BR0110112A - Derivados de pirrolidina e piperidina e seu uso para o tratamento de distúrbios neurodegenerativos - Google Patents
Derivados de pirrolidina e piperidina e seu uso para o tratamento de distúrbios neurodegenerativosInfo
- Publication number
- BR0110112A BR0110112A BR0110112-9A BR0110112A BR0110112A BR 0110112 A BR0110112 A BR 0110112A BR 0110112 A BR0110112 A BR 0110112A BR 0110112 A BR0110112 A BR 0110112A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxy
- bond
- treatment
- lower alkoxy
- chr
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title abstract 4
- 208000015122 neurodegenerative disease Diseases 0.000 title abstract 3
- 150000003053 piperidines Chemical class 0.000 title 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- -1 amino, nitro, benzyloxy Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004076 pyridyl group Chemical group 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000004770 neurodegeneration Effects 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
Abstract
"DERIVADOS DE PIRROLIDINA E PIPERIDINA E SEU USO PARA O TRATAMENTO DE DISTúRBIOS NEURODEGENERATIVOS". A invenção refere-se a compostos de fórmula (I) em que Ar^ 1^ é piridila ou fenila, substituída por hidróxi, alquila inferior, halogênio, amino, nitro, benzilóxi ou alcóxi inferior - alcóxi inferior, ou é o grupo (a), em que Z^ 1^ é um anel heterocíclico de cinco elementos, que contém um ou dois heteroátomos, selecionados dentre N ou O; R^ 1^ é hidrogênio, hidróxi ou um grupo oxo; Ar^ 2^ é piridila ou fenila, opcionalmente substituída por hidróxi, alquila inferior, halogênio, amino, nitro, benzilóxi ou alcóxi inferior - alcóxi inferior, ou é o grupo (b), em que Z^ 2^ é um anel de cinco ou seis elementos, que contém, opcionalmente, um ou dois heteroátomos, selecionados dentre N ou O; e Q é -S-, -S (O) - ou -S (O)~ 2~-; X é uma ligação, -CH (OH) - ou - (CH~ 2~)~ n~-; A é uma ligação ou - (CHR)~ m~-; R é hidrogênio, halogênio ou hidróxi, independentemente um do outro se m é 2 ou 3; Y é - (CR~ 2~)~ m~-, -O-, -C=C-, -C<154>C-, piperidin-1-ila, pirrolidin-1-ila OU C~ 4~-C~ 6~-cicloalquila, cujos anéis são opcionalmente substituídos por hidróxi; B é uma ligação, -O- ou - (CHR)~ m~-; n é 1 ou 2; e m é 1 a 3; e sais de adição de ácido farmaceuticamente aceitáveis dos mesmos, com a exceção de compostos, em que A e B são simultaneamente uma ligação e Y é -CHR-. Os compostos podem ser usados no tratamento de doenças neurodegenerativas.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00108610 | 2000-04-20 | ||
| PCT/EP2001/004171 WO2001081303A1 (en) | 2000-04-20 | 2001-04-11 | Pyrrolidine and piperidine derivatives and their use for the treament of neurodegenerative disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0110112A true BR0110112A (pt) | 2003-02-11 |
Family
ID=8168522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0110112-9A BR0110112A (pt) | 2000-04-20 | 2001-04-11 | Derivados de pirrolidina e piperidina e seu uso para o tratamento de distúrbios neurodegenerativos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6451819B2 (pt) |
| EP (1) | EP1278728B1 (pt) |
| JP (1) | JP4219590B2 (pt) |
| KR (1) | KR100501606B1 (pt) |
| CN (1) | CN1178911C (pt) |
| AR (1) | AR028343A1 (pt) |
| AT (1) | ATE274494T1 (pt) |
| AU (2) | AU2001273942B2 (pt) |
| BR (1) | BR0110112A (pt) |
| CA (1) | CA2404464C (pt) |
| DE (1) | DE60105144T2 (pt) |
| ES (1) | ES2225553T3 (pt) |
| MX (1) | MXPA02010261A (pt) |
| PE (1) | PE20011185A1 (pt) |
| PT (1) | PT1278728E (pt) |
| TR (1) | TR200402442T4 (pt) |
| WO (1) | WO2001081303A1 (pt) |
| ZA (1) | ZA200208015B (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2326777C (en) * | 1998-04-01 | 2011-12-20 | Nortran Pharmaceuticals Inc. | Aminocyclohexyl ether compounds and uses thereof |
| US6979685B1 (en) * | 1999-02-12 | 2005-12-27 | Cardiome Pharma Corp. | Cycloalkyl amine compounds and uses thereof |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US7524879B2 (en) * | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) * | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7199147B2 (en) | 2001-06-12 | 2007-04-03 | Dainippon Sumitomo Pharma Co., Ltd. | Rho kinase inhibitors |
| US6885903B2 (en) * | 2001-07-10 | 2005-04-26 | General Electric Company | Method and system for tracking repair of components |
| EP1467986A1 (en) * | 2002-01-17 | 2004-10-20 | Eli Lilly And Company | Aza-cyclic compounds as modulators of acetylcholine receptors |
| US7005432B2 (en) * | 2002-05-16 | 2006-02-28 | Hoffman-La Roche Inc. | Substituted imidazol-pyridazine derivatives |
| US7866517B2 (en) * | 2002-10-31 | 2011-01-11 | Fabio Pedrini | Vehicle-mounted equipment carrier |
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| ATE325789T1 (de) * | 2003-05-02 | 2006-06-15 | Cardiome Pharma Corp | Aminocyclohexylether-verbindungen und deren verwendung |
| US7345086B2 (en) * | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| US7674820B2 (en) * | 2003-08-07 | 2010-03-09 | Cardiome Pharma Corp. | Ion channel modulating activity I |
| US7345087B2 (en) * | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| GB0325956D0 (en) * | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| CA2561819A1 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| US8058304B2 (en) * | 2004-04-01 | 2011-11-15 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| JP5583325B2 (ja) * | 2004-11-08 | 2014-09-03 | カーディオム ファーマ コーポレイション | イオンチャネル調節化合物の投与レジメ |
| NZ588698A (en) * | 2008-03-27 | 2012-06-29 | Evotec Neurosciences Gmbh | Methods for treating disorders using nmda nr2b-subtype selective antagonist |
| EP2370451B1 (en) | 2008-12-02 | 2016-11-16 | Wave Life Sciences Japan, Inc. | Method for the synthesis of phosphorus atom modified nucleic acids |
| KR101885383B1 (ko) | 2009-07-06 | 2018-08-03 | 웨이브 라이프 사이언시스 리미티드 | 신규한 핵산 프로드러그 및 그의 사용 방법 |
| US10428019B2 (en) * | 2010-09-24 | 2019-10-01 | Wave Life Sciences Ltd. | Chiral auxiliaries |
| EP2734208B1 (en) | 2011-07-19 | 2017-03-01 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| CA2879066C (en) | 2012-07-13 | 2019-08-13 | Shin Nippon Biomedical Laboratories, Ltd. | Chiral nucleic acid adjuvant |
| PL2872485T3 (pl) | 2012-07-13 | 2021-05-31 | Wave Life Sciences Ltd. | Asymetryczna grupa pomocnicza |
| CN104661664B (zh) | 2012-07-13 | 2020-07-03 | 波涛生命科学有限公司 | 手性控制 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108048A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
| EP4137572A1 (en) | 2014-01-16 | 2023-02-22 | Wave Life Sciences Ltd. | Chiral design |
| AU2015287663B2 (en) * | 2014-07-10 | 2019-02-28 | SpecGx LLC | Process for preparing substituted phenylalkanes |
| WO2024099403A1 (zh) * | 2022-11-10 | 2024-05-16 | 北京普祺医药科技股份有限公司 | 一种具有软药性质的硫醚类化合物、药物组合物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL74140A (en) * | 1984-04-10 | 1988-05-31 | Robins Co Inc A H | Substituted n-((amino)alkyl)-1-pyrrolidine,-1-piperidine and-1-homopiperidine-carboxamides and pharmaceutical compositions containing them |
| ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
| US6015824A (en) * | 1998-02-10 | 2000-01-18 | Hoffmann-La Roche Ag | Pyrrolidine and piperidine derivatives and treatment of neurodegenerative disorders |
| TWI254043B (en) * | 1999-06-08 | 2006-05-01 | Hoffmann La Roche | Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor |
-
2001
- 2001-04-11 BR BR0110112-9A patent/BR0110112A/pt not_active IP Right Cessation
- 2001-04-11 EP EP01940321A patent/EP1278728B1/en not_active Expired - Lifetime
- 2001-04-11 KR KR10-2002-7014043A patent/KR100501606B1/ko not_active Expired - Fee Related
- 2001-04-11 ES ES01940321T patent/ES2225553T3/es not_active Expired - Lifetime
- 2001-04-11 TR TR2004/02442T patent/TR200402442T4/xx unknown
- 2001-04-11 JP JP2001578398A patent/JP4219590B2/ja not_active Expired - Fee Related
- 2001-04-11 AT AT01940321T patent/ATE274494T1/de not_active IP Right Cessation
- 2001-04-11 AU AU2001273942A patent/AU2001273942B2/en not_active Ceased
- 2001-04-11 WO PCT/EP2001/004171 patent/WO2001081303A1/en not_active Ceased
- 2001-04-11 PT PT01940321T patent/PT1278728E/pt unknown
- 2001-04-11 CA CA002404464A patent/CA2404464C/en not_active Expired - Fee Related
- 2001-04-11 DE DE60105144T patent/DE60105144T2/de not_active Expired - Fee Related
- 2001-04-11 MX MXPA02010261A patent/MXPA02010261A/es active IP Right Grant
- 2001-04-11 AU AU7394201A patent/AU7394201A/xx active Pending
- 2001-04-11 CN CNB018083099A patent/CN1178911C/zh not_active Expired - Fee Related
- 2001-04-12 US US09/833,450 patent/US6451819B2/en not_active Expired - Fee Related
- 2001-04-18 AR ARP010101809A patent/AR028343A1/es unknown
- 2001-04-18 PE PE2001000354A patent/PE20011185A1/es not_active Application Discontinuation
-
2002
- 2002-10-04 ZA ZA200208015A patent/ZA200208015B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA02010261A (es) | 2003-04-25 |
| DE60105144D1 (de) | 2004-09-30 |
| ATE274494T1 (de) | 2004-09-15 |
| KR100501606B1 (ko) | 2005-07-18 |
| CN1425002A (zh) | 2003-06-18 |
| CA2404464C (en) | 2008-03-11 |
| CA2404464A1 (en) | 2001-11-01 |
| ZA200208015B (en) | 2004-02-10 |
| WO2001081303A1 (en) | 2001-11-01 |
| AU7394201A (en) | 2001-11-07 |
| PE20011185A1 (es) | 2001-11-14 |
| ES2225553T3 (es) | 2005-03-16 |
| JP4219590B2 (ja) | 2009-02-04 |
| US20010047031A1 (en) | 2001-11-29 |
| TR200402442T4 (tr) | 2004-12-21 |
| KR20030013387A (ko) | 2003-02-14 |
| AU2001273942B2 (en) | 2005-09-01 |
| PT1278728E (pt) | 2004-10-29 |
| JP2003531190A (ja) | 2003-10-21 |
| EP1278728B1 (en) | 2004-08-25 |
| US6451819B2 (en) | 2002-09-17 |
| CN1178911C (zh) | 2004-12-08 |
| DE60105144T2 (de) | 2005-09-08 |
| EP1278728A1 (en) | 2003-01-29 |
| AR028343A1 (es) | 2003-05-07 |
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