BR0110098A - Polynucleotide, recombinant genetic construct, expression vector, host cell, transgenic animal, peptide, methods for screening an agent for pharmacological activity, inhibiting the binding of gnrh to its native receptor in vivo, and contraception, and uses of type ii gnrh-r or an extracellular domain thereof - Google Patents
Polynucleotide, recombinant genetic construct, expression vector, host cell, transgenic animal, peptide, methods for screening an agent for pharmacological activity, inhibiting the binding of gnrh to its native receptor in vivo, and contraception, and uses of type ii gnrh-r or an extracellular domain thereofInfo
- Publication number
- BR0110098A BR0110098A BR0110098-0A BR0110098A BR0110098A BR 0110098 A BR0110098 A BR 0110098A BR 0110098 A BR0110098 A BR 0110098A BR 0110098 A BR0110098 A BR 0110098A
- Authority
- BR
- Brazil
- Prior art keywords
- gnrh
- type
- polynucleotide
- peptide
- screening
- Prior art date
Links
- 102000040430 polynucleotide Human genes 0.000 title abstract 3
- 108091033319 polynucleotide Proteins 0.000 title abstract 3
- 239000002157 polynucleotide Substances 0.000 title abstract 3
- 241001465754 Metazoa Species 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 239000013604 expression vector Substances 0.000 title abstract 2
- 230000002068 genetic effect Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 230000000144 pharmacologic effect Effects 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000012216 screening Methods 0.000 title abstract 2
- 230000009261 transgenic effect Effects 0.000 title abstract 2
- 101150108262 gnrh1 gene Proteins 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 102100033851 Gonadotropin-releasing hormone receptor Human genes 0.000 abstract 2
- 101710082444 Gonadotropin-releasing hormone receptor Proteins 0.000 abstract 2
- 102000008238 LHRH Receptors Human genes 0.000 abstract 1
- 108010021290 LHRH Receptors Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 241001515942 marmosets Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gynecology & Obstetrics (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
POLINUCLEOTìDEO, CONSTRUçãO GENéTICA RECOMBINANTE, VETOR DE EXPRESSãO, CéLULA HOSPEDEIRA, ANIMAL TRANSGêNICO, PEPTìDEO, MéTODOS PARA TRIAGEM DE UM AGENTE QUANTO à ATIVIDADE FARMACOLóGICA, DE INIBIR A LIGAçãO DO GnRH A SEU RECEPTOR NATIVO IN VIVO, E DE CONTRACEPçãO, E, USOS DO GnRH-R DO TIPO II OU DE UM SEU DOMìNIO EXTRACELULAR. São providos polinucleotídeos codificando a sequência completa para os receptores de hormónios de liberação da gonadotropina do Tipo II de sagui e de seres humanos (GnRH-R Tipo II). As sequências de aminoácidos correspodentes são também providas.POLYNUCLEOTIDE, RECOMBINANT GENETIC CONSTRUCTION, EXPRESSION VECTOR, HOST CELL, TRANSGENIC ANIMAL, PEPTIDE, METHODS FOR SCREENING AN AGENT, PHARMACOLOGICAL ACTIVITY, INHIBITION OF THE INCEPTION AND GON INPRODUCTION, GnRH-R OF TYPE II OR AN EXTRACELLULAR DOMAIN. Polynucleotides encoding the full sequence for marmoset and human Type II gonadotropin releasing hormone receptor (GnRH-R Type II) are provided. Corresponding amino acid sequences are also provided.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0009269A GB0009269D0 (en) | 2000-04-15 | 2000-04-15 | Receptor |
| GB0014761A GB0014761D0 (en) | 2000-06-17 | 2000-06-17 | Receptor |
| US21523200P | 2000-06-30 | 2000-06-30 | |
| PCT/GB2001/001755 WO2001078796A1 (en) | 2000-04-15 | 2001-04-17 | Type ii gonadotropin-releasing hormone receptor and polynucleotides encoding therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0110098A true BR0110098A (en) | 2003-01-14 |
