BR0011274A - Derivados tipo indol como inibidores de p38 quinase - Google Patents
Derivados tipo indol como inibidores de p38 quinaseInfo
- Publication number
- BR0011274A BR0011274A BR0011274-7A BR0011274A BR0011274A BR 0011274 A BR0011274 A BR 0011274A BR 0011274 A BR0011274 A BR 0011274A BR 0011274 A BR0011274 A BR 0011274A
- Authority
- BR
- Brazil
- Prior art keywords
- substituent
- independently
- uninterrupted
- chain
- hydrogen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Patente de Invenção: "DERIVADOS TIPO INDOL COMO INIBIDORES DE p38 QUINASE". A invenção é dirigida a métodos para inibir atividade de p38-a quinase usando compostos de fórmula (I), e os sais dos mesmos farmaceuticamente aceitáveis, ou uma composição farmacêutica dos mesmos, caracterizados pelo fato de que (a) representa uma ligação única ou dupla; UM Z^ 2^ é CA ou CR^ 8^A e o outro é CR^ 1^, Cr^ 1^~ 2~, NR^ 6^ ou N em que cada R^ 1^, R^ 6^ e R^ 8^ é de modo independente hidrogênio ou substituinte não interposto; A é -W~ i~-COX~ j~Y em que Y é COR^ 2^ ou um isóstere do mesmo e R^ 2^ é hidrogênio ou um substituinte não interposto, cada de W e X é um espaçador de 2-6 <134>, e cada de i e j é de modo independente 0 ou 1; Z^ 3^ é NR^ 7^ ou O; cada R^ 3^ é de modo independente um substituinte não interposto; n é 0-3; cada de L^ 1^ e L^ 2^ é um encadeador; cada R^ 4^ é de modo independente um substituinte não interposto; m é 0-4; Z^ 1^ é CR^ 5^ ou N em que R^ 5^ é hidrogênio ou um substituinte não interposto; cada de l e k é um inteiro de 0-2 em que a soma de 1 e k é 0-3; Ar é um grupamento aril substituído com 0-5 substituintes não interpostos, em que dois substituintes não interpostos podem formar uma cadeia fundida; e a distância entre o átomo de Ar ligado a L^ 2^ e o centro da cadeia <244> é 4,5-24 <134>.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/316,761 US6589954B1 (en) | 1998-05-22 | 1999-05-21 | Compounds and methods to treat cardiac failure and other disorders |
| US15459499P | 1999-09-17 | 1999-09-17 | |
| US20260800P | 2000-05-09 | 2000-05-09 | |
| PCT/US2000/014003 WO2000071535A1 (en) | 1999-05-21 | 2000-05-19 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011274A true BR0011274A (pt) | 2002-02-26 |
Family
ID=27387611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011274-7A BR0011274A (pt) | 1999-05-21 | 2000-05-19 | Derivados tipo indol como inibidores de p38 quinase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1178983B1 (pt) |
| JP (1) | JP2003500403A (pt) |
| KR (1) | KR100743377B1 (pt) |
| CN (1) | CN1310906C (pt) |
| AT (1) | ATE376547T1 (pt) |
| AU (2) | AU772295B2 (pt) |
| BG (1) | BG106091A (pt) |
| BR (1) | BR0011274A (pt) |
| CA (1) | CA2372567A1 (pt) |
| CZ (1) | CZ20014126A3 (pt) |
| DE (1) | DE60036868D1 (pt) |
| HR (1) | HRP20010854A2 (pt) |
| HU (1) | HUP0201261A3 (pt) |
| IL (1) | IL146309A0 (pt) |
| MX (1) | MXPA01011976A (pt) |
| NO (1) | NO20015655L (pt) |
| NZ (1) | NZ515285A (pt) |
| PL (1) | PL352032A1 (pt) |
| SK (1) | SK16482001A3 (pt) |
| WO (1) | WO2000071535A1 (pt) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6541477B2 (en) | 1999-08-27 | 2003-04-01 | Scios, Inc. | Inhibitors of p38-a kinase |
| WO2001064676A2 (en) * | 2000-02-28 | 2001-09-07 | Scios, Inc. | INHIBITORS OF p38-α KINASE |
| US6573262B2 (en) | 2000-07-10 | 2003-06-03 | Bristol-Myers Sqibb Company | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives |
| DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
| ES2279837T3 (es) * | 2000-11-20 | 2007-09-01 | Scios Inc. | Inhibidores de tipo piperidina/piperazina de la quinasa p38. |
| AU2002237657A1 (en) * | 2000-11-20 | 2002-06-11 | Scios Inc. | Indole-type inhibitors of p38 kinase |
| IL157029A0 (en) * | 2001-02-02 | 2004-02-08 | Bristol Myers Squibb Co | Azaindoleoxoacetic piperazine derivatives and pharmaceutical compositions containing the same |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US20030207910A1 (en) * | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| EP1427416A2 (en) | 2001-09-13 | 2004-06-16 | Synta Pharmaceuticals Corporation | 3-glyoxlylamideindoles for treating cancer |
| WO2003022274A2 (en) * | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 2-aroylimidazole compounds for treating cancer |
| GB0124938D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| US20040009990A1 (en) * | 2001-11-09 | 2004-01-15 | Higgins Linda S. | Method to treat cystic fibrosis |
| BR0214345A (pt) * | 2001-11-22 | 2004-09-14 | Ono Pharmaceutical Co | Compostos derivados de piperidin-2-ona e composições farmacêuticas contendo estes compostos como ingrediente ativo |
| JP2005528374A (ja) * | 2002-04-05 | 2005-09-22 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 粘液分泌過多の治療方法 |
| GB0209818D0 (en) | 2002-04-30 | 2002-06-05 | Koninkl Philips Electronics Nv | Antenna arrangement |
| ES2278170T3 (es) | 2002-07-09 | 2007-08-01 | BOEHRINGER INGELHEIM PHARMA GMBH & CO.KG | Composiciones farmaceuticas de anticolinergicos e inhibidores de la quinasa p38 en el tratamiento de enfermedades respiratorias. |
| US7268139B2 (en) | 2002-08-29 | 2007-09-11 | Scios, Inc. | Methods of promoting osteogenesis |
| WO2004022712A2 (en) * | 2002-09-03 | 2004-03-18 | Scios Inc. | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE |
| WO2004032874A2 (en) * | 2002-10-09 | 2004-04-22 | Scios Inc. | AZAINDOLE DERIVATIVES AS INHIBITORS OF p38 KINASE |
| AU2003299652A1 (en) * | 2002-12-06 | 2004-06-30 | Scios Inc. | Methods for treating diabetes |
| RU2357957C2 (ru) | 2003-03-03 | 2009-06-10 | Эррэй Биофарма, Инк. | Ингибиторы р38 и способы их применения |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| EP2251343A1 (en) | 2003-05-15 | 2010-11-17 | Arqule, Inc. | Imidazothiazoles as p38-kinase-inhibitors |
| JPWO2004101529A1 (ja) * | 2003-05-19 | 2006-07-13 | 小野薬品工業株式会社 | 含窒素複素環化合物およびその医薬用途 |
| GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| WO2005030091A2 (en) | 2003-09-25 | 2005-04-07 | Scios Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
| GB0402138D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| GB0402140D0 (en) | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| WO2006010082A1 (en) | 2004-07-08 | 2006-01-26 | Arqule, Inc. | 1,4-disubstituted naphtalenes as inhibitors of p38 map kinase |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| CA2584368A1 (en) | 2004-10-19 | 2006-04-27 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase |
| US20060100432A1 (en) | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US7851476B2 (en) | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
| PL1981851T3 (pl) | 2006-01-31 | 2012-07-31 | Array Biopharma Inc | Inhibitory kinazy i sposoby ich stosowania |
| US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
| WO2008024391A1 (en) * | 2006-08-22 | 2008-02-28 | Scios Inc. | Pharmaceutical formulations of an indole-type derivative and related methods of use |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| AR072008A1 (es) * | 2008-06-13 | 2010-07-28 | Merck & Co Inc | Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38 |
| US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| EP2445877B1 (en) | 2008-12-03 | 2014-07-23 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| US8563558B2 (en) | 2010-12-06 | 2013-10-22 | Confluence Life Sciences, Inc. | Substituted pyridine urea compounds |
| WO2012078674A1 (en) * | 2010-12-06 | 2012-06-14 | Confluence Life Sciences, Inc. | Substituted indole/indazole-pyrimidinyl compounds |
| US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| JP5848775B2 (ja) | 2010-12-06 | 2016-01-27 | コンフルエンス・ライフ・サイエンシズ，インコーポレーテッド | 置換ピリジノンピリジニル化合物 |
| WO2013086208A1 (en) | 2011-12-06 | 2013-06-13 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
| JP6699909B2 (ja) | 2013-06-07 | 2020-05-27 | アクラリス セラピューティクス，インコーポレイテッド | メチル／フルオロ−ピリジニル−メトキシ置換ピリジノン−ピリジニル化合物及びフルオロ−ピリミジニル−メトキシ置換ピリジノン−ピリジニル化合物 |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| KR20200067170A (ko) | 2017-10-05 | 2020-06-11 | 풀크럼 쎄러퓨틱스, 인코포레이티드 | FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제 |
| AU2021244609A1 (en) | 2020-03-27 | 2022-09-15 | Aclaris Therapeutics, Inc. | Oral compositions of MK2 pathway inhibitor for treatment of immune conditions |
| KR20240054334A (ko) * | 2021-09-03 | 2024-04-25 | 선전 01 라이프 사이언스 앤 테크놀로지 컴파니 리미티드 | 인돌계 화합물 및 이의 제조 방법과 용도 |
| CN118546081A (zh) * | 2023-02-27 | 2024-08-27 | 上海交通大学 | 一类肉桂酰胺衍生物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283248A (en) * | 1989-11-21 | 1994-02-01 | Hoffmann-La Roche Inc. | Amino substituted pyrimido[1,6-2]benzimidazoles |
| CA2028530A1 (en) * | 1989-11-21 | 1991-05-22 | Christian Hubschwerlen | Substituted pyrimidobenzimidazole derivatives |
| WO1998006715A1 (en) * | 1996-08-09 | 1998-02-19 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| JP2002515891A (ja) * | 1997-12-19 | 2002-05-28 | スミスクライン・ビーチャム・コーポレイション | 新規なピペリジン含有化合物 |
| BR9911069A (pt) * | 1998-05-22 | 2001-02-06 | Scios Inc | Compostos heterocìclicos e métodos para tratar insuficiência cardìaca e outros distúrbios |
| MXPA01002173A (es) * | 1998-08-28 | 2003-07-14 | Scios Inc | Inhibidores de p38-alfa cinasa. |
-
2000
- 2000-05-19 CA CA002372567A patent/CA2372567A1/en not_active Abandoned
- 2000-05-19 CZ CZ20014126A patent/CZ20014126A3/cs unknown
- 2000-05-19 CN CNB00807724XA patent/CN1310906C/zh not_active Expired - Fee Related
- 2000-05-19 SK SK1648-2001A patent/SK16482001A3/sk unknown
- 2000-05-19 HU HU0201261A patent/HUP0201261A3/hu unknown
- 2000-05-19 JP JP2000619792A patent/JP2003500403A/ja active Pending
- 2000-05-19 MX MXPA01011976A patent/MXPA01011976A/es not_active Application Discontinuation
- 2000-05-19 EP EP00939322A patent/EP1178983B1/en not_active Expired - Lifetime
- 2000-05-19 AU AU54424/00A patent/AU772295B2/en not_active Ceased
- 2000-05-19 DE DE60036868T patent/DE60036868D1/de not_active Expired - Lifetime
- 2000-05-19 PL PL00352032A patent/PL352032A1/xx unknown
- 2000-05-19 KR KR1020017014870A patent/KR100743377B1/ko not_active Expired - Fee Related
- 2000-05-19 NZ NZ515285A patent/NZ515285A/xx not_active IP Right Cessation
- 2000-05-19 IL IL14630900A patent/IL146309A0/xx active IP Right Grant
- 2000-05-19 HR HR20010854A patent/HRP20010854A2/hr not_active Application Discontinuation
- 2000-05-19 AT AT00939322T patent/ATE376547T1/de not_active IP Right Cessation
- 2000-05-19 WO PCT/US2000/014003 patent/WO2000071535A1/en not_active Ceased
- 2000-05-19 BR BR0011274-7A patent/BR0011274A/pt not_active Application Discontinuation
-
2001
- 2001-11-08 BG BG106091A patent/BG106091A/xx unknown
- 2001-11-20 NO NO20015655A patent/NO20015655L/no unknown
-
2004
- 2004-07-22 AU AU2004203356A patent/AU2004203356A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BG106091A (en) | 2002-06-28 |
| AU2004203356A1 (en) | 2004-08-19 |
| NZ515285A (en) | 2004-01-30 |
| KR20020019919A (ko) | 2002-03-13 |
| IL146309A0 (en) | 2002-07-25 |
| AU5442400A (en) | 2000-12-12 |
| HUP0201261A3 (en) | 2003-12-29 |
| KR100743377B1 (ko) | 2007-07-30 |
| EP1178983A1 (en) | 2002-02-13 |
| MXPA01011976A (es) | 2002-05-06 |
| ATE376547T1 (de) | 2007-11-15 |
| HRP20010854A2 (en) | 2003-04-30 |
| PL352032A1 (en) | 2003-07-28 |
| NO20015655D0 (no) | 2001-11-20 |
| DE60036868D1 (de) | 2007-12-06 |
| CN1351599A (zh) | 2002-05-29 |
| CA2372567A1 (en) | 2000-11-30 |
| SK16482001A3 (sk) | 2002-04-04 |
| WO2000071535A1 (en) | 2000-11-30 |
| CN1310906C (zh) | 2007-04-18 |
| AU772295B2 (en) | 2004-04-22 |
| HUP0201261A2 (en) | 2002-08-28 |
| NO20015655L (no) | 2002-01-18 |
| CZ20014126A3 (cs) | 2002-03-13 |
| EP1178983B1 (en) | 2007-10-24 |
| JP2003500403A (ja) | 2003-01-07 |
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