BG108086A - Производни на фенетаноламин за лечение на болести на дихателните пътища - Google Patents

Производни на фенетаноламин за лечение на болести на дихателните пътища Download PDF

Info

Publication number: BG108086A
Authority: BG; Bulgaria
Prior art keywords: hydroxy; oxy; phenyl; hexyl; formula
Prior art date: 2001-02-14

Application number

BG108086A

Other languages

Bulgarian (bg)

English (en)

Inventor

Keith Biggadike

Diane Coe

Dean EDNEY

Abigail Halton

Brian Looker

Michael Monteith

Rebecca Moore

Rajnikant Patel

Panayiotis Procopiou

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-14

Filing date

2003-08-12

Publication date

2005-04-30

2001-11-09 Priority claimed from GB0126998A external-priority patent/GB0126998D0/en

2003-08-12 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2005-04-30 Publication of BG108086A publication Critical patent/BG108086A/bg

Links

238000011282 treatment Methods 0.000 title claims abstract description 23
208000023504 respiratory system disease Diseases 0.000 title abstract description 3
ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical class NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 title description 4
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238000000034 method Methods 0.000 claims abstract description 223
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
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238000011321 prophylaxis Methods 0.000 claims abstract description 4
-1 C (O) NR 8 R 9 Chemical group 0.000 claims description 218
239000000203 mixture Substances 0.000 claims description 107
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125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 86
150000003839 salts Chemical class 0.000 claims description 75
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 72
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KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims description 64
239000012453 solvate Substances 0.000 claims description 51
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AAXKMXAEFVWFDC-UHFFFAOYSA-N naphthalene;prop-2-enoic acid Chemical compound OC(=O)C=C.C1=CC=CC2=CC=CC=C21 AAXKMXAEFVWFDC-UHFFFAOYSA-N 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
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150000004885 piperazines Chemical class 0.000 description 1
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150000003335 secondary amines Chemical class 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
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238000007920 subcutaneous administration Methods 0.000 description 1
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YIIVONGCNAQATO-UHFFFAOYSA-N tert-butyl n-[2-(2,2-dimethyl-4h-1,3-benzodioxin-6-yl)-2-oxoethyl]carbamate Chemical compound O1C(C)(C)OCC2=CC(C(=O)CNC(=O)OC(C)(C)C)=CC=C21 YIIVONGCNAQATO-UHFFFAOYSA-N 0.000 description 1
MIJVBDSRMVBYAS-UHFFFAOYSA-N tert-butyl n-ethenylsulfonylcarbamate Chemical compound CC(C)(C)OC(=O)NS(=O)(=O)C=C MIJVBDSRMVBYAS-UHFFFAOYSA-N 0.000 description 1
150000003512 tertiary amines Chemical class 0.000 description 1
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125000005207 tetraalkylammonium group Chemical group 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
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229960000278 theophylline Drugs 0.000 description 1
231100001274 therapeutic index Toxicity 0.000 description 1
125000001113 thiadiazolyl group Chemical group 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
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LERNTVKEWCAPOY-DZZGSBJMSA-N tiotropium Chemical compound O([C@H]1C[C@@H]2[N+]([C@H](C1)[C@@H]1[C@H]2O1)(C)C)C(=O)C(O)(C=1SC=CC=1)C1=CC=CS1 LERNTVKEWCAPOY-DZZGSBJMSA-N 0.000 description 1
229940110309 tiotropium Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
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238000012546 transfer Methods 0.000 description 1
238000002834 transmittance Methods 0.000 description 1
125000004665 trialkylsilyl group Chemical group 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
XJGONMZLEDGBRM-UHFFFAOYSA-M tridihexethyl chloride Chemical compound [Cl-].C=1C=CC=CC=1C(O)(CC[N+](CC)(CC)CC)C1CCCCC1 XJGONMZLEDGBRM-UHFFFAOYSA-M 0.000 description 1
AQRLNPVMDITEJU-UHFFFAOYSA-N triethylsilane Chemical compound CC[SiH](CC)CC AQRLNPVMDITEJU-UHFFFAOYSA-N 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 1
229960004791 tropicamide Drugs 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000007762 w/o emulsion Substances 0.000 description 1
229950000339 xinafoate Drugs 0.000 description 1
229910052727 yttrium Inorganic materials 0.000 description 1
VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
229960001763 zinc sulfate Drugs 0.000 description 1
229910000368 zinc sulfate Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/26—Sulfur atoms
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
- C07C311/27—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pulmonology (AREA)
Neurology (AREA)
Dermatology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Neurosurgery (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Otolaryngology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Biomedical Technology (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)
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BG108086A 2001-02-14 2003-08-12 Производни на фенетаноламин за лечение на болести на дихателните пътища BG108086A (bg)

