BR0112035A - novispirin antimicrobial peptides - Google Patents
novispirin antimicrobial peptidesInfo
- Publication number
- BR0112035A BR0112035A BRPI0112035-2A BR0112035A BR0112035A BR 0112035 A BR0112035 A BR 0112035A BR 0112035 A BR0112035 A BR 0112035A BR 0112035 A BR0112035 A BR 0112035A
- Authority
- BR
- Brazil
- Prior art keywords
- novispirin
- peptides
- gram
- antimicrobial peptides
- negative bacterial
- Prior art date
Links
- 102000044503 Antimicrobial Peptides Human genes 0.000 title abstract 2
- 108700042778 Antimicrobial Peptides Proteins 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 239000002158 endotoxin Substances 0.000 abstract 2
- 208000027096 gram-negative bacterial infections Diseases 0.000 abstract 2
- 229920006008 lipopolysaccharide Polymers 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 230000003515 anti-microbian Effects 0.000 abstract 1
- 239000004599 antimicrobial Substances 0.000 abstract 1
- 230000003013 cytotoxicity Effects 0.000 abstract 1
- 231100000135 cytotoxicity Toxicity 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/04—Amoebicides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Manufacture, Treatment Of Glass Fibers (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Medicinal Preparation (AREA)
Abstract
"PEPTìDEOS ANTIMICROBIANOS DE NOVISPIRIN". Peptídeos de novispirin são agentes antimicrobianos com potente atividade contra bactérias gram-negativas. Os peptídeos são não hemolíticos, exibem reduzida citotoxicidade in vitro em relação a outros peptídeo antimicrobianos, e forma bem tolerado in vivo depois de injeção intravenosa. Novispirin também liga lipopolissacarídeo (LPS), uma propriedade que pode aliviar sintomas associados com infecção bacteriana por gram-negativos. Uma composição farmacêutica que compreende novispirin como um agente ativo é administrada a um paciente que sofre ou está predisposto a uma infecção microbiana, particularmente infecções bacterianas por gram-negativos."NOVISPIRIN ANTIMICROBIAN PEPTIDES". Novispirin peptides are antimicrobial agents with potent activity against gram-negative bacteria. The peptides are nonhemolytic, exhibit reduced in vitro cytotoxicity relative to other antimicrobial peptides, and are well tolerated in vivo after intravenous injection. Novispirin also binds lipopolysaccharide (LPS), a property that can alleviate symptoms associated with gram-negative bacterial infection. A pharmaceutical composition comprising novispirin as an active agent is administered to a patient suffering or predisposed to a microbial infection, particularly gram-negative bacterial infections.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60685800A | 2000-06-28 | 2000-06-28 | |
| US09/840,009 US6492328B2 (en) | 2000-06-28 | 2001-04-19 | Novispirins: antimicrobial peptides |
| PCT/US2001/019094 WO2002000839A2 (en) | 2000-06-28 | 2001-06-13 | Statement as to federally sponsored research |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0112035A true BR0112035A (en) | 2006-02-21 |
Family
ID=27085347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0112035-2A BR0112035A (en) | 2000-06-28 | 2001-06-13 | novispirin antimicrobial peptides |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1359930A4 (en) |
| JP (1) | JP2004526663A (en) |
| AU (1) | AU2001268421A1 (en) |
| BR (1) | BR0112035A (en) |
| CA (1) | CA2415236A1 (en) |
| IL (1) | IL153556A0 (en) |
| WO (1) | WO2002000839A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7071293B1 (en) * | 1999-08-18 | 2006-07-04 | The University Of Iowa Research Foundation | Alpha helical peptides with broad spectrum antimicrobial activity that are insensitive to salt |
| US20060264353A1 (en) * | 2002-03-21 | 2006-11-23 | Maxey Kirk M | Prostaglandin f2alpha analogs and their use in combination with antimicrobial proteins for the treatment of glaucoma and intraocular hypertension |
| WO2005092365A2 (en) * | 2004-03-29 | 2005-10-06 | Novozymes A/S | Pharmaceutical use of novispirins |
| US7148404B2 (en) | 2004-05-04 | 2006-12-12 | Novozymes A/S | Antimicrobial polypeptides |
| WO2008096814A1 (en) * | 2007-02-09 | 2008-08-14 | Genomidea Inc. | Novel polypeptide and antibacterial agent comprising the same as active ingredient |
| GB201115910D0 (en) | 2011-09-14 | 2011-10-26 | Univ Manchester | Peptides |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7470400A (en) * | 1999-08-18 | 2001-03-13 | Regents Of The University Of California, The | Cathelicidin-derived peptides with broad spectrum antimicrobial activity |
-
2001
- 2001-06-13 WO PCT/US2001/019094 patent/WO2002000839A2/en not_active Ceased
- 2001-06-13 AU AU2001268421A patent/AU2001268421A1/en not_active Abandoned
- 2001-06-13 JP JP2002505955A patent/JP2004526663A/en not_active Withdrawn
- 2001-06-13 EP EP01946359A patent/EP1359930A4/en not_active Withdrawn
- 2001-06-13 BR BRPI0112035-2A patent/BR0112035A/en not_active IP Right Cessation
- 2001-06-13 CA CA002415236A patent/CA2415236A1/en not_active Abandoned
- 2001-06-13 IL IL15355601A patent/IL153556A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002000839A3 (en) | 2003-08-28 |
| AU2001268421A1 (en) | 2002-01-08 |
| JP2004526663A (en) | 2004-09-02 |
| EP1359930A2 (en) | 2003-11-12 |
| CA2415236A1 (en) | 2002-01-03 |
| IL153556A0 (en) | 2003-07-06 |
| WO2002000839A2 (en) | 2002-01-03 |
| EP1359930A4 (en) | 2004-07-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GEP20053429B (en) | 3-Aminoquinazolin-2,4-Dione, Pharmaceutical Composition Containing Them and Use Thereof as Antibacterial Agents | |
| AR027391A1 (en) | BOTULIN TOXIN PHARMACEUTICAL COMPOSITIONS | |
| GEP20063799B (en) | Tropane derivatives useful in therapy | |
| BR0109875A (en) | Treatment of respiratory diseases | |
| BR9811535A (en) | Pharmaceutical compositions containing lysostaffin alone or in combination with an antibiotic for the treatment of staphylococcal infections | |
| DE69713151D1 (en) | CYCLOSPORINE DERIVATIVE, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITION | |
| BR9712523A (en) | New heterocyclyl-substituted pyrazole derivatives | |
| BR0307893A (en) | Ophthalmic formulation with gum system | |
| BRPI0112962B8 (en) | pharmaceutical compositions comprising hyaluronic acid, glycyrrhetinic acid and polyvinylpyrrolidone, and use of these compounds in the preparation of medicines | |
| PT806941E (en) | LIPOSOMIC ANTI-BACTERIAL COMPOSITIONS OF LOW RIGIDITY | |
| BR9811825A (en) | Use of lactobacillus to reduce the level of fibrinogen in the blood | |
| CY1110078T1 (en) | INJECTIONS WITH IODIDATED POVIDON FOR WASTE HEALING | |
| TR200200620T2 (en) | Levosimendan pharmaceutical solutions | |
| BR0110382A (en) | Use of azalide antibiotic compositions for the treatment or prevention of a bacterial or protozoal infection in mammals | |
| BR0111506A (en) | Macromolecular drug complexes and compositions containing same | |
| BR0010983A (en) | Preparations for the application of anti-inflammatory agents | |
| BR0112035A (en) | novispirin antimicrobial peptides | |
| DE60320034D1 (en) | TREATMENT OF MASTITIS WITH A COMBINATION OF PREDNISOLONE AND CEPHALOSPORIN | |
| GEP20032970B (en) | Pharmaceutical Compositions of Tizoxanide and Nitazoxanide | |
| AR045070A1 (en) | PREPARED PHARMACEUTICAL TOPICS OF ASCORBIC ACID WITH POST-ANTIMICOTIC EFFECT | |
| DE50113974D1 (en) | COMBINATION PREPARATIONS OF 3-N-FORMYLHYDROXYLAMINOPROPYLPHOSPHONIC ACID DERIVATIVES OR 3-N-ACETYLHYDROXYLAMINOPROPYLPHOSPHONIC ACID DERIVATIVES WITH SPECIAL PHARMACEUTICAL ACTIVE SUBSTANCES | |
| BRPI0410374A (en) | pharmaceutical composition comprising valsartan | |
| BR9807444A (en) | Antimicrobial product | |
| BR0011845A (en) | Pharmaceutical complex | |
| BR0214487A (en) | A pharmaceutical composition comprising a combination of metformin and a 4-oxobutanoic acid, and the use thereof for the treatment of diabetes. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADES |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2016 DE 25/08/2009. |