BR9609478A - Complexos de polímeros em cascatas processos para a sua preparação e os agentes farmacêuticos contendo os mesmos - Google Patents

Complexos de polímeros em cascatas processos para a sua preparação e os agentes farmacêuticos contendo os mesmos

Info

Publication number: BR9609478A
Authority: BR; Brazil
Prior art keywords: preparation; same; pharmaceutical agents; polymer complexes; agents containing
Prior art date: 1995-07-04

Application number

BR9609478A

Other languages

English (en)

Inventor

Heribert Schmitt-Willich

Johannes Platzek

Bernd Raduechel

Andreas Muehler

Thomas Frenzel

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-04

Filing date

1996-06-20

Publication date

1999-05-25

1996-06-20 Application filed by Schering Ag filed Critical Schering Ag

1999-05-25 Publication of BR9609478A publication Critical patent/BR9609478A/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
- A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/16—Dendrimers and dendritic polymers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Radiology & Medical Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyamides (AREA)
Compositions Of Macromolecular Compounds (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Processes Of Treating Macromolecular Substances (AREA)

BR9609478A 1995-07-04 1996-06-20 Complexos de polímeros em cascatas processos para a sua preparação e os agentes farmacêuticos contendo os mesmos BR9609478A (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19525924A DE19525924A1 (de)	1995-07-04	1995-07-04	Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
PCT/EP1996/002671 WO1997002051A2 (de)	1995-07-04	1996-06-20	Kaskaden-polymer-komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number	Publication Date
BR9609478A true BR9609478A (pt)	1999-05-25

Family

ID=7766984

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BR9609478A BR9609478A (pt)	1995-07-04	1996-06-20	Complexos de polímeros em cascatas processos para a sua preparação e os agentes farmacêuticos contendo os mesmos

Country Status (26)

Country	Link
US (6)	US5820849A (pt)
EP (1)	EP0836485B1 (pt)
JP (1)	JP3723219B2 (pt)
KR (1)	KR100428272B1 (pt)
CN (2)	CN1079679C (pt)
AT (1)	ATE220924T1 (pt)
BG (1)	BG62600B1 (pt)
BR (1)	BR9609478A (pt)
CA (1)	CA2225959A1 (pt)
CL (1)	CL2004001126A1 (pt)
CZ (1)	CZ294951B6 (pt)
DE (2)	DE19525924A1 (pt)
DK (1)	DK0836485T3 (pt)
ES (1)	ES2177792T3 (pt)
IL (2)	IL122554A (pt)
MX (1)	MX9800023A (pt)
NO (1)	NO324560B1 (pt)
NZ (1)	NZ312127A (pt)
PL (1)	PL187712B1 (pt)
PT (1)	PT836485E (pt)
RU (1)	RU2166501C2 (pt)
SK (1)	SK283838B6 (pt)
TW (2)	TW200306999A (pt)
UA (1)	UA61890C2 (pt)
WO (1)	WO1997002051A2 (pt)
ZA (1)	ZA965686B (pt)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4425857A1 (de) *	1994-07-07	1996-01-11	Schering Ag	Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19525924A1 (de) *	1995-07-04	1997-01-09	Schering Ag	Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19652387A1 (de) *	1996-12-04	1998-06-10	Schering Ag	Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
DE19728954C1 (de) *	1997-06-30	1999-04-22	Schering Ag	Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19729013A1 (de) *	1997-07-03	1999-02-04	Schering Ag	Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) *	1997-07-31	2000-02-01	Schering Aktiengesellschaft	Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US7745142B2 (en)	1997-09-15	2010-06-29	Molecular Devices Corporation	Molecular modification assays
US7070921B2 (en)	2000-04-28	2006-07-04	Molecular Devices Corporation	Molecular modification assays
US7632651B2 (en)	1997-09-15	2009-12-15	Mds Analytical Technologies (Us) Inc.	Molecular modification assays
US6982431B2 (en)	1998-08-31	2006-01-03	Molecular Devices Corporation	Sample analysis systems
US6297018B1 (en)	1998-04-17	2001-10-02	Ljl Biosystems, Inc.	Methods and apparatus for detecting nucleic acid polymorphisms
DE19758105A1 (de) *	1997-12-18	1999-06-24	Schering Ag	Dendritische Polymer-Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
US7405320B2 (en) *	1998-06-22	2008-07-29	Immunomedics, Inc.	Therapeutic and diagnostic conjugates for use with multispecific antibodies
CA2371818C (en) *	1999-02-18	2009-01-06	The Regents Of The University Of California	Salicylamide-lanthanide complexes for use as luminescent markers
US6515113B2 (en)	1999-02-18	2003-02-04	The Regents Of The University Of California	Phthalamide lanthanide complexes for use as luminescent markers
BR0013171A (pt) *	1999-07-29	2002-05-28	Epix Medical Inc	Agentes multimericos para formação de imagem de objetivação através de ligação multi-local
US6549798B2 (en)	2001-02-07	2003-04-15	Epix Medical, Inc.	Magnetic resonance angiography data
US20050019267A1 (en) *	2001-06-25	2005-01-27	Brechbiel Martin W	Macromolecular imaging agents for liver imaging
DE10135356C1 (de) *	2001-07-20	2003-04-17	Schering Ag	Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
TWI221406B (en)	2001-07-30	2004-10-01	Epix Medical Inc	Systems and methods for targeted magnetic resonance imaging of the vascular system
GB0122049D0 (en) *	2001-09-12	2001-10-31	Nycomed Imaging As	Method
US7648678B2 (en)	2002-12-20	2010-01-19	Dako Denmark A/S	Method and system for pretreatment of tissue slides
AR047692A1 (es) *	2003-07-10	2006-02-08	Epix Medical Inc	Imagenes de blancos estacionarios
EP1541568A1 (de) *	2003-12-09	2005-06-15	Deutsches Wollforschungsinstitut an der Rheinisch-Westfälischen Technischen Hochschule Aachen e.V.	Reaktive cyclische Carbonate und Harnstoffe zur Modifizierung von Biomolekülen, Polymeren und Oberflächen
US7199268B2 (en)	2003-12-16	2007-04-03	Schering Aktiengesellschaft	Process for the production of dendritic trimesic acid triamides
DE10361140B4 (de) *	2003-12-16	2006-11-09	Schering Ag	Verfahren zur Herstellung von dendritischen Trimesinsäuretriamiden, dabei verwendete Diethylentriaminderivate und Verwendung der Diethylentriaminderivate
EP1706452B1 (en) *	2003-12-30	2008-09-03	The Regents of the University of California, Office of the President	Aromatic triamide-lanthanide complexes
US20050171424A1 (en) *	2004-01-13	2005-08-04	The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services	Methods for imaging the lymphatic system using dendrimer-based contrast agents
DE102004062258B3 (de) *	2004-12-23	2006-01-05	Schering Ag	Hydroxypyridinon-Derivate, deren Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
US20060204443A1 (en) *	2005-03-11	2006-09-14	The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services	Methods for tumor treatment using dendrimer conjugates
WO2008008797A2 (en)	2006-07-10	2008-01-17	The Regents Of The University Of California	Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
EP2051968B1 (en) *	2006-08-15	2020-04-29	The Regents of the University of California	Luminescent macrocyclic lanthanide complexes
WO2008022263A2 (en) *	2006-08-17	2008-02-21	Epix Pharmaceuticals, Inc.	Methods for lymph system imaging
DE102007002726A1 (de) *	2007-01-18	2008-07-31	Bayer Schering Pharma Aktiengesellschaft	Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
EP2114905B1 (en) *	2007-01-25	2015-04-15	Lumiphore, Inc.	Multi-color time resolved fluorophores based on macrocyclic lanthanide complexes
DE102007058220A1 (de)	2007-12-03	2009-06-04	Bayer Schering Pharma Aktiengesellschaft	Dimere macrocyclisch substituierte Benzolderivate
WO2009127715A1 (en) *	2008-04-18	2009-10-22	Ge Healthcare As	Compounds comprising paramagnetic chelates arranged around a central core and their use in magneto resonance imaging and spectroscopy
US20100008864A1 (en) *	2008-07-10	2010-01-14	Andreas Meijer	Aromatic multimers
WO2010051544A2 (en) *	2008-10-31	2010-05-06	Lumiphore, Inc.	Rapid homogeneous diagnostic testing platform based on lanthanide fluorescent resonance energy transfer
US9273059B2 (en)	2009-08-24	2016-03-01	Lumiphore, Inc.	Macrocyclic HOPO chelators
WO2011079291A1 (en) *	2009-12-24	2011-06-30	Lumiphore, Inc.	Radiopharmaceutical complexes
KR101334780B1 (ko)	2010-08-13	2013-12-02	한국생명공학연구원	요오드를 함유한 방사형상의 고분자 화합물, 이의 제조방법 및 이를 포함하는 ｃｔ용 조영제 조성물
WO2013187971A2 (en) *	2012-05-31	2013-12-19	The Regents Of The University Of California	Macrocycles
WO2014078690A1 (en)	2012-11-16	2014-05-22	Lumiphore, Inc.	Di-macrocycles
US11453652B2 (en)	2013-03-15	2022-09-27	Lumiphore, Inc.	Di-macrocycles
EP3101012A1 (en)	2015-06-04	2016-12-07	Bayer Pharma Aktiengesellschaft	New gadolinium chelate compounds for use in magnetic resonance imaging
KR102464647B1 (ko)	2016-11-28	2022-11-08	바이엘 파마 악티엔게젤샤프트	자기 공명 영상화에 사용하기 위한 높은 이완도 가돌리늄 킬레이트 화합물
CN109503770B (zh) *	2018-10-18	2021-03-09	合肥工业大学	一种具有高弛豫率的水溶性交联纳米聚合物及其合成方法和用途
WO2020104602A1 (en)	2018-11-23	2020-05-28	Bayer Aktiengesellschaft	Formulation of contrast media and process of preparation thereof

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4587329A (en) *	1984-08-17	1986-05-06	The Dow Chemical Company	Dense star polymers having two dimensional molecular diameter
US5527524A (en) *	1986-08-18	1996-06-18	The Dow Chemical Company	Dense star polymer conjugates
US5135737A (en) *	1986-11-10	1992-08-04	The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon	Amplifier molecules for enhancement of diagnosis and therapy
US4863717A (en) *	1986-11-10	1989-09-05	The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon	Methods for circumventing the problem of free radial reduction associated with the use of stable nitroxide free radicals as contrast agents for magnetic reasonance imaging
DE440606T1 (de) *	1987-12-24	1992-02-27	Bracco Industria Chimica S.P.A., Mailand / Milano	Macrocyclische chelatisierungsmittel und daraus hergestellte chelate.
GB8801646D0 (en) *	1988-01-26	1988-02-24	Nycomed As	Chemical compounds
US5364613A (en) *	1989-04-07	1994-11-15	Sieving Paul F	Polychelants containing macrocyclic chelant moieties
GB8923843D0 (en) *	1989-10-23	1989-12-13	Salutar Inc	Compounds
US5446145A (en) *	1990-01-19	1995-08-29	Nycomed Salutar, Inc.	Polychelant compounds
DE3938992A1 (de) *	1989-11-21	1991-05-23	Schering Ag	Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4009119A1 (de) *	1990-03-19	1991-09-26	Schering Ag	1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5162109A (en) *	1990-09-13	1992-11-10	Mallinckrodt Medical, Inc.	Magnetic resonance imaging agents
GB9024208D0 (en) *	1990-11-07	1990-12-19	Salutar Inc	Compounds
US5385719A (en) *	1991-09-24	1995-01-31	Unger; Evan C.	Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5405601A (en) *	1993-07-02	1995-04-11	Mallinckrodt Medical Inc.	Functionalized tripodal ligands for imaging applications
US5534241A (en) *	1993-07-23	1996-07-09	Torchilin; Vladimir P.	Amphipathic polychelating compounds and methods of use
US5449761A (en) *	1993-09-28	1995-09-12	Cytogen Corporation	Metal-binding targeted polypeptide constructs
DE4344464A1 (de) *	1993-12-22	1995-06-29	Schering Ag	Kaskadenpolymere mit Iodaromaten
DE4344460A1 (de) *	1993-12-22	1995-06-29	Schering Ag	Metallkomplexe von dendrimeren Makromolekülen, diese enthaltende diagnostische Mittel sowie Verfahren zur Herstellung der Komplexe und Mittel
GB9404208D0 (en) *	1994-03-04	1994-04-20	Nycomed Salutar Inc	Chelants
GB9407812D0 (en) *	1994-04-20	1994-06-15	Nycomed Salutar Inc	Compounds
DE4425857A1 (de) *	1994-07-07	1996-01-11	Schering Ag	Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5634613A (en) *	1994-07-18	1997-06-03	Mccarthy; Peter T.	Tip vortex generation technology for creating a lift enhancing and drag reducing upwash effect
US5573750A (en) *	1995-05-22	1996-11-12	Nanosystems L.L.C.	Diagnostic imaging x-ray contrast agents
DE19525924A1 (de) *	1995-07-04	1997-01-09	Schering Ag	Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US5874061A (en) *	1995-12-22	1999-02-23	Schering Aktiengesellschaft	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
GB9624822D0 (en)	1996-11-28	1997-01-15	Nycomed Imaging As	Method