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Application Number	Priority Date	Filing Date	Title
GBGB0103630.0A GB0103630D0 (en)	2001-02-14	2001-02-14	Chemical compounds
GB0126998A GB0126998D0 (en)	2001-11-09	2001-11-09	Chemical compounds

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BG108086A true BG108086A (bg)	2005-04-30

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Country Status (30)

Country	Link
US (4)	US7135600B2 (fr)
EP (1)	EP1360174A1 (fr)
JP (1)	JP4029042B2 (fr)
KR (1)	KR100880763B1 (fr)
CN (1)	CN1266126C (fr)
AP (1)	AP2088A (fr)
AR (1)	AR035617A1 (fr)
AU (1)	AU2002240924B2 (fr)
BG (1)	BG108086A (fr)
BR (1)	BR0207694A (fr)
CA (1)	CA2437977A1 (fr)
CZ (1)	CZ20032189A3 (fr)
DZ (1)	DZ3500A1 (fr)
EA (1)	EA006646B1 (fr)
EC (1)	ECSP034732A (fr)
GB (1)	GB0103630D0 (fr)
HU (1)	HUP0400699A2 (fr)
IL (1)	IL157149A0 (fr)
MA (1)	MA26992A1 (fr)
MX (1)	MXPA03007262A (fr)
MY (1)	MY139552A (fr)
NO (1)	NO20033594L (fr)
NZ (1)	NZ527404A (fr)
OA (1)	OA12551A (fr)
PE (1)	PE20020872A1 (fr)
PL (1)	PL367403A1 (fr)
SK (1)	SK10212003A3 (fr)
UA (1)	UA76443C2 (fr)
WO (1)	WO2002066422A1 (fr)
ZA (1)	ZA200306234B (fr)

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2001
- 2001-02-14 GB GBGB0103630.0A patent/GB0103630D0/en not_active Ceased
2002
- 2002-02-11 WO PCT/EP2002/001387 patent/WO2002066422A1/fr not_active Ceased
- 2002-02-11 HU HU0400699A patent/HUP0400699A2/hu unknown
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- 2002-02-11 JP JP2002565940A patent/JP4029042B2/ja not_active Expired - Fee Related
- 2002-02-11 KR KR1020037010667A patent/KR100880763B1/ko not_active Expired - Fee Related
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- 2002-02-11 AP APAP/P/2003/002842A patent/AP2088A/en active
- 2002-02-11 AU AU2002240924A patent/AU2002240924B2/en not_active Ceased
- 2002-02-11 CA CA002437977A patent/CA2437977A1/fr not_active Abandoned
- 2002-02-11 CZ CZ20032189A patent/CZ20032189A3/cs unknown
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- 2002-02-11 MX MXPA03007262A patent/MXPA03007262A/es not_active Application Discontinuation
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- 2002-02-11 CN CNB02807923XA patent/CN1266126C/zh not_active Expired - Fee Related
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- 2002-02-11 EP EP02706735A patent/EP1360174A1/fr not_active Withdrawn
- 2002-02-11 EA EA200300776A patent/EA006646B1/ru unknown
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- 2002-02-11 BR BR0207694-2A patent/BR0207694A/pt not_active IP Right Cessation
- 2002-02-11 DZ DZ023500A patent/DZ3500A1/fr active
- 2002-02-12 AR ARP020100462A patent/AR035617A1/es unknown
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- 2002-11-02 UA UA2003087450A patent/UA76443C2/uk unknown
2003
- 2003-08-11 MA MA27272A patent/MA26992A1/fr unknown
- 2003-08-12 BG BG108086A patent/BG108086A/bg unknown
- 2003-08-12 ZA ZA200306234A patent/ZA200306234B/xx unknown
- 2003-08-13 NO NO20033594A patent/NO20033594L/no not_active Application Discontinuation
- 2003-08-14 EC EC2003004732A patent/ECSP034732A/es unknown
2005
- 2005-08-19 US US11/207,967 patent/US7442719B2/en not_active Expired - Fee Related
2006
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Also Published As

Publication number	Publication date
ZA200306234B (en)	2004-11-17
EP1360174A1 (fr)	2003-11-12
UA76443C2 (en)	2006-08-15
HUP0400699A2 (hu)	2004-07-28
CN1266126C (zh)	2006-07-26
US20060287389A1 (en)	2006-12-21
ECSP034732A (es)	2003-09-24
KR100880763B1 (ko)	2009-02-02
NZ527404A (en)	2005-07-29
US20040180876A1 (en)	2004-09-16
SK10212003A3 (sk)	2004-02-03
PE20020872A1 (es)	2002-11-19
JP4029042B2 (ja)	2008-01-09
MY139552A (en)	2009-10-30
EA006646B1 (ru)	2006-02-24
US7135600B2 (en)	2006-11-14
EA200300776A1 (ru)	2004-06-24
MA26992A1 (fr)	2004-12-20
US7442836B2 (en)	2008-10-28
NO20033594D0 (no)	2003-08-13
MXPA03007262A (es)	2003-12-08
CN1501911A (zh)	2004-06-02
AP2003002842A0 (en)	2003-09-30
BR0207694A (pt)	2004-04-06
DZ3500A1 (fr)	2002-09-29
IL157149A0 (en)	2004-02-08
GB0103630D0 (en)	2001-03-28
CA2437977A1 (fr)	2002-08-29
WO2002066422A1 (fr)	2002-08-29
KR20030077019A (ko)	2003-09-29
NO20033594L (no)	2003-10-02
US7442719B2 (en)	2008-10-28
AP2088A (en)	2010-01-11
CZ20032189A3 (cs)	2004-01-14
AU2002240924B2 (en)	2005-03-03
JP2004524308A (ja)	2004-08-12
PL367403A1 (en)	2005-02-21
OA12551A (en)	2006-05-06
AR035617A1 (es)	2004-06-16
US20070004807A1 (en)	2007-01-04
US7442837B2 (en)	2008-10-28
US20060287286A1 (en)	2006-12-21

Publication	Publication Date	Title
BG108086A (bg)	2005-04-30	Производни на фенетаноламин за лечение на болести на дихателните пътища
EP1370521B1 (fr)	2007-12-19	Derives formanilides utilises en tant qu'agonistes de l'adrenorecepteur beta2
USRE44874E1 (en)	2014-04-29	Phenethanolamine derivatives for treatment of respiratory diseases
US7271197B2 (en)	2007-09-18	Phenethanolamine derivatives
AU2002240924A1 (en)	2003-02-27	Phenethanolamine derivatives for treatment of respiratory diseases
WO2004039762A1 (fr)	2004-05-13	Derives de phenethanolamine permettant de traiter des maladies des voies respiratoires
US20070135490A1 (en)	2007-06-14	Phenetanolamine derivatives
BRPI0216127B1 (pt)	2017-07-18	Phenethanolamine derivative composition, pharmaceutical formulation, pharmaceutical combination, use of a compound, process for preparing a compound, and, intermediate