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BR0114681A - Processos para o isolamento ou purificação de pravastatina ou um sal farmacologicamente aceitável da mesma e para o isolamento ou purificação de pravastatina sódio, e, composição compreendendo pravastatina sódio - Google Patents

Processos para o isolamento ou purificação de pravastatina ou um sal farmacologicamente aceitável da mesma e para o isolamento ou purificação de pravastatina sódio, e, composição compreendendo pravastatina sódio

Info

Publication number
BR0114681A
BR0114681A BR0114681-5A BR0114681A BR0114681A BR 0114681 A BR0114681 A BR 0114681A BR 0114681 A BR0114681 A BR 0114681A BR 0114681 A BR0114681 A BR 0114681A
Authority
BR
Brazil
Prior art keywords
pravastatin
isolating
acceptable salt
sodium
pharmacologically acceptable
Prior art date
Application number
BR0114681-5A
Other languages
English (en)
Inventor
Nobunari Sugio
Shunshi Kojima
Mutsuo Suzuki
Kiyoshi Hamano
Yasuyuki Takamatsu
Minoru Hagisawa
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18794392&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0114681(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of BR0114681A publication Critical patent/BR0114681A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/58—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/28—Hydrogenated naphthalenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSOS PARA O ISOLAMENTO OU PURIFICAçãO DE PRAVASTATINA OU UM SAL FARMACOLOGICAMENTE ACEITáVEL DA MESMA E PARA O ISOLAMENTO OU PURIFICAçãO DE PRAVASTATINA SóDIO, E, COMPOSIçãO COMPREENDENDO PRAVASTATINA SóDIO". Um método para o isolamento ou purificação de pravastatina ou seu sal farmacologicamente aceitável da mesma caracterizado por envolver, no processo de isolamento ou purificação de pravastatina ou seu sal farmacologicamente aceitável da mesma, a etapa de extrair pravastatina usando um solvente orgânico representado pela fórmula CH~ 3~CO~ 2~R (em que R representa um grupo alquila tendo três ou mais carbonos) ou a etapa de decompor impurezas usando um ácido inorgânico ou uma base inorgânica, e composições contendo pravastatina sódio assim obtido.
BR0114681-5A 2000-10-16 2001-10-15 Processos para o isolamento ou purificação de pravastatina ou um sal farmacologicamente aceitável da mesma e para o isolamento ou purificação de pravastatina sódio, e, composição compreendendo pravastatina sódio BR0114681A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000315256A JP3236282B1 (ja) 2000-10-16 2000-10-16 プラバスタチンを精製する方法
PCT/JP2001/009045 WO2002032848A1 (en) 2000-10-16 2001-10-15 Method of purifying plavastatin

Publications (1)

Publication Number Publication Date
BR0114681A true BR0114681A (pt) 2003-12-09

Family

ID=18794392

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0114681-5A BR0114681A (pt) 2000-10-16 2001-10-15 Processos para o isolamento ou purificação de pravastatina ou um sal farmacologicamente aceitável da mesma e para o isolamento ou purificação de pravastatina sódio, e, composição compreendendo pravastatina sódio

Country Status (19)

Country Link
US (1) US20030216596A1 (pt)
EP (4) EP1514862A1 (pt)
JP (1) JP3236282B1 (pt)
KR (1) KR20030042018A (pt)
CN (4) CN1690037A (pt)
AU (1) AU2001294258A1 (pt)
BR (1) BR0114681A (pt)
CA (1) CA2425883A1 (pt)
CZ (1) CZ20031052A3 (pt)
HU (1) HUP0303106A3 (pt)
IL (1) IL155360A0 (pt)
MX (1) MXPA03003347A (pt)
NO (1) NO20031739L (pt)
NZ (3) NZ525256A (pt)
PL (1) PL360934A1 (pt)
RU (2) RU2260582C2 (pt)
SK (1) SK4532003A3 (pt)
WO (1) WO2002032848A1 (pt)
ZA (1) ZA200302966B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3422791B2 (ja) 2002-08-06 2003-06-30 三共株式会社 プラバスタチンの単離・精製方法
TW589178B (en) * 2003-02-21 2004-06-01 China Chemical & Pharmaceutica A novel industrial process to obtain pravastatin sodium of high purity
EP1452519A1 (en) * 2003-02-25 2004-09-01 Balkanpharma-Razgrad AD Method for the isolation and purification of pravastatin sodium
US20090042979A1 (en) * 2004-08-06 2009-02-12 Transform Pharmaceuticals Inc. Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
CA2573316A1 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel fenofibrate formulations and related methods of treatment
CA2576196A1 (en) * 2004-08-06 2006-02-16 Transform Pharmaceuticals, Inc. Novel statin pharmaceutical compositions and related methods of treatment
CN100361954C (zh) * 2005-05-16 2008-01-16 天津市冠东科技有限公司 制备普伐他汀结晶体的干燥方法
JP4813841B2 (ja) * 2005-07-25 2011-11-09 キユーピー株式会社 プラバスタチンナトリウムの製造方法
AU2009308707A1 (en) * 2008-10-31 2010-05-06 Biogen Idec Ma Inc. LIGHT targeting molecules and uses thereof
CN109796333B (zh) * 2019-01-25 2021-04-09 北大方正集团有限公司 一种从发酵液中提取纯化普伐他汀钠的方法
CN112778120B (zh) * 2019-11-08 2024-05-17 上海现代制药股份有限公司 一种降血脂类药物氧化杂质的制备方法
CN119915919A (zh) * 2023-10-31 2025-05-02 上海现代制药股份有限公司 普伐他汀有关物质的检测方法
CN119915920A (zh) * 2023-10-31 2025-05-02 上海现代制药股份有限公司 普伐他汀有关物质的检测方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK149080C (da) * 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
US5202029A (en) 1991-03-13 1993-04-13 Caron Kabushiki Kaisha Process for purification of hmg-coa reductase inhibitors
NZ250609A (en) * 1992-12-28 1995-07-26 Sankyo Co Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HU221636B1 (hu) * 1995-08-03 2002-12-28 Plus Chemicals B.V. Szelektív eljárás acilezett vegyületek dezacilezésére
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
SI20072A (sl) 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
JP2000279174A (ja) 1999-03-30 2000-10-10 Bml Inc ヒトｌｄｌレセプターに対するモノクローナル抗体及びこれを用いる家族性高脂血症の判定方法
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IL155194A0 (en) * 2000-10-05 2003-11-23 Biogal Pharmaceutical Co Ltd Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same

Also Published As

Publication number Publication date
SK4532003A3 (en) 2003-10-07
CN1690037A (zh) 2005-11-02
US20030216596A1 (en) 2003-11-20
WO2002032848A1 (en) 2002-04-25
HUP0303106A2 (hu) 2003-12-29
JP2002121174A (ja) 2002-04-23
CN1679535A (zh) 2005-10-12
MXPA03003347A (es) 2003-06-19
JP3236282B1 (ja) 2001-12-10
ZA200302966B (en) 2004-07-15
NZ525256A (en) 2005-01-28
EP1514863A1 (en) 2005-03-16
CA2425883A1 (en) 2003-04-15
NO20031739D0 (no) 2003-04-15
NO20031739L (no) 2003-06-13
EP1327626A1 (en) 2003-07-16
EP1514862A1 (en) 2005-03-16
HUP0303106A3 (en) 2004-10-28
PL360934A1 (en) 2004-09-20
KR20030042018A (ko) 2003-05-27
NZ536892A (en) 2005-05-27
CN1481353A (zh) 2004-03-10
AU2001294258A1 (en) 2002-04-29
CN1868996A (zh) 2006-11-29
NZ536891A (en) 2005-05-27
EP1522589A1 (en) 2005-04-13
RU2260582C2 (ru) 2005-09-20
RU2005113661A (ru) 2006-11-10
IL155360A0 (en) 2003-11-23
CZ20031052A3 (cs) 2003-09-17
EP1327626A4 (en) 2004-08-18

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 1964 DE 26/08/2008 E CONSIDERANDO A AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS.