[go: up one dir, main page]

BR9003527A - Sais do acido n5,n10-metilen-5,6,7,8-tetrahidrofolico,processo para sua preparacao,medicamento e aplicacao - Google Patents

Sais do acido n5,n10-metilen-5,6,7,8-tetrahidrofolico,processo para sua preparacao,medicamento e aplicacao

Info

Publication number
BR9003527A
BR9003527A BR909003527A BR9003527A BR9003527A BR 9003527 A BR9003527 A BR 9003527A BR 909003527 A BR909003527 A BR 909003527A BR 9003527 A BR9003527 A BR 9003527A BR 9003527 A BR9003527 A BR 9003527A
Authority
BR
Brazil
Prior art keywords
preparation
metilen
tetrahydrofolic
sales
medicine
Prior art date
Application number
BR909003527A
Other languages
English (en)
Inventor
Fabrizio Marazza
Attilio Melera
Rene Viterbo
Nando Toderi
Original Assignee
Sapec S A Finer Chemicals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25687132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9003527(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CH273689A external-priority patent/CH678854A5/de
Priority claimed from CH125690A external-priority patent/CH680732A5/de
Application filed by Sapec S A Finer Chemicals filed Critical Sapec S A Finer Chemicals
Publication of BR9003527A publication Critical patent/BR9003527A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR909003527A 1989-07-21 1990-07-20 Sais do acido n5,n10-metilen-5,6,7,8-tetrahidrofolico,processo para sua preparacao,medicamento e aplicacao BR9003527A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH273689A CH678854A5 (en) 1989-07-21 1989-07-21 N,N-methylene-5,6,7,8-tetra:hydro-folic acid salt (I)
CH125690A CH680732A5 (en) 1990-04-12 1990-04-12 N,N-methylene-5,6,7,8-tetra:hydro-folic acid salt (I)

Publications (1)

Publication Number Publication Date
BR9003527A true BR9003527A (pt) 1991-08-27

Family

ID=25687132

Family Applications (1)

Application Number Title Priority Date Filing Date
BR909003527A BR9003527A (pt) 1989-07-21 1990-07-20 Sais do acido n5,n10-metilen-5,6,7,8-tetrahidrofolico,processo para sua preparacao,medicamento e aplicacao

Country Status (11)

Country Link
EP (1) EP0409125B1 (pt)
JP (1) JPH03128380A (pt)
AT (1) ATE132498T1 (pt)
BR (1) BR9003527A (pt)
CA (1) CA2021042A1 (pt)
DE (1) DE59010025D1 (pt)
ES (1) ES2083983T3 (pt)
FI (1) FI903692A7 (pt)
IE (1) IE902656A1 (pt)
NO (1) NO903211L (pt)
PT (1) PT94782A (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
US5217974A (en) * 1991-03-29 1993-06-08 Eli Lilly And Company Method for treating gar-transformylase tumors in mammals and reducing mammalian toxicity
CH683690A5 (de) * 1991-12-21 1994-04-29 Sapec Fine Chemicals Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten.
CH684644A5 (de) 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
GB9223352D0 (en) * 1992-11-06 1992-12-23 Ici Plc Tricyclic compounds
GB9408936D0 (en) * 1994-05-05 1994-06-22 Cancer Res Inst Anti-cancer compounds
DK2245032T3 (da) * 2008-02-20 2015-06-22 Gnosis Spa Folater, sammensætninger og anvendelser deraf
US7947662B2 (en) 2008-02-20 2011-05-24 Gnosis S.P.A. Folates, compositions and uses thereof
EP3461826A1 (en) 2017-09-29 2019-04-03 Aprofol AG Multifunctional folate salts

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2063027A1 (de) * 1969-12-26 1971-07-01 Yamanouchi Pharmaceutical Co Ltd , Tokio Salz einer basischen Aminosäure der 5 6,7,8 Tetrahydrofolsaure
FR2137186A1 (en) * 1971-05-14 1972-12-29 Mauvernay Centre Europ Folic acid salts - used as neuro-stimulants and for dynamising muscular function
GB1572138A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Process for the preparation of d,1-5-methyltetrahydrofolic acid
CH673459A5 (pt) * 1987-05-15 1990-03-15 Eprova Ag
DE3821875C1 (pt) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch

Also Published As

Publication number Publication date
NO903211D0 (no) 1990-07-18
ES2083983T3 (es) 1996-05-01
AU619124B2 (en) 1992-01-16
JPH03128380A (ja) 1991-05-31
EP0409125A1 (de) 1991-01-23
IE902656A1 (en) 1991-02-27
FI903692A7 (fi) 1991-01-22
DE59010025D1 (de) 1996-02-15
EP0409125B1 (de) 1996-01-03
AU5905990A (en) 1991-01-24
PT94782A (pt) 1991-04-18
ATE132498T1 (de) 1996-01-15
CA2021042A1 (en) 1991-01-22
FI903692A0 (fi) 1990-07-20
NO903211L (no) 1991-01-22

Similar Documents

Publication Publication Date Title
MY109421A (en) Amidino derivatives and their use as nitric oxide synthase inhibitor
PT91231A (pt) Processo de preparacao de derivados substituidos purinona e de composicoes farmaceuticas que os contem
AU5431390A (en) Novel arylpyridazines, their manufacture, use and medicaments containing them
PT92437A (pt) Processo de preparacao de derivados da quinazolinona, dos seus intermediarios e de composicoes farmaceuticas que os contem
SE9103572D0 (sv) Organic salts of n,n'-diacetyl cystine
ES2081187T3 (es) Nuevas naftil-alquil-aminas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
DK0598770T3 (da) Pyrazinderivater samt fremstilling og anvendelse deraf
ES2056692T3 (es) Triacinas y pirimidinas trisustituidas, su procedimiento de preparacion y las composiciones farmaceuticas que las contienen.
ES2118203T3 (es) Nuevos derivados benzopiranicos, su procedimiento de preparacion y composiciones farmaceuticas que los contienen.
ATE38991T1 (de) In 2-stellung substituierte 1,3propyledendephosphonat-derivate, ihre herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
BR9003527A (pt) Sais do acido n5,n10-metilen-5,6,7,8-tetrahidrofolico,processo para sua preparacao,medicamento e aplicacao
FR2412565A1 (fr) Nouveaux derives de type n-acyl-2', n-alkyl-2', di-n-acyl-4,2', di-n-alkyl-4,2', n-acyl-4 n-alkyl-2' et n-alkyl-4 n-acyl-2', desoxy-2 fortimicine b
BG93114A (bg) Производни на бензонафтиридин-1,8 ,методи за получаването им и състави които ги съдържат
DE3688087D1 (de) Cephemverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate.
BG47648A3 (en) Method for preparing of triazolyl quanolinic compounds
ES523425A0 (es) Un metodo para preparar nuevos derivados de guanina
FI833200A0 (fi) Isokinolinderivat, foerfaranden foer deras framstaellning, pao dessa foereningar baserade farmaceutpreparat och deras anvaendning
ATE14724T1 (de) Alphacarbamoyl-pyrrolpropionitrile, verfahren zu ihrer herstellung, sowie pharmazeutische praeparate die diese verbindungen enthalten.
DK0571243T3 (da) Thiochromanderivater, fremgangsmåder til fremstilling heraf samt farmaceutiske midler indeholdende d isse
CA2038025A1 (en) Optically active alkylenedioxybenzene derivatives and their use in therapy
ES552871A0 (es) Procedimiento para preparar nuevos derivados 3-piridilmetilnaftilicos
PT99091A (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados da triazina e da pirimidina, como ingredientes activos, destinadas a reverter a resistencia aos agentes anticancerosos e antimalaricos
ATE9584T1 (de) Antibakterielle beta-lactam-verbindungen, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
DE3880304D1 (de) 2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung.
PT98275A (pt) Processo para a preparacao de polimetileno-iminas dissubstituidas