BG107849A - Кондензирани пуринови производни като антагонисти на а1 аденозин рецептори - Google Patents

Кондензирани пуринови производни като антагонисти на а1 аденозин рецептори Download PDF

Info

Publication number: BG107849A
Authority: BG; Bulgaria
Prior art keywords: group; alkyl; compound; amino; substituted
Prior art date: 2000-12-01

Application number

BG107849A

Other languages

Bulgarian (bg)

English (en)

Inventor

Ko-Chung Lin

Chi Vu

Original Assignee

Biogen, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-01

Filing date

2003-05-27

Publication date

2004-01-30

2003-05-27 Application filed by Biogen, Inc. filed Critical Biogen, Inc.

2004-01-30 Publication of BG107849A publication Critical patent/BG107849A/bg

Links

101150007969 ADORA1 gene Proteins 0.000 title abstract description 4
239000000296 purinergic P1 receptor antagonist Substances 0.000 title description 11
229940121359 adenosine receptor antagonist Drugs 0.000 title description 7
229940083251 peripheral vasodilators purine derivative Drugs 0.000 title 1
150000003212 purines Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 111
238000011282 treatment Methods 0.000 claims abstract description 11
206010007559 Cardiac failure congestive Diseases 0.000 claims abstract description 6
206010019280 Heart failures Diseases 0.000 claims abstract description 6
208000001647 Renal Insufficiency Diseases 0.000 claims abstract description 4
208000006673 asthma Diseases 0.000 claims abstract description 4
208000037765 diseases and disorders Diseases 0.000 claims abstract description 4
201000006370 kidney failure Diseases 0.000 claims abstract description 4
230000008085 renal dysfunction Effects 0.000 claims abstract description 4
208000037905 systemic hypertension Diseases 0.000 claims abstract description 4
206010012601 diabetes mellitus Diseases 0.000 claims abstract description 3
-1 alkenylsulfonylamino Chemical group 0.000 claims description 61
125000000217 alkyl group Chemical group 0.000 claims description 50
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 36
238000000034 method Methods 0.000 claims description 33
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 30
125000000304 alkynyl group Chemical group 0.000 claims description 26
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 25
125000000623 heterocyclic group Chemical group 0.000 claims description 24
125000003342 alkenyl group Chemical group 0.000 claims description 23
239000000203 mixture Substances 0.000 claims description 23
125000001424 substituent group Chemical group 0.000 claims description 22
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
239000008194 pharmaceutical composition Substances 0.000 claims description 20
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 19
108050000203 Adenosine receptors Proteins 0.000 claims description 18
102000009346 Adenosine receptors Human genes 0.000 claims description 18
239000002126 C01EB10 - Adenosine Substances 0.000 claims description 18
229960005305 adenosine Drugs 0.000 claims description 18
125000003118 aryl group Chemical group 0.000 claims description 18
201000010099 disease Diseases 0.000 claims description 18
125000003545 alkoxy group Chemical group 0.000 claims description 17
125000004663 dialkyl amino group Chemical group 0.000 claims description 17
239000002253 acid Substances 0.000 claims description 14
125000003282 alkyl amino group Chemical group 0.000 claims description 14
150000001414 amino alcohols Chemical class 0.000 claims description 14
229910052739 hydrogen Inorganic materials 0.000 claims description 14
239000001257 hydrogen Substances 0.000 claims description 14
238000006243 chemical reaction Methods 0.000 claims description 13
230000004913 activation Effects 0.000 claims description 12
125000005115 alkyl carbamoyl group Chemical group 0.000 claims description 12
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 11
SKOLWUPSYHWYAM-UHFFFAOYSA-N carbonodithioic O,S-acid Chemical compound SC(S)=O SKOLWUPSYHWYAM-UHFFFAOYSA-N 0.000 claims description 11
XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 11
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 10
125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 10
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 10
230000008569 process Effects 0.000 claims description 10
125000003107 substituted aryl group Chemical group 0.000 claims description 10
150000003568 thioethers Chemical class 0.000 claims description 10
BBTNLADSUVOPPN-UHFFFAOYSA-N 5,6-diaminouracil Chemical compound NC=1NC(=O)NC(=O)C=1N BBTNLADSUVOPPN-UHFFFAOYSA-N 0.000 claims description 9
238000002360 preparation method Methods 0.000 claims description 9
125000002252 acyl group Chemical group 0.000 claims description 8
125000004442 acylamino group Chemical group 0.000 claims description 8
125000003710 aryl alkyl group Chemical group 0.000 claims description 8
125000004093 cyano group Chemical group *C#N 0.000 claims description 8
125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims description 8
229910052736 halogen Inorganic materials 0.000 claims description 8
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
229910019142 PO4 Inorganic materials 0.000 claims description 7
150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 7
208000035475 disorder Diseases 0.000 claims description 7
150000002367 halogens Chemical class 0.000 claims description 7
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
230000009467 reduction Effects 0.000 claims description 7
125000004657 aryl sulfonyl amino group Chemical group 0.000 claims description 6
125000005279 aryl sulfonyloxy group Chemical group 0.000 claims description 6
125000004104 aryloxy group Chemical group 0.000 claims description 6
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
125000005646 oximino group Chemical group 0.000 claims description 6
125000006170 pentacyclic group Chemical group 0.000 claims description 6
239000010452 phosphate Substances 0.000 claims description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 6
125000006168 tricyclic group Chemical group 0.000 claims description 6
101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 claims description 5
125000004423 acyloxy group Chemical group 0.000 claims description 5
125000006323 alkenyl amino group Chemical group 0.000 claims description 5
125000005741 alkyl alkenyl group Chemical group 0.000 claims description 5
125000002619 bicyclic group Chemical group 0.000 claims description 5
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
229940125782 compound 2 Drugs 0.000 claims description 5
229940126214 compound 3 Drugs 0.000 claims description 5
125000006310 cycloalkyl amino group Chemical group 0.000 claims description 5
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239000003937 drug carrier Substances 0.000 claims description 5
125000004466 alkoxycarbonylamino group Chemical group 0.000 claims description 4
230000029936 alkylation Effects 0.000 claims description 4
238000005804 alkylation reaction Methods 0.000 claims description 4
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150000002148 esters Chemical class 0.000 claims description 4
125000005419 heteroarylsulfonylamino group Chemical group 0.000 claims description 4
238000007918 intramuscular administration Methods 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
125000000018 nitroso group Chemical group N(=O)* 0.000 claims description 4
230000002265 prevention Effects 0.000 claims description 4
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IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 4
150000003839 salts Chemical class 0.000 claims description 4
LXQJPKMORWPZGM-UHFFFAOYSA-N 4-hydroxybicyclo[2.2.2]octane-1-carboxylic acid Chemical compound C1CC2(O)CCC1(C(=O)O)CC2 LXQJPKMORWPZGM-UHFFFAOYSA-N 0.000 claims description 3
KTWOUYVBZDZRNV-UHFFFAOYSA-N 6-amino-1-propylpyrimidine-2,4-dione Chemical compound CCCN1C(N)=CC(=O)NC1=O KTWOUYVBZDZRNV-UHFFFAOYSA-N 0.000 claims description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 3
