BR9503881A - Heterociclilbenzoilguanidina processo para sua preparação processo para a produção de preparações farmacêuticas preparações farmacêuticas e utilização - Google Patents
Heterociclilbenzoilguanidina processo para sua preparação processo para a produção de preparações farmacêuticas preparações farmacêuticas e utilizaçãoInfo
- Publication number
- BR9503881A BR9503881A BR9503881A BR9503881A BR9503881A BR 9503881 A BR9503881 A BR 9503881A BR 9503881 A BR9503881 A BR 9503881A BR 9503881 A BR9503881 A BR 9503881A BR 9503881 A BR9503881 A BR 9503881A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical preparations
- halo
- heterocyclylbenzoylguanidine
- production
- ch2f
- Prior art date
Links
- 239000000825 pharmaceutical preparation Substances 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 5
- JNCMHMUGTWEVOZ-UHFFFAOYSA-N F[CH]F Chemical compound F[CH]F JNCMHMUGTWEVOZ-UHFFFAOYSA-N 0.000 abstract 3
- 108010081348 HRT1 protein Hairy Proteins 0.000 abstract 3
- 102100021881 Hairy/enhancer-of-split related with YRPW motif protein 1 Human genes 0.000 abstract 3
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 3
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000005004 perfluoroethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000004981 cycloalkylmethyl group Chemical group 0.000 abstract 1
- AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical compound NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/68—One oxygen atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Furan Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4430861A DE4430861A1 (de) | 1994-08-31 | 1994-08-31 | Heterocyclyl-benzoylguanidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9503881A true BR9503881A (pt) | 1996-09-17 |
Family
ID=6526985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9503881A BR9503881A (pt) | 1994-08-31 | 1995-08-31 | Heterociclilbenzoilguanidina processo para sua preparação processo para a produção de preparações farmacêuticas preparações farmacêuticas e utilização |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5753680A (pt) |
| EP (1) | EP0699666B1 (pt) |
| JP (1) | JP4023841B2 (pt) |
| KR (1) | KR100375788B1 (pt) |
| CN (1) | CN1058004C (pt) |
| AT (1) | ATE175406T1 (pt) |
| AU (1) | AU702258B2 (pt) |
| BR (1) | BR9503881A (pt) |
| CA (1) | CA2157146C (pt) |
| CZ (1) | CZ286400B6 (pt) |
| DE (2) | DE4430861A1 (pt) |
| DK (1) | DK0699666T3 (pt) |
| ES (1) | ES2129716T3 (pt) |
| GR (1) | GR3029894T3 (pt) |
| HU (1) | HUT73183A (pt) |
| NO (1) | NO305798B1 (pt) |
| PL (1) | PL183393B1 (pt) |
| RU (1) | RU2152390C1 (pt) |
| SK (1) | SK281446B6 (pt) |
| TW (1) | TW354783B (pt) |
| UA (1) | UA35609C2 (pt) |
| ZA (1) | ZA957284B (pt) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4328352A1 (de) | 1993-08-24 | 1995-03-02 | Hoechst Ag | Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| ZA967800B (en) * | 1995-09-20 | 1997-04-03 | Yamanouchi Pharma Co Ltd | Heteroaryllsubstituted acryloylguanidine derivatives and pharmaceutical compositions comprising them |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| NZ314105A (en) * | 1996-02-02 | 1997-12-19 | Sumitomo Pharma | Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring |
| DE19608162A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19608161A1 (de) * | 1996-03-04 | 1997-09-11 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19624178A1 (de) * | 1996-06-18 | 1998-01-08 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| WO1998039300A1 (en) * | 1997-03-06 | 1998-09-11 | Toa Eiyo Ltd. | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME |
| DE19738604A1 (de) * | 1997-09-04 | 1999-03-11 | Hoechst Marion Roussel De Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verminderung der Giftigkeit cardiotoxischer Stoffe |
| DE19833118C2 (de) | 1998-07-23 | 2000-07-27 | Merck Patent Gmbh | Verfahren zur Herstellung von orthoalkylierten Benzoesäurederivaten |
| JP2002530325A (ja) * | 1998-11-26 | 2002-09-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 非インスリン依存型真性糖尿病の治療へのベンゾイルグアニジンの使用 |
| DE19859727A1 (de) | 1998-12-23 | 2000-06-29 | Aventis Pharma Gmbh | Die Verwendung von Hemmern des Natrium-Wasserstoff-Austauschers zur Herstellung eines Medikaments zur Verhinderung von altersbedingten Organ-Dysfunktionen, altersbedingten Erkrankungen zur Lebensverlängerung |
| DE19903275A1 (de) * | 1999-01-28 | 2000-08-03 | Merck Patent Gmbh | Lyophilisate mit verbesserter Rekonstituierbarkeit |
| DE19919349A1 (de) * | 1999-04-28 | 2000-11-02 | Merck Patent Gmbh | Verfahren zur Herstellung eines Benzoylguanidinderivates |
| DE19929857A1 (de) * | 1999-06-29 | 2001-01-04 | Merck Patent Gmbh | Verfahren zur Herstellung eines 4-(Pyrrol-1-yl)-benzoylguanidinderivates |
| DE19950898A1 (de) | 1999-10-22 | 2001-04-26 | Aventis Pharma Gmbh | Heterocyclisch substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE10001879A1 (de) * | 2000-01-19 | 2001-07-19 | Aventis Pharma Gmbh | Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| IL147696A0 (en) * | 2001-01-25 | 2002-08-14 | Pfizer Prod Inc | Combination therapy |
| EP2174933B1 (en) * | 2003-03-13 | 2019-04-03 | Idemitsu Kosan Co., Ltd. | Benzimidazole derivatives for use in organic electroluminescent devices |
| CN1784381A (zh) * | 2003-05-06 | 2006-06-07 | 默克专利股份公司 | 胍盐的结晶方法 |
| KR100658698B1 (ko) * | 2004-12-27 | 2006-12-19 | 한국화학연구원 | 벤조싸이오펜-2-카르보닐구아니딘 유도체, 이의 제조방법및 이를 포함하는 약학적 조성물 |
| US7875625B2 (en) * | 2005-02-16 | 2011-01-25 | Toa Eiyo Ltd. | Cyclohepta[b]pyridine-3-carbonylguanidine derivative and pharmaceutical product containing same |
| CN100371328C (zh) * | 2006-01-19 | 2008-02-27 | 中国药科大学 | 取代苯甲酰基胍衍生物、其制备方法及其医药用途 |
| JP2011527677A (ja) * | 2008-07-08 | 2011-11-04 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| EP0556673B1 (de) * | 1992-02-15 | 1997-09-17 | Hoechst Aktiengesellschaft | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| CZ284456B6 (cs) * | 1992-02-15 | 1998-12-16 | Hoechst Aktiengesellschaft | Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje |
| EP0556674B1 (de) * | 1992-02-15 | 1996-06-19 | Hoechst Aktiengesellschaft | 3,5-Substituierte Benzoylguanidine, mit antiarrythmischer Wirkung und inhibierender Wirkung auf die Proliferationen von Zellen |
| DE4328869A1 (de) * | 1993-08-27 | 1995-03-02 | Hoechst Ag | Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE4404183A1 (de) * | 1994-02-10 | 1995-08-17 | Merck Patent Gmbh | 4-Amino-1-piperidylbenzoylguanidine |
-
1994
- 1994-08-31 DE DE4430861A patent/DE4430861A1/de not_active Withdrawn
-
1995
- 1995-07-21 TW TW084107588A patent/TW354783B/zh active
- 1995-08-21 SK SK1029-95A patent/SK281446B6/sk unknown
- 1995-08-23 UA UA95083918A patent/UA35609C2/uk unknown
- 1995-08-24 AT AT95113307T patent/ATE175406T1/de not_active IP Right Cessation
- 1995-08-24 DE DE59504721T patent/DE59504721D1/de not_active Expired - Lifetime
- 1995-08-24 EP EP95113307A patent/EP0699666B1/de not_active Expired - Lifetime
- 1995-08-24 ES ES95113307T patent/ES2129716T3/es not_active Expired - Lifetime
- 1995-08-24 DK DK95113307T patent/DK0699666T3/da active
- 1995-08-24 AU AU30250/95A patent/AU702258B2/en not_active Ceased
- 1995-08-29 CA CA002157146A patent/CA2157146C/en not_active Expired - Fee Related
- 1995-08-29 CZ CZ19952202A patent/CZ286400B6/cs not_active IP Right Cessation
- 1995-08-30 CN CN95116901A patent/CN1058004C/zh not_active Expired - Fee Related
- 1995-08-30 PL PL95310224A patent/PL183393B1/pl not_active IP Right Cessation
- 1995-08-30 ZA ZA957284A patent/ZA957284B/xx unknown
- 1995-08-30 NO NO953404A patent/NO305798B1/no not_active IP Right Cessation
- 1995-08-30 RU RU95114847/04A patent/RU2152390C1/ru not_active IP Right Cessation
- 1995-08-30 US US08/520,780 patent/US5753680A/en not_active Expired - Lifetime
- 1995-08-30 HU HU9502548A patent/HUT73183A/hu unknown
- 1995-08-31 BR BR9503881A patent/BR9503881A/pt not_active Application Discontinuation
- 1995-08-31 KR KR1019950027957A patent/KR100375788B1/ko not_active Expired - Fee Related
- 1995-08-31 JP JP24515195A patent/JP4023841B2/ja not_active Expired - Fee Related
-
1999
- 1999-04-07 GR GR990400985T patent/GR3029894T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5753680A (en) | 1998-05-19 |
| NO305798B1 (no) | 1999-07-26 |
| HUT73183A (en) | 1996-06-28 |
| DE59504721D1 (de) | 1999-02-18 |
| AU3025095A (en) | 1996-03-14 |
| EP0699666A1 (de) | 1996-03-06 |
| DE4430861A1 (de) | 1996-03-07 |
| CN1126720A (zh) | 1996-07-17 |
| NO953404D0 (no) | 1995-08-30 |
| HU9502548D0 (en) | 1995-10-30 |
| CZ220295A3 (en) | 1996-08-14 |
| JP4023841B2 (ja) | 2007-12-19 |
| ES2129716T3 (es) | 1999-06-16 |
| ATE175406T1 (de) | 1999-01-15 |
| EP0699666B1 (de) | 1999-01-07 |
| PL310224A1 (en) | 1996-03-04 |
| CA2157146A1 (en) | 1996-03-01 |
| SK102995A3 (en) | 1996-06-05 |
| DK0699666T3 (da) | 1999-08-30 |
| CZ286400B6 (en) | 2000-04-12 |
| KR100375788B1 (ko) | 2003-07-18 |
| SK281446B6 (sk) | 2001-03-12 |
| PL183393B1 (pl) | 2002-06-28 |
| CN1058004C (zh) | 2000-11-01 |
| AU702258B2 (en) | 1999-02-18 |
| GR3029894T3 (en) | 1999-07-30 |
| NO953404L (no) | 1996-03-01 |
| KR960007564A (ko) | 1996-03-22 |
| JPH0873427A (ja) | 1996-03-19 |
| CA2157146C (en) | 2007-05-22 |
| UA35609C2 (uk) | 2001-04-16 |
| TW354783B (en) | 1999-03-21 |
| RU2152390C1 (ru) | 2000-07-10 |
| ZA957284B (en) | 1996-04-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9503881A (pt) | Heterociclilbenzoilguanidina processo para sua preparação processo para a produção de preparações farmacêuticas preparações farmacêuticas e utilização | |
| FI955024A0 (fi) | Uudet piperidiiniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset | |
| BR9503817A (pt) | Derivados de ácido benzóico orto-substituídos processo para sua preparação processo para a produção de uma preparação farmacêutica preparação farmacêutica e uso | |
| NO305242B1 (no) | Arylbenzoylguanidiner, farmas°ytiske preparater som inneholder minst Ún slik forbindelse, samt anvendelse av forbindelsene til fremstilling av legemidler | |
| BR9503854A (pt) | Alquilbenzoilguanidinas compostos processo para a preparação de derivados de alquilbenzoilguanidina processo para produzir preparações farmacêuticas preparação farmacêutica e uso | |
| NO306991B1 (no) | Alkenylbenzoylguanidinderivater, farmasoeytiske preparater som inneholder slike, samt anvendelse av forbindelsene til fremstilling av legemidler | |
| BR9504489A (pt) | Derivados de benzoilguanidinas processo para sua preparaçao processo para a produçao de preparados farmacêuticos preparado farmacêutico e uso | |
| DK0694537T3 (da) | Heterocyclyloxy-benzoylguanidinderivater, fremstilling deraf og anvendelse deraf som inhibitorer for den cellulære Na+/H+-antiporter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |