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BR9007477A - Protease de subtilisina mutante e processo para a determinacao ou selecao da(s)posicao(oes)e do(s)aminoacido(s)a remover,substituir ou inserir no lugar do(s)aminoacido(s)da enzima mae - Google Patents

Protease de subtilisina mutante e processo para a determinacao ou selecao da(s)posicao(oes)e do(s)aminoacido(s)a remover,substituir ou inserir no lugar do(s)aminoacido(s)da enzima mae

Info

Publication number
BR9007477A
BR9007477A BR909007477A BR9007477A BR9007477A BR 9007477 A BR9007477 A BR 9007477A BR 909007477 A BR909007477 A BR 909007477A BR 9007477 A BR9007477 A BR 9007477A BR 9007477 A BR9007477 A BR 9007477A
Authority
BR
Brazil
Prior art keywords
maine
enzyme
replace
insert
selecting
Prior art date
Application number
BR909007477A
Other languages
English (en)
Inventor
Sven Branner
Sven Hastrup
Ole Hvisted Olsen
Leif Norskov-Lauritsen
Merete Simonsen
Dorrit Aaslyng
Eric Casteleijn
Maarten Robert Egmond
Johan Haverkamp
John David Marugg
Arnoldus Theodorus Anth Mooren
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8119873&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9007477(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of BR9007477A publication Critical patent/BR9007477A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38636—Preparations containing enzymes, e.g. protease or amylase containing enzymes other than protease, amylase, lipase, cellulase, oxidase or reductase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Detergent Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
BR909007477A 1989-06-26 1990-06-26 Protease de subtilisina mutante e processo para a determinacao ou selecao da(s)posicao(oes)e do(s)aminoacido(s)a remover,substituir ou inserir no lugar do(s)aminoacido(s)da enzima mae BR9007477A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK316989A DK316989D0 (da) 1989-06-26 1989-06-26 Enzymer
PCT/DK1990/000164 WO1991000345A1 (en) 1989-06-26 1990-06-26 A mutated subtilisin protease

Publications (1)

Publication Number Publication Date
BR9007477A true BR9007477A (pt) 1992-06-02

Family

ID=8119873

Family Applications (1)

Application Number Title Priority Date Filing Date
BR909007477A BR9007477A (pt) 1989-06-26 1990-06-26 Protease de subtilisina mutante e processo para a determinacao ou selecao da(s)posicao(oes)e do(s)aminoacido(s)a remover,substituir ou inserir no lugar do(s)aminoacido(s)da enzima mae

Country Status (12)

Country Link
EP (5) EP0945502B1 (pt)
JP (3) JP3343115B2 (pt)
KR (1) KR100258459B1 (pt)
AT (5) ATE293687T1 (pt)
AU (1) AU5956690A (pt)
BR (1) BR9007477A (pt)
CA (1) CA2062732C (pt)
DE (6) DE69034187T2 (pt)
DK (3) DK316989D0 (pt)
ES (2) ES2152209T3 (pt)
FI (3) FI102907B1 (pt)
WO (1) WO1991000345A1 (pt)

Families Citing this family (178)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6287841B1 (en) 1988-02-11 2001-09-11 Genencor International, Inc. High alkaline serine protease
US5352603A (en) * 1989-08-31 1994-10-04 Kali-Chemie Ag Highly alkaline proteases
DE4023458A1 (de) * 1989-08-31 1991-03-07 Kali Chemie Ag Neue hochalkalische proteasen
US6271012B1 (en) * 1989-10-11 2001-08-07 Genencor International, Inc. Protease muteins and their use in detergents
DK271490D0 (da) * 1990-11-14 1990-11-14 Novo Nordisk As Detergentkomposition
DK0561907T3 (da) * 1990-12-05 1999-05-31 Novo Nordisk As Proteiner med ændrede epitoper og fremgangsmåder til fremstilling deraf
US5482849A (en) * 1990-12-21 1996-01-09 Novo Nordisk A/S Subtilisin mutants
BR9107258A (pt) * 1990-12-21 1994-02-22 Novo Nordisk As Protease mutante e processo compreendendo o tratamento de uma protease
DE4106525A1 (de) * 1991-03-01 1992-09-10 Solvay Enzymes Gmbh & Co Kg Verfahren zur verbesserung der stabilitaet von hochalkalischen proteasen
ES2090481T3 (es) * 1991-05-01 1996-10-16 Unilever Nv Composiciones detergentes que contienen enzimas estabilizadas.
DE69226182T2 (de) * 1991-05-01 1999-01-21 Novo Nordisk A/S, Bagsvaerd Stabilisierte enzyme und waschmittelzusammensetzungen
US5275945A (en) * 1991-10-08 1994-01-04 Vista Chemical Company Alkaline proteases stable in heavy-duty detergent liquids
EP0608258A1 (en) * 1991-10-16 1994-08-03 Unilever Plc Aqueous enzymatic detergent compositions
PL178045B1 (pl) * 1992-07-17 2000-02-29 Genencor Int Mutant proteazy do stosowania w detergentach, sekwencja DNA kodująca mutanta proteazy, sposób otrzymywania mutanta proteazy oraz kompozycja detergentowa
EP1431389A3 (en) * 1992-10-06 2004-06-30 Novozymes A/S Cellulase variants
DE4304161A1 (de) * 1993-02-12 1994-08-25 Solvay Enzymes Gmbh & Co Kg Verbesserte hochalkalische Proteasen
DK39093D0 (da) * 1993-04-01 1993-04-01 Novo Nordisk As Enzym
US6436690B1 (en) 1993-09-15 2002-08-20 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis wherein one or more loop regions are substituted
US6440717B1 (en) 1993-09-15 2002-08-27 The Procter & Gamble Company BPN′ variants having decreased adsorption and increased hydrolysis
FI961502A7 (fi) * 1993-10-04 1996-05-30 Novozymes As Modifioitua entsyymiä sisältävä entsyymivalmiste
JP2888986B2 (ja) * 1993-10-14 1999-05-10 ザ、プロクター、エンド、ギャンブル、カンパニー プロテアーゼ酵素を含んでなる漂白組成物
MA23346A1 (fr) 1993-10-14 1995-04-01 Genencor Int Variantes de la subtilisine
WO1995010591A1 (en) * 1993-10-14 1995-04-20 The Procter & Gamble Company Protease-containing cleaning compositions
ATE390487T1 (de) 1994-02-24 2008-04-15 Henkel Kgaa Verbesserte enzyme und diese enthaltene detergentien
ES2364774T3 (es) 1994-02-24 2011-09-14 HENKEL AG & CO. KGAA Enzimas mejoradas y detergentes que las contienen.
US6110884A (en) * 1994-03-29 2000-08-29 Novo Nordisk A/S Protease variants
US6599730B1 (en) 1994-05-02 2003-07-29 Procter & Gamble Company Subtilisin 309 variants having decreased adsorption and increased hydrolysis
US6066611A (en) * 1994-10-13 2000-05-23 The Procter & Gamble Company Bleaching compositions comprising protease enzymes
US6455295B1 (en) 1995-03-08 2002-09-24 The Procter & Gamble Company Subtilisin Carlsberg variants having decreased adsorption and increased hydrolysis
IL117350A0 (en) 1995-03-09 1996-07-23 Procter & Gamble Proteinase k variants having decreased adsorption and increased hydrolysis
IL117352A0 (en) * 1995-03-09 1996-07-23 Procter & Gamble Thermitase variants having decreased adsorption and increased hydrolysis
US6475765B1 (en) 1995-03-09 2002-11-05 Procter & Gamble Company Subtilisin DY variants having decreased adsorption and increased hydrolysis
US6682924B1 (en) 1995-05-05 2004-01-27 Novozymes A/S Protease variants and compositions
US5837517A (en) 1995-05-05 1998-11-17 Novo Nordisk A/S Protease variants and compositions
CN100387712C (zh) * 1995-05-05 2008-05-14 诺沃奇梅兹有限公司 蛋白酶变体和组合物
DE19530816A1 (de) 1995-08-23 1997-02-27 Cognis Bio Umwelt Verwendung von mutierter Subtilisin-Protease in kosmetischen Produkten
ATE409743T1 (de) 1996-11-04 2008-10-15 Novozymes As Subtilase varianten und verbindungen
WO1998020115A1 (en) 1996-11-04 1998-05-14 Novo Nordisk A/S Subtilase variants and compositions
AU8798198A (en) 1997-08-29 1999-03-22 Novo Nordisk A/S Protease variants and compositions
BR9811412A (pt) 1997-08-29 2000-08-22 Novo Nordisk As Variante de enzima subtilase tendo melhorado desempenho de lavagem em detergentes, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, processos para produzir uma variante e para identificar uma variante de protease, composição, e, uso de uma variante de subtilase
MA25044A1 (fr) * 1997-10-23 2000-10-01 Procter & Gamble Compositions de lavage contenant des variants de proteases multisubstituees.
RU2269572C2 (ru) * 1997-10-23 2006-02-10 Джененкор Интернэшнл, Инк. Варианты протеазы, замещенные в нескольких положениях
ES2367505T3 (es) 1997-10-23 2011-11-04 Danisco Us Inc. Variantes de proteasa con sustituciones múltiples con carga neta alterada para usar en detergentes.
US6773907B2 (en) 1997-11-21 2004-08-10 Peter Kamp Hansen Subtilase enzymes
US6780629B2 (en) 1997-11-21 2004-08-24 Novozymes A/S Subtilase enzymes
AU1225099A (en) 1997-11-21 1999-06-15 Novo Nordisk A/S Protease variants and compositions
CA2313950A1 (en) † 1997-12-24 1999-07-08 James T. Kellis, Jr. An improved method of assaying for a preferred enzyme and /or preferred detergent composition
US6908757B1 (en) 1998-03-26 2005-06-21 The Procter & Gamble Company Serine protease variants having amino acid deletions and substitutions
JP2003512012A (ja) * 1998-10-23 2003-04-02 ザ、プロクター、エンド、ギャンブル、カンパニー 洗剤組成物に用いられるプロテアーゼ変異体のスクリーニング法
CA2355579C (en) * 1998-12-18 2011-11-22 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having an additional amino acid residue in an active site loop region
DE69943346D1 (de) 1998-12-18 2011-05-19 Novozymes As Subtilase Enzyme der I-S1- und I-S2-Untergruppen mit einem zusätzlichen Aminosäurerest in einer aktiven Schleifenregion
DE69936933T2 (de) * 1998-12-18 2008-05-15 Novozymes A/S SUBTILASE ENZYME DER I-S1 und I-S2 UNTERGRUPPEN MIT EINEM ZUSÄTZLICHEN AMINOSÄUREREST IN EINER AKTIVEN SCHLEIFENREGION
ATE408678T1 (de) 1999-05-20 2008-10-15 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 129 und 130
DE60040287D1 (de) 1999-05-20 2008-10-30 Novozymes As Subtilase enzyme der i-s1 und i-s2 untergruppen mit mindestens einer zusätzlichen aminosäure zwischen position 128 und 129
WO2000071689A1 (en) 1999-05-20 2000-11-30 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 127 and 128
EP1183340B1 (en) 1999-05-20 2008-09-03 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 126 and 127
BR0010738A (pt) † 1999-05-20 2002-02-19 Novozymes As Enzima subtilase do sub gupo i-s1 ou i-s20, enazima subtilase isolada, variante de subtilase, sequência de dna isolada, vetor de expressão, célula hospedeira microbiana, hospedeiro microbiano, método para a produção de uma subtilase ou uma variante de subtilase, composição, e, uso de uma subtilase ou uma variante de subtilase
EP1183337B1 (en) 1999-05-20 2008-09-17 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 132 and 133
EP1183343B2 (en) 1999-05-20 2013-11-27 Novozymes A/S Subtilase enzymes of the i-s1 and i-s2 sub-groups having at least one additional amino acid residue between positions 125 and 126
US6946128B1 (en) 1999-07-22 2005-09-20 The Procter & Gamble Company Protease conjugates having sterically protected epitope regions
US6727085B2 (en) 1999-12-15 2004-04-27 Fanoe Tina Sejersgaard Subtilase variants having an improved wash performance on egg stains
US6777218B1 (en) 2000-03-14 2004-08-17 Novozymes A/S Subtilase enzymes having an improved wash performance on egg stains
EP1313846B1 (en) 2000-08-21 2013-10-16 Novozymes A/S Subtilase enzymes
AU2002210379A1 (en) 2000-10-13 2002-04-22 Novozymes A/S Subtilase variants
FI111728B (fi) * 2000-10-13 2003-09-15 Valtion Teknillinen Menetelmä proteiinin rakenteen muuttamiseksi
US6673580B2 (en) 2000-10-27 2004-01-06 Genentech, Inc. Identification and modification of immunodominant epitopes in polypeptides
US6803222B2 (en) 2000-11-22 2004-10-12 Kao Corporation Alkaline proteases
GB0102929D0 (en) * 2001-02-06 2001-03-21 Inpharmatica Ltd Novel proteins
US20050101012A1 (en) 2001-03-12 2005-05-12 Gerold Schuler CD4+CD25+ regulatory T cells from human blood
DK200101090A (da) 2001-07-12 2001-08-16 Novozymes As Subtilase variants
DE10153792A1 (de) 2001-10-31 2003-05-22 Henkel Kgaa Neue Alkalische Protease-Varianten und Wasch- und Reinigungsmittel enthaltend diese neuen Alkalischen Protease-Varianten
DE10162727A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14391) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
DE10162728A1 (de) 2001-12-20 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus gibsonii (DSM 14393) und Wasch-und Reinigungsmittel enthaltend diese neue Alkalische Protease
EP1321513A1 (en) * 2001-12-21 2003-06-25 Direvo Biotech AG Subtilisin variants with improved characteristics
DE10163884A1 (de) 2001-12-22 2003-07-10 Henkel Kgaa Neue Alkalische Protease aus Bacillus sp. (DSM 14392) und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease
JP4703113B2 (ja) * 2002-01-16 2011-06-15 ジェネンコー・インターナショナル・インク 複数置換プロテアーゼ変異体
AU2003214037A1 (en) 2002-03-27 2003-10-08 Novozymes A/S Granules with filamentous coatings
US8222033B2 (en) 2002-08-12 2012-07-17 Argos Therapeutics, Inc. CD4+CD25− T cells and Tr1-like regulatory T cells
TWI319007B (en) 2002-11-06 2010-01-01 Novozymes As Subtilase variants
US7888093B2 (en) 2002-11-06 2011-02-15 Novozymes A/S Subtilase variants
EP1590455B1 (en) 2003-01-27 2010-03-17 Novozymes A/S Stabilization of granules
ATE368105T1 (de) 2003-02-07 2007-08-15 Novozymes As Proteasen
DE602004021242D1 (de) 2003-03-18 2009-07-09 Novozymes As Umhüllte enzymkörnchen
CN1784490A (zh) 2003-05-07 2006-06-07 诺和酶股份有限公司 变体枯草杆菌蛋白酶(枯草杆菌酶)
EP1673451B1 (en) 2003-10-10 2010-12-15 Novozymes A/S Protease variants
WO2005040372A1 (en) 2003-10-23 2005-05-06 Novozymes A/S Protease with improved stability in detergents
TWI356821B (en) 2003-12-01 2012-01-21 Cambridge Entpr Ltd Anti-inflammatory agents
EP2305821A3 (en) 2004-02-13 2011-04-13 Novozymes A/S Protease variants
ES2380105T3 (es) * 2004-06-21 2012-05-08 Novozymes A/S Proteasas de Nocardiopsis
CN101040052A (zh) 2004-09-10 2007-09-19 诺维信北美公司 防止、去除、减少或破坏生物膜的方法
PL1804592T3 (pl) 2004-09-27 2010-04-30 Novozymes As Granulki z enzymem
ATE529505T1 (de) 2005-07-08 2011-11-15 Novozymes As Subtilase varianten
EP1934342B1 (en) 2005-09-30 2014-12-10 Novozymes A/S Immobilization of enzymes
WO2007098756A1 (en) 2006-03-02 2007-09-07 Novozymes A/S High capacity encapsulation process
EP2383330A1 (en) 2006-03-31 2011-11-02 Novozymes A/S A stabilized liquid enzyme composition
EP2007942B1 (en) 2006-04-14 2014-07-09 Danisco US Inc. One-step treatment of textiles
JP2009534022A (ja) 2006-04-20 2009-09-24 ノボザイムス アクティーゼルスカブ 卵のシミに対する洗浄能力が向上したサビナーゼ変異体
AU2007256780B2 (en) 2006-06-02 2013-08-29 President And Fellows Of Harvard College Protein surface remodeling
JP5396270B2 (ja) * 2006-06-02 2014-01-22 プレジデント アンド フェロウズ オブ ハーバード カレッジ タンパク質表面のリモデリング
JP2009543577A (ja) * 2006-07-18 2009-12-10 ダニスコ・ユーエス・インク、ジェネンコー・ディビジョン 幅広い温度におけるプロテアーゼ変異体の活性
US20080031998A1 (en) 2006-08-07 2008-02-07 Novozymes A/S Enzyme Granules for Animal Feed
EP2051590B1 (en) 2006-08-07 2016-04-20 Novozymes A/S Enzyme granules for animal feed
WO2008040818A1 (en) 2006-10-06 2008-04-10 Novozymes A/S Detergent compositions and the use of enzyme combinations therein
JP2008212084A (ja) 2007-03-06 2008-09-18 Kao Corp アルカリプロテアーゼ
WO2008134343A1 (en) 2007-04-30 2008-11-06 Danisco Us Inc., Genencor Division Use of protein hydrolysates to stabilize metalloprotease detergent formulations
US9133425B2 (en) * 2007-06-06 2015-09-15 Danisco Us Inc. Methods for improving multiple protein properties
SG148934A1 (en) 2007-06-11 2009-01-29 Novozymes As A process for combined biopolishing and bleach clean-up
EP2262885B1 (en) 2008-03-28 2013-05-15 Novozymes A/S Triggered release system
EP3095859A1 (en) * 2008-06-06 2016-11-23 Danisco US Inc. Compositions and methods comprising variant microbial proteases
ES2569913T3 (es) 2008-07-07 2016-05-13 Basf Se Composición de enzima que comprende partículas poliméricas que contienen enzima
CN202181298U (zh) 2008-09-12 2012-04-04 荷兰联合利华有限公司 用于粘性液体的分配器和预处理器
RU2011123911A (ru) * 2008-11-11 2012-12-20 ДАНИСКО ЮЭс ИНК. Композиции, содержащие варианты сериновых протеаз, и способы
MX2011004802A (es) 2008-11-11 2011-06-16 Danisco Inc Bacilos de subtilisina que comprenden una o mas mutaciones combinables.
EP2202290A1 (en) 2008-12-23 2010-06-30 Unilever PLC A flowable laundry composition and packaging therefor
EP2424877A4 (en) 2009-04-28 2013-01-02 Harvard College SUPRAGELADENE PROTEINS FOR CELL PENETRATION
FI121711B (fi) 2009-04-30 2011-03-15 Ab Enzymes Oy Sieniperäinen seriiniproteaasi ja sen käyttö
FI121712B (fi) 2009-04-30 2011-03-15 Ab Enzymes Oy Uusi sieniperäinen proteaasi ja sen käyttö
FI121851B (fi) 2009-07-08 2011-05-13 Ab Enzymes Oy Sieniperäinen proteaasi ja sen käyttö
CA2782613C (en) 2009-12-09 2016-08-23 The Procter & Gamble Company Fabric and home care products
JP5813753B2 (ja) * 2010-05-06 2015-11-17 ザ プロクター アンド ギャンブルカンパニー プロテアーゼ変異体を有する消費者製品
DE102010028951A1 (de) 2010-05-12 2011-11-17 Henkel Ag & Co. Kgaa Lagerstabiles flüssiges Wasch- oder Reinigungsmittel enthaltend Protease und Lipase
CN106120422B (zh) 2010-07-01 2018-11-20 诺维信公司 纸浆的漂白
EP2606146A1 (en) 2010-08-19 2013-06-26 Novozymes A/S Induced sporulation screening method
FI123942B (fi) 2010-10-29 2013-12-31 Ab Enzymes Oy Sieniperäisen seriiniproteaasin variantteja
DE102011005354A1 (de) * 2011-03-10 2012-09-13 Henkel Ag & Co. Kgaa Leistungsverbesserte Proteasevarianten
FI123425B (fi) 2011-03-31 2013-04-30 Ab Enzymes Oy Proteaasientsyymi ja sen käytöt
GB201106408D0 (en) 2011-04-15 2011-06-01 Revolymer Ltd Novel composite
GB201106409D0 (en) 2011-04-15 2011-06-01 Revolymer Ltd Novel composite
GB201106391D0 (en) 2011-04-15 2011-06-01 Reckitt & Colman Overseas Novel composite
DK2702153T3 (en) 2011-04-28 2019-03-18 Novozymes Inc Polypeptides with endoglucanase activity and polynucleotides encoding them
US9856466B2 (en) * 2011-05-05 2018-01-02 Danisco Us Inc. Compositions and methods comprising serine protease variants
JP5933688B2 (ja) * 2011-05-05 2016-06-15 ザ プロクター アンド ギャンブル カンパニー セリンプロテアーゼ変異体を含む組成物及び方法
PH12014500304A1 (en) 2011-08-18 2014-04-07 Unilever Nv Enzyme system
WO2013036898A2 (en) 2011-09-09 2013-03-14 Novozymes A/S Improving properties of paper materials
AU2013258083A1 (en) 2012-05-10 2014-11-20 Unilever Plc Care enzyme system
WO2014067933A1 (en) 2012-10-31 2014-05-08 C-Lecta Gmbh Bioactive carrier preparation for enhanced safety in care products and food
EP2740840A1 (en) 2012-12-07 2014-06-11 Novozymes A/S Improving drainage of paper pulp
BR112017000102B1 (pt) 2014-07-04 2023-11-07 Novozymes A/S Variantes de subtilase de uma subtilase progenitora, composição detergente, uso da mesma e método para a produção de uma variante de subtilase que tem atividade de protease
EP3739029A1 (en) * 2014-07-04 2020-11-18 Novozymes A/S Subtilase variants and polynucleotides encoding same
WO2016007309A1 (en) 2014-07-07 2016-01-14 Novozymes A/S Use of prehydrolysate liquor in engineered wood
EP3690037A1 (en) 2014-12-04 2020-08-05 Novozymes A/S Subtilase variants and polynucleotides encoding same
PL3608403T3 (pl) * 2014-12-15 2025-06-23 Henkel Ag & Co. Kgaa Kompozycja detergentowa zawierająca warianty subtylazy
EP3234125B1 (en) 2014-12-19 2020-04-15 Novozymes A/S Protease variants
EP3234124B1 (en) 2014-12-19 2020-11-11 Novozymes A/S Protease variants
DK3234093T3 (da) 2014-12-19 2020-08-17 Novozymes As Proteasevarianter og polynukleotider, som koder for dem
WO2016097350A1 (en) 2014-12-19 2016-06-23 Novozymes A/S Protease variants and polynucleotides encoding same
EP3280791A1 (en) 2015-04-10 2018-02-14 Novozymes A/S Laundry method, use of dnase and detergent composition
US20180105772A1 (en) 2015-04-10 2018-04-19 Novozymes A/S Detergent composition
WO2017050441A1 (en) 2015-09-24 2017-03-30 Unilever N.V. Substrate washing device
WO2017089456A1 (en) * 2015-11-24 2017-06-01 Novozymes A/S Polypeptides having protease activity and polynucleotides encoding same
EP3464582A1 (en) 2016-06-03 2019-04-10 Novozymes A/S Subtilase variants and polynucleotides encoding same
CN110998014A (zh) 2017-06-09 2020-04-10 荷兰联合利华有限公司 洗衣液分配系统
EP3636735B1 (en) 2018-10-12 2024-03-27 AB Enzymes Oy Protease enzyme variants and uses thereof
WO2020099491A1 (en) 2018-11-14 2020-05-22 Novozymes A/S Oral care composition comprising a polypeptide having dnase activity
WO2020115179A1 (en) 2018-12-05 2020-06-11 Novozymes A/S Use of an enzyme granule
CN114402105B (zh) 2019-07-26 2024-01-30 诺维信公司 纸浆的酶处理
CN112852788B (zh) * 2019-11-26 2022-10-11 江南大学 一种碱性底物选择性提高的枯草蛋白酶e突变体及其应用
EP4069813B1 (en) 2019-12-05 2023-09-13 Unilever IP Holdings B.V. Biodegradable package containing water-soluble capsules
WO2021239950A1 (en) 2020-05-29 2021-12-02 Novozymes A/S Method for controlling slime in a pulp or paper making process
US20230332124A1 (en) 2020-08-24 2023-10-19 Novozymes A/S Oral care composition comprising a fructanase
BR112023005128A2 (pt) * 2020-09-22 2023-04-25 Basf Se Composição, composição de detergente, método para prover uma composição de detergente com estabilidade e/ou desempenho de lavagem melhorados, e, uso de uma composição
FR3122869A1 (fr) 2021-05-14 2022-11-18 Unilever Ip Holdings B.V. Conditionnement contenant des capsules solubles dans l’eau
US20240253852A1 (en) 2021-05-14 2024-08-01 Conopco, Inc., D/B/A Unilever Package containing water-soluble capsules
WO2022238440A1 (en) 2021-05-14 2022-11-17 Unilever Ip Holdings B.V. Package containing water-soluble capsules
WO2022238449A1 (en) 2021-05-14 2022-11-17 Unilever Ip Holdings B.V. Package containing water-soluble capsules
BR112023023757A2 (pt) 2021-05-14 2024-01-30 Unilever Ip Holdings B V Embalagem
GB2607442A (en) 2021-05-14 2022-12-07 Unilever Global Ip Ltd Package containing water-soluble capsules
FR3123330A1 (fr) 2021-05-25 2022-12-02 Unilever Ip Holdings B.V. Conditionnement contenant des capsules solubles dans l'eau
CA3220135A1 (en) 2021-06-16 2022-12-22 Novozymes A/S Method for controlling slime in a pulp or paper making process
WO2023078594A1 (en) 2021-11-05 2023-05-11 Unilever Ip Holdings B.V. Package containing water-soluble capsules
EP4444844A1 (en) 2021-12-07 2024-10-16 Unilever IP Holdings B.V. Package containing water-soluble capsules
DE202022102651U1 (de) 2022-05-13 2022-05-30 Unilever Global Ip Limited Wasserlösliche Kapseln enthaltende Packung
DE202022102650U1 (de) 2022-05-13 2022-06-13 Unilever Global Ip Limited Wasserlösliche Kapseln enthaltende Packung
EP4630528A1 (en) * 2022-12-05 2025-10-15 Novozymes A/S Protease variants and polynucleotides encoding same
WO2025202382A1 (en) * 2024-03-27 2025-10-02 Basf Se Polypeptides having protease activity for use in cleaning compositions
WO2025202374A1 (en) * 2024-03-27 2025-10-02 Basf Se Polypeptides having protease activity for use in detergent compositions
WO2025202369A1 (en) * 2024-03-27 2025-10-02 Basf Se Polypeptides having protease activity for use in detergent compositions
CN119614539A (zh) * 2024-12-23 2025-03-14 青岛蔚蓝生物股份有限公司 一种碱性蛋白酶突变体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1234445A (pt) 1967-10-03 1971-06-03
US3929887A (en) 1970-05-18 1975-12-30 Endo Lab Alkylenepoly(aralkylamines) and the salts thereof
US4760025A (en) * 1984-05-29 1988-07-26 Genencor, Inc. Modified enzymes and methods for making same
US5013657A (en) * 1988-04-12 1991-05-07 Bryan Philip N Subtilisin mutations
US4990452A (en) * 1986-02-12 1991-02-05 Genex Corporation Combining mutations for stabilization of subtilisin
EP0260299A4 (en) * 1986-02-12 1988-11-24 Genex Corp MUTAGENESIS AND SCREENING PROCESS AND PRODUCT OBTAINED.
US4914031A (en) * 1987-04-10 1990-04-03 Amgen, Inc. Subtilisin analogs
DK6488D0 (da) * 1988-01-07 1988-01-07 Novo Industri As Enzymer

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