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BR0014016A - Método para separar um composto de alto peso molecular contendo lactona - Google Patents

Método para separar um composto de alto peso molecular contendo lactona

Info

Publication number
BR0014016A
BR0014016A BR0014016-3A BR0014016A BR0014016A BR 0014016 A BR0014016 A BR 0014016A BR 0014016 A BR0014016 A BR 0014016A BR 0014016 A BR0014016 A BR 0014016A
Authority
BR
Brazil
Prior art keywords
molecular weight
high molecular
weight compound
separating
mixture
Prior art date
Application number
BR0014016-3A
Other languages
English (en)
Other versions
BR0014016B1 (pt
Inventor
Tomoji Higaki
Takashi Yoshiyasu
Norihiro Hashimoto
Keiji Honda
Hiroshi Hatanaka
Michio Yamashita
Original Assignee
Fujisawa Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co
Publication of BR0014016A publication Critical patent/BR0014016A/pt
Publication of BR0014016B1 publication Critical patent/BR0014016B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

"MéTODO PARA SEPARAR UM COMPOSTO DE ALTO PESO MOLECULAR CONTENDO LACTONA". Método para separar um composto de alto peso molecular contendo lactona, compreendendo submeter uma mistura de um composto de alto peso molecular contendo lactona tendo, como sua cadeia lateral, pelo menos um de um grupo alquenila inferior e de um grupo alcoxi inferior e seu(s) composto(s) análogo(s) a qualquer uma ou a ambas as etapas, em qualquer ordem, de uma etapa (A) para adsorver a mistura numa resina de adsorção não-iónica e eluir com um solvente aquoso contendo íons de prata, e uma etapa para adsorver a mistura numa alumina ativa básica e eluir com um solvente orgânico para separar cada um dos compostos.
BRPI0014016-3A 1999-09-08 2000-09-05 método para separar um composto de alto peso molecular contendo lactona. BR0014016B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25381399 1999-09-08
JP11/253813 1999-09-08
PCT/JP2000/006023 WO2001018007A2 (en) 1999-09-08 2000-09-05 Method for separating lactone-containing high-molecular weight compounds

Publications (2)

Publication Number Publication Date
BR0014016A true BR0014016A (pt) 2002-05-21
BR0014016B1 BR0014016B1 (pt) 2011-07-12

Family

ID=17256507

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0014016-3A BR0014016B1 (pt) 1999-09-08 2000-09-05 método para separar um composto de alto peso molecular contendo lactona.

Country Status (23)

Country Link
US (2) US6576135B1 (pt)
EP (1) EP1210351B1 (pt)
JP (1) JP3925198B2 (pt)
CN (1) CN1195760C (pt)
AR (1) AR025598A1 (pt)
AT (1) ATE263773T1 (pt)
AU (1) AU779331B2 (pt)
BR (1) BR0014016B1 (pt)
CA (1) CA2384440C (pt)
CZ (1) CZ302625B6 (pt)
DE (1) DE60009723T2 (pt)
DK (1) DK1210351T3 (pt)
ES (1) ES2214307T3 (pt)
HU (1) HU230126B1 (pt)
MX (1) MXPA02002370A (pt)
NO (1) NO328422B1 (pt)
NZ (1) NZ517473A (pt)
PL (1) PL195650B1 (pt)
PT (1) PT1210351E (pt)
RU (1) RU2245338C2 (pt)
TR (1) TR200200593T2 (pt)
TW (1) TW553946B (pt)
WO (1) WO2001018007A2 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW553946B (en) * 1999-09-08 2003-09-21 Fujisawa Pharmaceutical Co Method for separating lactone-containing high-molecular weight compounds
HRP20040765A2 (en) 2002-02-13 2005-02-28 Biogal Gyogyszergyar Rt. Method for extracting a macrolide from biomatter
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
PL1558622T3 (pl) * 2003-07-24 2008-06-30 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Sposób oczyszczania makrolidów
RU2317991C1 (ru) * 2003-12-05 2008-02-27 Байокон Лимитид Способ выделения и очистки макролидов
US7704725B2 (en) * 2004-04-12 2010-04-27 Biocon Limited Process for the production of macrolides using a novel strain, Streptomyces sp. BICC 7522
KR20070057910A (ko) * 2004-09-10 2007-06-07 아이박스 파마슈티컬스 에스.알.오. 결정질 타크롤리무스의 분리 방법
ITMI20042098A1 (it) * 2004-11-03 2005-02-03 Antibioticos Spa Processo per la purificazione di tacrolimus
JP2007523069A (ja) * 2004-12-01 2007-08-16 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ 非吸湿性及び粉末性非晶質ピメクロリマス
CA2586700A1 (en) * 2004-12-22 2006-06-29 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method of purifying tacrolimus
MX2007006119A (es) * 2005-01-05 2007-07-19 Teva Gyogyszergyar Zartkoruen Tacrolimus amorfo y preparacion de el.
WO2007013017A1 (en) * 2005-07-29 2007-02-01 Ranbaxy Laboratories Limited A process for purification of macrolides
ITMI20051549A1 (it) * 2005-08-05 2007-02-06 Antibioticos Spa Purificazione del tacrolimus su supporti dimorigine vegetale
WO2007106587A2 (en) * 2006-03-15 2007-09-20 Teva Gyogyszergyar Zartköruen Muködo Reszvenytarsasag Process for purifying tacrolimus
DE602007006601D1 (de) * 2006-03-15 2010-07-01 Teva Gyogyszergyar Zartkoeruee Verfahren zur reinigung von tacrolimus
KR20100053536A (ko) * 2007-06-29 2010-05-20 아트피셜 머슬, 인코퍼레이션 감각적 피드백을 부여하는 전기활성 고분자 변환기
KR101022067B1 (ko) 2008-05-30 2011-03-17 이연제약주식회사 고순도 타크로리무스의 회수방법
KR100910165B1 (ko) * 2008-09-18 2009-07-30 (주) 제노텍 은 이온 용액 추출을 이용한 불포화 알킬기를 가진 락톤 화합물 정제방법
US20110318277A1 (en) 2010-06-25 2011-12-29 APT Pharmaceuticals, Inc. University of Maryland, Baltimore Tacrolimus compositions for aerosol administration
KR20150028245A (ko) 2012-07-06 2015-03-13 고도 슈세이 가부시키가이샤 고리형 매크로라이드계 화합물의 분리 방법
RU2694354C1 (ru) * 2018-09-25 2019-07-11 Закрытое акционерное общество "БиоХимМак СТ" Способ сорбционно-хроматографического выделения и очистки такролимуса

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8406218D0 (en) * 1984-03-09 1984-04-11 Glaxo Group Ltd Process
AU600187B2 (en) * 1987-12-15 1990-08-02 Unilever Plc Process for concentrating lactones, as well as the use of the concentrate thus obtained for flavouring foodstuffs
NO176766C (no) * 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
JPH03191788A (ja) 1989-12-19 1991-08-21 Nippon Kayaku Co Ltd 新規抗生物質ｎｋ１５５１４１およびその製造法
TW553946B (en) * 1999-09-08 2003-09-21 Fujisawa Pharmaceutical Co Method for separating lactone-containing high-molecular weight compounds

Also Published As

Publication number Publication date
AR025598A1 (es) 2002-12-04
PL195650B1 (pl) 2007-10-31
WO2001018007A2 (en) 2001-03-15
CA2384440A1 (en) 2001-03-15
JP2003508536A (ja) 2003-03-04
DE60009723D1 (de) 2004-05-13
EP1210351B1 (en) 2004-04-07
NO20021024L (no) 2002-05-02
NZ517473A (en) 2004-01-30
DK1210351T3 (da) 2004-08-02
CN1373764A (zh) 2002-10-09
AU6871300A (en) 2001-04-10
RU2245338C2 (ru) 2005-01-27
NO20021024D0 (no) 2002-03-01
HUP0203196A2 (hu) 2002-12-28
CN1195760C (zh) 2005-04-06
US6881341B2 (en) 2005-04-19
MXPA02002370A (es) 2002-08-20
EP1210351A2 (en) 2002-06-05
PL353802A1 (en) 2003-12-01
BR0014016B1 (pt) 2011-07-12
PT1210351E (pt) 2004-08-31
JP3925198B2 (ja) 2007-06-06
DE60009723T2 (de) 2005-04-28
US20030168409A1 (en) 2003-09-11
HUP0203196A3 (en) 2003-12-29
ATE263773T1 (de) 2004-04-15
HK1048991A1 (en) 2003-04-25
AU779331B2 (en) 2005-01-20
WO2001018007A3 (en) 2001-07-26
CA2384440C (en) 2009-02-17
CZ302625B6 (cs) 2011-08-10
ES2214307T3 (es) 2004-09-16
TW553946B (en) 2003-09-21
TR200200593T2 (tr) 2002-07-22
US6576135B1 (en) 2003-06-10
HU230126B1 (hu) 2015-08-28
NO328422B1 (no) 2010-02-15
CZ2002860A3 (cs) 2002-08-14

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP)

Free format text: TRANSFERIDO POR FUSAO DE: FUJISAWA PHARMACEUTICAL CO., LTD.

B25D Requested change of name of applicant approved

Owner name: ASTELLAS PHARMA INC. (JP)

Free format text: ALTERADO DE: YAMANOUCHI PHARMACEUTICAL CO., LTD.

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 12/07/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 12.07.2021