BG106276A - Диаминотиазоли и употребата им за инхибиране на протеин кинази - Google Patents

Диаминотиазоли и употребата им за инхибиране на протеин кинази Download PDF

Info

Publication number: BG106276A
Authority: BG; Bulgaria
Prior art keywords: formula; group; aryl; amino; substituted
Prior art date: 1999-06-04

Application number

BG106276A

Other languages

Bulgarian (bg)

English (en)

Inventor

Shao CHU

Larry ALEGRIA

Steven Bender

Suzanne BENEDICT

Allen Borchardt

Robert Kania

Mitchell NAMBU

Anna Tempczyk-Russell

Sepehr Sarshar

Dilip Bhumralkar

Zhengwei Peng

Yi Yang

Original Assignee

Agouron Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-04

Filing date

2002-01-03

Publication date

2002-10-31

2002-01-03 Application filed by Agouron Pharmaceuticals, Inc. filed Critical Agouron Pharmaceuticals, Inc.

2002-10-31 Publication of BG106276A publication Critical patent/BG106276A/bg

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6536—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
- C07F9/6539—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BG106276A 1999-06-04 2002-01-03 Диаминотиазоли и употребата им за инхибиране на протеин кинази BG106276A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13781099P	1999-06-04	1999-06-04
PCT/US2000/015188 WO2000075120A1 (en)	1999-06-04	2000-06-02	Diaminothiazoles and their use for inhibiting protein kinases

Publications (1)

Publication Number	Publication Date
BG106276A true BG106276A (bg)	2002-10-31

Family

ID=22479135

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG106276A BG106276A (bg)	1999-06-04	2002-01-03	Диаминотиазоли и употребата им за инхибиране на протеин кинази

Country Status (34)

Country	Link
US (1)	US6620828B2 (de)
EP (1)	EP1181283B1 (de)
JP (1)	JP2003501420A (de)
KR (1)	KR20020015333A (de)
CN (1)	CN1359380A (de)
AP (1)	AP2001002341A0 (de)
AT (1)	ATE288424T1 (de)
AU (1)	AU778071B2 (de)
BG (1)	BG106276A (de)
BR (1)	BR0011585A (de)
CA (1)	CA2371158A1 (de)
CZ (1)	CZ20014213A3 (de)
DE (1)	DE60017894T2 (de)
EA (1)	EA200101268A1 (de)
EE (1)	EE200100659A (de)
ES (1)	ES2234628T3 (de)
HR (1)	HRP20020008A2 (de)
HU (1)	HUP0202897A3 (de)
IL (1)	IL146094A0 (de)
IS (1)	IS6183A (de)
MA (1)	MA25530A1 (de)
MX (1)	MXPA01012483A (de)
NO (1)	NO20015045L (de)
NZ (1)	NZ514881A (de)
OA (1)	OA11959A (de)
PE (1)	PE20010211A1 (de)
PL (1)	PL352714A1 (de)
SK (1)	SK17302001A3 (de)
SV (1)	SV2002000096A (de)
UA (1)	UA71971C2 (de)
UY (1)	UY26190A1 (de)
WO (1)	WO2000075120A1 (de)
YU (1)	YU85601A (de)
ZA (1)	ZA200108291B (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20020150921A1 (en) *	1996-02-09	2002-10-17	Francis Barany	Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
ID24372A (id) *	1997-10-27	2000-07-13	Agouron Pharma	SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs
US6262096B1 (en)	1997-11-12	2001-07-17	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
US20040226056A1 (en) *	1998-12-22	2004-11-11	Myriad Genetics, Incorporated	Compositions and methods for treating neurological disorders and diseases
ES2391550T3 (es)	1999-04-15	2012-11-27	Bristol-Myers Squibb Company	Inhibidores cíclicos de la proteína tirosina quinasa
US7125875B2 (en)	1999-04-15	2006-10-24	Bristol-Myers Squibb Company	Cyclic protein tyrosine kinase inhibitors
WO2002050071A1 (en)	2000-12-21	2002-06-27	Bristol-Myers Squibb Company	Thiazolyl inhibitors of tec family tyrosine kinases
US6756374B2 (en)	2001-01-22	2004-06-29	Hoffmann-La Roche Inc.	Diaminothiazoles having antiproliferative activity
UA76977C2 (en)	2001-03-02	2006-10-16	Icos Corp	Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers
US7041685B2 (en) *	2001-06-08	2006-05-09	Cytovia, Inc.	Substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
EP1467981A1 (de) *	2002-01-25	2004-10-20	Kylix Pharmaceuticals B.V.	4-(hetero)aryl-substituierte (thia-/oxa-/pyra)zole zur inhibierung von tie-2
US6818663B2 (en) *	2002-05-17	2004-11-16	Hoffmann-La Roches	Diaminothiazoles
US20050239852A1 (en)	2002-08-02	2005-10-27	Ab Science	2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors
US8450302B2 (en)	2002-08-02	2013-05-28	Ab Science	2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors
PE20040609A1 (es)	2002-11-01	2004-10-29	Takeda Pharmaceutical	Compuestos heterociclicos aromaticos como promotores de un factor neurotrofico
BRPI0407618A (pt) *	2003-02-21	2006-02-21	Pfizer	derivados de tiazole amino substituidos com cicloalquilo contendo n e composições farmacêuticas para inibição da proliferação celular e métodos para a sua utilização
US7078419B2 (en)	2003-03-10	2006-07-18	Boehringer Ingelheim Pharmaceuticals, Inc.	Cytokine inhibitors
ES2770035T3 (es)	2003-04-11	2020-06-30	Ptc Therapeutics Inc	Compuesto de ácido 1,2,4-oxadiazol benzoico y su uso para la supresión sin sentido y el tratamiento de enfermedades
EP1618133A1 (de) *	2003-04-17	2006-01-25	Pfizer Inc.	Kristallstukturen von vegfrkd:ligandkomplexen und verfahren zur deren verwendung
EP1644323B1 (de) *	2003-07-07	2015-03-18	Georgetown University	Histondeacetylaseinhibitoren und verfahren zu deren anwendung
AU2004268621C1 (en) *	2003-08-29	2011-08-18	Exelixis, Inc.	c-Kit modulators and methods of use
CA2762955A1 (en) *	2003-10-16	2005-04-28	Imclone Llc	Fibroblast growth factor receptor-1 inhibitors and methods of treatment thereof
EP1709019B1 (de) *	2004-01-12	2007-08-08	Applied Research Systems ARS Holding N.V.	Thiazolderivate und deren verwendung
JPWO2005108370A1 (ja) *	2004-04-16	2008-03-21	味の素株式会社	ベンゼン化合物
US7211576B2 (en)	2004-04-20	2007-05-01	Hoffmann-La Roche Inc.	Diaminothiazoles
WO2006017216A1 (en) *	2004-07-12	2006-02-16	Merck & Co., Inc.	Histone deacetylase inhibitors
MX2007014886A (es)	2005-05-24	2008-02-19	Serono Lab	Derivados de tiazol y uso de los mismos.
KR20080015119A (ko) *	2005-05-24	2008-02-18	라보라뚜와르 세로노 에스. 에이.	티아졸 유도체 및 그의 용도
DK2395002T3 (da)	2005-11-08	2014-09-08	Vertex Pharma	Farmaceutisk sammensætning indeholdende en heterocyclisk modulator af ATP-bindende kassettetransportører
AU2012244242B2 (en) *	2005-12-28	2015-05-21	Vertex Pharmaceuticals Incorporated	1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
NZ569327A (en) *	2005-12-28	2011-09-30	Vertex Pharma	1-(benzo [d] [1,3] dioxol-5-yl) -n- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-binding cassette transporters for the treatment of cystic fibrosis
AU2007207743B2 (en) *	2006-01-18	2010-07-08	Amgen Inc.	Thiazole compounds as protein kinase B (PKB) inhibitors
CN101384568B (zh) *	2006-02-15	2012-12-12	雅培制药有限公司	乙酰辅酶a羧化酶(acc)抑制剂及其在糖尿病、肥胖症和代谢综合征中的应用
JP5369257B2 (ja) *	2006-02-15	2013-12-18	アッヴィ・インコーポレイテッド	新規なアセチル−ＣｏＡカルボキシラーゼ（ＡＣＣ）阻害薬およびそれらの糖尿病、肥満および代謝症候群での使用
WO2007117438A2 (en)	2006-03-30	2007-10-18	Ptc Therapeutics, Inc.	Methods for the production of functional protein from dna having a nonsense mutation and the treatment of disorders associated therewith
NZ574621A (en)	2006-07-07	2012-03-30	Boehringer Ingelheim Int	Phenyl substituted heteroaryl-derivatives and use thereof as anti-tumour agents
US7879856B2 (en)	2006-12-22	2011-02-01	Rigel Pharmaceuticals, Inc.	Diaminothiazoles useful as Axl inhibitors
CN102863432B (zh)	2007-05-09	2016-09-07	沃泰克斯药物股份有限公司	Cftr调节剂
PE20090837A1 (es)	2007-07-02	2009-07-24	Boehringer Ingelheim Int	Nuevos compuestos quimicos
JP2010531850A (ja) *	2007-07-02	2010-09-30	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規化合物
WO2009011871A2 (en) *	2007-07-17	2009-01-22	Amgen Inc.	Thiadiazole modulators of pkb
CA2692713A1 (en)	2007-07-17	2009-01-22	Amgen Inc.	Heterocyclic modulators of pkb
MX2010006183A (es)	2007-12-07	2010-10-15	Vertex Pharma	Procesos para producir acidos cicloalquilcarboxamido-piridin benzoicos.
SG186638A1 (en)	2007-12-07	2013-01-30	Vertex Pharma	Solid forms of 3-(6-(1-(2,2-difluorobenzo[d][1,3] dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl) benzoic acid
EP2231625A4 (de) *	2007-12-13	2010-12-29	Glaxosmithkline Llc	Thiazole und oxazole als kinaseinhibitoren
NZ703814A (en)	2008-02-28	2016-06-24	Vertex Pharma	Heteroaryl derivatives as cftr modulators
UA103319C2 (en) *	2008-05-06	2013-10-10	Глаксосмитклайн Ллк	Thiazole- and oxazole-benzene sulfonamide compounds
MX2011003292A (es)	2008-09-29	2011-04-21	Boehringer Ingelheim Int	Compuestos antiproliferativos.
CA2749843C (en)	2009-01-16	2017-09-05	Rigel Pharmaceuticals, Inc.	Axl inhibitors for use in combination therapy for preventing, treating or managing metastatic cancer
JPWO2011048936A1 (ja) *	2009-10-19	2013-03-07	大正製薬株式会社	アミノチアゾール誘導体
WO2011117382A1 (en)	2010-03-26	2011-09-29	Boehringer Ingelheim International Gmbh	Pyridyltriazoles
EP2552905B1 (de)	2010-03-26	2016-10-05	Boehringer Ingelheim International GmbH	Inhibitoren der B-Raf Kinase
CN106943403A (zh)	2010-04-07	2017-07-14	弗特克斯药品有限公司	药物组合物和其给药方法
US8710055B2 (en)	2010-12-21	2014-04-29	Boehringer Ingelheim International Gmbh	Triazolylphenyl sulfonamides as serine/threonine kinase inhibitors
PL2806859T3 (pl)	2012-01-25	2019-11-29	Vertex Pharma	Formulacje kwasu 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5- ilo)cyklopropanokarboksyamido)-3-metylopirydyn-2-ylo)benzoesowego
US9242977B2 (en)	2012-04-26	2016-01-26	Ono Pharmaceutical Co., Ltd.	Trk-inhibiting compound
EP3800183A1 (de)	2013-02-19	2021-04-07	ONO Pharmaceutical Co., Ltd.	Harnstoff derivate als trk-hemmende verbindungen
GB201309333D0 (en)	2013-05-23	2013-07-10	Agency Science Tech & Res	Purine diones as WNT pathway modulators
PT3068392T (pt)	2013-11-12	2021-05-14	Vertex Pharma	Processo de preparação de composições farmacêuticas para o tratamento de doenças mediadas por condutância transmembrana da fibrose quística (cftr)
CA2942147C (en)	2014-03-06	2022-12-13	Ptc Therapeutics, Inc.	Pharmaceutical compositions and salts of a 1,2,4-oxadiazole benzoic acid
CN107110831B (zh)	2014-11-18	2020-02-21	弗特克斯药品有限公司	进行高通量试验高效液相色谱的方法
CN108348527A (zh)	2015-10-30	2018-07-31	Ptc医疗公司	用于治疗癫痫的方法
WO2018052967A1 (en) *	2016-09-13	2018-03-22	Arbutus Biopharma, Inc.	Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same
CN111233786B (zh) *	2020-02-04	2021-11-26	中国人民解放军军事科学院军事医学研究院	含五元杂环的苯磺酰胺类化合物及其制备方法和用途
WO2025007859A1 (en) *	2023-07-03	2025-01-09	Insilico Medicine Ip Limited	Substituted thiazole compounds as cdk2/4/6 inhibitors and methods of use thereof
CN116874442B (zh) *	2023-07-27	2025-10-24	武汉呈瑞生物医药科技有限公司	一种有机化合物及其应用

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE273062C (de)	1912-04-19	1914-04-20	Deylen Sohn Firma	Vorrichtung zum Schränken von Plattenzündspänen
AU558132B2 (en)	1981-05-27	1987-01-22	Labatt Brewing Co. Ltd.	Malt sterilisation with hydrogen peroxide
US4994479A (en)	1985-04-03	1991-02-19	Yamanouchi Pharmaceutical Co., Ltd.	Phenylene derivatives and anti-allergic use thereof
SG64322A1 (en) *	1991-05-10	1999-04-27	Rhone Poulenc Rorer Int	Bis mono and bicyclic aryl and heteroaryl compounds which inhibit egf and/or pdgf receptor tyrosine kinase
EP0636123A1 (de)	1992-03-24	1995-02-01	MERCK SHARP & DOHME LTD.	3-ureido substituierte benzpdiazepin-2-one mit cholecystokimin und/oder antagonistischer aktivität und ihre therapeutische verwendung
US5631156A (en)	1994-06-21	1997-05-20	The University Of Michigan	DNA encoding and 18 KD CDK6 inhibiting protein
ES2219670T3 (es)	1994-11-10	2004-12-01	Millennium Pharmaceuticals, Inc.	Utilizacion de compuestos de pirazola para el tratamiento de la glomerulonefritis, cancer, ateroesclerosis o restenosis.
PL184490B1 (pl)	1995-02-02	2002-11-29	Smithkline Beecham Plc	Nowe pochodne indolu jako antagonista receptora T
US5710173A (en)	1995-06-07	1998-01-20	Sugen, Inc.	Thienyl compounds for inhibition of cell proliferative disorders
WO1997003967A1 (en)	1995-07-22	1997-02-06	Rhone-Poulenc Rorer Limited	Substituted aromatic compounds and their pharmaceutical use
US5705499A (en)	1995-10-06	1998-01-06	Boehringer Ingelheim Pharmaceuticals, Inc.	8-arylalkyl- and 8-arylheteroalkyl-5,11-dihydro-6H-dipyrido 3,2-B:2',3'-e! 1!diazepines and their use in the treatment of HIV-1 infection
US5733920A (en)	1995-10-31	1998-03-31	Mitotix, Inc.	Inhibitors of cyclin dependent kinases
US5760028A (en)	1995-12-22	1998-06-02	The Dupont Merck Pharmaceutical Company	Integrin receptor antagonists
WO1997034876A1 (en)	1996-03-15	1997-09-25	Zeneca Limited	Cinnoline derivatives and use as medicine
DE69709493T2 (de)	1996-06-27	2002-10-31	Pfizer Inc., New York	Substituierte Indazolderivate
BR9712005A (pt)	1996-09-04	1999-08-24	Pfizer	Derivados de indazol e seus usos como inibidores de fosfodiesterase (pde) tipo IV e produ-Æo do fator de necrose de tumor (tnf)
ID18494A (id)	1996-10-02	1998-04-16	Novartis Ag	Turunan pirazola leburan dan proses pembuatannya
ID24372A (id) *	1997-10-27	2000-07-13	Agouron Pharma	SENYAWA-SENYAWA 4-AMINO-TIAZOL-2-IL SEBAGAI PENGHAMBAT-PENGHAMBAT CDKs
EA200000385A1 (ru)	1997-11-04	2000-10-30	Пфайзер Продактс Инк.	Терапевтически активные соединения на основе индазольной биоизостерической замены катехина в ингибиторах фосфодиэстеразы типа vi (pde4)
EA200000488A1 (ru)	1997-11-04	2000-10-30	Пфайзер Продактс Инк.	Замена катехина на биоизостеру индазола в терапевтически активных соединениях
US6040321A (en) *	1997-11-12	2000-03-21	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
ATE288904T1 (de) *	1998-06-18	2005-02-15	Bristol Myers Squibb Co	Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen
WO2000018761A1 (en)	1998-09-29	2000-04-06	American Cyanamid Company	Substituted 3-cyanoquinolines as protein tyrosine kinases inhibitors

2000
- 2000-02-06 UA UA2001129215A patent/UA71971C2/uk unknown
- 2000-06-02 PL PL00352714A patent/PL352714A1/xx not_active Application Discontinuation
- 2000-06-02 CN CN00808440A patent/CN1359380A/zh active Pending
- 2000-06-02 SV SV2000000096A patent/SV2002000096A/es unknown
- 2000-06-02 AU AU57254/00A patent/AU778071B2/en not_active Ceased
- 2000-06-02 AP APAP/P/2001/002341A patent/AP2001002341A0/en unknown
- 2000-06-02 IL IL14609400A patent/IL146094A0/xx unknown
- 2000-06-02 CA CA002371158A patent/CA2371158A1/en not_active Abandoned
- 2000-06-02 EA EA200101268A patent/EA200101268A1/ru unknown
- 2000-06-02 SK SK1730-2001A patent/SK17302001A3/sk unknown
- 2000-06-02 BR BR0011585-1A patent/BR0011585A/pt not_active IP Right Cessation
- 2000-06-02 YU YU85601A patent/YU85601A/sh unknown
- 2000-06-02 KR KR1020017015384A patent/KR20020015333A/ko not_active Withdrawn
- 2000-06-02 HU HU0202897A patent/HUP0202897A3/hu unknown
- 2000-06-02 OA OA1200100321A patent/OA11959A/en unknown
- 2000-06-02 CZ CZ20014213A patent/CZ20014213A3/cs unknown
- 2000-06-02 ES ES00942660T patent/ES2234628T3/es not_active Expired - Lifetime
- 2000-06-02 MX MXPA01012483A patent/MXPA01012483A/es not_active Application Discontinuation
- 2000-06-02 PE PE2000000553A patent/PE20010211A1/es not_active Application Discontinuation
- 2000-06-02 NZ NZ514881A patent/NZ514881A/en unknown
- 2000-06-02 AT AT00942660T patent/ATE288424T1/de not_active IP Right Cessation
- 2000-06-02 HR HR20020008A patent/HRP20020008A2/hr not_active Application Discontinuation
- 2000-06-02 UY UY26190A patent/UY26190A1/es not_active Application Discontinuation
- 2000-06-02 DE DE60017894T patent/DE60017894T2/de not_active Expired - Fee Related
- 2000-06-02 WO PCT/US2000/015188 patent/WO2000075120A1/en not_active Ceased
- 2000-06-02 EP EP00942660A patent/EP1181283B1/de not_active Expired - Lifetime
- 2000-06-02 EE EEP200100659A patent/EE200100659A/xx unknown
- 2000-06-02 JP JP2001501601A patent/JP2003501420A/ja not_active Abandoned
2001
- 2001-02-15 US US09/783,584 patent/US6620828B2/en not_active Expired - Fee Related
- 2001-10-09 ZA ZA200108291A patent/ZA200108291B/xx unknown
- 2001-10-17 NO NO20015045A patent/NO20015045L/no not_active Application Discontinuation
- 2001-11-29 IS IS6183A patent/IS6183A/is unknown
2002
- 2002-01-02 MA MA26465A patent/MA25530A1/fr unknown
- 2002-01-03 BG BG106276A patent/BG106276A/bg unknown

Also Published As

Publication number	Publication date
ES2234628T3 (es)	2005-07-01
EP1181283A1 (de)	2002-02-27
EA200101268A1 (ru)	2002-06-27
NZ514881A (en)	2003-10-31
EE200100659A (et)	2003-02-17
EP1181283B1 (de)	2005-02-02
DE60017894T2 (de)	2005-12-29
AP2001002341A0 (en)	2001-12-31
HRP20020008A2 (en)	2004-02-29
NO20015045D0 (no)	2001-10-17
ATE288424T1 (de)	2005-02-15
OA11959A (en)	2006-04-17
PL352714A1 (en)	2003-09-08
HUP0202897A2 (hu)	2002-12-28
UY26190A1 (es)	2000-12-29
US6620828B2 (en)	2003-09-16
ZA200108291B (en)	2002-12-24
IL146094A0 (en)	2002-07-25
KR20020015333A (ko)	2002-02-27
PE20010211A1 (es)	2001-03-16
IS6183A (is)	2001-11-29
SV2002000096A (es)	2002-06-07
NO20015045L (no)	2002-02-04
SK17302001A3 (sk)	2004-01-08
CA2371158A1 (en)	2000-12-14
AU778071B2 (en)	2004-11-11
WO2000075120A1 (en)	2000-12-14
MA25530A1 (fr)	2002-10-01
DE60017894D1 (de)	2005-03-10
MXPA01012483A (es)	2002-07-30
AU5725400A (en)	2000-12-28
BR0011585A (pt)	2002-03-19
UA71971C2 (en)	2005-01-17
US20020025976A1 (en)	2002-02-28
CN1359380A (zh)	2002-07-17
HUP0202897A3 (en)	2004-12-28
CZ20014213A3 (cs)	2002-04-17
YU85601A (sh)	2004-09-03
JP2003501420A (ja)	2003-01-14

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