Family
ID=27255670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0110098-0A BR0110098A (en) | 2000-04-15 | 2001-04-17 | Polynucleotide, recombinant genetic construct, expression vector, host cell, transgenic animal, peptide, methods for screening an agent for pharmacological activity, inhibiting the binding of gnrh to its native receptor in vivo, and contraception, and uses of type ii gnrh-r or an extracellular domain thereof |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1337282A2 (en) |
| JP (1) | JP2003530837A (en) |
| KR (1) | KR20020097218A (en) |
| AU (1) | AU2001248599A1 (en) |
| BR (1) | BR0110098A (en) |
| CA (1) | CA2404127A1 (en) |
| HU (1) | HUP0301666A2 (en) |
| IL (1) | IL152011A0 (en) |
| NO (1) | NO20024937L (en) |
| PL (1) | PL357684A1 (en) |
| WO (1) | WO2001078796A1 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002000701A2 (en) * | 2000-06-26 | 2002-01-03 | Bayer Aktiengesellschaft | Regulation of human gonadotropin releasing hormone receptor-like g protein-coupled receptor |
| AU2002249304A1 (en) * | 2001-03-01 | 2002-09-19 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Novel human gnrh receptor |
| US20050282745A1 (en) * | 2001-08-28 | 2005-12-22 | Siler-Khodr Theresa M | Non-mammalian GnRH analogs and uses thereof in regulation of fertility and pregnancy |
| WO2004010145A2 (en) * | 2002-07-22 | 2004-01-29 | Ardana Bioscience Limited | Screening method |
| WO2004009636A2 (en) * | 2002-07-22 | 2004-01-29 | Ardana Bioscience Limited | Gnrh modulator |
| WO2004010146A1 (en) | 2002-07-22 | 2004-01-29 | Ardana Bioscience Limited | Screening method and anti-tumor drug candidate obtained therefrom |
| KR101038183B1 (en) * | 2010-12-27 | 2011-06-01 | 강범준 | Prefabricated corrugated block and shoreline slope coating method |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4542793A (en) * | 1992-06-23 | 1994-01-24 | Mt. Sinai School of Medicine of the City University of New York, The | Cloning and expression of gonadotropin-releasing hormone receptor |
| WO1997047743A1 (en) * | 1996-06-13 | 1997-12-18 | Zymogenetics, Inc. | Human type ii gonadotropin-releasing hormone receptor |
-
2001
- 2001-04-17 HU HU0301666A patent/HUP0301666A2/en unknown
- 2001-04-17 BR BR0110098-0A patent/BR0110098A/en not_active Application Discontinuation
- 2001-04-17 WO PCT/GB2001/001755 patent/WO2001078796A1/en not_active Ceased
- 2001-04-17 EP EP01921629A patent/EP1337282A2/en not_active Withdrawn
- 2001-04-17 IL IL15201101A patent/IL152011A0/en unknown
- 2001-04-17 PL PL01357684A patent/PL357684A1/en unknown
- 2001-04-17 CA CA002404127A patent/CA2404127A1/en not_active Abandoned
- 2001-04-17 JP JP2001576095A patent/JP2003530837A/en active Pending
- 2001-04-17 KR KR1020027013776A patent/KR20020097218A/en not_active Withdrawn
- 2001-04-17 AU AU2001248599A patent/AU2001248599A1/en not_active Abandoned
-
2002
- 2002-10-14 NO NO20024937A patent/NO20024937L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001078796A3 (en) | 2003-04-24 |
| IL152011A0 (en) | 2003-04-10 |
| AU2001248599A1 (en) | 2001-10-30 |
| NO20024937L (en) | 2002-12-09 |
| CA2404127A1 (en) | 2001-10-25 |
| NO20024937D0 (en) | 2002-10-14 |
| PL357684A1 (en) | 2004-07-26 |
| WO2001078796A9 (en) | 2002-02-28 |
| JP2003530837A (en) | 2003-10-21 |
| EP1337282A2 (en) | 2003-08-27 |
| WO2001078796A1 (en) | 2001-10-25 |
| HUP0301666A2 (en) | 2003-08-28 |
| KR20020097218A (en) | 2002-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |