Mutlib

Susan M Chesson

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-12

Filing date

1997-03-07

Publication date

1999-08-03

1997-03-07 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1999-08-03 Publication of BR9708655A publication Critical patent/BR9708655A/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurosurgery (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

BR9708655A 1996-04-12 1997-03-07 Derivados de isatina como inibidores de acetilcolinesterase e analgésicos BR9708655A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US63187096A	1996-04-12	1996-04-12
PCT/US1997/003598 WO1997038993A1 (en)	1996-04-12	1997-03-07	Isatin derivatives as acetylcholinesterase inhibitors and analgesics

Publications (1)

Publication Number	Publication Date
BR9708655A true BR9708655A (pt)	1999-08-03

Family

ID=24533114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9708655A BR9708655A (pt)	1996-04-12	1997-03-07	Derivados de isatina como inibidores de acetilcolinesterase e analgésicos

Country Status (19)

Country	Link
EP (1)	EP0892796B1 (pt)
JP (1)	JP4109718B2 (pt)
KR (1)	KR20000005379A (pt)
CN (1)	CN1215399A (pt)
AR (1)	AR006606A1 (pt)
AT (1)	ATE207483T1 (pt)
BR (1)	BR9708655A (pt)
CA (1)	CA2252039C (pt)
DE (1)	DE69707659T2 (pt)
DK (1)	DK0892796T3 (pt)
ES (1)	ES2165586T3 (pt)
GR (1)	GR3037006T3 (pt)
HU (1)	HUP9903473A3 (pt)
IL (1)	IL126308A0 (pt)
NO (1)	NO984740D0 (pt)
PT (1)	PT892796E (pt)
TW (1)	TW426678B (pt)
WO (1)	WO1997038993A1 (pt)
ZA (1)	ZA972990B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6218383B1 (en)	1998-08-07	2001-04-17	Targacept, Inc.	Pharmaceutical compositions for the prevention and treatment of central nervous system disorders
JP5379692B2 (ja)	2006-11-09	2013-12-25	プロビオドルグエージー	潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (en)	2006-11-30	2012-04-18	Probiodrug AG	Novel inhibitors of glutaminyl cyclase
EP2117540A1 (en)	2007-03-01	2009-11-18	Probiodrug AG	New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en)	2007-04-18	2008-10-30	Probiodrug Ag	Thiourea derivatives as glutaminyl cyclase inhibitors
WO2011029920A1 (en)	2009-09-11	2011-03-17	Probiodrug Ag	Heterocylcic derivatives as inhibitors of glutaminyl cyclase
EA202092673A3 (ru)	2010-02-09	2021-05-31	Дзе Джонс Хопкинс Юниверсити	Способы и композиции для улучшения когнитивной функции
WO2011101774A1 (en)	2010-02-16	2011-08-25	Pfizer Inc.	(r)-4-((4-((4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazol-3-yloxy)methyl)piperidin-1-yl)methyl)tetrahydro-2h-pyran-4-ol, a partial agonist of 5-ht4 receptors
WO2011107530A2 (en)	2010-03-03	2011-09-09	Probiodrug Ag	Novel inhibitors
ES2481823T3 (es)	2010-03-10	2014-07-31	Probiodrug Ag	Inhibidores heterocíclicos de glutaminil ciclasa (QC, EC 2.3.2.5)
EP2560953B1 (en)	2010-04-21	2016-01-06	Probiodrug AG	Inhibitors of glutaminyl cyclase
ES2570167T3 (es)	2011-03-16	2016-05-17	Probiodrug Ag	Derivados de benzimidazol como inhibidores de glutaminil ciclasa
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia
WO2014090929A1 (en)	2012-12-13	2014-06-19	H. Lundbeck A/S	Compositions comprising vortioxetine and donepezil
JP6433482B2 (ja)	2013-03-15	2018-12-05	エージンバイオ，インコーポレイテッド	認知機能を改善するための方法および組成物
EP2968237A4 (en)	2013-03-15	2016-08-31	Univ Johns Hopkins	METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
WO2016179157A1 (en) *	2015-05-05	2016-11-10	Carafe Drug Innovation, Llc	Substituted 5-hydroxyoxindoles and their use as analgesics and fever reducers
BR112017025031B1 (pt)	2015-05-22	2023-03-21	Agenebio, Inc	Composições farmacêuticas de liberação prolongada de levetiracetam
EP3461819B1 (en)	2017-09-29	2020-05-27	Probiodrug AG	Inhibitors of glutaminyl cyclase
CA3237487A1 (en) *	2021-11-05	2023-05-11	The Regents Of The University Of California	Alpha-2a adrenergic receptor modulators and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4994472A (en) *	1989-08-02	1991-02-19	Hoechst-Roussel Pharmaceuticals Incorporated	1-(pyridinylamino)-2-pyrrolidinones as pain relievers
US5296488A (en) *	1989-08-02	1994-03-22	Hoechst-Roussel Pharmaceuticals Inc.	Method of using 2,3-dihydro-1-(pyridinylamino)-indoles as anticonvulsants and for the enhancement of memory
US5006537A (en) *	1989-08-02	1991-04-09	Hoechst-Roussel Pharmaceuticals, Inc.	1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones

1997
- 1997-03-07 ES ES97908942T patent/ES2165586T3/es not_active Expired - Lifetime
- 1997-03-07 WO PCT/US1997/003598 patent/WO1997038993A1/en not_active Ceased
- 1997-03-07 IL IL12630897A patent/IL126308A0/xx unknown
- 1997-03-07 DK DK97908942T patent/DK0892796T3/da active
- 1997-03-07 HU HU9903473A patent/HUP9903473A3/hu unknown
- 1997-03-07 CN CN97193728A patent/CN1215399A/zh active Pending
- 1997-03-07 AT AT97908942T patent/ATE207483T1/de not_active IP Right Cessation
- 1997-03-07 EP EP97908942A patent/EP0892796B1/en not_active Expired - Lifetime
- 1997-03-07 JP JP53708497A patent/JP4109718B2/ja not_active Expired - Fee Related
- 1997-03-07 PT PT97908942T patent/PT892796E/pt unknown
- 1997-03-07 CA CA002252039A patent/CA2252039C/en not_active Expired - Fee Related
- 1997-03-07 DE DE69707659T patent/DE69707659T2/de not_active Expired - Fee Related
- 1997-03-07 BR BR9708655A patent/BR9708655A/pt not_active Application Discontinuation
- 1997-04-07 TW TW086104363A patent/TW426678B/zh active
- 1997-04-08 ZA ZA9702990A patent/ZA972990B/xx unknown
- 1997-04-11 AR ARP970101447A patent/AR006606A1/es unknown
1998
- 1998-10-09 NO NO984740A patent/NO984740D0/no unknown
- 1998-10-12 KR KR1019980708105A patent/KR20000005379A/ko not_active Abandoned
2001
- 2001-10-25 GR GR20010401584T patent/GR3037006T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
TW426678B (en)	2001-03-21
AR006606A1 (es)	1999-09-08
EP0892796B1 (en)	2001-10-24
GR3037006T3 (en)	2002-01-31
HUP9903473A2 (hu)	2000-05-28
CN1215399A (zh)	1999-04-28
PT892796E (pt)	2002-03-28
KR20000005379A (en)	2000-01-25
JP4109718B2 (ja)	2008-07-02
NO984740L (no)	1998-10-09
AU716997B2 (en)	2000-03-16
DE69707659T2 (de)	2002-05-08
WO1997038993A1 (en)	1997-10-23
IL126308A0 (en)	1999-05-09
HUP9903473A3 (en)	2000-09-28
CA2252039A1 (en)	1997-10-23
NO984740D0 (no)	1998-10-09
DK0892796T3 (da)	2001-11-19
ZA972990B (en)	1997-11-03
EP0892796A1 (en)	1999-01-27
JP2001508400A (ja)	2001-06-26
AU2072597A (en)	1997-11-07
ES2165586T3 (es)	2002-03-16
ATE207483T1 (de)	2001-11-15
DE69707659D1 (de)	2001-11-29
CA2252039C (en)	2002-12-24

Publication	Publication Date	Title
BR9708655A (pt)	1999-08-03	Derivados de isatina como inibidores de acetilcolinesterase e analgésicos
DE69723446D1 (de)	2003-08-14	Oxindole derivate
PT946512E (pt)	2004-01-30	Derivados de 6-fenilpiridil-2-amina uteis como inibidores de nos
BR9709105A (pt)	1999-08-03	Sulfonamidas de quinolina como inibidoras de tnf e como inobidoras de pde-iv
HUP9901155A3 (en)	2003-04-28	Quinazoline derivatives as vegf inhibitors
PT1042287E (pt)	2005-08-31	Derivados de indole como inibidores do factor xa
ID17948A (id)	1998-02-12	Piridine bersumbu heterosiklik
DE69729947D1 (de)	2004-08-26	N-substituierte 2-cyanopyrrolidine
BR9700850A (pt)	1998-09-01	Derivados de quinazolina substituídos
BR9710606A (pt)	1999-08-17	Barreira acÚstica e conjunto de barreira acÚstica
DE69903143D1 (de)	2002-10-31	Chromanon und thiochromanon derivate
NO992104D0 (no)	1999-04-30	Isokinoloner
DE59708262D1 (de)	2002-10-24	Distanzschutzverfahren
DE50001834D1 (de)	2003-05-28	Vliesanlage und Betriebsverfahren
DE59914173D1 (de)	2007-03-15	Zündanlage und zündsteuerverfahren
DE69634991D1 (de)	2005-09-01	Elektrotherapiegerät
DK0912553T3 (da)	2002-04-22	Benzo[g]quinolin-derivater
EE04494B1 (et)	2005-06-15	1-oksa-, asa- ja tianaftaleen-2-oon biseetrid fosfolambaani inhibiitoritena
ES1034733Y (es)	1997-06-16	Cenicero perfeccionado
NO970431D0 (no)	1997-01-31	Tetrahydroisokinolin-derivater
DE69715979D1 (de)	2002-11-07	Chinolinderivate und ihre Anwendung
ATA18796A (de)	1999-07-15	Sicherheitshaus
SI0892796T1 (en)	2002-04-30	Isatin derivatives as acetylcholinesterase inhibitors and analgesics
FI964569L (fi)	1998-05-15	Lähetinyksikkö ja tukiasema
UA22363A (uk)	1998-03-03	Вмоhтоваhий диhамічhий захист

Legal Events

Date	Code	Title	Description
2004-06-22	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2004-12-14	B11B	Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements