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BR0209179A - Processo para a preparação de 2-[5-(4-fluorofenil)-3-piridilmeti-laminometil]croman o - Google Patents

Processo para a preparação de 2-[5-(4-fluorofenil)-3-piridilmeti-laminometil]croman o

Info

Publication number
BR0209179A
BR0209179A BR0209179-8A BR0209179A BR0209179A BR 0209179 A BR0209179 A BR 0209179A BR 0209179 A BR0209179 A BR 0209179A BR 0209179 A BR0209179 A BR 0209179A
Authority
BR
Brazil
Prior art keywords
chroman
fluorophenyl
preparation
laminomethyl
pyridylmethyl
Prior art date
Application number
BR0209179-8A
Other languages
English (en)
Inventor
Heinz-Hermann Bokel
Steffen Neunfeld
Ludwig Gantzert
Ralf Knierieme
Elke Simon
Ralf Devant
Udo Helm
Helmut Reubold
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0209179A publication Critical patent/BR0209179A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE 2-[5-4FLUOROFENIL)-3-PIRIDILMETI-LAMINOMETIL]CROMANO ". A presente invenção refere-se a um processo para a preparação de 2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano, os enanciómeros e seus sais, caracterizado pelo fato de que 5-(4-fluorofenil)piridina-3-carbaldeído é reagido diretamente com aminometilcromano ou seus sais sob condições de redução para produzir 2-[5-(4-fluorofenil)-3-piridilmetilaminometil]-cromano, e o último é, se desejado, convertido em um de seus sais fisiologicamente aceitáveis tratando-se com um ácido.
BR0209179-8A 2001-04-26 2002-04-08 Processo para a preparação de 2-[5-(4-fluorofenil)-3-piridilmeti-laminometil]croman o BR0209179A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10120619A DE10120619A1 (de) 2001-04-26 2001-04-26 2-(5-(4-Fluorphenyl)-3-pyridylmethylaminomethyl-chroman
PCT/EP2002/003857 WO2002088117A2 (de) 2001-04-26 2002-04-08 Verfahren zur herstellung von 2-[-5-(4-fluorphenyl)-3-pyridylmethylaminomethyl]-chroman

Publications (1)

Publication Number Publication Date
BR0209179A true BR0209179A (pt) 2004-08-03

Family

ID=7682908

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0209179-8A BR0209179A (pt) 2001-04-26 2002-04-08 Processo para a preparação de 2-[5-(4-fluorofenil)-3-piridilmeti-laminometil]croman o

Country Status (23)

Country Link
US (1) US7045629B2 (pt)
EP (1) EP1383763B1 (pt)
JP (1) JP2004526797A (pt)
KR (1) KR100839168B1 (pt)
CN (1) CN100430391C (pt)
AR (1) AR033262A1 (pt)
AT (1) ATE306485T1 (pt)
AU (1) AU2002257763B2 (pt)
BR (1) BR0209179A (pt)
CA (1) CA2445207C (pt)
CZ (1) CZ301615B6 (pt)
DE (2) DE10120619A1 (pt)
DK (1) DK1383763T3 (pt)
ES (1) ES2250647T3 (pt)
HU (1) HU229151B1 (pt)
MX (1) MXPA03009684A (pt)
MY (1) MY130616A (pt)
PL (1) PL208705B1 (pt)
RU (1) RU2288229C2 (pt)
SI (1) SI1383763T1 (pt)
SK (1) SK287477B6 (pt)
WO (1) WO2002088117A2 (pt)
ZA (1) ZA200309164B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4896518B2 (ja) * 2002-12-13 2012-03-14 ワイエム・バイオサイエンシズ・オーストラリア・ピーティーワイ・リミテッド ニコチンアミド系キナーゼ阻害薬
PA8663501A1 (es) * 2005-02-17 2006-11-09 Wyeth Wyeth Derivados de indol, benzotiofeno, benzofurano e indeno cicloalquilcondensados
RU2007139541A (ru) * 2005-04-22 2009-05-27 Вайет (Us) Производные хромана и хромена и их применение
US8093270B2 (en) * 2005-06-21 2012-01-10 Merck Patent Gmbh Solid pharmaceutical composition comprising (R)-(−)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]chroman
MX2008013428A (es) * 2006-04-18 2008-11-04 Abbott Lab Antagonistas del receptor de vanilloides del subtipo (vr1) y usos de los mismos.
WO2012012391A2 (en) * 2010-07-20 2012-01-26 Glaxo Group Limited Process for preparing pyrano - [2,3-c]pyridine derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4135474A1 (de) * 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
FR2701479B1 (fr) 1993-02-11 1995-05-12 Pf Medicament Nouveaux dérivés hétérocycliques de l'aminométhyl-4 pipéridine, leur préparation et leur application en thérapeutique.
DE69433401T2 (de) * 1993-08-19 2004-09-16 Janssen Pharmaceutica N.V. Gefässverengende dihydrobenzopyranderivate
GB9318431D0 (en) * 1993-09-06 1993-10-20 Boots Co Plc Therapeutic agents
SI0707007T1 (en) * 1994-10-14 2002-04-30 Merck Patent Gmbh (R)-(-)-2-(5-(4-fluorophenyl)-3-pyridylmethylaminomethyl)chromane as CNS active agent
DE10005150A1 (de) 2000-02-07 2001-08-09 Merck Patent Gmbh Verfahren zur Herstellung von 5-Arylnicotinaldehyden

Also Published As

Publication number Publication date
WO2002088117A3 (de) 2002-12-27
DE50204535D1 (de) 2006-02-23
CZ301615B6 (cs) 2010-05-05
AU2002257763B2 (en) 2007-03-15
HUP0303969A3 (en) 2011-02-28
MXPA03009684A (es) 2004-02-12
SK287477B6 (sk) 2010-11-08
SI1383763T1 (sl) 2006-04-30
RU2288229C2 (ru) 2006-11-27
HUP0303969A2 (hu) 2004-04-28
KR20040010616A (ko) 2004-01-31
EP1383763A2 (de) 2004-01-28
HK1077302A1 (en) 2006-02-10
DK1383763T3 (da) 2006-02-06
RU2003132433A (ru) 2005-04-20
CZ20033214A3 (cs) 2004-02-18
US20040138266A1 (en) 2004-07-15
CN1622944A (zh) 2005-06-01
AR033262A1 (es) 2003-12-10
ATE306485T1 (de) 2005-10-15
EP1383763B1 (de) 2005-10-12
PL208705B1 (pl) 2011-05-31
US7045629B2 (en) 2006-05-16
HU229151B1 (hu) 2013-09-30
SK14332003A3 (sk) 2004-04-06
JP2004526797A (ja) 2004-09-02
ZA200309164B (en) 2004-09-29
PL363281A1 (en) 2004-11-15
KR100839168B1 (ko) 2008-06-17
CA2445207A1 (en) 2002-11-07
CN100430391C (zh) 2008-11-05
CA2445207C (en) 2010-03-02
MY130616A (en) 2007-07-31
WO2002088117A2 (de) 2002-11-07
ES2250647T3 (es) 2006-04-16
DE10120619A1 (de) 2002-10-31

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT.CL: C07D 405/12, C07D 311/58

Ipc: C07D 405/12 (2011.01), C07D 311/58 (2011.01), A61P

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.