BR9704641A - Sistema de expressão de antígenos heterólogos como proteínas de fusão - Google Patents

Sistema de expressão de antígenos heterólogos como proteínas de fusão

Info

Publication number: BR9704641A
Authority: BR; Brazil
Prior art keywords: fusion proteins; expression system; heterologous antigens; heterologous; antigens
Prior art date: 1996-01-17

Application number

BR9704641A

Other languages

English (en)

Other versions

BR9704641B1 (pt

Inventor

Dunn Alejandro Miguel Martin

Angulo Maria De Jesus Leal

Galvez Consuelo Nazabal

Vazquez Diogenes Quitana

Rodriguez Ricardo De La Silva

Cano Carlos Antonio Duarte

Rodriguez Carmen Elena Gomez

Munoz Emilio Luis Carpio

Acosta Anabel Alvarez

Nieto Gerardo Enrique Guillen

Original Assignee

Ingenieria Genetic Y Biotecnol

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-17

Filing date

1997-01-17

Publication date

1998-06-09

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=5459182&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9704641(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-01-17 Application filed by Ingenieria Genetic Y Biotecnol filed Critical Ingenieria Genetic Y Biotecnol

1998-06-09 Publication of BR9704641A publication Critical patent/BR9704641A/pt

2010-03-09 Publication of BR9704641B1 publication Critical patent/BR9704641B1/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/82—Proteins from microorganisms
- Y10S530/825—Bacteria

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Virology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Oncology (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Immunology (AREA)
Tropical Medicine & Parasitology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

BRPI9704641-8A 1996-01-17 1997-01-17 proteìna de fusão, vetor de expressão de proteìnas de fusão em e. coli, cepa recombinante e composição de vacina. BR9704641B1 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
CU10/96		1996-01-17
CU1996010A CU22559A1 (es)	1996-01-17	1996-01-17	Sistema de expresión de antígenos heterologos en e. coli como proteínas de fusión
PCT/CU1997/000001 WO1997026359A1 (es)	1996-01-17	1997-01-17	Sistema de expresion de antigenos heterologos como proteinas de fusion

Publications (2)

Publication Number	Publication Date
BR9704641A true BR9704641A (pt)	1998-06-09
BR9704641B1 BR9704641B1 (pt)	2010-03-09

Family

ID=5459182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI9704641-8A BR9704641B1 (pt)	1996-01-17	1997-01-17	proteìna de fusão, vetor de expressão de proteìnas de fusão em e. coli, cepa recombinante e composição de vacina.

Country Status (22)

Country	Link
US (2)	US6146635A (pt)
EP (1)	EP0816506B1 (pt)
JP (1)	JP4071282B2 (pt)
KR (1)	KR100500782B1 (pt)
CN (1)	CN1107115C (pt)
AR (1)	AR005651A1 (pt)
AT (1)	ATE198491T1 (pt)
AU (1)	AU722317B2 (pt)
BR (1)	BR9704641B1 (pt)
CA (1)	CA2214840A1 (pt)
CU (1)	CU22559A1 (pt)
CZ (1)	CZ291097A3 (pt)
DE (1)	DE69703813T2 (pt)
DK (1)	DK0816506T3 (pt)
EA (1)	EA000307B1 (pt)
ES (1)	ES2157060T3 (pt)
GR (1)	GR3035690T3 (pt)
HU (1)	HUP9800730A3 (pt)
IL (1)	IL121614A (pt)
MX (1)	MX9707071A (pt)
PT (1)	PT816506E (pt)
WO (1)	WO1997026359A1 (pt)

Families Citing this family (51)

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GB9726398D0 (en)	1997-12-12	1998-02-11	Isis Innovation	Polypeptide and coding sequences
CN1224708C (zh)	1998-01-14	2005-10-26	启龙股份公司	脑膜炎奈瑟氏球菌抗原
GB9808866D0 (en)	1998-04-24	1998-06-24	Smithkline Beecham Biolog	Novel compounds
GB9810276D0 (en)	1998-05-13	1998-07-15	Smithkline Beecham Biolog	Novel compounds
GB9818004D0 (en) *	1998-08-18	1998-10-14	Smithkline Beecham Biolog	Novel compounds
US7935805B1 (en) *	1998-12-31	2011-05-03	Novartis Vaccines & Diagnostics, Inc	Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
AU2221600A (en)	1998-12-31	2000-07-31	Chiron Corporation	Improved expression of hiv polypeptides and production of virus-like particles
JP2003523721A (ja) *	1998-12-31	2003-08-12	カイロンコーポレイション	抗原性ｈｉｖｃ型ポリペプチドをコードするポリヌクレオチド、ポリペプチド、およびそれらの使用
US6689879B2 (en) *	1998-12-31	2004-02-10	Chiron Corporation	Modified HIV Env polypeptides
AUPQ347199A0 (en) *	1999-10-15	1999-11-11	Csl Limited	Novel polypeptide fragments
ATE429643T1 (de)	2000-07-12	2009-05-15	Agensys Inc	Neues tumor antigen das für diagnose und therapie von blasen-, eierstock-, lungen- und nierenkrebs verwendet werden kann
WO2002018578A2 (en)	2000-08-28	2002-03-07	Agensys, Inc.	Nucleic acid and corresponding protein entitled 85p1b3 useful in treatment and detection of cancer
US6924358B2 (en)	2001-03-05	2005-08-02	Agensys, Inc.	121P1F1: a tissue specific protein highly expressed in various cancers
US7271240B2 (en)	2001-03-14	2007-09-18	Agensys, Inc.	125P5C8: a tissue specific protein highly expressed in various cancers
US20030191073A1 (en)	2001-11-07	2003-10-09	Challita-Eid Pia M.	Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer
AU2002318112B2 (en)	2001-04-10	2007-12-06	Agensys, Inc.	Nucleic acids and corresponding proteins useful in the detection and treatment of various cancers
EP2280074A3 (en) *	2001-07-05	2011-06-22	Novartis Vaccines and Diagnostics, Inc.	Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof
WO2003004620A2 (en)	2001-07-05	2003-01-16	Chiron, Corporation	Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
CU23245A1 (es) *	2001-07-16	2007-10-17	Inst De Medicina Tropical Pedr	CADENAS QUIMéRICAS CODIFICANTES PARA PROTEINAS INDUCTORAS DE EFECTOS CONTRA VIRUS. PREPARADOS UTILIZANDO PROTEINAS QUIMéRICAS
GB0121591D0 (en) *	2001-09-06	2001-10-24	Chiron Spa	Hybrid and tandem expression of neisserial proteins
KR100447530B1 (ko) *	2001-08-14	2004-09-08	한국과학기술원	ＯｍｐＦ를 이용하여 목적 단백질을 대장균 세포외로분비생산하는 방법
US20030170614A1 (en) *	2001-08-31	2003-09-11	Megede Jan Zur	Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
WO2003020876A2 (en) *	2001-08-31	2003-03-13	Chiron Corporation	Polynucleotides encoding antigenic hiv type b polypeptides, polypeptides and uses thereof
EP2287186B1 (en)	2001-09-06	2014-12-31	Agensys, Inc.	Nucleic acid and corresponding protein entitled STEAP-1 useful in treatment and detection of cancer
MX339524B (es) *	2001-10-11	2016-05-30	Wyeth Corp	Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica.
US20040081653A1 (en)	2002-08-16	2004-04-29	Raitano Arthur B.	Nucleic acids and corresponding proteins entitled 251P5G2 useful in treatment and detection of cancer
EP1565200A4 (en)	2002-11-27	2009-06-24	Agensys Inc	NUCLEIC ACID 24P4C12 AND CORRESPONDING PROTEIN FOR THE TREATMENT AND DETECTION OF CANCER
CA2860151A1 (en)	2003-02-10	2004-08-26	Agensys, Inc.	Nucleic acid and corresponding protein named 158p1d7 useful in the treatment and detection of bladder and other cancers
AU2004263823B2 (en)	2003-05-30	2008-09-18	Agensys, Inc.	Prostate stem cell antigen (PSCA) variants and subsequences thereof
US20050040037A1 (en) *	2003-08-20	2005-02-24	Walton Scott G.	Electron beam enhanced large area deposition system
CU23236A1 (es) *	2003-12-03	2007-09-26	Ct Ingenieria Genetica Biotech	PROTEINA NMB0928 Y SU USO EN FORMULACIONES FARMACéUTICAS P
CU23237A1 (es) *	2003-12-03	2007-09-26	Ct Ingenieria Genetica Biotech	PROTEINA NMB1125 Y SU USO EN FORMULACIONES FARMACéUTICAS
EP2428522A1 (en)	2004-05-28	2012-03-14	Agensys, Inc.	Antibodies that bind to PSCA proteins for diagnosis of cancer
CN100518818C (zh) *	2004-11-15	2009-07-29	中国人民解放军军事医学科学院生物工程研究所	一种预防和/或治疗消化系统肿瘤的疫苗
WO2006105488A2 (en)	2005-03-31	2006-10-05	Agensys, Inc.	Antibodies and related molecules that bind to 161p2f10b proteins
CU23578A1 (es)	2005-09-16	2010-09-30	Ct Ingenieria Genetica Biotech	Proteína de la cápsida del virus dengue inductora de respuesta protectora y composición vacunal
CU23630A1 (es)	2006-10-30	2011-02-24	Ct Ingenieria Genetica Biotech	Moléculas peptídicas quiméricas con propiedades antivirales contra los virus de la familia flaviviridae
US20110110974A1 (en) *	2007-10-29	2011-05-12	Erik Depla	Methods and kits for inducing a ctl response using a prime boost regimen
ES2625406T3 (es)	2010-03-25	2017-07-19	Oregon Health & Science University	Glicoproteínas de CMV y vectores recombinantes
EP2530159A1 (en) *	2011-06-03	2012-12-05	Sandoz Ag	Transcription terminator sequences
WO2012170765A2 (en)	2011-06-10	2012-12-13	Oregon Health & Science University	Cmv glycoproteins and recombinant vectors
EP2568289A3 (en)	2011-09-12	2013-04-03	International AIDS Vaccine Initiative	Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2586461A1 (en)	2011-10-27	2013-05-01	Christopher L. Parks	Viral particles derived from an enveloped virus
EP2679596B1 (en)	2012-06-27	2017-04-12	International Aids Vaccine Initiative	HIV-1 env glycoprotein variant
EP2848937A1 (en)	2013-09-05	2015-03-18	International Aids Vaccine Initiative	Methods of identifying novel HIV-1 immunogens
EP2873423B1 (en)	2013-10-07	2017-05-31	International Aids Vaccine Initiative	Soluble hiv-1 envelope glycoprotein trimers
EP3069730A3 (en)	2015-03-20	2017-03-15	International Aids Vaccine Initiative	Soluble hiv-1 envelope glycoprotein trimers
US9931394B2 (en)	2015-03-23	2018-04-03	International Aids Vaccine Initiative	Soluble HIV-1 envelope glycoprotein trimers
CU24705B1 (es)	2020-10-22	2024-06-11	Ct Ingenieria Genetica Biotecnologia	Antígeno quimérico que comprende el dominio extracelular de pd-l1
CU20230023A7 (es)	2023-05-12	2024-12-09	Ct Ingenieria Genetica Biotecnologia	Antígeno quimérico multiblanco para la inmunoterapia de la enfermedad de alzheimer
CN118126132B (zh) *	2024-03-06	2024-08-16	广东医保药业有限公司	多肽及其与头孢噻肟舒巴坦的组合

Family Cites Families (2)

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Publication number	Priority date	Publication date	Assignee	Title
EP0472658A4 (en) *	1989-05-19	1992-08-26	Biotechnology Res & Dev	Fusion proteins having an in vivo post-translational modification site and methods of manufacture and purification
CU22302A1 (es) *	1990-09-07	1995-01-31	Cigb	Secuencia nucleotidica codificante para una proteina de la membrana externa de neisseria meningitidis y uso de dicha proteina en preparados vacunales

1996
- 1996-01-17 CU CU1996010A patent/CU22559A1/es not_active IP Right Cessation
1997
- 1997-01-17 WO PCT/CU1997/000001 patent/WO1997026359A1/es not_active Ceased
- 1997-01-17 IL IL121614A patent/IL121614A/en not_active IP Right Cessation
- 1997-01-17 MX MX9707071A patent/MX9707071A/es not_active IP Right Cessation
- 1997-01-17 JP JP52556497A patent/JP4071282B2/ja not_active Expired - Fee Related
- 1997-01-17 US US08/930,917 patent/US6146635A/en not_active Expired - Fee Related
- 1997-01-17 CZ CZ972910A patent/CZ291097A3/cs unknown
- 1997-01-17 PT PT97901516T patent/PT816506E/pt unknown
- 1997-01-17 KR KR1019970706451A patent/KR100500782B1/ko not_active Expired - Fee Related
- 1997-01-17 EA EA199700244A patent/EA000307B1/ru not_active IP Right Cessation
- 1997-01-17 DE DE69703813T patent/DE69703813T2/de not_active Expired - Fee Related
- 1997-01-17 CN CN97190017A patent/CN1107115C/zh not_active Expired - Fee Related
- 1997-01-17 AU AU15396/97A patent/AU722317B2/en not_active Ceased
- 1997-01-17 ES ES97901516T patent/ES2157060T3/es not_active Expired - Lifetime
- 1997-01-17 HU HU9800730A patent/HUP9800730A3/hu unknown
- 1997-01-17 AR ARP970100192A patent/AR005651A1/es active IP Right Grant
- 1997-01-17 BR BRPI9704641-8A patent/BR9704641B1/pt not_active IP Right Cessation
- 1997-01-17 CA CA002214840A patent/CA2214840A1/en not_active Abandoned
- 1997-01-17 EP EP97901516A patent/EP0816506B1/en not_active Expired - Lifetime
- 1997-01-17 DK DK97901516T patent/DK0816506T3/da active
- 1997-01-17 AT AT97901516T patent/ATE198491T1/de not_active IP Right Cessation
2000
- 2000-07-10 US US09/612,925 patent/US6921809B1/en not_active Expired - Fee Related
2001
- 2001-04-02 GR GR20010400539T patent/GR3035690T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
IL121614A0 (en)	1998-02-08
KR19980703043A (ko)	1998-09-05
AU1539697A (en)	1997-08-11
DK0816506T3 (da)	2001-05-21
PT816506E (pt)	2001-06-29
CN1107115C (zh)	2003-04-30
US6921809B1 (en)	2005-07-26
HUP9800730A3 (en)	1999-07-28
EP0816506A1 (en)	1998-01-07
EA000307B1 (ru)	1999-04-29
CZ291097A3 (cs)	1998-11-11
AR005651A1 (es)	1999-07-14
DE69703813D1 (de)	2001-02-08
ATE198491T1 (de)	2001-01-15
CA2214840A1 (en)	1997-07-24
HUP9800730A2 (hu)	1998-07-28
AU722317B2 (en)	2000-07-27
BR9704641B1 (pt)	2010-03-09
EP0816506B1 (en)	2001-01-03
CU22559A1 (es)	1999-05-03
JPH11503617A (ja)	1999-03-30
KR100500782B1 (ko)	2005-11-25
EA199700244A1 (ru)	1998-02-26
GR3035690T3 (en)	2001-07-31
US6146635A (en)	2000-11-14
JP4071282B2 (ja)	2008-04-02
IL121614A (en)	2006-10-31
WO1997026359A1 (es)	1997-07-24
ES2157060T3 (es)	2001-08-01
CN1177982A (zh)	1998-04-01
MX9707071A (es)	1997-11-29
DE69703813T2 (de)	2001-08-09

Publication	Publication Date	Title
BR9704641A (pt)	1998-06-09	Sistema de expressão de antígenos heterólogos como proteínas de fusão
PT1226904E (pt)	2003-11-28	Sistema de barbear
BR9708346A (pt)	1999-08-03	Sistema de barbear
NO20001240D0 (no)	2000-03-09	Kay-A immunsystemprotein
NO20016243D0 (no)	2001-12-19	Anti-alfav-beta3-rekombinante humane antistoffer, nukleinsyrer som koder for de samme og fremgangsmåter foranvendelse
BR9503617A (pt)	1996-04-09	Sistema de fixaçao rápido
BR9503531A (pt)	1996-05-28	Sistema de suspensão para transdutores
BR9704567A (pt)	1999-01-26	Elementos de sistemas de fusão
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