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BR0212468A - Compoto de uréia ativos como antagonistas de receptor de vanilóides para o tratamento de dor - Google Patents

Compoto de uréia ativos como antagonistas de receptor de vanilóides para o tratamento de dor

Info

Publication number
BR0212468A
BR0212468A BR0212468-8A BR0212468A BR0212468A BR 0212468 A BR0212468 A BR 0212468A BR 0212468 A BR0212468 A BR 0212468A BR 0212468 A BR0212468 A BR 0212468A
Authority
BR
Brazil
Prior art keywords
compounds
receptor antagonists
vanilloid receptor
pain treatment
urea compound
Prior art date
Application number
BR0212468-8A
Other languages
English (en)
Inventor
Harshad Kantilal Rami
Mervyn Thompson
Paul Adrian Wyman
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0122156A external-priority patent/GB0122156D0/en
Priority claimed from GB0130505A external-priority patent/GB0130505D0/en
Priority claimed from GB0130503A external-priority patent/GB0130503D0/en
Priority claimed from GB0130547A external-priority patent/GB0130547D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of BR0212468A publication Critical patent/BR0212468A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

"COMPOSTOS DE URéIA ATIVOS COMO ANTAGONISTAS DE RECEPTOR DE VANILóIDES PARA O TRATAMENTO DE DOR". Certos compostos de fórmula (I) : ou um sal farmaceuticamente aceitável do mesmo, ou um solvato do mesmo, em que R^ 1^, R~ 2~, P, P<39>,n, p, q, r e s são como definidos no relatório descritivo, um processo para preparar tais compostos, uma composição farmacêutica compreendendo tais compostos e o uso de tais compostos e da composição para o tratamento de distúrbios que se relacionam ao receptor de vanilóides (VR1) , tais como a dor, a enxaqueca, a neuropatia, a isquemia, a neurodegeneração, o acidente vascular cerebral, a esclerose múltipla, a asma, as doenças inflamatórias.
BR0212468-8A 2001-09-13 2002-09-13 Compoto de uréia ativos como antagonistas de receptor de vanilóides para o tratamento de dor BR0212468A (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0122156A GB0122156D0 (en) 2001-09-13 2001-09-13 Novel compounds
GB0130505A GB0130505D0 (en) 2001-12-20 2001-12-20 Novel compounds
GB0130503A GB0130503D0 (en) 2001-12-20 2001-12-20 Novel compounds
GB0130547A GB0130547D0 (en) 2001-12-20 2001-12-20 Novel compounds
PCT/GB2002/004206 WO2003022809A2 (en) 2001-09-13 2002-09-13 Urea-compounds active as vanilloid receptor antagonists for the treatment of pain

Publications (1)

Publication Number Publication Date
BR0212468A true BR0212468A (pt) 2004-10-19

Family

ID=27447989

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0212468-8A BR0212468A (pt) 2001-09-13 2002-09-13 Compoto de uréia ativos como antagonistas de receptor de vanilóides para o tratamento de dor

Country Status (31)

Country Link
US (1) US8063078B2 (pt)
EP (3) EP2298757A3 (pt)
JP (2) JP4463552B2 (pt)
KR (3) KR20100082390A (pt)
CN (1) CN1247568C (pt)
AP (1) AP1818A (pt)
AR (1) AR038786A1 (pt)
AT (1) ATE420083T1 (pt)
AU (1) AU2002329397B2 (pt)
BR (1) BR0212468A (pt)
CA (1) CA2458632C (pt)
CY (1) CY1109449T1 (pt)
DE (1) DE60230773D1 (pt)
DK (1) DK1425277T3 (pt)
EA (1) EA007731B1 (pt)
ES (1) ES2316607T3 (pt)
HU (1) HUP0401923A3 (pt)
IL (2) IL160755A0 (pt)
MA (1) MA26216A1 (pt)
MX (1) MXPA04002379A (pt)
MY (1) MY138086A (pt)
NO (3) NO327009B1 (pt)
NZ (1) NZ531137A (pt)
OA (1) OA12659A (pt)
PE (1) PE20030417A1 (pt)
PL (1) PL213639B1 (pt)
PT (1) PT1425277E (pt)
SI (1) SI1425277T1 (pt)
TW (1) TWI283665B (pt)
UY (1) UY27446A1 (pt)
WO (1) WO2003022809A2 (pt)

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WO2003022809A2 (en) 2003-03-20
EP2036902A3 (en) 2009-05-06
ATE420083T1 (de) 2009-01-15
IL160755A (en) 2009-09-01
CN1247568C (zh) 2006-03-29
EP1425277B1 (en) 2009-01-07
AR038786A1 (es) 2005-01-26
HUP0401923A3 (en) 2012-09-28
KR100955967B1 (ko) 2010-05-04
NO20085077L (no) 2004-06-04
EP2036902A2 (en) 2009-03-18
SI1425277T1 (sl) 2009-04-30
CA2458632A1 (en) 2003-03-20
NO327009B1 (no) 2009-04-06
HK1066534A1 (en) 2005-03-24
PL369026A1 (en) 2005-04-18
NZ531137A (en) 2006-08-31
WO2003022809A3 (en) 2003-07-17
HUP0401923A2 (hu) 2005-01-28
DE60230773D1 (de) 2009-02-26
PE20030417A1 (es) 2003-08-06
UY27446A1 (es) 2003-04-30
JP2010100632A (ja) 2010-05-06
OA12659A (en) 2006-06-19
PT1425277E (pt) 2009-03-05
US20090163506A1 (en) 2009-06-25
CY1109449T1 (el) 2014-08-13
ES2316607T3 (es) 2009-04-16
KR101063679B1 (ko) 2011-09-07
EP1425277A2 (en) 2004-06-09
NO20085078L (no) 2004-06-04
AP2004002982A0 (en) 2004-03-31
PL213639B1 (pl) 2013-04-30
EA200400432A1 (ru) 2004-12-30
EP2298757A2 (en) 2011-03-23
EP2298757A3 (en) 2011-12-28
KR20040041610A (ko) 2004-05-17
CA2458632C (en) 2011-08-23
AU2002329397B2 (en) 2006-04-27
US8063078B2 (en) 2011-11-22
KR20090026369A (ko) 2009-03-12
TWI283665B (en) 2007-07-11
JP2005504074A (ja) 2005-02-10
CN1553905A (zh) 2004-12-08
EP1425277B8 (en) 2009-04-01
MA26216A1 (fr) 2004-07-01
KR20100082390A (ko) 2010-07-16
AP1818A (en) 2008-01-07
MXPA04002379A (es) 2004-05-31
MY138086A (en) 2009-04-30
EA007731B1 (ru) 2006-12-29
IL160755A0 (en) 2004-08-31
JP4463552B2 (ja) 2010-05-19
NO20041003L (no) 2004-06-04
DK1425277T3 (da) 2009-03-16

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