AR005416A1 - A COMPOUND OF (5R, 6S) -2- [1-ETIL-5-METHYLPIRAZOLE-3-IL] -6 - [(1R) -1- HYDROXYETHYL] -CARBAPEN-2-EM-3-CARBOXYLATE, A PROCEDURE FOR PREPARE IT, A PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND THE USE OF SUCH COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT BACTERIAL INFECTIONS - Google Patents
A COMPOUND OF (5R, 6S) -2- [1-ETIL-5-METHYLPIRAZOLE-3-IL] -6 - [(1R) -1- HYDROXYETHYL] -CARBAPEN-2-EM-3-CARBOXYLATE, A PROCEDURE FOR PREPARE IT, A PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND THE USE OF SUCH COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT BACTERIAL INFECTIONSInfo
- Publication number
- AR005416A1 AR005416A1 ARP960102434A AR10243496A AR005416A1 AR 005416 A1 AR005416 A1 AR 005416A1 AR P960102434 A ARP960102434 A AR P960102434A AR 10243496 A AR10243496 A AR 10243496A AR 005416 A1 AR005416 A1 AR 005416A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- bacterial infections
- carbapen
- carboxylate
- hydroxyethyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 208000035143 Bacterial infection Diseases 0.000 title abstract 3
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- -1 isobutyryloxymethyl Chemical group 0.000 abstract 3
- CWSOMYSZKNMLHZ-GGZOMVNGSA-N (5r,6s)-3-(1-ethyl-5-methylpyrazol-3-yl)-6-[(1r)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid Chemical compound C1=C(C)N(CC)N=C1C1=C(C(O)=O)N2C(=O)[C@H]([C@@H](C)O)[C@H]2C1 CWSOMYSZKNMLHZ-GGZOMVNGSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/02—Preparation
- C07D477/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C07D477/08—Modification of a carboxyl group directly attached in position 2, e.g. esterification
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se refiere a un nuevo compuesto de (5R,6S)-2-[1-etil-5-metilpirazol-3-il] -6-[(1R)-1-hidroxietil]-carbapen-2-em-3-carboxilato de fórmula (I), en la queR se selecciona entre el grupo formado por isobutiriloximetilo, (5-metil-2-oxo- 1,3-dioxolen-4-il)metilo y benzoiloximetilo es útil en el tratamiento deinfecciones bacterianas. También se refiere a un procedimiento para prepararlo, a una composición farmacéutica que lo contiene y al uso de dicho compuesto parala publicación de un medicamento para tratar infecciones bacterianas.It refers to a new compound of (5R, 6S) -2- [1-ethyl-5-methylpyrazol-3-yl] -6 - [(1R) -1-hydroxyethyl] -carbapen-2-em-3-carboxylate of formula (I), in which R is selected from the group consisting of isobutyryloxymethyl, (5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl and benzoyloxymethyl is useful in the treatment of bacterial infections. It also refers to a process for preparing it, a pharmaceutical composition containing it and the use of said compound for the publication of a medicament for treating bacterial infections.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9508955.3A GB9508955D0 (en) | 1995-05-03 | 1995-05-03 | Novel compounds |
| GBGB9508956.1A GB9508956D0 (en) | 1995-05-03 | 1995-05-03 | Novel compounds |
| GBGB9508957.9A GB9508957D0 (en) | 1995-05-03 | 1995-05-03 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR005416A1 true AR005416A1 (en) | 1999-06-23 |
Family
ID=27267696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102434A AR005416A1 (en) | 1995-05-03 | 1996-05-03 | A COMPOUND OF (5R, 6S) -2- [1-ETIL-5-METHYLPIRAZOLE-3-IL] -6 - [(1R) -1- HYDROXYETHYL] -CARBAPEN-2-EM-3-CARBOXYLATE, A PROCEDURE FOR PREPARE IT, A PHARMACEUTICAL COMPOSITION THAT CONTAINS IT AND THE USE OF SUCH COMPOUND FOR THE MANUFACTURE OF A MEDICINAL PRODUCT TO TREAT BACTERIAL INFECTIONS |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0823910A1 (en) |
| JP (1) | JPH11504910A (en) |
| KR (1) | KR19990008355A (en) |
| CN (1) | CN1185783A (en) |
| AR (1) | AR005416A1 (en) |
| AU (1) | AU5813996A (en) |
| BG (1) | BG102014A (en) |
| BR (1) | BR9608313A (en) |
| CA (1) | CA2217990A1 (en) |
| CZ (1) | CZ347597A3 (en) |
| EA (1) | EA199700293A1 (en) |
| HU (1) | HUP9801066A3 (en) |
| IL (1) | IL118092A0 (en) |
| MA (1) | MA23853A1 (en) |
| MX (1) | MX9708421A (en) |
| NO (1) | NO974994D0 (en) |
| OA (1) | OA10632A (en) |
| PE (1) | PE50697A1 (en) |
| PL (1) | PL323141A1 (en) |
| SK (1) | SK146497A3 (en) |
| TR (1) | TR199701286T1 (en) |
| WO (1) | WO1996034868A1 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2902659A1 (en) | 2006-06-23 | 2007-12-28 | Pierre Fabre Medicament Sa | DHA ESTER AND ITS USE IN THE TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASES |
| WO2013157583A1 (en) * | 2012-04-18 | 2013-10-24 | 大日本住友製薬株式会社 | Novel carbapenem compound |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1593524A (en) * | 1976-11-19 | 1981-07-15 | Merck & Co Inc | 1-carba-2-penem-3-carboxylic acids |
| CA1212105A (en) * | 1980-04-30 | 1986-09-30 | Shoji Ikeda | Ampicillin esters and production thereof |
| WO1995005380A1 (en) * | 1993-08-18 | 1995-02-23 | Sankyo Company, Limited | Crystalline carbapenem derivatives |
| EP0725783B1 (en) * | 1993-10-29 | 2002-12-18 | SmithKline Beecham plc | 2-(pyrazol-3-yl)carbapenem derivatives |
-
1996
- 1996-05-01 IL IL11809296A patent/IL118092A0/en unknown
- 1996-05-02 WO PCT/EP1996/001880 patent/WO1996034868A1/en not_active Ceased
- 1996-05-02 BR BR9608313A patent/BR9608313A/en not_active Application Discontinuation
- 1996-05-02 HU HU9801066A patent/HUP9801066A3/en unknown
- 1996-05-02 CZ CZ973475A patent/CZ347597A3/en unknown
- 1996-05-02 CA CA002217990A patent/CA2217990A1/en not_active Abandoned
- 1996-05-02 EP EP96919678A patent/EP0823910A1/en not_active Withdrawn
- 1996-05-02 JP JP8533020A patent/JPH11504910A/en active Pending
- 1996-05-02 KR KR1019970707881A patent/KR19990008355A/en not_active Withdrawn
- 1996-05-02 AU AU58139/96A patent/AU5813996A/en not_active Abandoned
- 1996-05-02 CN CN96194191A patent/CN1185783A/en active Pending
- 1996-05-02 EA EA199700293A patent/EA199700293A1/en unknown
- 1996-05-02 SK SK1464-97A patent/SK146497A3/en unknown
- 1996-05-02 TR TR97/01286T patent/TR199701286T1/en unknown
- 1996-05-02 PL PL96323141A patent/PL323141A1/en unknown
- 1996-05-02 MA MA24218A patent/MA23853A1/en unknown
- 1996-05-02 MX MX9708421A patent/MX9708421A/en unknown
- 1996-05-03 AR ARP960102434A patent/AR005416A1/en unknown
- 1996-05-03 PE PE1996000312A patent/PE50697A1/en not_active Application Discontinuation
-
1997
- 1997-10-30 NO NO974994A patent/NO974994D0/en not_active Application Discontinuation
- 1997-11-03 BG BG102014A patent/BG102014A/en unknown
- 1997-11-03 OA OA70122A patent/OA10632A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9608313A (en) | 1999-01-26 |
| JPH11504910A (en) | 1999-05-11 |
| SK146497A3 (en) | 1998-05-06 |
| CZ347597A3 (en) | 1998-08-12 |
| HUP9801066A2 (en) | 1998-08-28 |
| PL323141A1 (en) | 1998-03-16 |
| MX9708421A (en) | 1998-02-28 |
| KR19990008355A (en) | 1999-01-25 |
| EA199700293A1 (en) | 1998-06-25 |
| IL118092A0 (en) | 1996-09-12 |
| NO974994L (en) | 1997-10-30 |
| PE50697A1 (en) | 1997-12-18 |
| NO974994D0 (en) | 1997-10-30 |
| AU5813996A (en) | 1996-11-21 |
| OA10632A (en) | 2002-09-16 |
| HUP9801066A3 (en) | 1999-01-28 |
| EP0823910A1 (en) | 1998-02-18 |
| CA2217990A1 (en) | 1996-11-07 |
| TR199701286T1 (en) | 1998-02-21 |
| MA23853A1 (en) | 1996-12-31 |
| CN1185783A (en) | 1998-06-24 |
| BG102014A (en) | 1998-11-30 |
| WO1996034868A1 (en) | 1996-11-07 |
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