BR0209689A - Uso de fragmento de hmg como agente anti-inflamatório - Google Patents
Uso de fragmento de hmg como agente anti-inflamatórioInfo
- Publication number
- BR0209689A BR0209689A BR0209689-7A BR0209689A BR0209689A BR 0209689 A BR0209689 A BR 0209689A BR 0209689 A BR0209689 A BR 0209689A BR 0209689 A BR0209689 A BR 0209689A
- Authority
- BR
- Brazil
- Prior art keywords
- hmg
- inflammatory agent
- vertebrate
- fragment
- inhibiting
- Prior art date
Links
- 229940121363 anti-inflammatory agent Drugs 0.000 title abstract 2
- 239000002260 anti-inflammatory agent Substances 0.000 title abstract 2
- 239000012634 fragment Substances 0.000 title 1
- 102000004127 Cytokines Human genes 0.000 abstract 4
- 108090000695 Cytokines Proteins 0.000 abstract 4
- 241000251539 Vertebrata <Metazoa> Species 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- 230000002757 inflammatory effect Effects 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 230000000770 proinflammatory effect Effects 0.000 abstract 2
- 102000040350 B family Human genes 0.000 abstract 1
- 108091072128 B family Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29103401P | 2001-05-15 | 2001-05-15 | |
| PCT/US2002/015329 WO2002092004A2 (en) | 2001-05-15 | 2002-05-15 | Use of hmg fragment as anti-inflammatory agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0209689A true BR0209689A (pt) | 2006-02-07 |
Family
ID=23118552
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0209689-7A BR0209689A (pt) | 2001-05-15 | 2002-05-15 | Uso de fragmento de hmg como agente anti-inflamatório |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US20030060410A1 (is) |
| EP (1) | EP1392844A4 (is) |
| JP (1) | JP2005512507A (is) |
| KR (1) | KR20040018370A (is) |
| CN (1) | CN100447154C (is) |
| AU (1) | AU2002309829B2 (is) |
| BR (1) | BR0209689A (is) |
| CA (1) | CA2447576C (is) |
| CZ (1) | CZ20033402A3 (is) |
| HU (1) | HUP0500042A3 (is) |
| IL (3) | IL158643A0 (is) |
| IS (1) | IS7037A (is) |
| MX (1) | MXPA03010449A (is) |
| NO (1) | NO20035087L (is) |
| NZ (1) | NZ529423A (is) |
| PL (1) | PL367132A1 (is) |
| SK (1) | SK15422003A3 (is) |
| WO (1) | WO2002092004A2 (is) |
Families Citing this family (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
| US7151082B2 (en) | 1999-02-11 | 2006-12-19 | The Feinstein Institute For Medical Research | Antagonists of HMG1 for treating inflammatory conditions |
| ITMI20010562A1 (it) * | 2001-03-16 | 2002-09-16 | Marco E Bianchi | Inibitori o antagonisti della proteina hmg1 per il trattamento di disordini vascolari |
| US7220723B2 (en) * | 2001-05-15 | 2007-05-22 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| US7304034B2 (en) | 2001-05-15 | 2007-12-04 | The Feinstein Institute For Medical Research | Use of HMGB fragments as anti-inflammatory agents |
| DE60326453D1 (de) * | 2002-07-03 | 2009-04-16 | Ct Cardiologico Monzino S P A | Die verwendung von hmgb1 zur behandlung von gewebeverletzungen und/oder zur unterstützung der gewebewiederherstellung |
| US20040156851A1 (en) * | 2002-11-20 | 2004-08-12 | Critical Therapeutics, Inc. | HMGB1 combination therapies |
| US20040141948A1 (en) * | 2002-11-20 | 2004-07-22 | Critical Therapeutics, Inc. | Use of HMGB fragments as anti-inflammatory agents |
| EP1567544A4 (en) * | 2002-11-20 | 2009-07-22 | Long Island Jewish Res Inst | USE OF HMGB POLYPEPTIDES TO IMPROVE THE IMMUNE REACTIONS |
| ATE378048T1 (de) * | 2002-12-06 | 2007-11-15 | The Feinstein Inst Medical Res | Hemmung von entzündungen unter verwendungvon alpha-7-rezeptor verbindenden cholinergen agonisten |
| US20090069227A9 (en) * | 2003-04-29 | 2009-03-12 | Capogrossi Maurizio C | Use of HMGB1 to promote stem cell migration and/or proliferation |
| US7696169B2 (en) * | 2003-06-06 | 2010-04-13 | The Feinstein Institute For Medical Research | Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents |
| WO2005025604A2 (en) * | 2003-09-10 | 2005-03-24 | The General Hospital Corporation | Use of hmgb and hmgb fragments to decrease specific immune response |
| EP1668035A2 (en) | 2003-09-11 | 2006-06-14 | Critical Therapeutics, Inc. | Monoclonal antibodies against hmgb1 |
| EP1768698A4 (en) | 2004-06-17 | 2009-01-28 | Medimmune Inc | IMMUNOGENIC COMPOSITIONS COMPRISING HMGB1 POLYPEPTIDES |
| EP1771565B1 (en) | 2004-07-20 | 2012-09-05 | The Feinstein Institute for Medical Research | Rage protein derivatives |
| US20080075728A1 (en) * | 2004-07-20 | 2008-03-27 | Walter Newman | Combination Therapies Of Hmgb And Complement Inhibitors Against Inflammation |
| WO2006024547A2 (en) * | 2004-09-03 | 2006-03-09 | Creabilis Therapeutics S.P.A. | Protease resistant human and non-human hmgb1 box-a mutants and their therapeutic/diagnostic use |
| US8129130B2 (en) | 2004-10-22 | 2012-03-06 | The Feinstein Institute For Medical Research | High affinity antibodies against HMGB1 and methods of use thereof |
| CN102731654A (zh) * | 2004-10-22 | 2012-10-17 | 米迪缪尼有限公司 | 抗hmgb1的高亲和力抗体及其用法 |
| US8354106B2 (en) | 2005-06-16 | 2013-01-15 | The Feinstein Institute For Medical Research | Antibodies against HMGB1 and fragments thereof |
| US20100040608A1 (en) * | 2005-07-18 | 2010-02-18 | Marie Wahren-Herlenius | Use of HMGB1 antagonists for the treatment of inflammatory skin conditions |
| JP3876325B1 (ja) * | 2005-10-24 | 2007-01-31 | 国立大学法人 岡山大学 | 脳梗塞抑制剤 |
| US20100172909A1 (en) * | 2005-10-24 | 2010-07-08 | Masahiro Nishibori | Cerebral edema suppressant |
| CA2631212A1 (en) * | 2005-11-28 | 2007-07-05 | Medimmune, Llc | Antagonists of hmgb1 and/or rage and methods of use thereof |
| WO2007130725A2 (en) * | 2006-02-06 | 2007-11-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of hmgb1 for protection against ischemia reperfusion injury |
| WO2007102410A1 (ja) * | 2006-02-24 | 2007-09-13 | National University Corporation Kanazawa University | Rageポリペプチドの新規用途 |
| JP3882090B1 (ja) | 2006-05-19 | 2007-02-14 | 国立大学法人 岡山大学 | 脳血管攣縮抑制剤 |
| SI2068935T1 (sl) * | 2006-09-15 | 2011-07-29 | Creabilis Therapeutics S R L | Polimerni konjugati od Box-A od HMGB1 in Box-A variante od HMGB1 |
| AU2007296843C1 (en) | 2006-09-15 | 2012-08-16 | Creabilis Therapeutics S.P.A. | Polymer conjugates of Box-A of HMGB1 and Box-A variants of HMGB1 |
| EP2123299A4 (en) * | 2007-02-15 | 2011-10-05 | Univ Kyushu Nat Univ Corp | THERAPEUTIC AGENT FOR INTERSTITIAL PULMONARY DISEASE COMPRISING ANTI-HMGB-1 ANTIBODY |
| WO2008099913A1 (ja) * | 2007-02-15 | 2008-08-21 | Kumamoto University | ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 |
| TW200846366A (en) * | 2007-02-15 | 2008-12-01 | Univ Fukuoka | Agent for suppressing rejection in organ transplantation comprising anti-hmgb-1 antibody |
| JP5660889B2 (ja) | 2008-04-30 | 2015-01-28 | 株式会社ジェノミックス | 末梢循環への骨髄由来多能性幹細胞動員薬 |
| US9919010B2 (en) | 2008-04-30 | 2018-03-20 | Genomix Co., Ltd. | Method for collecting functional cells in vivo with high efficiency |
| JP5467313B2 (ja) | 2009-09-28 | 2014-04-09 | 国立大学法人 岡山大学 | アテローム動脈硬化抑制剤 |
| CN104825491A (zh) | 2009-10-28 | 2015-08-12 | 吉诺米克斯股份有限公司 | 利用骨髓间充质干细胞和/或多能干细胞的血中动员的组织再生促进剂 |
| US8956618B2 (en) | 2010-01-21 | 2015-02-17 | The Texas A&M University System | Vaccine vectors and methods of enhancing immune responses |
| NZ718006A (en) | 2010-06-09 | 2017-06-30 | Univ Arkansas | Vaccine and methods to reduce campylobacter infection |
| EP2613797B1 (en) * | 2010-09-09 | 2015-11-04 | University Of Southern California | Compositions and methods for the removal of biofilms |
| KR102113809B1 (ko) | 2011-04-26 | 2020-05-21 | 가부시키가이샤 스템림 | 조직 재생을 유도하기 위한 펩티드 및 그의 이용 |
| WO2012170740A2 (en) * | 2011-06-07 | 2012-12-13 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
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| EP1392844A2 (en) | 2004-03-03 |
| HUP0500042A2 (hu) | 2005-03-29 |
| EP1392844A4 (en) | 2006-09-06 |
| US20030060410A1 (en) | 2003-03-27 |
| WO2002092004A3 (en) | 2003-10-09 |
| CA2447576C (en) | 2014-04-08 |
| US20040005316A1 (en) | 2004-01-08 |
| CZ20033402A3 (cs) | 2004-10-13 |
| CN100447154C (zh) | 2008-12-31 |
| HUP0500042A3 (en) | 2010-01-28 |
| KR20040018370A (ko) | 2004-03-03 |
| PL367132A1 (en) | 2005-02-21 |
| AU2002309829B2 (en) | 2007-08-23 |
| IS7037A (is) | 2003-11-14 |
| WO2002092004A2 (en) | 2002-11-21 |
| CN1516739A (zh) | 2004-07-28 |
| IL158643A (en) | 2010-12-30 |
| SK15422003A3 (sk) | 2005-01-03 |
| NO20035087D0 (no) | 2003-11-14 |
| NO20035087L (no) | 2003-12-09 |
| NZ529423A (en) | 2008-10-31 |
| IL208892A (en) | 2015-04-30 |
| JP2005512507A (ja) | 2005-05-12 |
| CA2447576A1 (en) | 2002-11-21 |
| IL208892A0 (en) | 2011-07-31 |
| MXPA03010449A (es) | 2004-12-06 |
| WO2002092004A8 (en) | 2003-11-27 |
| IL158643A0 (en) | 2004-05-12 |
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