1995
- 1995-07-04 DE DE19525924A patent/DE19525924A1/de not_active Ceased
1996
- 1996-06-20 NZ NZ312127A patent/NZ312127A/xx unknown
- 1996-06-20 IL IL12255496A patent/IL122554A/en not_active IP Right Cessation
- 1996-06-20 UA UA98020587A patent/UA61890C2/uk unknown
- 1996-06-20 CZ CZ19983A patent/CZ294951B6/cs not_active IP Right Cessation
- 1996-06-20 ES ES96922859T patent/ES2177792T3/es not_active Expired - Lifetime
- 1996-06-20 IL IL15025896A patent/IL150258A/en not_active IP Right Cessation
- 1996-06-20 BR BR9609478A patent/BR9609478A/pt not_active IP Right Cessation
- 1996-06-20 EP EP96922859A patent/EP0836485B1/de not_active Expired - Lifetime
- 1996-06-20 KR KR10-1998-0700006A patent/KR100428272B1/ko not_active Expired - Fee Related
- 1996-06-20 CA CA002225959A patent/CA2225959A1/en not_active Abandoned
- 1996-06-20 DK DK96922859T patent/DK0836485T3/da active
- 1996-06-20 WO PCT/EP1996/002671 patent/WO1997002051A2/de not_active Ceased
- 1996-06-20 RU RU98101903/04A patent/RU2166501C2/ru not_active IP Right Cessation
- 1996-06-20 PT PT96922859T patent/PT836485E/pt unknown
- 1996-06-20 JP JP50475697A patent/JP3723219B2/ja not_active Expired - Fee Related
- 1996-06-20 SK SK1779-97A patent/SK283838B6/sk not_active IP Right Cessation
- 1996-06-20 DE DE59609487T patent/DE59609487D1/de not_active Expired - Fee Related
- 1996-06-20 CN CN96195200A patent/CN1079679C/zh not_active Expired - Fee Related
- 1996-06-20 AT AT96922859T patent/ATE220924T1/de not_active IP Right Cessation
- 1996-06-20 PL PL96324342A patent/PL187712B1/pl not_active IP Right Cessation
- 1996-07-03 US US08/674,844 patent/US5820849A/en not_active Expired - Fee Related
- 1996-07-04 ZA ZA965686A patent/ZA965686B/xx unknown
- 1996-09-26 TW TW092119038A patent/TW200306999A/zh unknown
- 1996-09-26 TW TW085111771A patent/TW579380B/zh not_active IP Right Cessation
1997
- 1997-12-11 BG BG102111A patent/BG62600B1/bg unknown
1998
- 1998-01-02 NO NO19980002A patent/NO324560B1/no unknown
- 1998-01-07 MX MX9800023A patent/MX9800023A/es not_active IP Right Cessation
- 1998-03-18 US US09/040,364 patent/US6063361A/en not_active Expired - Fee Related
- 1998-03-19 US US09/044,254 patent/US6177060B1/en not_active Expired - Fee Related
2000
- 2000-07-20 US US09/620,989 patent/US6426059B1/en not_active Expired - Fee Related
2001
- 2001-09-11 CN CNB011421010A patent/CN1148360C/zh not_active Expired - Fee Related
2002
- 2002-05-06 US US10/138,651 patent/US6861043B2/en not_active Expired - Fee Related
2003
- 2003-10-17 US US10/686,717 patent/US7211241B2/en not_active Expired - Fee Related
2004
- 2004-05-19 CL CL200401126A patent/CL2004001126A1/es unknown

Also Published As

Publication number	Publication date
CZ398A3 (cs)	1998-04-15
KR19990028708A (ko)	1999-04-15
CN1079679C (zh)	2002-02-27
HK1050898A1 (en)	2003-07-11
NO980002D0 (no)	1998-01-02
IL122554A0 (en)	1998-06-15
IL150258A (en)	2004-06-20
SK283838B6 (sk)	2004-03-02
WO1997002051A3 (de)	1997-03-27
DE59609487D1 (de)	2002-08-29
SK177997A3 (en)	1998-07-08
US5820849A (en)	1998-10-13
CZ294951B6 (cs)	2005-04-13
US6177060B1 (en)	2001-01-23
RU2166501C2 (ru)	2001-05-10
DE19525924A1 (de)	1997-01-09
EP0836485B1 (de)	2002-07-24
ATE220924T1 (de)	2002-08-15
ES2177792T3 (es)	2002-12-16
US20040091426A1 (en)	2004-05-13
PT836485E (pt)	2002-12-31
BG102111A (en)	1998-08-31
HK1013915A1 (en)	1999-09-17
WO1997002051A2 (de)	1997-01-23
TW579380B (en)	2004-03-11
JP3723219B2 (ja)	2005-12-07
DK0836485T3 (da)	2002-09-30
IL122554A (en)	2004-06-20
JPH11510834A (ja)	1999-09-21
CN1148360C (zh)	2004-05-05
US6063361A (en)	2000-05-16
US7211241B2 (en)	2007-05-01
MX9800023A (es)	1998-07-31
AU713470B2 (en)	1999-12-02
CA2225959A1 (en)	1997-01-23
PL187712B1 (pl)	2004-09-30
NO324560B1 (no)	2007-11-19
CN1377881A (zh)	2002-11-06
NZ312127A (en)	2000-01-28
AU6358696A (en)	1997-02-05
CN1189779A (zh)	1998-08-05
US6861043B2 (en)	2005-03-01
KR100428272B1 (ko)	2004-06-16
US6426059B1 (en)	2002-07-30
PL324342A1 (en)	1998-05-25
IL150258A0 (en)	2002-12-01
CL2004001126A1 (es)	2005-03-28
UA61890C2 (en)	2003-12-15
US20020187101A1 (en)	2002-12-12
EP0836485A2 (de)	1998-04-22
TW200306999A (en)	2003-12-01
ZA965686B (en)	1997-01-24
NO980002L (no)	1998-03-04
BG62600B1 (bg)	2000-03-31

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