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AU5905990A - Salts of n5,n10-methylene-5,6,7,8-tetrahydrofolic acid - Google Patents

Salts of n5,n10-methylene-5,6,7,8-tetrahydrofolic acid

Info

Publication number
AU5905990A
AU5905990A AU59059/90A AU5905990A AU5905990A AU 5905990 A AU5905990 A AU 5905990A AU 59059/90 A AU59059/90 A AU 59059/90A AU 5905990 A AU5905990 A AU 5905990A AU 5905990 A AU5905990 A AU 5905990A
Authority
AU
Australia
Prior art keywords
salts
methylene
tetrahydrofolic acid
formulae
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU59059/90A
Other versions
AU619124B2 (en
AU619124C (en
Inventor
Fabrizio Marazza
Attilio Melera
Nando Toderi
Rene Viterbo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sapec Fine Chemicals SA
Original Assignee
Sapec Fine Chemicals SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25687132&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AU5905990(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from CH273689A external-priority patent/CH678854A5/en
Priority claimed from CH125690A external-priority patent/CH680732A5/en
Application filed by Sapec Fine Chemicals SA filed Critical Sapec Fine Chemicals SA
Publication of AU5905990A publication Critical patent/AU5905990A/en
Publication of AU619124B2 publication Critical patent/AU619124B2/en
Application granted granted Critical
Publication of AU619124C publication Critical patent/AU619124C/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

There are described salts of N<5>,N<10>-methylene-5,6,7,8-tetrahydro- folic acid, of the formulae Ia and Ib, <IMAGE> in the form of the (6RS) diastereoisomer mixture or in the form of the individual (6R) or (6S) diastereoisomers. The substituents are defined in Claim 1. There are also described three processes for the preparation of these salts. The abovementioned salts of the formulae Ia and Ib can be used for producing a pharmaceutical to act as a synergist with a compound for combating cancer, and/or for reducing the toxicity of a compound for combating cancer, and/or for protecting human and/or animal cells.
AU59059/90A 1989-07-21 1990-07-16 Salts of N5,N10-methylene-5,6,7,8-tetrahydrofolic acid Ceased AU619124C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH2736/89 1989-07-21
CH273689A CH678854A5 (en) 1989-07-21 1989-07-21 N,N-methylene-5,6,7,8-tetra:hydro-folic acid salt (I)
CH125690A CH680732A5 (en) 1990-04-12 1990-04-12 N,N-methylene-5,6,7,8-tetra:hydro-folic acid salt (I)
CH1256/90 1990-04-12

Publications (3)

Publication Number Publication Date
AU5905990A true AU5905990A (en) 1991-01-24
AU619124B2 AU619124B2 (en) 1992-01-16
AU619124C AU619124C (en) 1992-07-30

Family

ID=

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661591B2 (en) * 1992-07-13 1995-07-27 Eprova Ag 5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661591B2 (en) * 1992-07-13 1995-07-27 Eprova Ag 5,10-methylenetetrahydrofolic acid-cyclodextrin inclusion compounds

Also Published As

Publication number Publication date
JPH03128380A (en) 1991-05-31
IE902656A1 (en) 1991-02-27
FI903692A0 (en) 1990-07-20
NO903211D0 (en) 1990-07-18
PT94782A (en) 1991-04-18
EP0409125A1 (en) 1991-01-23
FI903692A7 (en) 1991-01-22
BR9003527A (en) 1991-08-27
NO903211L (en) 1991-01-22
AU619124B2 (en) 1992-01-16
ES2083983T3 (en) 1996-05-01
EP0409125B1 (en) 1996-01-03
CA2021042A1 (en) 1991-01-22
DE59010025D1 (en) 1996-02-15
ATE132498T1 (en) 1996-01-15

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