BR9611448A - Combinação de glibenclamida-metformina para o tratamento de diabetes melito do tipo ii - Google Patents
Combinação de glibenclamida-metformina para o tratamento de diabetes melito do tipo iiInfo
- Publication number
- BR9611448A BR9611448A BR9611448A BR9611448A BR9611448A BR 9611448 A BR9611448 A BR 9611448A BR 9611448 A BR9611448 A BR 9611448A BR 9611448 A BR9611448 A BR 9611448A BR 9611448 A BR9611448 A BR 9611448A
- Authority
- BR
- Brazil
- Prior art keywords
- glibenclamide
- diabetes mellitus
- treatment
- type
- metformin combination
- Prior art date
Links
- 229960003105 metformin Drugs 0.000 title abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 2
- 229960004580 glibenclamide Drugs 0.000 abstract 1
- ZNNLBTZKUZBEKO-UHFFFAOYSA-N glyburide Chemical compound COC1=CC=C(Cl)C=C1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCCCC2)C=C1 ZNNLBTZKUZBEKO-UHFFFAOYSA-N 0.000 abstract 1
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI002337A IT1276130B1 (it) | 1995-11-14 | 1995-11-14 | Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo |
| PCT/EP1996/004860 WO1997017975A1 (en) | 1995-11-14 | 1996-11-07 | A glibenclamide-metformin combination for the treatment of diabetes mellitus of type ii |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9611448A true BR9611448A (pt) | 1999-03-23 |
Family
ID=11372517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9611448A BR9611448A (pt) | 1995-11-14 | 1996-11-07 | Combinação de glibenclamida-metformina para o tratamento de diabetes melito do tipo ii |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5922769A (pt) |
| EP (1) | EP0869796B1 (pt) |
| AT (1) | ATE238802T1 (pt) |
| AU (1) | AU7566896A (pt) |
| BR (1) | BR9611448A (pt) |
| DE (2) | DE69627883T2 (pt) |
| DK (1) | DK0869796T3 (pt) |
| ES (1) | ES2150889T3 (pt) |
| IT (1) | IT1276130B1 (pt) |
| PT (1) | PT869796E (pt) |
| WO (1) | WO1997017975A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6291495B1 (en) | 1997-02-24 | 2001-09-18 | Robert B. Rieveley | Method and composition for the treatment of diabetes |
| CA2312990C (en) * | 1997-12-08 | 2008-04-29 | Bristol-Myers Squibb Company | Novel salts of metformin and method |
| US6099859A (en) * | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| HRP990080B1 (en) * | 1999-03-12 | 2003-04-30 | Vladimir Leko | Plant mixture and a medical preparation for the treatment of diabetes mellitus, type ii, obtained therefrom |
| ATE250418T1 (de) * | 1998-07-15 | 2003-10-15 | Merck Sante Sas | Tabletten enthaltend eine kombination von glibenclamid und metformin |
| US6099862A (en) * | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
| AU753933B2 (en) * | 1998-09-18 | 2002-10-31 | The, Yong | Telephonic transaction system |
| US6958324B2 (en) * | 1998-12-02 | 2005-10-25 | Inotek Pharmaceuticals Corporation | Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease |
| US7056539B2 (en) | 1999-03-12 | 2006-06-06 | Vladimir Leko | Process and product extracted from herbal composition useful in controlling diabetes mellitus type II |
| JP2003520759A (ja) * | 1999-08-31 | 2003-07-08 | アンドルックス ファーマスーティカルズ インコーポレーテッド | 単位核を有する徐放性錠剤 |
| RU2275915C2 (ru) * | 1999-11-03 | 2006-05-10 | Бристол-Маерс Сквибб Компани | Способ лечения диабета |
| US6586438B2 (en) * | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| US20010036479A1 (en) * | 2000-01-14 | 2001-11-01 | Gillian Cave | Glyburide composition |
| AU2001229601A1 (en) * | 2000-01-24 | 2001-07-31 | Inotek Corporation | Method and composition for modulating an immune response |
| WO2002028181A1 (en) * | 2000-10-02 | 2002-04-11 | Usv Limited | Sustained release pharmaceutical compositions containing metformin and method of its production |
| US6866866B1 (en) * | 2000-11-03 | 2005-03-15 | Andrx Labs, Llc | Controlled release metformin compositions |
| US20060034922A1 (en) * | 2000-11-03 | 2006-02-16 | Andrx Labs, Llc | Controlled release metformin compositions |
| FR2816840B1 (fr) * | 2000-11-17 | 2004-04-09 | Flamel Tech Sa | Medicament a base de microcapsules d'anti-hyperclycemiant a liberation prolongee et son procede de preparation |
| FR2816841B1 (fr) * | 2000-11-22 | 2004-02-06 | Lipha | Nouvelles compositions pharmaceutiques a action antidiabetique et leur procede de preparation |
| JP4633329B2 (ja) | 2001-01-12 | 2011-02-16 | サン・ファーマ・アドバンスド・リサーチ・カンパニー・リミテッド | スペーストドラッグデリバリーシステム |
| RU2351317C2 (ru) * | 2001-01-12 | 2009-04-10 | Сан Фармасьютикал Индастриз Лимитед | Система раздельной доставки лекарственных средств |
| PT1377276E (pt) * | 2001-04-10 | 2011-12-30 | Sun Pharma Advanced Res Co Ltd | Composição de libertação temporizada por pulso |
| FR2825023B1 (fr) * | 2001-05-23 | 2005-04-15 | Flamel Tech Sa | Forme pharmaceutique orale antidiabetique "une prise par jour"comprenant une biguanide et au moins un autre principe actif |
| NZ530990A (en) * | 2001-08-31 | 2005-08-26 | Australian Biomedical Company | Preparation and diabetic use of gibberellins |
| EP1435931A2 (en) * | 2001-09-28 | 2004-07-14 | Sun Pharmaceuticals Industries Ltd. | Dosage form for treatment of diabetes mellitus |
| FR2830447B1 (fr) * | 2001-10-09 | 2004-04-16 | Flamel Tech Sa | Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques |
| US8101209B2 (en) | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| ITFI20010230A1 (it) * | 2001-11-29 | 2003-05-29 | Menarini Int Operations Lu Sa | Composizioni farmaceutiche per il trattamento del diabete mellito di tipo ii |
| US7183321B2 (en) * | 2001-12-17 | 2007-02-27 | Bristol-Myers Squibb Company | Antidiabetic formulation and method |
| DE60219963T2 (de) | 2002-01-25 | 2008-02-07 | Laboratorios Silanes, S.A. De C.V. | Pharmazeutische zusammensetzung, die zur glukosekontrolle im blut von patienten mit diabetes typ 2 eingesetzt wird |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| WO2003068209A1 (en) * | 2002-02-14 | 2003-08-21 | Sonus Pharmaceuticals, Inc. | Metformin salts of lipophilic acids |
| US7811593B2 (en) * | 2002-03-25 | 2010-10-12 | Jian Luo | Pharmaceutical composition with combined active agents and methods for using the same |
| KR20050005437A (ko) * | 2002-04-09 | 2005-01-13 | 플라멜 테크놀로지스 | 아목시실린의 변형 방출을 위한 마이크로캡슐 수성 현탁액형태의 경구 제약학적 제제 |
| EP1492511B3 (fr) | 2002-04-09 | 2012-05-02 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| AU2002356419A1 (en) | 2002-06-17 | 2003-12-31 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
| JP2005537298A (ja) | 2002-08-02 | 2005-12-08 | ペンウェスト ファーマシューティカルズ カンパニー | メトホルミンの徐放性製剤 |
| FR2853831A1 (fr) * | 2003-03-05 | 2004-10-22 | Usv Ltd | Forme posologique solide a usage oral de metformine et de glyburide et son procede de preparation |
| WO2004108067A2 (en) * | 2003-04-03 | 2004-12-16 | Sun Pharmaceutical Industries Limited | Programmed drug delivery system |
| US20050013863A1 (en) * | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
| AU2005284798B2 (en) * | 2004-09-15 | 2012-02-02 | The President And Fellows Of Harvard College | Reducing ER stress in the treatment of obesity and diabetes |
| US20060073213A1 (en) * | 2004-09-15 | 2006-04-06 | Hotamisligil Gokhan S | Reducing ER stress in the treatment of obesity and diabetes |
| JOP20180109A1 (ar) * | 2005-09-29 | 2019-01-30 | Novartis Ag | تركيبة جديدة |
| FR2896157B1 (fr) | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents de stimulation de secretion d'insuline. |
| WO2008062273A2 (en) * | 2006-11-20 | 2008-05-29 | Cadila Pharmaceuticals Limited | Solid oral dosage form having antidiabetic drug combination |
| CN105030793A (zh) * | 2015-08-25 | 2015-11-11 | 瑞阳制药有限公司 | 二甲双胍格列本脲胶囊及其制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2325581A1 (de) | 1973-05-19 | 1974-12-05 | Hoechst Ag | Partiell hydrierte 1h-indeno eckige klammer auf 1,2-b eckige klammer zu -pyridin-derivate und verfahren zu ihrer herstellung |
| JPS5936885B2 (ja) | 1976-06-24 | 1984-09-06 | 第一製薬株式会社 | 糖尿病治療剤 |
| DE2720926C2 (de) | 1977-05-10 | 1983-02-17 | Hoechst Ag, 6000 Frankfurt | Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung |
| GB8613688D0 (en) | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| GB8613689D0 (en) | 1986-06-05 | 1986-07-09 | Euro Celtique Sa | Pharmaceutical composition |
| US5260275A (en) | 1990-08-14 | 1993-11-09 | Amylin Pharmaceuticals, Inc. | Hypoglycemics |
| JP3338119B2 (ja) | 1993-04-14 | 2002-10-28 | 呉羽化学工業株式会社 | 抗糖尿病剤 |
-
1995
- 1995-11-14 IT IT95MI002337A patent/IT1276130B1/it active IP Right Grant
-
1996
- 1996-11-07 BR BR9611448A patent/BR9611448A/pt not_active Application Discontinuation
- 1996-11-07 DE DE69627883T patent/DE69627883T2/de not_active Expired - Lifetime
- 1996-11-07 EP EP96938124A patent/EP0869796B1/en not_active Expired - Lifetime
- 1996-11-07 AU AU75668/96A patent/AU7566896A/en not_active Abandoned
- 1996-11-07 ES ES96938124T patent/ES2150889T3/es not_active Expired - Lifetime
- 1996-11-07 WO PCT/EP1996/004860 patent/WO1997017975A1/en not_active Ceased
- 1996-11-07 DK DK96938124T patent/DK0869796T3/da active
- 1996-11-07 US US09/029,371 patent/US5922769A/en not_active Ceased
- 1996-11-07 US US09/610,548 patent/USRE37330E1/en not_active Expired - Lifetime
- 1996-11-07 DE DE0869796T patent/DE869796T1/de active Pending
- 1996-11-07 AT AT96938124T patent/ATE238802T1/de active
- 1996-11-07 PT PT96938124T patent/PT869796E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2150889T1 (es) | 2000-12-16 |
| US5922769A (en) | 1999-07-13 |
| ATE238802T1 (de) | 2003-05-15 |
| DE69627883D1 (de) | 2003-06-05 |
| ITMI952337A1 (it) | 1997-05-14 |
| EP0869796A1 (en) | 1998-10-14 |
| DK0869796T3 (da) | 2003-08-18 |
| AU7566896A (en) | 1997-06-05 |
| PT869796E (pt) | 2003-09-30 |
| USRE37330E1 (en) | 2001-08-14 |
| ITMI952337A0 (pt) | 1995-11-14 |
| HK1011525A1 (en) | 1999-07-16 |
| EP0869796B1 (en) | 2003-05-02 |
| DE869796T1 (de) | 2001-04-19 |
| ES2150889T3 (es) | 2004-01-01 |
| WO1997017975A1 (en) | 1997-05-22 |
| IT1276130B1 (it) | 1997-10-27 |
| DE69627883T2 (de) | 2004-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Change of name | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: OPINO PELO INDERFERIMENTO DO PEDIDO, PRESENTE COM BASE NO ARTIGO 37 DA LEI 9.279 DE 14/05/1996 COMBINADO O ARTIGO 229-A DA LEI 10.196 DE 14/02/2001. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A E 11A ANUIDADES. |
|
| B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1917 DE 02/10/2007 POR TER SIDO INDEVIDO. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL. |