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BR0316868A - Processo para a produção de pró-medicamentos de nucleosìdeo-3' - Google Patents

Processo para a produção de pró-medicamentos de nucleosìdeo-3'

Info

Publication number
BR0316868A
BR0316868A BR0316868-9A BR0316868A BR0316868A BR 0316868 A BR0316868 A BR 0316868A BR 0316868 A BR0316868 A BR 0316868A BR 0316868 A BR0316868 A BR 0316868A
Authority
BR
Brazil
Prior art keywords
production
nucleoside
prodrugs
nucleosidide
acylation
Prior art date
Application number
BR0316868-9A
Other languages
English (en)
Inventor
Richard Storer
Adel Moussa
Steven Mathieu
Original Assignee
Idenix Cayman Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Cayman Ltd filed Critical Idenix Cayman Ltd
Publication of BR0316868A publication Critical patent/BR0316868A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA A PRODUçãO DE PRó-MEDICAMENTOS DE NUCLEOSìDEO-3". é fornecido um processo de etapa única para a 3<39>acilação seletiva de um nucleosídeo de ribofuranosil ramificado em 2<39> ou 3<39>. Esses compostos são úteis como agentes antivirais, e em particular, podem ser usados para tratar infecções por Flaviviridae em um hospedeiro em necessidade desse.
BR0316868-9A 2002-12-23 2003-12-23 Processo para a produção de pró-medicamentos de nucleosìdeo-3' BR0316868A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43615002P 2002-12-23 2002-12-23
PCT/US2003/041603 WO2004058792A1 (en) 2002-12-23 2003-12-23 Process for the production of 3'-nucleoside prodrugs

Publications (1)

Publication Number Publication Date
BR0316868A true BR0316868A (pt) 2005-10-25

Family

ID=32682350

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0316868-9A BR0316868A (pt) 2002-12-23 2003-12-23 Processo para a produção de pró-medicamentos de nucleosìdeo-3'

Country Status (16)

Country Link
US (1) US20040181051A1 (pt)
EP (1) EP1575971A4 (pt)
JP (1) JP2006514038A (pt)
KR (1) KR20050110611A (pt)
CN (1) CN100335492C (pt)
AU (1) AU2003300434A1 (pt)
BR (1) BR0316868A (pt)
CA (1) CA2511616A1 (pt)
IL (1) IL169314A0 (pt)
MX (1) MXPA05006865A (pt)
NO (1) NO20053557L (pt)
NZ (1) NZ540913A (pt)
PL (1) PL377608A1 (pt)
RU (1) RU2005123395A (pt)
WO (1) WO2004058792A1 (pt)
ZA (1) ZA200505040B (pt)

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MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
MXPA02011691A (es) 2000-05-26 2004-05-17 Idenix Cayman Ltd Metodos y composiciones para el tratamiento de flavivirus y pestivirus.
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
JP2005533824A (ja) 2002-06-28 2005-11-10 イデニクス（ケイマン）リミテツド フラビウイルス科感染の治療のための２’−ｃ−メチル−３’−ｏ−ｌ−バリンエステルリボフラノシルシチジン
PL377342A1 (pl) 2002-11-15 2006-01-23 Idenix (Cayman) Limited Nukleozydy rozgałęzione w pozycji 2' oraz mutacja Flaviviridae
AU2003300901A1 (en) 2002-12-12 2004-06-30 Idenix (Cayman) Limited Process for the production of 2'-branched nucleosides
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WO2007113159A1 (en) 2006-04-04 2007-10-11 F. Hoffmann-La Roche Ag 3',5'-di-o-acylated nucleosides for hcv treatment
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EA201100851A1 (ru) 2008-12-23 2012-04-30 Фармассет, Инк. Аналоги нуклеозидов
EA019341B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Фосфорамидаты нуклеозидов
KR20110120886A (ko) 2009-01-09 2011-11-04 유니버시티 칼리지 오브 카디프 컨설턴트 리미티드 바이러스 감염 치료용 구아노신 뉴클레오사이드 화합물의 포스포라미데이트 유도체
MX2012011171A (es) 2010-03-31 2013-02-01 Gilead Pharmasset Llc Fosforamidatos de nucleosido.
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MX2021006121A (es) * 2018-11-25 2021-10-13 Tnt Medical Corp Profarmaco de gemcitabina oralmente activo.

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Also Published As

Publication number Publication date
ZA200505040B (en) 2006-04-26
PL377608A1 (pl) 2006-02-06
NZ540913A (en) 2008-02-29
WO2004058792A1 (en) 2004-07-15
NO20053557L (no) 2005-09-08
CN100335492C (zh) 2007-09-05
MXPA05006865A (es) 2005-12-12
JP2006514038A (ja) 2006-04-27
US20040181051A1 (en) 2004-09-16
KR20050110611A (ko) 2005-11-23
RU2005123395A (ru) 2006-01-27
EP1575971A4 (en) 2008-03-05
AU2003300434A1 (en) 2004-07-22
EP1575971A1 (en) 2005-09-21
IL169314A0 (en) 2007-07-04
CN1751058A (zh) 2006-03-22
CA2511616A1 (en) 2004-07-15

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A., 7A. E 8A. ANUIDADE(S),

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.