BG21235A3 - METHOD FOR PREPARING AMIDE DERIVATIVES OF LEVROSIDINE - Google Patents

METHOD FOR PREPARING AMIDE DERIVATIVES OF LEVROSIDINE

Info

Publication number: BG21235A3
Authority: BG; Bulgaria
Prior art keywords: levrosidine; amide derivatives; preparing amide; preparing; derivatives
Prior art date: 1973-04-02

Application number

BG028514A

Other languages

Bulgarian (bg)

Inventor

George Cillinan

Koer Gerson

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1973-04-02

Filing date

1974-04-02

Publication date

1976-03-20

1974-04-02 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

1976-03-20 Publication of BG21235A3 publication Critical patent/BG21235A3/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Fodder In General (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG028514A 1973-04-02 1974-04-02 METHOD FOR PREPARING AMIDE DERIVATIVES OF LEVROSIDINE BG21235A3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US34727573A	1973-04-02	1973-04-02

Publications (1)

Publication Number	Publication Date
BG21235A3 true BG21235A3 (en)	1976-03-20

Family

ID=23363051

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
BG028513A BG21612A3 (en)	1973-04-02	1974-04-02	METHOD FOR OBTAINING AMIDE DERIVATIVES OF LEVROCRISTIN
BG028514A BG21235A3 (en)	1973-04-02	1974-04-02	METHOD FOR PREPARING AMIDE DERIVATIVES OF LEVROSIDINE
BG026279A BG22831A3 (en)	1973-04-02	1974-04-02	METHOD FOR OBTAINING AMIDE DERIVATIVES OF VINBLASTINE

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BG028513A BG21612A3 (en)	1973-04-02	1974-04-02	METHOD FOR OBTAINING AMIDE DERIVATIVES OF LEVROCRISTIN

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
BG026279A BG22831A3 (en)	1973-04-02	1974-04-02	METHOD FOR OBTAINING AMIDE DERIVATIVES OF VINBLASTINE

Country Status (28)

Country	Link
JP (2)	JPS5919117B2 (en)
AR (2)	AR204004A1 (en)
AT (1)	AT340605B (en)
BE (1)	BE813168A (en)
BG (3)	BG21612A3 (en)
CA (1)	CA1042428A (en)
CH (1)	CH603669A5 (en)
CS (1)	CS185223B2 (en)
CY (1)	CY1044A (en)
DD (1)	DD113538A5 (en)
DE (1)	DE2415980A1 (en)
DK (1)	DK141511B (en)
ES (2)	ES424882A1 (en)
FR (1)	FR2223044B1 (en)
GB (1)	GB1463575A (en)
HK (1)	HK20180A (en)
HU (1)	HU171572B (en)
IE (1)	IE39071B1 (en)
IL (1)	IL44415A (en)
KE (1)	KE3028A (en)
MY (1)	MY8100025A (en)
NL (1)	NL181079C (en)
PH (1)	PH13623A (en)
RO (2)	RO73524B (en)
SE (1)	SE416206B (en)
SU (4)	SU731900A3 (en)
YU (3)	YU39719B (en)
ZA (1)	ZA741674B (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL48685A (en) *	1975-01-09	1980-03-31	Lilly Co Eli	Amides of vincadioline and vinblastine
GR69783B (en) *	1976-09-08	1982-07-07	Lilly Co Eli
US4096148A (en) *	1976-12-06	1978-06-20	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30560E (en) *	1976-12-06	1981-03-31	Eli Lilly And Company	Oxazolidinedione derivatives of Vinca alkaloids
USRE30561E (en)	1976-12-06	1981-03-31	Eli Lilly And Company	Vinca alkaloid intermediates
US4203898A (en)	1977-08-29	1980-05-20	Eli Lilly And Company	Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids
US4199504A (en) *	1978-05-15	1980-04-22	Eli Lilly And Company	Bridged cathranthus alkaloid dimers
US4210584A (en)	1979-01-15	1980-07-01	Eli Lilly And Company	Vindesine synthesis
US4357334A (en)	1980-03-20	1982-11-02	Eli Lilly And Company	Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms
LU83822A1 (en) *	1981-12-08	1983-09-01	Omnichem Sa	N- (VINBLASTINOYL-23) DERIVATIVES OF AMINO ACIDS, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
OA06421A (en) *	1980-06-10	1981-09-30	Omnium Chimique Sa	Process for the preparation of N- (vinblastinoyl-23) derivatives of amino acids and peptides.
FR2623504B1 (en) *	1987-11-25	1990-03-09	Adir	NOVEL N- (VINBLASTINOYL-23) DERIVATIVES OF 1-AMINO METHYLPHOSPHONIC ACID, PROCESSES FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
HUT76925A (en) *	1995-04-04	1998-01-28	MTA Enzimológiai Intézet	Bis-indole derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US5948750A (en) *	1996-10-30	1999-09-07	Merck & Co., Inc.	Conjugates useful in the treatment of prostate cancer
US6326402B1 (en)	1998-08-12	2001-12-04	Octamer, Inc.	Methods for treating viral infections using a compound capable of inhibiting microtubules
CN101146532B (en)	2005-01-21	2012-05-09	阿斯泰克斯治疗有限公司	Pharmaceutical compounds
BRPI0613783A2 (en)	2005-07-18	2011-02-01	Bipar Sciences Inc	cancer treatment
CN101534836B (en)	2006-09-05	2011-09-28	彼帕科学公司	Use of PARP inhibitors in the preparation of medicines for treating obesity
EP2059498A4 (en)	2006-09-05	2011-01-12	Bipar Sciences Inc	Treatment of cancer
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
NZ586125A (en)	2007-11-12	2012-12-21	Bipar Sciences Inc	Treatment of breast cancer with a parp inhibitor alone or in combination with anti-tumor agents
CN105121447B (en) *	2013-04-19	2018-02-02	暨南大学	Vinblastine derivatives and their preparation methods and applications
CN113456797B (en) *	2021-06-18	2024-03-08	暨南大学	Application of vinblastine derivatives in preparation of medicines for treating osteosarcoma and/or soft tissue sarcoma

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3097137A (en) *	1960-05-19	1963-07-09	Canadian Patents Dev	Vincaleukoblastine