239000002671 adjuvant Substances 0.000 claims description 3
125000002877 alkyl aryl group Chemical group 0.000 claims description 3
125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 3
125000005278 alkyl sulfonyloxy group Chemical group 0.000 claims description 3
229940125898 compound 5 Drugs 0.000 claims description 3
230000002497 edematous effect Effects 0.000 claims description 3
125000001188 haloalkyl group Chemical group 0.000 claims description 3
238000001990 intravenous administration Methods 0.000 claims description 3
239000002609 medium Substances 0.000 claims description 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
229910052760 oxygen Inorganic materials 0.000 claims description 3
125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims description 3
238000007920 subcutaneous administration Methods 0.000 claims description 3
125000000547 substituted alkyl group Chemical group 0.000 claims description 3
229910052717 sulfur Inorganic materials 0.000 claims description 3
229910004727 OSO3H Inorganic materials 0.000 claims description 2
230000000903 blocking effect Effects 0.000 claims description 2
239000003795 chemical substances by application Substances 0.000 claims description 2
229940125904 compound 1 Drugs 0.000 claims description 2
230000008878 coupling Effects 0.000 claims description 2
238000010168 coupling process Methods 0.000 claims description 2
238000005859 coupling reaction Methods 0.000 claims description 2
230000009935 nitrosation Effects 0.000 claims description 2
238000007034 nitrosation reaction Methods 0.000 claims description 2
230000003647 oxidation Effects 0.000 claims description 2
238000007254 oxidation reaction Methods 0.000 claims description 2
208000024891 symptom Diseases 0.000 claims description 2
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 24
239000004202 carbamide Substances 0.000 claims 12
235000013877 carbamide Nutrition 0.000 claims 12
150000002431 hydrogen Chemical class 0.000 claims 4
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims 2
150000008052 alkyl sulfonates Chemical class 0.000 claims 2
KVOACUMJSXEJQT-UHFFFAOYSA-N bicyclo[2.2.2]octane-1,4-dicarboxylic acid Chemical compound C1CC2(C(O)=O)CCC1(C(=O)O)CC2 KVOACUMJSXEJQT-UHFFFAOYSA-N 0.000 claims 2
125000004122 cyclic group Chemical group 0.000 claims 2
125000003302 alkenyloxy group Chemical group 0.000 claims 1
125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
239000005557 antagonist Substances 0.000 abstract description 14
239000011541 reaction mixture Substances 0.000 description 29
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229940035048 sorbitan monostearate Drugs 0.000 description 1
238000009987 spinning Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000003153 stable transfection Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
150000007970 thio esters Chemical class 0.000 description 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
125000004568 thiomorpholinyl group Chemical group 0.000 description 1
238000012546 transfer Methods 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
125000004953 trihalomethyl group Chemical group 0.000 description 1
238000003828 vacuum filtration Methods 0.000 description 1
230000025033 vasoconstriction Effects 0.000 description 1
230000000304 vasodilatating effect Effects 0.000 description 1
230000024883 vasodilation Effects 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
210000002268 wool Anatomy 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Cardiology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Obesity (AREA)
Oncology (AREA)
Hospice & Palliative Care (AREA)
Emergency Medicine (AREA)
Urology & Nephrology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG107849A 2000-12-01 2003-05-27 Кондензирани пуринови производни като антагонисти на а1 аденозин рецептори BG107849A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25065800P	2000-12-01	2000-12-01
PCT/US2001/044991 WO2002044182A1 (en)	2000-12-01	2001-11-30	Condensed purine derivatives as a1 adenosine receptor antagonists

Publications (1)

Publication Number	Publication Date
BG107849A true BG107849A (bg)	2004-01-30

Family

ID=22948640

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107849A BG107849A (bg)	2000-12-01	2003-05-27	Кондензирани пуринови производни като антагонисти на а1 аденозин рецептори

Country Status (32)

Country	Link
US (2)	US6605601B2 (es)
EP (1)	EP1347981B1 (es)
JP (2)	JP2004514723A (es)
KR (1)	KR20040011439A (es)
CN (1)	CN100497340C (es)
AR (1)	AR035400A1 (es)
AT (1)	ATE394402T1 (es)
AU (2)	AU2002219977B2 (es)
BG (1)	BG107849A (es)
BR (1)	BR0115833A (es)
CA (1)	CA2430508C (es)
CZ (1)	CZ20031513A3 (es)
DE (1)	DE60133931D1 (es)
EA (1)	EA009814B1 (es)
EE (1)	EE200300260A (es)
ES (1)	ES2305139T3 (es)
GE (1)	GEP20094697B (es)
HU (1)	HUP0400530A3 (es)
IL (1)	IL156046A0 (es)
IS (1)	IS6821A (es)
MX (1)	MXPA03004857A (es)
MY (1)	MY127120A (es)
NO (1)	NO20032483L (es)
NZ (1)	NZ526511A (es)
PL (1)	PL362642A1 (es)
SK (1)	SK6552003A3 (es)
TR (1)	TR200300766T2 (es)
TW (1)	TWI293301B (es)
UA (1)	UA75625C2 (es)
WO (1)	WO2002044182A1 (es)
YU (1)	YU42903A (es)
ZA (2)	ZA200304067B (es)

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WO2001047931A1 (en) *	1999-12-24	2001-07-05	Kyowa Hakko Kogyo Co., Ltd.	Fused purine derivatives
AU2002219977B2 (en) *	2000-12-01	2008-01-24	Biogen Idec Ma Inc.	Condensed purine derivatives as A1 adenosine receptor antagonists
EP1601649A4 (en) *	2003-02-19	2009-03-04	Endacea Inc	A1-adenosine receptor antagonistic
US20040229901A1 (en) *	2003-02-24	2004-11-18	Lauren Otsuki	Method of treatment of disease using an adenosine A1 receptor antagonist
AR044069A1 (es)	2003-04-25	2005-08-24	Nova Cardia Inc	Un metodo de diuresis mejorada en individuos con funcion renal deteriorada
WO2004096812A1 (ja) *	2003-04-25	2004-11-11	Kyowa Hakko Kogyo Co., Ltd.	縮合ピリミジン誘導体
US7247639B2 (en) *	2003-06-06	2007-07-24	Endacea, Inc.	A1 adenosine receptor antagonists
MX2007010984A (es) *	2005-03-11	2008-03-18	Aderis Pharmaceuticals Inc	9-alquiladeninas sustituidas y uso de las mismas.
WO2007095161A2 (en) *	2006-02-14	2007-08-23	New York University	Methods and compositions for treating disorders associated with increased bone turnover and osteopenia
CN101420958A (zh) *	2006-04-06	2009-04-29	挪瓦卡尔迪阿公司	共投与腺苷a1受体拮抗剂和抗惊厥药
PT2018380E (pt)	2006-05-19	2012-01-17	Abbott Lab	Derivados de alcanos azabicíclicos substituídos com biciclo-heterociclo fundidos activos no cns
EP2035009A1 (en) *	2006-06-16	2009-03-18	Novacardia, Inc.	Prolonged improvement of renal function comprising infrequent administration of an aa1ra
EP2049544B9 (en)	2006-06-23	2011-07-20	Incyte Corporation	Purinone derivatives as hm74a agonists
KR20090025261A (ko)	2006-06-23	2009-03-10	인사이트 코포레이션	Ｈｍ７４ａ 아고니스트로서의 퓨리논 유도체
WO2008121882A1 (en) *	2007-03-29	2008-10-09	Novacardia, Inc.	Improved methods of administration of adenosine a1 receptor antagonists
US20090197900A1 (en) *	2007-03-29	2009-08-06	Howard Dittrich	Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist
WO2011063268A2 (en) *	2009-11-19	2011-05-26	Biogen Idec Ma Inc	Novel synthetic methods
US20130109645A1 (en)	2010-03-31	2013-05-02	The united States of America,as represented by Secretary,Dept.,of Health and Human Services	Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders
SG11202006435XA (en)	2018-01-04	2020-08-28	Impetis Biosciences Ltd	Tricyclic compounds, compositions and medicinal applications thereof

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Publication number	Priority date	Publication date	Assignee	Title
JPH06102662B2 (ja) *	1989-09-01	1994-12-14	協和醗酵工業株式会社	キサンチン誘導体
ES2152207T3 (es) *	1989-10-20	2001-02-01	Kyowa Hakko Kogyo Kk	Derivados condensados de la purina.
SG97130A1 (en)	1991-09-23	2003-07-18	Univ Florida State	Preparation of substituted isoserine esters using metal alkoxides and betalactams
EP0884318A4 (en) *	1996-10-07	2002-10-23	Kyowa Hakko Kogyo Kk	CONDENSED PURINE DERIVATIVES
EP1014995A4 (en)	1997-06-18	2005-02-16	Aderis Pharmaceuticals Inc	COMPOSITIONS AND METHODS FOR PREVENTING RESTENOSES CONSECUTIVE TO REVASCULARIZATION INTERVENTIONS
AU4396899A (en) *	1998-07-02	2000-01-24	Kyowa Hakko Kogyo Co. Ltd.	Remedies for diabetes
WO2001047931A1 (en) *	1999-12-24	2001-07-05	Kyowa Hakko Kogyo Co., Ltd.	Fused purine derivatives
AU2002219977B2 (en) *	2000-12-01	2008-01-24	Biogen Idec Ma Inc.	Condensed purine derivatives as A1 adenosine receptor antagonists

2001
- 2001-11-30 AU AU2002219977A patent/AU2002219977B2/en not_active Ceased
- 2001-11-30 IL IL15604601A patent/IL156046A0/xx unknown
- 2001-11-30 CA CA2430508A patent/CA2430508C/en not_active Expired - Fee Related
- 2001-11-30 GE GEAP20017016A patent/GEP20094697B/en unknown
- 2001-11-30 HU HU0400530A patent/HUP0400530A3/hu unknown
- 2001-11-30 AT AT01998550T patent/ATE394402T1/de not_active IP Right Cessation
- 2001-11-30 CN CNB018208711A patent/CN100497340C/zh not_active Expired - Fee Related
- 2001-11-30 KR KR10-2003-7007322A patent/KR20040011439A/ko not_active Abandoned
- 2001-11-30 BR BR0115833-3A patent/BR0115833A/pt not_active Application Discontinuation
- 2001-11-30 DE DE60133931T patent/DE60133931D1/de not_active Expired - Lifetime
- 2001-11-30 JP JP2002546552A patent/JP2004514723A/ja active Pending
- 2001-11-30 NZ NZ526511A patent/NZ526511A/en unknown
- 2001-11-30 EE EEP200300260A patent/EE200300260A/xx unknown
- 2001-11-30 MX MXPA03004857A patent/MXPA03004857A/es active IP Right Grant
- 2001-11-30 AR ARP010105594A patent/AR035400A1/es unknown
- 2001-11-30 EA EA200300629A patent/EA009814B1/ru not_active IP Right Cessation
- 2001-11-30 CZ CZ20031513A patent/CZ20031513A3/cs unknown
- 2001-11-30 US US09/997,740 patent/US6605601B2/en not_active Expired - Fee Related
- 2001-11-30 TR TR2003/00766T patent/TR200300766T2/xx unknown
- 2001-11-30 PL PL01362642A patent/PL362642A1/xx not_active Application Discontinuation
- 2001-11-30 UA UA2003066041A patent/UA75625C2/uk unknown
- 2001-11-30 EP EP01998550A patent/EP1347981B1/en not_active Expired - Lifetime
- 2001-11-30 YU YU42903A patent/YU42903A/sh unknown
- 2001-11-30 MY MYPI20015481A patent/MY127120A/en unknown
- 2001-11-30 SK SK655-2003A patent/SK6552003A3/sk not_active Application Discontinuation
- 2001-11-30 AU AU1997702A patent/AU1997702A/xx active Pending
- 2001-11-30 WO PCT/US2001/044991 patent/WO2002044182A1/en not_active Ceased
- 2001-11-30 ES ES01998550T patent/ES2305139T3/es not_active Expired - Lifetime
- 2001-11-30 TW TW090129678A patent/TWI293301B/zh active
2003
- 2003-05-20 IS IS6821A patent/IS6821A/is unknown
- 2003-05-26 ZA ZA200304067A patent/ZA200304067B/en unknown
- 2003-05-27 BG BG107849A patent/BG107849A/bg unknown
- 2003-05-27 US US10/446,573 patent/US7022686B2/en not_active Expired - Fee Related
- 2003-06-02 NO NO20032483A patent/NO20032483L/no not_active Application Discontinuation
2004
- 2004-10-28 ZA ZA200408755A patent/ZA200408755B/xx unknown
2009
- 2009-12-07 JP JP2009278047A patent/JP2010053148A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
JP2004514723A (ja)	2004-05-20
EA009814B1 (ru)	2008-04-28
HUP0400530A3 (en)	2007-05-29
ZA200408755B (en)	2005-07-27
SK6552003A3 (en)	2003-12-02
CA2430508A1 (en)	2002-06-06
YU42903A (sh)	2006-05-25
HUP0400530A2 (hu)	2004-06-28
NO20032483L (no)	2003-07-30
CN100497340C (zh)	2009-06-10
US20020111333A1 (en)	2002-08-15
BR0115833A (pt)	2003-10-28
NO20032483D0 (no)	2003-06-02
EA200300629A1 (ru)	2003-12-25
EE200300260A (et)	2003-08-15
HK1059927A1 (en)	2004-07-23
MY127120A (en)	2006-11-30
CN1481387A (zh)	2004-03-10
CZ20031513A3 (cs)	2003-09-17
GEP20094697B (en)	2009-06-10
JP2010053148A (ja)	2010-03-11
IS6821A (is)	2003-05-20
ZA200304067B (en)	2005-05-30
KR20040011439A (ko)	2004-02-05
AU2002219977B2 (en)	2008-01-24
MXPA03004857A (es)	2003-08-19
AR035400A1 (es)	2004-05-26
US7022686B2 (en)	2006-04-04
ATE394402T1 (de)	2008-05-15
WO2002044182A1 (en)	2002-06-06
TWI293301B (en)	2008-02-11
DE60133931D1 (de)	2008-06-19
CA2430508C (en)	2010-05-18
NZ526511A (en)	2005-04-29
PL362642A1 (en)	2004-11-02
UA75625C2 (en)	2006-05-15
TR200300766T2 (tr)	2004-09-21
AU1997702A (en)	2002-06-11
US20030220358A1 (en)	2003-11-27
IL156046A0 (en)	2003-12-23
ES2305139T3 (es)	2008-11-01
US6605601B2 (en)	2003-08-12
EP1347981B1 (en)	2008-05-07
EP1347981A1 (en)	2003-10-01

Publication	Publication Date	Title
BG107849A (bg)	2004-01-30	Кондензирани пуринови производни като антагонисти на а1 аденозин рецептори
AU2002219977A1 (en)	2002-08-15	Condensed purine derivatives as A1 adenosine receptor antagonists
US20080004293A1 (en)	2008-01-03	Adenosine receptor antagonists and methods of making and using the same
BG65720B1 (bg)	2009-08-31	Полициклоалкилпурини, антагонисти на аденозин рецептор
JP2022500359A (ja)	2022-01-04	ピリダジノン及びその使用法
US5015647A (en)	1991-05-14	Method for treating viral infections
US5017577A (en)	1991-05-21	Methods for treating viral infection
HK1059927B (en)	2009-04-24	Condensed purine derivatives as a1 adenosine receptor antagonists
JP2023543089A (ja)	2023-10-12	炎症性障害および自己免疫障害の治療のためのラベキシモド（ｒａｂｅｘｉｍｏｄ）のチオノエステル誘導体
HUP0203369A2 (hu)	2003-01-28	Adenozin receptor antagonista hatású policikloalkilpurinok, eljárás az előállításukra és alkalmazásuk