BR112017022320A2 - métodos para tratamento de câncer de pulmão - Google Patents
métodos para tratamento de câncer de pulmãoInfo
- Publication number
- BR112017022320A2 BR112017022320A2 BR112017022320A BR112017022320A BR112017022320A2 BR 112017022320 A2 BR112017022320 A2 BR 112017022320A2 BR 112017022320 A BR112017022320 A BR 112017022320A BR 112017022320 A BR112017022320 A BR 112017022320A BR 112017022320 A2 BR112017022320 A2 BR 112017022320A2
- Authority
- BR
- Brazil
- Prior art keywords
- fra
- patient
- expression level
- lung cancer
- methods
- Prior art date
Links
- 206010058467 Lung neoplasm malignant Diseases 0.000 title abstract 4
- 201000005202 lung cancer Diseases 0.000 title abstract 4
- 208000020816 lung neoplasm Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 230000008685 targeting Effects 0.000 abstract 3
- 239000012472 biological sample Substances 0.000 abstract 1
- 229940014144 folate Drugs 0.000 abstract 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 1
- 235000019152 folic acid Nutrition 0.000 abstract 1
- 239000011724 folic acid Substances 0.000 abstract 1
- 230000004044 response Effects 0.000 abstract 1
- 230000004043 responsiveness Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
a presente invenção refere-se a métodos para predição de uma probabilidade de uma responsividade a tratamento com um agente de direcionamento a alfa receptor de folato (fra) em um paciente tendo um câncer de pulmão expressando fra. são também providos métodos para tratamento de um câncer de pulmão expressando fra em um paciente com um agente de direcionamento a fra. os métodos envolvem quantificação ou determinação do nível de expressão de fra do paciente em uma amostra biológica e comparação do nível de expressão de fra do paciente com um padrão de referência usado para quantificar nível de expressão de fra, onde o paciente é provável responder a tratamento com o agente de direcionamento a fra se o nível de expressão de fra do paciente for igual a ou exceder o nível de expressão de fra de referência. são ainda providos kits relacionados para predição de resposta e tratamento da população identificada de pacientes com câncer de pulmão expressando fra.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562149184P | 2015-04-17 | 2015-04-17 | |
| PCT/US2016/027497 WO2016168440A1 (en) | 2015-04-17 | 2016-04-14 | Methods for treating lung cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112017022320A2 true BR112017022320A2 (pt) | 2018-07-24 |
Family
ID=55809240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112017022320A BR112017022320A2 (pt) | 2015-04-17 | 2016-04-14 | métodos para tratamento de câncer de pulmão |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20180125970A1 (pt) |
| EP (1) | EP3283886B1 (pt) |
| JP (1) | JP2018516244A (pt) |
| KR (1) | KR20170137848A (pt) |
| CN (1) | CN107624071A (pt) |
| AU (1) | AU2016248222A1 (pt) |
| BR (1) | BR112017022320A2 (pt) |
| CA (1) | CA2983126A1 (pt) |
| IL (1) | IL255079A0 (pt) |
| MX (1) | MX2017013390A (pt) |
| RU (1) | RU2718780C9 (pt) |
| SG (1) | SG11201708546UA (pt) |
| WO (1) | WO2016168440A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060239910A1 (en) * | 2005-04-22 | 2006-10-26 | Morphotek Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| US20170247449A1 (en) * | 2014-06-06 | 2017-08-31 | Kyowa Hakko Kirin Co., Ltd | Therapeutic method and medicament for cancer patients by folr1-targeting drug and an antagonist for folic acid metabolism |
| EP3544999A1 (en) | 2016-11-23 | 2019-10-02 | Eisai R&D Management Co., Ltd. | Anti-folate receptor alpha antibodies and uses thereof |
| SG11202007494TA (en) | 2018-03-13 | 2020-09-29 | Phanes Therapeutics Inc | Anti-folate receptor 1 antibodies and uses thereof |
| SG11202012576QA (en) * | 2018-06-18 | 2021-01-28 | Medimmune Ltd | Combination of lif inhibitors and platinum-based antineoplastic agents for use in treating cancer |
| CN110221052B (zh) * | 2019-06-17 | 2022-09-23 | 昆山德诺瑞尔生物科技有限公司 | Ppfibp1蛋白在制备肝癌术后预后评估试剂盒中的应用 |
| KR20240162086A (ko) * | 2022-03-11 | 2024-11-14 | 아스트라제네카 아베 | 항-FRα 항체-약물 접합체 치료법에 대한 점수 산정 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3101034A1 (en) | 2004-02-12 | 2016-12-07 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
| US20060239910A1 (en) | 2005-04-22 | 2006-10-26 | Morphotek Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
| GB0718167D0 (en) * | 2007-09-18 | 2007-10-31 | Cancer Rec Tech Ltd | Cancer marker and therapeutic target |
| CN103687618A (zh) | 2010-11-05 | 2014-03-26 | 莫福特克公司 | 叶酸受体α作为用于表达叶酸受体α的癌症的诊断和预后标记 |
| PT2731972T (pt) * | 2011-07-15 | 2018-03-09 | Eisai R&D Man Co Ltd | Anticorpos anti-recetor alfa de folatos (frα) e utilizações dos mesmos |
-
2016
- 2016-04-14 MX MX2017013390A patent/MX2017013390A/es unknown
- 2016-04-14 SG SG11201708546UA patent/SG11201708546UA/en unknown
