[go: up one dir, main page]

BR0112024A - Processo de separação da lovastatina - Google Patents

Processo de separação da lovastatina

Info

Publication number
BR0112024A
BR0112024A BR0112024-7A BR0112024A BR0112024A BR 0112024 A BR0112024 A BR 0112024A BR 0112024 A BR0112024 A BR 0112024A BR 0112024 A BR0112024 A BR 0112024A
Authority
BR
Brazil
Prior art keywords
lovastatin
separation process
substance
lactonizing
purity
Prior art date
Application number
BR0112024-7A
Other languages
English (en)
Inventor
Parveen Kumar
Pardeep Narula
S Raman
Original Assignee
Ranbaxy Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd filed Critical Ranbaxy Lab Ltd
Publication of BR0112024A publication Critical patent/BR0112024A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO DE SEPARAçãO DA LOVASTATINA". A presente invenção refere-se a um processo para a preparação e separação da substância ativa hipolipidêmica lovastatina na forma substancialmente pura, tendo grau de pureza de pelo menos 95%, compreendendo a lactonização do ácido mevinolínico para obter a substância lovastatina em um meio totalmente aquoso.
BR0112024-7A 2000-06-30 2001-06-20 Processo de separação da lovastatina BR0112024A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN630DE2000 IN192861B (pt) 2000-06-30 2000-06-30
PCT/IB2001/001087 WO2002000615A2 (en) 2000-06-30 2001-06-20 Process for the isolation of lovastatin

Publications (1)

Publication Number Publication Date
BR0112024A true BR0112024A (pt) 2003-09-09

Family

ID=11097066

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0112024-7A BR0112024A (pt) 2000-06-30 2001-06-20 Processo de separação da lovastatina

Country Status (10)

Country Link
US (1) US7052886B2 (pt)
EP (1) EP1299340A4 (pt)
AU (1) AU2001264173A1 (pt)
BR (1) BR0112024A (pt)
CA (1) CA2412566A1 (pt)
HU (1) HUP0301423A2 (pt)
IN (1) IN192861B (pt)
PL (1) PL359560A1 (pt)
WO (1) WO2002000615A2 (pt)
ZA (1) ZA200300006B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2204285B1 (es) * 2002-05-20 2005-03-01 Ercros Industrial, S.A. Procedimiento para el aislamiento y purificacion de lovastatina.
AU2003263579A1 (en) * 2003-08-04 2005-02-15 Biocon Limited Lactonization process
EP1673361B1 (en) * 2003-10-14 2009-05-27 Lupin Limited A method for the manufacture of lovastatin
US7777056B2 (en) 2004-03-30 2010-08-17 Lupin Ltd. Method for manufacture of 4-hydroxy pyran-2-one derivatives
CN100451644C (zh) * 2005-12-19 2009-01-14 北京维信学知科技发展有限公司 一种血脂康胶囊的质量检测方法
WO2009148709A1 (en) * 2008-04-16 2009-12-10 University Of Utah Research Foundation Pharmacological targeting of vascular malformations
IN2009MU00380A (pt) * 2009-02-18 2010-04-02
CN102344426A (zh) * 2010-07-30 2012-02-08 北大方正集团有限公司 一种提取并纯化洛伐他汀的方法
CN102993145B (zh) * 2011-09-19 2015-06-03 北大方正集团有限公司 一种提取纯化洛伐他汀的方法
CN103172602B (zh) * 2011-12-22 2015-04-29 北大方正集团有限公司 一种纯化洛伐他汀的方法
CN103172603B (zh) * 2011-12-22 2014-12-17 北大方正集团有限公司 一种高选择性酯化处理洛伐他汀酸的洛伐他汀提取方法
CN102875505B (zh) * 2012-08-02 2015-08-05 丽珠集团新北江制药股份有限公司 一种美伐他汀的提取精制工艺
CN106496174B (zh) * 2016-09-30 2019-06-04 丽珠集团(宁夏)制药有限公司 一种洛伐他汀的提取精制工艺
CN106518824B (zh) * 2016-09-30 2019-06-04 丽珠集团(宁夏)制药有限公司 一种洛伐他汀的提取工艺
CN115947708B (zh) * 2022-12-20 2024-07-12 浙江天草生物科技股份有限公司 一种从红曲中分离高纯度酸式洛伐他汀的方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5925599B2 (ja) 1979-02-20 1984-06-19 三共株式会社 新生理活性物質モナコリンｋおよびその製造法
US4231938A (en) 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
US4319039A (en) 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
US4282155A (en) 1980-02-04 1981-08-04 Merck & Co., Inc. Antihypercholesterolemic compounds
US4432996A (en) * 1980-11-17 1984-02-21 Merck & Co., Inc. Hypocholesterolemic fermentation products and process of preparation
HU208997B (en) 1992-06-17 1994-02-28 Gyogyszerkutato Intezet Microbiological method for producing mevinoline
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
DE877742T1 (de) 1995-12-06 1999-07-22 Antibiotic Co., Razgrad Verfahren zur herstellung von lovastatin
US5763646A (en) 1997-03-13 1998-06-09 Ranbaxy Laboratories, Ltd. Process for manufacturing simvastatin from lovastatin or mevinolinic acid
SI9800046A (sl) * 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
SI20527A (sl) * 1999-06-29 2001-10-31 Kaneka Corporation Postopek za selektivno laktonizacijo
US7194013B2 (en) * 2001-07-02 2007-03-20 Nichia Corporation GaN semiconductor laser device, and optical disk information system using the laser device

Also Published As

Publication number Publication date
WO2002000615A2 (en) 2002-01-03
AU2001264173A1 (en) 2002-01-08
PL359560A1 (en) 2004-08-23
WO2002000615A3 (en) 2002-05-30
IN192861B (pt) 2004-05-22
HUP0301423A2 (hu) 2003-08-28
US7052886B2 (en) 2006-05-30
US20030215932A1 (en) 2003-11-20
EP1299340A4 (en) 2004-06-30
CA2412566A1 (en) 2002-01-03
ZA200300006B (en) 2003-10-27
EP1299340A2 (en) 2003-04-09

Similar Documents

Publication Publication Date Title
BR0112024A (pt) Processo de separação da lovastatina
BR0200452A (pt) Método para produzir ácido l-glut mico pela fermentação
BR9912574A (pt) Processos para produzir um nanocompósito aniÈnico para o uso como um auxiliador de retenção e drenagem na fabricação de papel, e para aumentar a retenção e drenagem na fabricação de papel, e, nanocompósito aniÈnico para o uso como um auxiliador de retenção e drenagem na fabricação de papel.
BR9906287A (pt) Bactéria pertencente ao gênero escherichia e que tem uma capacidade para produzir um l-aminoácido, e, processo para produzir um l-aminoácido
BR9802011A (pt) Processo para a produção de vanilina.
BR0015202A (pt) Processo para a purificação de uma solução contendo aminoácido por meio de eletrodiálise, e processo integrado para a produção de um aminoácido livre
FR2627696B1 (fr) Nouvelle forme galenique du fenofibrate
BR9913383A (pt) Pirazol-carboxanilidas
BR0308385A (pt) Cristais de ácido (met) acrìlico e processo para produzir e purificar ácido (met) acrìlico aquoso
BR0307330A (pt) Produção do delta-9-tetraidrocanabinol
TR200201270T2 (tr) Epinastin içeren çözeltiler.
EP1456439A4 (en) METHOD FOR PRODUCING MULTILAYER GRAPHITE NUTS
BRPI9814894A (pt) processo para a preparação de ácidos 8-metóxi-quinolonocarboxílicos.
BR0107847A (pt) Processo para purificar ácido (met) acrìlico por cristalização
BR0115036A (pt) Processo para a preparação de um composto
ES2124750T3 (es) Composiciones farmaceuticas orales que contienen antocianosidos.
BR0109442B1 (pt) processo para a preparaÇço de derivados de 4,6-bis(arilàxi)pirimidina assimÉtricos.
BR0210338B1 (pt) composição aquosa, método para a preparação de uma composição aquosa, processo para a produção de papel a partir de uma suspensão aquosa contendo fibras celulósicas, e, uso da composição aquosa.
BR0200487A (pt) Método para produzir ácido l-glutâmico pela fermentação
UY26494A1 (es) " estabilización de vino"
BR0114380A (pt) Derivados-1-aminobutan-3-ol-substituìdos
BR0007982A (pt) Processo para a preparação de um composto, e,composto
AU2001263633A1 (en) Method for increasing the antioxidative potential of selenium-containing aqueous solutions
CA2411582A1 (en) Method for increasing the antioxidative potential of selenium-containing aqueous solutions
BR0113650A (pt) N-(3,5-dicloro-2-metoxifenil)-4-metóxi-3-piperazina-1-il a-benzenossulfonamida

Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]