BG107469A - Имидазолови производни - Google Patents

Имидазолови производни Download PDF

Info

Publication number: BG107469A
Authority: BG; Bulgaria
Prior art keywords: imidazol; cyclobutyl; cis; acetylamino; naphthalen
Prior art date: 2000-07-31

Application number

BG107469A

Other languages

Bulgarian (bg)

English (en)

Inventor

Michael AHLIJANIAN

Christopher Cooper

Christopher HELAL

Lit-Fui Lau

Frank MENNITI

Mark SANNER

Patricia SEYMOUR

Anabella Villalobos

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-31

Filing date

2003-01-16

Publication date

2003-09-30

2003-01-16 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2003-09-30 Publication of BG107469A publication Critical patent/BG107469A/bg

Links

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208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 106
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 58
230000000694 effects Effects 0.000 claims abstract description 48
150000003839 salts Chemical class 0.000 claims abstract description 48
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims abstract description 32
230000002159 abnormal effect Effects 0.000 claims abstract description 26
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-1 1-cyclopentyl-1H-imidazol-4-yl Chemical group 0.000 claims description 99
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239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 claims description 8
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125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 5
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229910004013 NO 2 Inorganic materials 0.000 claims description 4
QOIGKGMMAGJZNZ-UHFFFAOYSA-N gepirone Chemical compound O=C1CC(C)(C)CC(=O)N1CCCCN1CCN(C=2N=CC=CN=2)CC1 QOIGKGMMAGJZNZ-UHFFFAOYSA-N 0.000 claims description 4
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DOIQUBXJDRUMAB-UHFFFAOYSA-N phenyl n-(1-cyclobutylimidazol-4-yl)carbamate Chemical compound C=1C=CC=CC=1OC(=O)NC(N=C1)=CN1C1CCC1 DOIQUBXJDRUMAB-UHFFFAOYSA-N 0.000 claims description 4
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NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
239000012312 sodium hydride Substances 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
235000010288 sodium nitrite Nutrition 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000012453 solvate Substances 0.000 description 1
241000894007 species Species 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
238000003860 storage Methods 0.000 description 1
208000023516 stroke disease Diseases 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
230000015883 synaptic transmission, dopaminergic Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000006188 syrup Substances 0.000 description 1
229960001685 tacrine Drugs 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
102000013498 tau Proteins Human genes 0.000 description 1
108010026424 tau Proteins Proteins 0.000 description 1
208000001608 teratocarcinoma Diseases 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005207 tetraalkylammonium group Chemical group 0.000 description 1
DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 description 1
JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical compound [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 description 1
DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
125000001113 thiadiazolyl group Chemical group 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
229960000187 tissue plasminogen activator Drugs 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000009466 transformation Effects 0.000 description 1
125000004306 triazinyl group Chemical group 0.000 description 1
YLGRTLMDMVAFNI-UHFFFAOYSA-N tributyl(prop-2-enyl)stannane Chemical compound CCCC[Sn](CCCC)(CCCC)CC=C YLGRTLMDMVAFNI-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
COIOYMYWGDAQPM-UHFFFAOYSA-N tris(2-methylphenyl)phosphane Chemical compound CC1=CC=CC=C1P(C=1C(=CC=CC=1)C)C1=CC=CC=C1C COIOYMYWGDAQPM-UHFFFAOYSA-N 0.000 description 1
IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
229910052722 tritium Inorganic materials 0.000 description 1
229960002004 valdecoxib Drugs 0.000 description 1
LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
238000005406 washing Methods 0.000 description 1
229940009065 wellbutrin Drugs 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

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- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/88—Nitrogen atoms, e.g. allantoin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
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- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
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General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
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BG107469A 2000-07-31 2003-01-16 Имидазолови производни BG107469A (bg)

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US22172400P	2000-07-31	2000-07-31
PCT/IB2001/001335 WO2002010141A1 (fr)	2000-07-31	2001-07-25	Derives d'imidazole

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JP (2)	JP4166084B2 (fr)
KR (1)	KR20030019644A (fr)
CN (1)	CN1444567A (fr)
AP (1)	AP2001002232A0 (fr)
AR (1)	AR032629A1 (fr)
AU (1)	AU2001270944A1 (fr)
BG (1)	BG107469A (fr)
BR (1)	BR0112862A (fr)
CA (1)	CA2418115A1 (fr)
CR (1)	CR6861A (fr)
CZ (1)	CZ2003225A3 (fr)
DO (1)	DOP2001000220A (fr)
EA (1)	EA200300097A1 (fr)
EC (1)	ECSP034445A (fr)
EE (1)	EE200300049A (fr)
GT (1)	GT200100147A (fr)
HR (1)	HRP20030048A2 (fr)
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MX (1)	MXPA03000939A (fr)
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PL (1)	PL365134A1 (fr)
SK (1)	SK1042003A3 (fr)
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TN (1)	TNSN01114A1 (fr)
UY (1)	UY26862A1 (fr)
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JP2002534468A (ja)	1999-01-13	2002-10-15	バイエルコーポレイション	ｐ３８キナーゼ阻害剤としてのω−カルボキシアリール置換ジフェニル尿素
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DE10233817A1 (de) *	2002-07-25	2004-02-12	Aventis Pharma Deutschland Gmbh	Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
GB0308968D0 (en) *	2003-04-17	2003-05-28	Glaxo Group Ltd	Medicaments
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WO2007053596A1 (fr)	2005-10-31	2007-05-10	Braincells, Inc.	Modulation de la neurogenese dont la mediation est assuree par recepteur gaba
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Publication number	Publication date
CZ2003225A3 (cs)	2004-02-18
ZA200300819B (en)	2004-04-20
EE200300049A (et)	2004-10-15
NO20030472D0 (no)	2003-01-30
TNSN01114A1 (fr)	2005-11-10
HUP0303069A3 (en)	2004-04-28
NZ523272A (en)	2004-08-27
MA26932A1 (fr)	2004-12-20
SK1042003A3 (en)	2004-05-04
IS6662A (is)	2002-12-19
SV2002000571A (es)	2002-10-24
WO2002010141A1 (fr)	2002-02-07
AP2001002232A0 (en)	2001-09-30
UY26862A1 (es)	2002-02-28
IL153787A0 (en)	2003-07-31
JP4166084B2 (ja)	2008-10-15
HRP20030048A2 (en)	2003-04-30
AR032629A1 (es)	2003-11-19
PA8523701A1 (es)	2002-04-25
KR20030019644A (ko)	2003-03-06
MXPA03000939A (es)	2003-06-24
JP2008255123A (ja)	2008-10-23
DOP2001000220A (es)	2002-05-15
HUP0303069A2 (hu)	2004-03-01
BR0112862A (pt)	2003-07-01
CR6861A (es)	2004-03-11
NO20030472L (no)	2003-03-27
PE20020337A1 (es)	2002-05-08
EP1305295A1 (fr)	2003-05-02
ECSP034445A (es)	2003-03-10
CA2418115A1 (fr)	2002-02-07
OA12345A (en)	2004-04-13
PL365134A1 (en)	2004-12-27
AU2001270944A1 (en)	2002-02-13
CN1444567A (zh)	2003-09-24
JP2004505111A (ja)	2004-02-19
EA200300097A1 (ru)	2003-06-26
GT200100147A (es)	2002-06-25

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BG107469A (bg)	2003-09-30	Имидазолови производни
US6756385B2 (en)	2004-06-29	Imidazole derivatives
JP2002338556A (ja)	2002-11-27	チアゾール誘導体
KR20030027093A (ko)	2003-04-03	피라졸 유도체 및 단백질 키나제 억제제로서 그의 용도
US8362065B2 (en)	2013-01-29	Carbazole carboxamide compounds useful as kinase inhibitors
US20050209297A1 (en)	2005-09-22	Pyrazole derivatives
US20020103185A1 (en)	2002-08-01	Pyrazole derivatives
US20030083352A1 (en)	2003-05-01	Synthesis of imidazole intermediates
HK1055953A (en)	2004-01-30	Imidazole derivatives