BG62600B1 - Стъпаловидни полимерни комплекси, метод за тяхното получаванеи съдържащи ги фармацевтични средства - Google Patents

Стъпаловидни полимерни комплекси, метод за тяхното получаванеи съдържащи ги фармацевтични средства Download PDF

Info

Publication number: BG62600B1
Authority: BG; Bulgaria
Prior art keywords: group; coch; groups; con; optionally
Prior art date: 1995-07-04

Application number

BG102111A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG102111A (en

Inventor

Heribert Schmitt-Willich

Johannes Platzek

Bernd Raduechel

Andreas Muehler

Thomas Frenzel

Original Assignee

Schering Aktiengesellschaft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-04

Filing date

1997-12-11

Publication date

2000-03-31

1997-12-11 Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft

1998-08-31 Publication of BG102111A publication Critical patent/BG102111A/xx

2000-03-31 Publication of BG62600B1 publication Critical patent/BG62600B1/bg

Links

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JHVLLYQQQYIWKX-UHFFFAOYSA-N benzyl 2-bromoacetate Chemical compound BrCC(=O)OCC1=CC=CC=C1 JHVLLYQQQYIWKX-UHFFFAOYSA-N 0.000 description 1
FDPDUUSXIPHFEB-UHFFFAOYSA-N benzyl 3-(2-bromopropanoylamino)propanoate Chemical compound CC(Br)C(=O)NCCC(=O)OCC1=CC=CC=C1 FDPDUUSXIPHFEB-UHFFFAOYSA-N 0.000 description 1
FRHWYVGCFUQMJR-UHFFFAOYSA-N benzyl 3-aminopropanoate;4-methylbenzenesulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.NCCC(=O)OCC1=CC=CC=C1 FRHWYVGCFUQMJR-UHFFFAOYSA-N 0.000 description 1
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GDZIODIYBLTRRJ-UHFFFAOYSA-N benzyl cyanoformate Chemical compound N#CC(=O)OCC1=CC=CC=C1 GDZIODIYBLTRRJ-UHFFFAOYSA-N 0.000 description 1
GYSNIACWQIDGCF-UHFFFAOYSA-N benzyl n,n-bis(2-aminoethyl)carbamate Chemical compound NCCN(CCN)C(=O)OCC1=CC=CC=C1 GYSNIACWQIDGCF-UHFFFAOYSA-N 0.000 description 1
KRJUUSWHKZZYGY-UHFFFAOYSA-N benzyl n,n-bis[2-[(2,2,2-trifluoroacetyl)amino]ethyl]carbamate Chemical compound FC(F)(F)C(=O)NCCN(CCNC(=O)C(F)(F)F)C(=O)OCC1=CC=CC=C1 KRJUUSWHKZZYGY-UHFFFAOYSA-N 0.000 description 1
125000006367 bivalent amino carbonyl group Chemical group [H]N([*:1])C([*:2])=O 0.000 description 1
238000004820 blood count Methods 0.000 description 1
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GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
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150000001649 bromium compounds Chemical class 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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DGAIEPBNLOQYER-UHFFFAOYSA-N iopromide Chemical compound COCC(=O)NC1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)N(C)CC(O)CO)=C1I DGAIEPBNLOQYER-UHFFFAOYSA-N 0.000 description 1
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238000002955 isolation Methods 0.000 description 1
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TYQCGQRIZGCHNB-JLAZNSOCSA-N l-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
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229910001425 magnesium ion Inorganic materials 0.000 description 1
MMIPFLVOWGHZQD-UHFFFAOYSA-N manganese(3+) Chemical compound [Mn+3] MMIPFLVOWGHZQD-UHFFFAOYSA-N 0.000 description 1
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238000004519 manufacturing process Methods 0.000 description 1
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239000001923 methylcellulose Substances 0.000 description 1
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238000002156 mixing Methods 0.000 description 1
230000002107 myocardial effect Effects 0.000 description 1
208000010125 myocardial infarction Diseases 0.000 description 1
BTYJSJKBQMQWHD-UHFFFAOYSA-N n'-[2-[2-(2-aminoethylamino)ethylamino]ethyl]ethane-1,2-diamine;n'-[2-(2-aminoethylamino)ethyl]ethane-1,2-diamine Chemical compound NCCNCCNCCN.NCCNCCNCCNCCN BTYJSJKBQMQWHD-UHFFFAOYSA-N 0.000 description 1
QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 description 1
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NXJCBFBQEVOTOW-UHFFFAOYSA-L palladium(2+);dihydroxide Chemical compound O[Pd]O NXJCBFBQEVOTOW-UHFFFAOYSA-L 0.000 description 1
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QLNJFJADRCOGBJ-UHFFFAOYSA-N propionamide Chemical compound CCC(N)=O QLNJFJADRCOGBJ-UHFFFAOYSA-N 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000018102 proteins Nutrition 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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230000000637 radiosensitizating effect Effects 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
230000010076 replication Effects 0.000 description 1
KZUNJOHGWZRPMI-UHFFFAOYSA-N samarium atom Chemical compound [Sm] KZUNJOHGWZRPMI-UHFFFAOYSA-N 0.000 description 1
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230000035807 sensation Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
229910001415 sodium ion Inorganic materials 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
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RINCXYDBBGOEEQ-UHFFFAOYSA-N succinic anhydride Chemical compound O=C1CCC(=O)O1 RINCXYDBBGOEEQ-UHFFFAOYSA-N 0.000 description 1
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GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
238000004448 titration Methods 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
230000009466 transformation Effects 0.000 description 1
238000000844 transformation Methods 0.000 description 1
125000004665 trialkylsilyl group Chemical group 0.000 description 1
ZOKXUAHZSKEQSS-UHFFFAOYSA-N tribufos Chemical compound CCCCSP(=O)(SCCCC)SCCCC ZOKXUAHZSKEQSS-UHFFFAOYSA-N 0.000 description 1
125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 description 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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210000001364 upper extremity Anatomy 0.000 description 1
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239000000341 volatile oil Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
- A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/76—Metal complexes of amino carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/16—Dendrimers and dendritic polymers

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Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
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Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Proteomics, Peptides & Aminoacids (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Optics & Photonics (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyamides (AREA)
Compositions Of Macromolecular Compounds (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Processes Of Treating Macromolecular Substances (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Steroid Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG102111A 1995-07-04 1997-12-11 Стъпаловидни полимерни комплекси, метод за тяхното получаванеи съдържащи ги фармацевтични средства BG62600B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19525924A DE19525924A1 (de)	1995-07-04	1995-07-04	Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
PCT/EP1996/002671 WO1997002051A2 (de)	1995-07-04	1996-06-20	Kaskaden-polymer-komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (2)

Publication Number	Publication Date
BG102111A BG102111A (en)	1998-08-31
BG62600B1 true BG62600B1 (bg)	2000-03-31

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BG102111A BG62600B1 (bg)	1995-07-04	1997-12-11	Стъпаловидни полимерни комплекси, метод за тяхното получаванеи съдържащи ги фармацевтични средства

Country Status (26)

Country	Link
US (6)	US5820849A (pt)
EP (1)	EP0836485B1 (pt)
JP (1)	JP3723219B2 (pt)
KR (1)	KR100428272B1 (pt)
CN (2)	CN1079679C (pt)
AT (1)	ATE220924T1 (pt)
BG (1)	BG62600B1 (pt)
BR (1)	BR9609478A (pt)
CA (1)	CA2225959A1 (pt)
CL (1)	CL2004001126A1 (pt)
CZ (1)	CZ294951B6 (pt)
DE (2)	DE19525924A1 (pt)
DK (1)	DK0836485T3 (pt)
ES (1)	ES2177792T3 (pt)
IL (2)	IL150258A (pt)
MX (1)	MX9800023A (pt)
NO (1)	NO324560B1 (pt)
NZ (1)	NZ312127A (pt)
PL (1)	PL187712B1 (pt)
PT (1)	PT836485E (pt)
RU (1)	RU2166501C2 (pt)
SK (1)	SK283838B6 (pt)
TW (2)	TW579380B (pt)
UA (1)	UA61890C2 (pt)
WO (1)	WO1997002051A2 (pt)
ZA (1)	ZA965686B (pt)

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1995
- 1995-07-04 DE DE19525924A patent/DE19525924A1/de not_active Ceased
1996
- 1996-06-20 CZ CZ19983A patent/CZ294951B6/cs not_active IP Right Cessation
- 1996-06-20 AT AT96922859T patent/ATE220924T1/de not_active IP Right Cessation
- 1996-06-20 NZ NZ312127A patent/NZ312127A/xx unknown
- 1996-06-20 DK DK96922859T patent/DK0836485T3/da active
- 1996-06-20 KR KR10-1998-0700006A patent/KR100428272B1/ko not_active Expired - Fee Related
- 1996-06-20 RU RU98101903/04A patent/RU2166501C2/ru not_active IP Right Cessation
- 1996-06-20 CA CA002225959A patent/CA2225959A1/en not_active Abandoned
- 1996-06-20 SK SK1779-97A patent/SK283838B6/sk not_active IP Right Cessation
- 1996-06-20 CN CN96195200A patent/CN1079679C/zh not_active Expired - Fee Related
- 1996-06-20 ES ES96922859T patent/ES2177792T3/es not_active Expired - Lifetime
- 1996-06-20 EP EP96922859A patent/EP0836485B1/de not_active Expired - Lifetime
- 1996-06-20 DE DE59609487T patent/DE59609487D1/de not_active Expired - Fee Related
- 1996-06-20 BR BR9609478A patent/BR9609478A/pt not_active IP Right Cessation
- 1996-06-20 WO PCT/EP1996/002671 patent/WO1997002051A2/de not_active Ceased
- 1996-06-20 UA UA98020587A patent/UA61890C2/uk unknown
- 1996-06-20 PT PT96922859T patent/PT836485E/pt unknown
- 1996-06-20 IL IL15025896A patent/IL150258A/en not_active IP Right Cessation
- 1996-06-20 IL IL12255496A patent/IL122554A/en not_active IP Right Cessation
- 1996-06-20 JP JP50475697A patent/JP3723219B2/ja not_active Expired - Fee Related
- 1996-06-20 PL PL96324342A patent/PL187712B1/pl not_active IP Right Cessation
- 1996-07-03 US US08/674,844 patent/US5820849A/en not_active Expired - Fee Related
- 1996-07-04 ZA ZA965686A patent/ZA965686B/xx unknown
- 1996-09-26 TW TW085111771A patent/TW579380B/zh not_active IP Right Cessation
- 1996-09-26 TW TW092119038A patent/TW200306999A/zh unknown
1997
- 1997-12-11 BG BG102111A patent/BG62600B1/bg unknown
1998
- 1998-01-02 NO NO19980002A patent/NO324560B1/no unknown
- 1998-01-07 MX MX9800023A patent/MX9800023A/es not_active IP Right Cessation
- 1998-03-18 US US09/040,364 patent/US6063361A/en not_active Expired - Fee Related
- 1998-03-19 US US09/044,254 patent/US6177060B1/en not_active Expired - Fee Related
2000
- 2000-07-20 US US09/620,989 patent/US6426059B1/en not_active Expired - Fee Related
2001
- 2001-09-11 CN CNB011421010A patent/CN1148360C/zh not_active Expired - Fee Related
2002
- 2002-05-06 US US10/138,651 patent/US6861043B2/en not_active Expired - Fee Related
2003
- 2003-10-17 US US10/686,717 patent/US7211241B2/en not_active Expired - Fee Related
2004
- 2004-05-19 CL CL200401126A patent/CL2004001126A1/es unknown

Also Published As

Publication number	Publication date
EP0836485B1 (de)	2002-07-24
RU2166501C2 (ru)	2001-05-10
JP3723219B2 (ja)	2005-12-07
WO1997002051A2 (de)	1997-01-23
DE59609487D1 (de)	2002-08-29
IL150258A (en)	2004-06-20
DK0836485T3 (da)	2002-09-30
WO1997002051A3 (de)	1997-03-27
CN1189779A (zh)	1998-08-05
JPH11510834A (ja)	1999-09-21
US6426059B1 (en)	2002-07-30
DE19525924A1 (de)	1997-01-09
NZ312127A (en)	2000-01-28
BG102111A (en)	1998-08-31
CN1079679C (zh)	2002-02-27
ATE220924T1 (de)	2002-08-15
US5820849A (en)	1998-10-13
CZ294951B6 (cs)	2005-04-13
KR19990028708A (ko)	1999-04-15
TW579380B (en)	2004-03-11
SK283838B6 (sk)	2004-03-02
CN1148360C (zh)	2004-05-05
NO980002D0 (no)	1998-01-02
UA61890C2 (en)	2003-12-15
IL122554A0 (en)	1998-06-15
KR100428272B1 (ko)	2004-06-16
ES2177792T3 (es)	2002-12-16
TW200306999A (en)	2003-12-01
EP0836485A2 (de)	1998-04-22
PT836485E (pt)	2002-12-31
US6177060B1 (en)	2001-01-23
PL324342A1 (en)	1998-05-25
AU713470B2 (en)	1999-12-02
IL122554A (en)	2004-06-20
CA2225959A1 (en)	1997-01-23
US20020187101A1 (en)	2002-12-12
BR9609478A (pt)	1999-05-25
NO980002L (no)	1998-03-04
MX9800023A (es)	1998-07-31
HK1050898A1 (en)	2003-07-11
ZA965686B (en)	1997-01-24
US6861043B2 (en)	2005-03-01
US20040091426A1 (en)	2004-05-13
AU6358696A (en)	1997-02-05
CZ398A3 (cs)	1998-04-15
NO324560B1 (no)	2007-11-19
PL187712B1 (pl)	2004-09-30
SK177997A3 (en)	1998-07-08
CN1377881A (zh)	2002-11-06
HK1013915A1 (en)	1999-09-17
CL2004001126A1 (es)	2005-03-28
IL150258A0 (en)	2002-12-01
US6063361A (en)	2000-05-16
US7211241B2 (en)	2007-05-01

Publication	Publication Date	Title
BG62600B1 (bg)	2000-03-31	Стъпаловидни полимерни комплекси, метод за тяхното получаванеи съдържащи ги фармацевтични средства
US6248306B1 (en)	2001-06-19	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
US6057419A (en)	2000-05-02	Cascade polymer complexes, process for producing the same and pharmaceuticals containing the same
US5874061A (en)	1999-02-23	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
US6166200A (en)	2000-12-26	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
AU726604B2 (en)	2000-11-16	Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
AU726034B2 (en)	2000-10-26	Cascade polymer complexes, process for their production and pharmaceutical agents that contain the latter
AU5502100A (en)	2000-11-09	Cascade polymer complexes, process for producing the same and pharmaceuticals containing the same