BR9708480A - Uso dos derivados das tetrahidro-beta-cabolinas como agentes antimetastáticos - Google Patents

Uso dos derivados das tetrahidro-beta-cabolinas como agentes antimetastáticos

Info

Publication number: BR9708480A
Authority: BR; Brazil
Prior art keywords: pct; beta; derivatives; cabolines; tetrahydro
Prior art date: 1996-04-04

Application number

BR9708480A

Other languages

English (en)

Inventor

Hans-Willi Krell

Ernesto Menta

Silvano Spinelli

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-04

Filing date

1997-03-27

Publication date

1999-04-13

1996-04-04 Priority claimed from ITMI960664 external-priority patent/IT1283574B1/it

1996-10-29 Priority claimed from IT96MI002241 external-priority patent/IT1286060B1/it

1997-03-27 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1999-04-13 Publication of BR9708480A publication Critical patent/BR9708480A/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Gynecology & Obstetrics (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)

BR9708480A 1996-04-04 1997-03-27 Uso dos derivados das tetrahidro-beta-cabolinas como agentes antimetastáticos BR9708480A (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI960664 IT1283574B1 (it)	1996-04-04	1996-04-04	Uso di derivati beta-carbolinici come agenti antimetastatici
IT96MI002241 IT1286060B1 (it)	1996-10-29	1996-10-29	Uso di derivati tetraidro-beta-carbolinici come agenti antimetastatici
PCT/EP1997/001582 WO1997037658A1 (en)	1996-04-04	1997-03-27	Use of derivatives of tetrahydro-beta-carbolines as antimetastatic agents

Publications (1)

Publication Number	Publication Date
BR9708480A true BR9708480A (pt)	1999-04-13

Family

ID=26331376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9708480A BR9708480A (pt)	1996-04-04	1997-03-27	Uso dos derivados das tetrahidro-beta-cabolinas como agentes antimetastáticos

Country Status (15)

Country	Link
US (1)	US6069150A (pt)
EP (1)	EP0891187B1 (pt)
JP (1)	JP2000508302A (pt)
KR (1)	KR20000005175A (pt)
CN (1)	CN1113648C (pt)
AT (1)	ATE212549T1 (pt)
AU (1)	AU710079B2 (pt)
BR (1)	BR9708480A (pt)
CA (1)	CA2250898A1 (pt)
DE (1)	DE69710182T2 (pt)
DK (1)	DK0891187T3 (pt)
ES (1)	ES2169857T3 (pt)
PT (1)	PT891187E (pt)
TR (1)	TR199801970T2 (pt)
WO (1)	WO1997037658A1 (pt)

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US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US20040253891A1 (en) *	2000-09-12	2004-12-16	Schierenbeck Alan W.	Composite structure for protective garment
US6720331B2 (en)	2001-04-03	2004-04-13	National Sun Yat-Sen University	1-substituted 1,2,3,4-tetrahydro-β-carboline and 3,4-dihydro-β-carboline and analogs as antitumor agents
EP1383765B1 (en) *	2001-04-25	2006-12-13	Lilly Icos LLC	Carboline derivatives as inhibitors of phosphodiesterase 5 (PDE5) for the treatment of cardiovascular diseases and erectile dysfunction
US6933303B2 (en) *	2001-10-19	2005-08-23	Transtech Pharma, Inc.	Heteroaryl-fused nitrogen heterocycles as therapeutic agents
CN100503607C (zh) *	2003-06-02	2009-06-24	新疆华世丹药物研究有限责任公司	去氢骆驼蓬碱衍生物类化合物及其应用
US20050101623A1 (en) *	2003-07-23	2005-05-12	Pharmacia Corporation	Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
US20060074124A1 (en) *	2003-09-12	2006-04-06	Andrew Napper	Methods of treating a disorder
MXPA06008211A (es) *	2004-01-23	2006-08-31	Chiron Corp	Compuestos de tetrahidrocarbolina como agentes anticancer.
US8076352B2 (en)	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Administration of carboline derivatives useful in the treatment of cancer and other diseases
US7767689B2 (en)	2004-03-15	2010-08-03	Ptc Therapeutics, Inc.	Carboline derivatives useful in the treatment of cancer
US8076353B2 (en) *	2004-03-15	2011-12-13	Ptc Therapeutics, Inc.	Inhibition of VEGF translation
CN1980672B (zh) *	2004-03-15	2011-05-04	Ptc医疗公司	用于抑制血管生成的咔啉衍生物
CN100360129C (zh) *	2004-09-03	2008-01-09	首都医科大学	去氢胡秃子碱衍生物、其合成方法及其应用
WO2006070385A1 (en) *	2004-12-27	2006-07-06	Council Of Scientific And Industrial Research	2-alkyl/aryl sulphonyl-1,2,3,4-tetrahydro-9h-pyrido (3,4-b) indole-3-carboxylic acid esters/amides useful as antithrombotic agents
ITMI20071163A1 (it) *	2007-06-08	2008-12-09	C4T S C A R L	Arilsolfonammidi dela beta-carbolina metodo per prepararle e composizione che le comprende
CN104387382A (zh)	2008-03-24	2015-03-04	梅迪维新技术公司	吡啶并[3,4-b]吲哚和应用方法
TW201100419A (en)	2009-05-27	2011-01-01	Ptc Therapeutics Inc	Processes for the preparation of substituted tetrahydro beta-carbolines
US8703726B2 (en)	2009-05-27	2014-04-22	Ptc Therapeutics, Inc.	Methods for treating prostate conditions
WO2010138652A1 (en)	2009-05-27	2010-12-02	Ptc Therapeutics, Inc.	Methods for treating kaposi sarcoma
CA3184380A1 (en)	2009-05-27	2010-12-02	Ptc Therapeutics, Inc.	Methods for treating cancer and non-neoplastic conditions
CN101906102B (zh) *	2009-06-02	2012-08-29	首都医科大学	β-咔啉类生物碱衍生物及其制备方法和应用
WO2011063223A1 (en) *	2009-11-20	2011-05-26	Southern Research Institute	TETRAHYDRO-β-CARBOLINE DERIVATIVES, SYNTHESIS AND USE THEREOF
CN104744460B (zh)	2013-12-30	2017-06-16	南开大学	β‑咔啉，二氢‑β‑咔啉和四氢‑β‑咔啉生物碱衍生物及其制备方法和在防治植物病毒、杀菌、杀虫方面的应用
CN106536520B (zh)	2014-06-27	2020-08-14	诺格拉制药有限公司	芳基受体调制剂及其制备和使用方法
WO2016105499A1 (en)	2014-12-23	2016-06-30	Intellectual Property Associates, Llc	Methods and formulations for transdermal administration
EP3436005B1 (en) *	2016-03-29	2026-01-28	Georgia State University Research Foundation, Inc.	L-1,2,3,4-tetrahydronorharman-3-carboxylic acid (tnca) for use in the treatment of diseases associated with mutated or abnormal calcium sensing receptor protein (casr)
CN111093774A (zh) *	2017-04-17	2020-05-01	安珀桑德生物制药有限责任公司	用于抑制实体瘤的转移、色素沉着过度和痛风的缓冲剂的肠胃外非全身性施用
WO2019028171A1 (en)	2017-08-01	2019-02-07	Ptc Therapeutics, Inc.	DHODH INHIBITOR FOR USE IN THE TREATMENT OF HEMATOLOGICAL CANCERS
EP3681479B1 (en)	2017-09-15	2024-01-31	Dyve Biosciences, Inc.	Sodium bicarbonate for use in the treatment of gout and related disorders

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FR3395M (fr) *	1963-07-30	1965-06-28	Roussel Uclaf	Nouveau médicament notamment pour le traitement des états neurodépressifs et des psychoses d'anxiété.
NZ194747A (en) *	1979-08-29	1988-11-29	Schering Ag	9h-pyrido(3,4-b)indol-3-ylcarboxylic acid derivatives
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US5162336A (en) *	1990-06-21	1992-11-10	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists
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CN1105799A (zh) *	1993-03-18	1995-07-26	大制药株式会社	作为基质金属蛋白酶抑制剂的喹诺酮衍生物
GB9323165D0 (en) *	1993-11-10	1994-01-05	Chiros Ltd	Compounds

1997
- 1997-03-27 WO PCT/EP1997/001582 patent/WO1997037658A1/en not_active Ceased
- 1997-03-27 DK DK97916410T patent/DK0891187T3/da active
- 1997-03-27 AU AU25069/97A patent/AU710079B2/en not_active Ceased
- 1997-03-27 JP JP9535798A patent/JP2000508302A/ja not_active Ceased
- 1997-03-27 EP EP97916410A patent/EP0891187B1/en not_active Expired - Lifetime
- 1997-03-27 KR KR1019980707846A patent/KR20000005175A/ko not_active Ceased
- 1997-03-27 PT PT97916410T patent/PT891187E/pt unknown
- 1997-03-27 BR BR9708480A patent/BR9708480A/pt not_active Application Discontinuation
- 1997-03-27 CA CA002250898A patent/CA2250898A1/en not_active Abandoned
- 1997-03-27 ES ES97916410T patent/ES2169857T3/es not_active Expired - Lifetime
- 1997-03-27 US US09/142,058 patent/US6069150A/en not_active Expired - Fee Related
- 1997-03-27 AT AT97916410T patent/ATE212549T1/de not_active IP Right Cessation
- 1997-03-27 TR TR1998/01970T patent/TR199801970T2/xx unknown
- 1997-03-27 DE DE69710182T patent/DE69710182T2/de not_active Expired - Fee Related
- 1997-03-27 CN CN97193568A patent/CN1113648C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU2506997A (en)	1997-10-29
EP0891187A1 (en)	1999-01-20
JP2000508302A (ja)	2000-07-04
DK0891187T3 (da)	2002-04-29
CA2250898A1 (en)	1997-10-16
PT891187E (pt)	2002-06-28
DE69710182T2 (de)	2002-08-29
CN1113648C (zh)	2003-07-09
DE69710182D1 (de)	2002-03-14
ATE212549T1 (de)	2002-02-15
EP0891187B1 (en)	2002-01-30
WO1997037658A1 (en)	1997-10-16
KR20000005175A (ko)	2000-01-25
TR199801970T2 (xx)	2000-10-23
CN1215333A (zh)	1999-04-28
AU710079B2 (en)	1999-09-16
ES2169857T3 (es)	2002-07-16
US6069150A (en)	2000-05-30

Publication	Publication Date	Title
BR9708480A (pt)	1999-04-13	Uso dos derivados das tetrahidro-beta-cabolinas como agentes antimetastáticos
BR9813228A (pt)	2000-08-29	Formulação de 2-metil-tieno-benzodiazepina
ES2158537T3 (es)	2001-09-01	Derivados de acidos ciclopropilalcanoicos.
TR200101961T2 (tr)	2001-12-21	1,2-halkalı kinolin türevleri
ES2160949T3 (es)	2001-11-16	Derivados de fenilen-sulfonamida sustituidos en meta.
DK0889877T3 (da)	2001-10-01	Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
ATE219064T1 (de)	2002-06-15	Piperazinderivative als tachykinin antagonisten
WO1997030677A3 (en)	1997-11-20	Pentafluorobenzenesulfonamides and analogs
EA200100774A1 (ru)	2002-02-28	Гетероциклические производные с функциональными группами (варианты), фармацевтическая композиция и комбинация, способ модулирования активности рецептора хемокина (варианты), способ профилактики инфицирования вич и лечения инфекции вич, замедления проявления спид и лечения спид, способ лечения воспалительных процессов
TR200000025T2 (tr)	2000-06-21	Azetidinilpropilpiperidin türevleri, ara bağlarıyla tacikinin antagonistleri olarak kullanımları.
ES2193154T3 (es)	2003-11-01	Procedimiento para la preparacion de 9-desoxotaxanos.
AU3563695A (en)	1996-05-31	Novel piperidine derivatives with paf antagonist activity
MX9300779A (es)	1993-09-30	3-(1h-tetrazol-5-y1)-4h-pyrido[1,2-a]pirimidina-4-onas composiciones farmaceuticas que las contienen y su preparacion de las mismas
PT1119359E (pt)	2004-08-31	Formulacao de 2-metil-tieno-benzodiazepina
RU94038042A (ru)	1996-09-10	Производные гексагидроазепинов, фармацевтическая композиция на их основе и антипсихотропный агент
NO983444D0 (no)	1998-07-24	Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer
US5563157B1 (en)	1999-02-02	Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
AR008474A1 (es)	2000-01-19	Derivado de 9-dihidroeritromicina a 6,9; 11,12-diciclocarbonato, composicion farmaceutica y preparacion bactericida que lo contienen y su uso
IT1294932B1 (it)	1999-04-23	Uso di 2-amminotetraline-6,7 sostituite per la preparazione di composizioni farmaceutiche atte al trattamento di patologie
PT914129E (pt)	2002-04-29	Utilizacao de aspirocloro ou derivados seus como agentes imunossupresivos
TR199802419T2 (xx)	1999-02-22	Yepyeni Piridazin Bile�ikleri.
MY111366A (en)	1999-12-31	Piperdine derivatives.

Legal Events

Date	Code	Title	Description
2006-01-10	B07A	Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
2006-08-15	B09B	Patent application refused [chapter 9.2 patent gazette]	Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE COMO INVENCAO - DE ACORDO COM O ART. 8O DA LPI.