1974
- 1974-01-01 AR AR253105A patent/AR204004A1/en active
- 1974-03-13 IL IL44415A patent/IL44415A/en unknown
- 1974-03-13 IE IE532/74A patent/IE39071B1/en unknown
- 1974-03-13 ZA ZA00741674A patent/ZA741674B/en unknown
- 1974-03-22 CA CA195,760A patent/CA1042428A/en not_active Expired
- 1974-03-25 GB GB1310174A patent/GB1463575A/en not_active Expired
- 1974-03-25 YU YU817/74A patent/YU39719B/en unknown
- 1974-03-25 CY CY1044A patent/CY1044A/en unknown
- 1974-03-29 CH CH446374A patent/CH603669A5/xx not_active IP Right Cessation
- 1974-03-29 FR FR7411519A patent/FR2223044B1/fr not_active Expired
- 1974-03-29 PH PH15676A patent/PH13623A/en unknown
- 1974-04-01 NL NLAANVRAGE7404423,A patent/NL181079C/en not_active IP Right Cessation
- 1974-04-01 SE SE7404380A patent/SE416206B/en not_active IP Right Cessation
- 1974-04-01 HU HU74EI00000538A patent/HU171572B/en unknown
- 1974-04-01 DK DK178774AA patent/DK141511B/en not_active IP Right Cessation
- 1974-04-01 CS CS7400002335A patent/CS185223B2/en unknown
- 1974-04-01 AT AT267974A patent/AT340605B/en not_active IP Right Cessation
- 1974-04-01 SU SU742013753A patent/SU731900A3/en active
- 1974-04-02 RO RO78274A patent/RO73524B/en unknown
- 1974-04-02 JP JP49037765A patent/JPS5919117B2/en not_active Expired
- 1974-04-02 BE BE1005847A patent/BE813168A/en not_active IP Right Cessation
- 1974-04-02 DE DE2415980A patent/DE2415980A1/en active Granted
- 1974-04-02 DD DD177632A patent/DD113538A5/xx unknown
- 1974-04-02 ES ES424882A patent/ES424882A1/en not_active Expired
- 1974-04-02 RO RO7498695A patent/RO77533A/en unknown
- 1974-04-02 BG BG028513A patent/BG21612A3/en unknown
- 1974-04-02 BG BG028514A patent/BG21235A3/en unknown
- 1974-04-02 BG BG026279A patent/BG22831A3/en unknown
1975
- 1975-01-08 AR AR257228A patent/AR203882A1/en active
- 1975-07-04 SU SU752151512A patent/SU784783A3/en active
- 1975-07-09 SU SU752152020A patent/SU652896A3/en active
1976
- 1976-03-31 ES ES446571A patent/ES446571A1/en not_active Expired
- 1976-12-20 SU SU762429453A patent/SU623522A3/en active
1980
- 1980-02-27 KE KE3028A patent/KE3028A/en unknown
- 1980-04-17 HK HK201/80A patent/HK20180A/en unknown
- 1980-04-25 YU YU1138/80A patent/YU39875B/en unknown
- 1980-04-25 YU YU1139/80A patent/YU39876B/en unknown
1981
- 1981-12-30 MY MY25/81A patent/MY8100025A/en unknown
1983
- 1983-12-16 JP JP58238722A patent/JPS6033837B2/en not_active Expired

Also Published As

Publication number	Publication date
ES424882A1 (en)	1976-12-16
SU623522A3 (en)	1978-09-05
RO73524A (en)	1984-10-31
CA1042428A (en)	1978-11-14
AU6671974A (en)	1975-09-18
IL44415A0 (en)	1974-06-30
YU113980A (en)	1982-05-31
DE2415980A1 (en)	1974-10-10
RO73524B (en)	1984-11-30
DE2415980C2 (en)	1989-11-09
ES446571A1 (en)	1977-06-16
IE39071L (en)	1974-10-02
DK141511B (en)	1980-04-08
SE416206B (en)	1980-12-08
SU784783A3 (en)	1980-11-30
JPS49128000A (en)	1974-12-07
DD113538A5 (en)	1975-06-12
NL7404423A (en)	1974-10-04
GB1463575A (en)	1977-02-02
RO77533A (en)	1982-02-01
KE3028A (en)	1980-03-28
CY1044A (en)	1980-08-01
HU171572B (en)	1978-02-28
BG22831A3 (en)	1977-04-20
HK20180A (en)	1980-04-25
SU731900A3 (en)	1980-04-30
YU39875B (en)	1985-04-30
PH13623A (en)	1980-08-07
YU113880A (en)	1982-05-31
BG21612A3 (en)	1976-07-20
BE813168A (en)	1974-10-02
AR204004A1 (en)	1975-11-12
NL181079C (en)	1987-06-16
SU652896A3 (en)	1979-03-15
FR2223044A1 (en)	1974-10-25
JPS59193895A (en)	1984-11-02
YU81774A (en)	1982-05-31
NL181079B (en)	1987-01-16
IE39071B1 (en)	1978-08-02
DK141511C (en)	1980-09-29
YU39719B (en)	1985-04-30
CH603669A5 (en)	1978-08-31
AR203882A1 (en)	1975-10-31
FR2223044B1 (en)	1978-06-30
YU39876B (en)	1985-04-30
ZA741674B (en)	1975-10-29
JPS5919117B2 (en)	1984-05-02
IL44415A (en)	1978-08-31
AT340605B (en)	1977-12-27
JPS6033837B2 (en)	1985-08-05
MY8100025A (en)	1981-12-31
ATA267974A (en)	1977-04-15
CS185223B2 (en)	1978-09-15

Publication	Publication Date	Title
BG21235A3 (en)	1976-03-20	METHOD FOR PREPARING AMIDE DERIVATIVES OF LEVROSIDINE
BG21859A3 (en)	1976-09-20	METHOD FOR PREPARING 7-SUBSTITUTED-5-METHYL-ISOFLAVONE DERIVATIVES
BG25792A3 (en)	1978-12-12	METHOD FOR OBTAINING GUANIDINE DERIVATIVES
BG26531A4 (en)	1979-04-12	METHOD FOR OBTAINING BENZOXAZOLE DERIVATIVES
BG21606A3 (en)	1976-07-20	METHOD FOR PREPARING PIPERAZINYLQUINOXALINE DERIVATIVES
BG20335A3 (en)	1975-11-05	METHOD FOR THE PREPARATION OF 1-ARYLOXY-2-HYDROXY-3-ALKYNYLAMINOPROPANE
BG25082A3 (en)	1978-07-12	METHOD FOR THE PREPARATION OF 1-AROYL-2-ARYLAMINO-2-IMIDAZOLE DERIVATIVES
BG25992A3 (en)	1979-01-12	METHOD FOR OBTAINING OXAZOLE DERIVATIVES
BG25797A3 (en)	1978-12-12	METHOD OF PREPARING AZAPURINONES
BG22390A3 (en)	1977-02-20	METHOD FOR OBTAINING ISOQUINOLINE DERIVATIVES
BG25068A3 (en)	1978-07-12	METHOD FOR OBTAINING ALPHA-SUBSTITUTED BENZHYDROLIC DERIVATIVES
BG26396A3 (en)	1979-03-15	METHOD FOR PREPARATION OF POLY-N-ALKYLIMINOALANES
BG26527A3 (en)	1979-04-12	METHOD FOR PREPARATION OF 2-ARYLAMINO-2-IMIDAZOLINE DERIVATIVES
SE419543B (en)	1981-08-10	PROCEDURE FOR PREPARING CERTAIN STATED ISOQINOLINE DERIVATIVES
BG25793A3 (en)	1978-12-12	METHOD FOR OBTAINING CARBAZOLE DERIVATIVES
FR2277077A1 (en)	1976-01-30	PROCESS FOR PREPARATION OF DERIVATIVES OF PHENYLISOPROPYLUREE
BG21849A3 (en)	1976-09-20	METHOD FOR OBTAINING SUBSTITUTED NITROBENZOPHENONE DERIVATIVES
BG25231A3 (en)	1978-08-10	METHOD FOR OBTAINING DERIVATIVES OF RIFAMICYIN SV
AR198411A1 (en)	1974-06-21	NEW METHOD OF PREPARING N- (DIELTHYLAMINOETHYL) -2-METHOXY-4-AMINO-5-CHLOROBENZAMIDE
BG24406A3 (en)	1978-02-10	METHOD FOR THE PREPARATION OF 1-ACYLOXYPHENYL-1-HYDROXY-2-N- ALKYLAMINO-ETHANES
BG24796A3 (en)	1978-05-12	METHOD FOR OBTAINING PROPANOL DERIVATIVES
BG21033A3 (en)	1976-01-20	METHOD FOR OBTAINING DERIVATIVES OF 6-AMINOPENICILLIC ACID
BG24229A3 (en)	1978-01-10	METHOD FOR OBTAINING N-SUBSTITUTED CYCLOSERINES
AR200304A1 (en)	1974-10-31	METHOD OF PREPARING N- (1-ETHYL-2-PYRROLIDYLMETHYL) -2-METOXY-5SULFAMIDOBENZAMIDE
BG25993A3 (en)	1979-01-12	METHOD FOR OBTAINING BENZOXAZOLE DERIVATIVES