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BG102014A - Carbapenem esters - Google Patents

Carbapenem esters

Info

Publication number
BG102014A
BG102014A BG102014A BG10201497A BG102014A BG 102014 A BG102014 A BG 102014A BG 102014 A BG102014 A BG 102014A BG 10201497 A BG10201497 A BG 10201497A BG 102014 A BG102014 A BG 102014A
Authority
BG
Bulgaria
Prior art keywords
carbapenem
esters
carbapenem esters
methyl
benzoyloxyemethyl
Prior art date
Application number
BG102014A
Other languages
Bulgarian (bg)
Inventor
George Burton
Stephen MOSS
Alfred EGLINGTON
Original Assignee
Smithkline Beecham P.L.C.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9508955.3A external-priority patent/GB9508955D0/en
Priority claimed from GBGB9508956.1A external-priority patent/GB9508956D0/en
Priority claimed from GBGB9508957.9A external-priority patent/GB9508957D0/en
Application filed by Smithkline Beecham P.L.C. filed Critical Smithkline Beecham P.L.C.
Publication of BG102014A publication Critical patent/BG102014A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The ester are used for the treatment of bacterial infections.They have the formulawhere R is selected from the group isobutyryloxymethyl,(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl and benzoyloxyemethyl.9 claims
BG102014A 1995-05-03 1997-11-03 Carbapenem esters BG102014A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9508955.3A GB9508955D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508956.1A GB9508956D0 (en) 1995-05-03 1995-05-03 Novel compounds
GBGB9508957.9A GB9508957D0 (en) 1995-05-03 1995-05-03 Novel compounds
PCT/EP1996/001880 WO1996034868A1 (en) 1995-05-03 1996-05-02 Esters of carbapenems

Publications (1)

Publication Number Publication Date
BG102014A true BG102014A (en) 1998-11-30

Family

ID=27267696

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102014A BG102014A (en) 1995-05-03 1997-11-03 Carbapenem esters

Country Status (22)

Country Link
EP (1) EP0823910A1 (en)
JP (1) JPH11504910A (en)
KR (1) KR19990008355A (en)
CN (1) CN1185783A (en)
AR (1) AR005416A1 (en)
AU (1) AU5813996A (en)
BG (1) BG102014A (en)
BR (1) BR9608313A (en)
CA (1) CA2217990A1 (en)
CZ (1) CZ347597A3 (en)
EA (1) EA199700293A1 (en)
HU (1) HUP9801066A3 (en)
IL (1) IL118092A0 (en)
MA (1) MA23853A1 (en)
MX (1) MX9708421A (en)
NO (1) NO974994L (en)
OA (1) OA10632A (en)
PE (1) PE50697A1 (en)
PL (1) PL323141A1 (en)
SK (1) SK146497A3 (en)
TR (1) TR199701286T1 (en)
WO (1) WO1996034868A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2902659A1 (en) 2006-06-23 2007-12-28 Pierre Fabre Medicament Sa DHA ESTER AND ITS USE IN THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES
WO2013157583A1 (en) * 2012-04-18 2013-10-24 大日本住友製薬株式会社 Novel carbapenem compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
CA1212105A (en) * 1980-04-30 1986-09-30 Shoji Ikeda Ampicillin esters and production thereof
WO1995005380A1 (en) * 1993-08-18 1995-02-23 Sankyo Company, Limited Crystalline carbapenem derivatives
CA2175054C (en) * 1993-10-29 2005-07-12 Steven Coulton 2-(pyrazol-3-yl)carbapenem derivatives

Also Published As

Publication number Publication date
SK146497A3 (en) 1998-05-06
EP0823910A1 (en) 1998-02-18
KR19990008355A (en) 1999-01-25
CN1185783A (en) 1998-06-24
HUP9801066A2 (en) 1998-08-28
AR005416A1 (en) 1999-06-23
BR9608313A (en) 1999-01-26
CA2217990A1 (en) 1996-11-07
IL118092A0 (en) 1996-09-12
HUP9801066A3 (en) 1999-01-28
AU5813996A (en) 1996-11-21
PL323141A1 (en) 1998-03-16
EA199700293A1 (en) 1998-06-25
CZ347597A3 (en) 1998-08-12
MA23853A1 (en) 1996-12-31
WO1996034868A1 (en) 1996-11-07
TR199701286T1 (en) 1998-02-21
PE50697A1 (en) 1997-12-18
JPH11504910A (en) 1999-05-11
NO974994D0 (en) 1997-10-30
MX9708421A (en) 1998-02-28
NO974994L (en) 1997-10-30
OA10632A (en) 2002-09-16

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