BG106708A - Пиролидинацетамидни производни самостоятелно или в комбинация за лечение на разстройства на цнс - Google Patents
Пиролидинацетамидни производни самостоятелно или в комбинация за лечение на разстройства на цнс Download PDFInfo
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- BG106708A BG106708A BG106708A BG10670802A BG106708A BG 106708 A BG106708 A BG 106708A BG 106708 A BG106708 A BG 106708A BG 10670802 A BG10670802 A BG 10670802A BG 106708 A BG106708 A BG 106708A
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- Prior art keywords
- levetiracetam
- valproate
- amount
- treatment
- pain
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Classifications
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
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- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99123803 | 1999-12-01 | ||
| EP99124269 | 1999-12-01 | ||
| PCT/EP2000/011808 WO2001039779A1 (en) | 1999-12-01 | 2000-11-27 | A pyrrolidineacetamide derivative alone or in combination for treatment of cns disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG106708A true BG106708A (bg) | 2003-02-28 |
Family
ID=26153183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG106708A BG106708A (bg) | 1999-12-01 | 2002-05-16 | Пиролидинацетамидни производни самостоятелно или в комбинация за лечение на разстройства на цнс |
Country Status (32)
| Country | Link |
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| EP (4) | EP1244456B1 (et) |
| JP (2) | JP4249415B2 (et) |
| KR (1) | KR20030016205A (et) |
| CN (1) | CN100525761C (et) |
| AR (1) | AR026610A1 (et) |
| AT (1) | ATE361751T1 (et) |
| AU (1) | AU773418B2 (et) |
| BG (1) | BG106708A (et) |
| BR (1) | BR0015974A (et) |
| CA (2) | CA2392879C (et) |
| CO (1) | CO5261590A1 (et) |
| CZ (1) | CZ20021904A3 (et) |
| DE (1) | DE60034815T2 (et) |
| EE (1) | EE200200274A (et) |
| ES (1) | ES2287039T3 (et) |
| HK (1) | HK1052647B (et) |
| HU (1) | HUP0204023A3 (et) |
| IL (2) | IL149530A0 (et) |
| IS (1) | IS6377A (et) |
| MX (1) | MXPA02005275A (et) |
| MY (1) | MY127980A (et) |
| NO (1) | NO20022585L (et) |
| NZ (1) | NZ518901A (et) |
| PL (1) | PL357472A1 (et) |
| RO (1) | RO121085B1 (et) |
| RU (1) | RU2261093C2 (et) |
| SA (1) | SA01210655B1 (et) |
| SK (1) | SK7492002A3 (et) |
| TW (1) | TWI238062B (et) |
| WO (1) | WO2001039779A1 (et) |
| YU (1) | YU37602A (et) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0004297D0 (en) | 2000-02-23 | 2000-04-12 | Ucb Sa | 2-oxo-1 pyrrolidine derivatives process for preparing them and their uses |
| US6756379B2 (en) | 2001-07-26 | 2004-06-29 | Taro Pharmaceutical Industries Ltd. | Non-sedating barbiturate compounds as neuroprotective agents |
| US7683071B2 (en) | 2000-07-26 | 2010-03-23 | Taro Pharmaceuticals Industries Ltd. | Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid |
| MXPA03005889A (es) * | 2000-12-28 | 2005-02-14 | Daiichi Seiyaku Co | Agente para tratamiento terapeutico y profilactico del dolor neuropatico. |
| AU2002245486B2 (en) * | 2001-02-23 | 2006-11-16 | Ucb Pharma, S.A. | Treatment of tics, tremors and related disorders |
| WO2003000180A2 (en) * | 2001-06-20 | 2003-01-03 | Merck & Co., Inc. | Dipeptidyl peptidase inhibitors for the treatment of diabetes |
| US7544681B2 (en) | 2001-09-27 | 2009-06-09 | Ramot At Tel Aviv University Ltd. | Conjugated psychotropic drugs and uses thereof |
| PL370529A1 (en) * | 2001-10-08 | 2005-05-30 | Ucb, S.A. | Use of 2-oxo-1-pyrrolidine derivatives for the preparation of a drug |
| WO2003094913A1 (en) * | 2002-05-14 | 2003-11-20 | Ucb, S.A. | Use of 2-oxo-1-pyrrolidone derivatives for the preparation of a drug |
| JP2006516390A (ja) | 2002-12-03 | 2006-07-06 | ユ セ ベ ソシエテ アノニム | 発作、神経系疾患、内分泌障害及びホルモン疾患の治療用薬剤の同定方法 |
| CN101569626B (zh) | 2002-12-11 | 2012-02-08 | 塔罗制药工业有限公司 | 使用巴比土酸衍生物治疗运动障碍的方法 |
| TR200503397T1 (tr) * | 2003-03-18 | 2007-03-21 | Hetero Drugs Limited | Levetirasetam'ın yeni kristal formları. |
| GB0307860D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Organic compounds |
| JPWO2004093910A1 (ja) * | 2003-04-22 | 2006-07-13 | アステラス製薬株式会社 | ＰＰＡＲδアゴニストによる脳神経変性疾患治療剤 |
| EP1685832B1 (en) * | 2003-10-03 | 2011-04-06 | Ono Pharmaceutical Co., Ltd. | Nerve regeneration promoters |
| WO2006102750A1 (en) * | 2005-03-30 | 2006-10-05 | Genpharm Inc. | Combined-step process for pharmaceutical compositions |
| US20060252745A1 (en) | 2005-05-06 | 2006-11-09 | Almeida Jose L D | Methods of preparing pharmaceutical compositions comprising eslicarbazepine acetate and methods of use |
| WO2006127300A1 (en) * | 2005-05-24 | 2006-11-30 | Cambrex Charles City, Inc. | SYNTHESIS OF (S)-α-ETHYL-2-OXO-1-PYRROLIDINEACETAMIDE |
| AU2006274263B2 (en) | 2005-07-26 | 2011-01-27 | Ucb Pharma, S.A. | Pharmaceutical compositions comprising levetiracetam and process for their preparation |
| US20070043120A1 (en) * | 2005-08-18 | 2007-02-22 | Bettina Beyreuther | Therapeutic combination for painful medical conditions |
| EP1754476A1 (en) * | 2005-08-18 | 2007-02-21 | Schwarz Pharma Ag | Lacosamide (SPM 927) for treating myalgia, e.g. fibromyalgia |
| FR2890563B1 (fr) * | 2005-09-09 | 2007-10-19 | Servier Lab | Nouvelle association entre l'agomelatine et un agent thymoregulateur et les compositions pharmaceutiques qui la contiennent |
| DE602006003617D1 (de) * | 2006-01-24 | 2008-12-24 | Teva Pharma | Zusammensetzungen enthaltend Levetiracetam und Verfahren zu deren Herstellung. |
| AU2007260207B2 (en) * | 2006-06-15 | 2012-11-08 | Ucb Pharma Gmbh | Pharmaceutical composition with synergistic anticonvulsant effect |
| EP2051735B1 (en) * | 2006-07-17 | 2012-08-29 | Ramot, at Tel Aviv University Ltd. | Conjugates comprising a psychotropic drug or a gaba agonist and an organic acid and their use treating pain and other cns disorders |
| GB0700773D0 (en) | 2007-01-15 | 2007-02-21 | Portela & Ca Sa | Drug therapies |
| WO2008095221A1 (en) | 2007-02-07 | 2008-08-14 | Gosforth Centre (Holdings) Pty Ltd | Treatment of adhd |
| ITMI20070770A1 (it) * | 2007-04-16 | 2008-10-17 | Brane Discovery S R L | Impiego di dimiracetam nel trattamento del dolore cronico |
| AU2012201853B2 (en) * | 2007-04-16 | 2013-06-27 | Neurotune Ag | Use of dimiracetam in the treatment of chronic pain |
| US8207369B2 (en) | 2008-02-11 | 2012-06-26 | Ramot At Tel-Aviv University Ltd. | Conjugates for treating neurodegenerative diseases and disorders |
| WO2010015029A1 (en) | 2008-08-06 | 2010-02-11 | Gosforth Centre (Holdings) Pty Ltd | Compositions and methods for treating psychiatric disorders |
| WO2010044878A1 (en) | 2008-10-16 | 2010-04-22 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| PL389364A1 (pl) * | 2009-10-23 | 2011-04-26 | Uniwersytet Jagielloński | Nowe zastosowanie pochodnych 2-pirolidonu |
| CA2789654A1 (en) | 2010-02-24 | 2011-09-01 | Ramot At Tel-Aviv University Ltd. | Crystalline forms of the tri-mesylate salt of perphenazine-gaba and process of producing the same |
| WO2011126733A2 (en) * | 2010-03-28 | 2011-10-13 | Children's Medical Center Corporation | Combination therapies: inhibitors of gaba transaminase and nkcc1 |
| US8916610B2 (en) | 2010-09-22 | 2014-12-23 | Ramot At Tel-Aviv University Ltd. | Acid addition salt of a nortriptyline-GABA conjugate and a process of preparing same |
| AU2018208662B2 (en) * | 2012-11-14 | 2020-07-23 | The Johns Hopkins University | Methods and Compositions for Treating Schizophrenia |
| US20140206667A1 (en) * | 2012-11-14 | 2014-07-24 | Michela Gallagher | Methods and compositions for treating schizophrenia |
| EP2968237A4 (en) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| ES2881081T3 (es) | 2013-03-15 | 2021-11-26 | Agenebio Inc | Procedimientos y composiciones para mejorar la función cognitiva |
| KR101690175B1 (ko) * | 2013-07-02 | 2016-12-27 | 경희대학교 산학협력단 | 고본 추출물을 유효성분으로 포함하는 불면증의 예방 또는 치료용 약학적 조성물 |
| RU2538724C1 (ru) * | 2013-12-19 | 2015-01-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Способ лечения эпилепсии |
| PH12019500127B1 (en) | 2014-01-21 | 2022-05-04 | Janssen Pharmaceutica Nv | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use |
| SMT201900545T1 (it) * | 2014-01-21 | 2019-11-13 | Janssen Pharmaceutica Nv | Combinazioni comprendenti modulatori allosterici positivi o agonisti ortosterici del recettore glutammatergico metabotropico sottotipo 2 e loro utilizzo |
| RU2563124C1 (ru) * | 2014-04-28 | 2015-09-20 | Федеральное государственное бюджетное учреждение "Федеральный медицинский исследовательский центр психиатрии и наркологии имени В.П. Сербского" Министерства здравоохранения Российской Федерации (ФГБУ "ФМИЦПН им. В.П. Сербского" Минздрава России) | Способ диагностики шизофрении |
| CA2986598C (en) | 2015-05-22 | 2023-09-26 | Agenebio, Inc. | Extended release pharmaceutical compositions of levetiracetam |
| WO2018071893A1 (en) * | 2016-10-14 | 2018-04-19 | Falci Scott P | Treating neuropathic pain in spinal cord injured individuals |
| PL244071B1 (pl) * | 2019-01-07 | 2023-11-27 | Univ Jagiellonski | Pochodne (2,5-dioksopirolidyn-1-ylo)(fenylo)-acetamidu i ich zastosowanie do leczenia chorób o podłożu neurologicznym |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB8412357D0 (en) | 1984-05-15 | 1984-06-20 | Ucb Sa | Pharmaceutical composition |
| GB8827389D0 (en) | 1988-11-23 | 1988-12-29 | Ucb Sa | Process for preparation of(s)alpha-ethyl-2-oxo-1-pyrrolidineacetamide |
| EP0408782A1 (en) | 1989-07-18 | 1991-01-23 | Nauchnoissledovatelski Chimikopharmatzevtichen Institut | Antihypoxic agent |
| GB9319732D0 (en) | 1993-09-24 | 1993-11-10 | Ucb Sa | Use of (s)-alpha-ethyl-2-oxo-l-pyrrolidineacetamide for the treatment of anxiety |
| US5998380A (en) * | 1995-10-13 | 1999-12-07 | New England Medical Center Hospitals, Inc. | Treatment of migraine |
| AU765802B2 (en) | 1997-12-16 | 2003-10-02 | Warner-Lambert Company | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
| AU2463099A (en) | 1998-01-23 | 1999-08-09 | Warner-Lambert Company | Gabapentin and its derivatives for the treatment of muscular and skeletal pain |
| DE19820381B4 (de) * | 1998-05-07 | 2007-01-25 | Trw Fahrwerksysteme Gmbh & Co Kg | Verfahren zur Beeinflussung der Ventilkennlinie |
| EP2332580A1 (en) * | 1998-12-23 | 2011-06-15 | NeuroTherapeutics Pharma, Inc. | A composition for the treatment of the central nervous system |
| US6495601B1 (en) | 1998-12-23 | 2002-12-17 | Cytoscan Sciences Llc | Methods and compositions for treating conditions of the central and peripheral nervous systems using non-synaptic mechanisms |
| EP2090312A1 (en) * | 1999-07-01 | 2009-08-19 | Pharmacia & Upjohn Company LLC | (S,S) reboxetine for treating attention deficit disorder |
| CA2479672A1 (en) * | 2002-03-18 | 2003-10-02 | Roger K. Cady | Preemptive prophylaxis of migraine |
| US20040116506A1 (en) * | 2002-06-20 | 2004-06-17 | Krusz John Claude | Use of levetiracetam for treating or preventing acute headaches |
| JP2006516390A (ja) * | 2002-12-03 | 2006-07-06 | ユ セ ベ ソシエテ アノニム | 発作、神経系疾患、内分泌障害及びホルモン疾患の治療用薬剤の同定方法 |
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- 2000-11-27 NZ NZ518901A patent/NZ518901A/en unknown
- 2000-11-27 RO ROA200200730A patent/RO121085B1/ro unknown
- 2000-11-27 CN CNB008165378A patent/CN100525761C/zh not_active Expired - Fee Related
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- 2000-11-27 EP EP05019212A patent/EP1600169A3/en not_active Withdrawn
- 2000-11-27 EP EP05019211A patent/EP1600168A3/en not_active Withdrawn
- 2000-11-27 WO PCT/EP2000/011808 patent/WO2001039779A1/en not_active Ceased
- 2000-11-27 KR KR1020027006987A patent/KR20030016205A/ko not_active Ceased
- 2000-11-27 AT AT00977580T patent/ATE361751T1/de not_active IP Right Cessation
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- 2000-11-27 HU HU0204023A patent/HUP0204023A3/hu unknown
- 2000-11-27 DE DE60034815T patent/DE60034815T2/de not_active Expired - Lifetime
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- 2000-11-27 ES ES00977580T patent/ES2287039T3/es not_active Expired - Lifetime
- 2000-11-27 CA CA002475026A patent/CA2475026A1/en not_active Abandoned
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- 2000-11-27 BR BR0015974-3A patent/BR0015974A/pt not_active Application Discontinuation
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2001
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2002
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2005
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