- 2016-04-14 AU AU2016248222A patent/AU2016248222A1/en not_active Abandoned
- 2016-04-14 WO PCT/US2016/027497 patent/WO2016168440A1/en not_active Ceased
- 2016-04-14 US US15/566,888 patent/US20180125970A1/en not_active Abandoned
- 2016-04-14 JP JP2017554475A patent/JP2018516244A/ja active Pending
- 2016-04-14 RU RU2017136863A patent/RU2718780C9/ru not_active IP Right Cessation
- 2016-04-14 EP EP16718820.0A patent/EP3283886B1/en active Active
- 2016-04-14 BR BR112017022320A patent/BR112017022320A2/pt not_active Application Discontinuation
- 2016-04-14 CA CA2983126A patent/CA2983126A1/en not_active Abandoned
- 2016-04-14 CN CN201680028727.8A patent/CN107624071A/zh active Pending
- 2016-04-14 KR KR1020177032864A patent/KR20170137848A/ko not_active Withdrawn
-
2017
- 2017-10-17 IL IL255079A patent/IL255079A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016168440A1 (en) | 2016-10-20 |
| EP3283886B1 (en) | 2020-01-15 |
| RU2017136863A3 (pt) | 2019-08-21 |
| AU2016248222A1 (en) | 2017-11-09 |
| EP3283886A1 (en) | 2018-02-21 |
| CN107624071A (zh) | 2018-01-23 |
| RU2718780C9 (ru) | 2020-07-08 |
| CA2983126A1 (en) | 2016-10-20 |
| US20180125970A1 (en) | 2018-05-10 |
| MX2017013390A (es) | 2018-06-13 |
| RU2017136863A (ru) | 2019-05-17 |
| KR20170137848A (ko) | 2017-12-13 |
| IL255079A0 (en) | 2017-12-31 |
| RU2718780C2 (ru) | 2020-04-14 |
| JP2018516244A (ja) | 2018-06-21 |
| SG11201708546UA (en) | 2017-11-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112017022320A2 (pt) | métodos para tratamento de câncer de pulmão | |
| BR112014018331A8 (pt) | Biomarcadores e terapias combinadas usando vírus oncolítico e imunomodulação | |
| MX2023010805A (es) | Metodos terapeuticos y de diagnostico para el cancer. | |
| MX2017014736A (es) | Metodos terapeuticos y diagnosticos para cancer. | |
| BR112016004963A2 (pt) | biomarcadores para determinação precoce de uma resposta crítica ou de risco de vida para resposta de tratamento e/ou doença | |
| MX2018010361A (es) | Métodos terapéuticos y de diagnóstico para el cáncer. | |
| MX2017014381A (es) | Metodos terapeuticos y diagnosticos para cancer. | |
| BR112017025297A2 (pt) | anticorpos anti-gitr para diagnóstico do câncer | |
| BR112013027124A2 (pt) | método e sistema para analisar características de tecido | |
| BR112014030750A2 (pt) | Método para diagnóstico, prognóstico e tratamento da metástase do câncer pulmonar | |
| BR112016018205A8 (pt) | métodos de tratamento de mal de alzheimer, de seleção de pacientes, de identificação de pacientes, de previsão, de otimização da eficácia terapêutica, kit, uso de agente e uso in vitro de agente | |
| BR112012025593A2 (pt) | biomarcadores em circulação para doença | |
| BR112015004229A2 (pt) | ensaios de diagnósticos e kits para a deteção de receptor 1 do folato | |
| BR112015023120A2 (pt) | método para identificar um indivíduo com uma doença ou disfunção, método para prever a responsividade de um indivíduo com uma doença ou disfunção, método para determinar a probabilidade de que um indivíduo com uma doença ou disfunção exibirá benefício do tratamento, método para selecionar uma terapia, usos de um antagonista de ligação do eixo pd-l1, ensaio para identificar um indivíduo com uma doença, kit de diagnóstico, método para avaliar uma resposta ao tratamento e método para monitorar a resposta de um indivíduo tratado | |
| BR112014011127A2 (pt) | métodos para tratar, diagnosticar e monitorar doença de alzheimer | |
| BR112019006004A2 (pt) | método e sistema para criação de um intervalo de referência personalizado, e, método para analisar associações clínicas. | |
| BR112014024219A8 (pt) | Métodos de determinação, de otimização da eficácia terapêutica, de monitoramento, de seleção de terapia e de diagnóstico de distúrbio e kit | |
| MX2020000186A (es) | Ensayos para evaluar los niveles de anticuerpos neutralizantes en sujetos tratados con un fármaco biológico y usos de los mismos en medicina personalizada. | |
| BR112018071583A2 (pt) | métodos para determinar dpp3 e métodos terapêuticos | |
| CL2019002438A1 (es) | Uso de biomarcadores en la identificación de pacientes con cáncer que serán sensibles al tratamiento con un inhibidor de prmt5. | |
| BR112019025056A2 (pt) | Inibidores de fgfr2 para o tratamento de colangiocarcinoma | |
| BR112015008255A2 (pt) | método para o diagnóstico, prognóstico e tratamento de metástase de câncer de próstata | |
| MX2017006242A (es) | Determinacion de niveles de glicosaminoglicanos mediante espectrometria de masas. | |
| MX390884B (es) | Método para la cuantificación de los miembros del filogrupo i y/o del filogrupo ii de faecalibacterium prausnitzii y el uso de los mismos como biomarcadores. | |
| BR112016024143A2 (pt) | tratamento de câncer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: EISAI INC. (US) |
|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5A ANUIDADE. |
|
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |