BG106218A - Устройства и методи за образуване на аерозолни фармацевтични форми за приложение - Google Patents
Устройства и методи за образуване на аерозолни фармацевтични форми за приложение Download PDFInfo
- Publication number
- BG106218A BG106218A BG106218A BG10621801A BG106218A BG 106218 A BG106218 A BG 106218A BG 106218 A BG106218 A BG 106218A BG 10621801 A BG10621801 A BG 10621801A BG 106218 A BG106218 A BG 106218A
- Authority
- BG
- Bulgaria
- Prior art keywords
- flow
- valve
- inhalation
- duct
- housing
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 43
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 13
- 239000007789 gas Substances 0.000 claims abstract description 152
- 210000004072 lung Anatomy 0.000 claims abstract description 71
- 239000000443 aerosol Substances 0.000 claims abstract description 49
- 239000003814 drug Substances 0.000 claims abstract description 28
- 230000007246 mechanism Effects 0.000 claims abstract description 28
- 239000000284 extract Substances 0.000 claims abstract description 3
- 238000012387 aerosolization Methods 0.000 claims description 50
- 239000003570 air Substances 0.000 claims description 50
- 239000012528 membrane Substances 0.000 claims description 29
- 239000000843 powder Substances 0.000 claims description 24
- 229940079593 drug Drugs 0.000 claims description 21
- 230000004888 barrier function Effects 0.000 claims description 13
- 239000002552 dosage form Substances 0.000 claims description 13
- 239000000428 dust Substances 0.000 claims description 12
- 230000001105 regulatory effect Effects 0.000 claims description 11
- 230000000670 limiting effect Effects 0.000 claims description 10
- 230000001965 increasing effect Effects 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 6
- 239000012080 ambient air Substances 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 4
- 230000008713 feedback mechanism Effects 0.000 claims description 3
- 238000009790 rate-determining step (RDS) Methods 0.000 claims 2
- 241001610351 Ipsa Species 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 238000005086 pumping Methods 0.000 claims 1
- 230000003716 rejuvenation Effects 0.000 claims 1
- 210000002345 respiratory system Anatomy 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 abstract description 8
- 230000000149 penetrating effect Effects 0.000 description 14
- 239000002245 particle Substances 0.000 description 10
- 230000029058 respiratory gaseous exchange Effects 0.000 description 10
- 239000013543 active substance Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 238000003860 storage Methods 0.000 description 9
- 238000009472 formulation Methods 0.000 description 8
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 6
- BLUGYPPOFIHFJS-UUFHNPECSA-N (2s)-n-[(2s)-1-[[(3r,4s,5s)-3-methoxy-1-[(2s)-2-[(1r,2r)-1-methoxy-2-methyl-3-oxo-3-[[(1s)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamid Chemical compound CN[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@H](C=1SC=CN=1)CC1=CC=CC=C1 BLUGYPPOFIHFJS-UUFHNPECSA-N 0.000 description 5
- 208000007934 ACTH-independent macronodular adrenal hyperplasia Diseases 0.000 description 5
- 241000272525 Anas platyrhynchos Species 0.000 description 5
- 241000669069 Chrysomphalus aonidum Species 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 230000009467 reduction Effects 0.000 description 5
- MZZINWWGSYUHGU-UHFFFAOYSA-J ToTo-1 Chemical compound [I-].[I-].[I-].[I-].C12=CC=CC=C2C(C=C2N(C3=CC=CC=C3S2)C)=CC=[N+]1CCC[N+](C)(C)CCC[N+](C)(C)CCC[N+](C1=CC=CC=C11)=CC=C1C=C1N(C)C2=CC=CC=C2S1 MZZINWWGSYUHGU-UHFFFAOYSA-J 0.000 description 4
- 210000003323 beak Anatomy 0.000 description 4
- 238000005192 partition Methods 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 230000002685 pulmonary effect Effects 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 102000004877 Insulin Human genes 0.000 description 3
- 108090001061 Insulin Proteins 0.000 description 3
- -1 anti-adrenal Substances 0.000 description 3
- 230000033228 biological regulation Effects 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 229940088597 hormone Drugs 0.000 description 3
- 239000005556 hormone Substances 0.000 description 3
- 229940125396 insulin Drugs 0.000 description 3
- 230000001960 triggered effect Effects 0.000 description 3
- 229960005486 vaccine Drugs 0.000 description 3
- 108700012941 GNRH1 Proteins 0.000 description 2
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 102000003982 Parathyroid hormone Human genes 0.000 description 2
- 108090000445 Parathyroid hormone Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 description 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000006037 cell lysis Effects 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 238000005520 cutting process Methods 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000013013 elastic material Substances 0.000 description 2
- 229920001971 elastomer Polymers 0.000 description 2
- 239000000806 elastomer Substances 0.000 description 2
- 239000003925 fat Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 229940100563 gas for inhalation Drugs 0.000 description 2
- 230000003434 inspiratory effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000199 parathyroid hormone Substances 0.000 description 2
- 229960001319 parathyroid hormone Drugs 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000008249 pharmaceutical aerosol Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000001766 physiological effect Effects 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 229940125723 sedative agent Drugs 0.000 description 2
- 239000000932 sedative agent Substances 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 2
- 230000004936 stimulating effect Effects 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- RLLPVAHGXHCWKJ-IEBWSBKVSA-N (3-phenoxyphenyl)methyl (1s,3s)-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(Cl)Cl)[C@@H]1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-IEBWSBKVSA-N 0.000 description 1
- DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 description 1
- 108060003345 Adrenergic Receptor Proteins 0.000 description 1
- 102000017910 Adrenergic receptor Human genes 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- 241001260012 Bursa Species 0.000 description 1
- 241001212149 Cathetus Species 0.000 description 1
- 102000009660 Cholinergic Receptors Human genes 0.000 description 1
- 108010009685 Cholinergic Receptors Proteins 0.000 description 1
- 102100022641 Coagulation factor IX Human genes 0.000 description 1
- 241000254173 Coleoptera Species 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 108010036949 Cyclosporine Proteins 0.000 description 1
- 241000134884 Ericales Species 0.000 description 1
- 108010076282 Factor IX Proteins 0.000 description 1
- 108010054218 Factor VIII Proteins 0.000 description 1
- 102000001690 Factor VIII Human genes 0.000 description 1
- 240000006829 Ficus sundaica Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 102000002265 Human Growth Hormone Human genes 0.000 description 1
- 108010000521 Human Growth Hormone Proteins 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- 102000003996 Interferon-beta Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 102000008070 Interferon-gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 108010025020 Nerve Growth Factor Proteins 0.000 description 1
- 102000015336 Nerve Growth Factor Human genes 0.000 description 1
- 108010016076 Octreotide Proteins 0.000 description 1
- 241000218657 Picea Species 0.000 description 1
- 108700005075 Regulator Genes Proteins 0.000 description 1
- 102100022831 Somatoliberin Human genes 0.000 description 1
- 101710142969 Somatoliberin Proteins 0.000 description 1
- 102000005157 Somatostatin Human genes 0.000 description 1
- 108010056088 Somatostatin Proteins 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 239000000150 Sympathomimetic Substances 0.000 description 1
- JXASPPWQHFOWPL-UHFFFAOYSA-N Tamarixin Natural products C1=C(O)C(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 JXASPPWQHFOWPL-UHFFFAOYSA-N 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 108010046075 Thymosin Proteins 0.000 description 1
- 102000007501 Thymosin Human genes 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 239000004479 aerosol dispenser Substances 0.000 description 1
- 239000003741 agents affecting lipid metabolism Substances 0.000 description 1
- BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 description 1
- 108010060162 alglucerase Proteins 0.000 description 1
- 239000011717 all-trans-retinol Substances 0.000 description 1
- 235000019169 all-trans-retinol Nutrition 0.000 description 1
- 229940024142 alpha 1-antitrypsin Drugs 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940125681 anticonvulsant agent Drugs 0.000 description 1
- 239000001961 anticonvulsive agent Substances 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 229940033495 antimalarials Drugs 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- KBZOIRJILGZLEJ-LGYYRGKSSA-N argipressin Chemical class C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 KBZOIRJILGZLEJ-LGYYRGKSSA-N 0.000 description 1
- NBMKJKDGKREAPL-DVTGEIKXSA-N beclomethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O NBMKJKDGKREAPL-DVTGEIKXSA-N 0.000 description 1
- 229940092705 beclomethasone Drugs 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 231100000315 carcinogenic Toxicity 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960001265 ciclosporin Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 229930182912 cyclosporin Natural products 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 229940037395 electrolytes Drugs 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 description 1
- 229960004943 ergotamine Drugs 0.000 description 1
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 210000000744 eyelid Anatomy 0.000 description 1
- 229960004222 factor ix Drugs 0.000 description 1
- 229960000301 factor viii Drugs 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229960000676 flunisolide Drugs 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
- 229960002714 fluticasone Drugs 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- JCYWCSGERIELPG-UHFFFAOYSA-N imes Chemical class CC1=CC(C)=CC(C)=C1N1C=CN(C=2C(=CC(C)=CC=2C)C)[C]1 JCYWCSGERIELPG-UHFFFAOYSA-N 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229950000038 interferon alfa Drugs 0.000 description 1
- 229960003130 interferon gamma Drugs 0.000 description 1
- 229960001388 interferon-beta Drugs 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 210000003041 ligament Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 239000006194 liquid suspension Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000003055 low molecular weight heparin Substances 0.000 description 1
- 229940127215 low-molecular weight heparin Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 229940053128 nerve growth factor Drugs 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 229960002700 octreotide Drugs 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 210000004197 pelvis Anatomy 0.000 description 1
- 229960001624 pentamidine isethionate Drugs 0.000 description 1
- YBVNFKZSMZGRAD-UHFFFAOYSA-N pentamidine isethionate Chemical compound OCCS(O)(=O)=O.OCCS(O)(=O)=O.C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 YBVNFKZSMZGRAD-UHFFFAOYSA-N 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000001012 protector Effects 0.000 description 1
- 239000003368 psychostimulant agent Substances 0.000 description 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 235000015067 sauces Nutrition 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229960000553 somatostatin Drugs 0.000 description 1
- 229940075620 somatostatin analogue Drugs 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 210000005070 sphincter Anatomy 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 229940127230 sympathomimetic drug Drugs 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- LCJVIYPJPCBWKS-NXPQJCNCSA-N thymosin Chemical compound SC[C@@H](N)C(=O)N[C@H](CO)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CO)C(=O)N[C@H](CO)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@H]([C@H](C)O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](C(C)C)C(=O)N[C@H](C(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(O)=O)C(O)=O LCJVIYPJPCBWKS-NXPQJCNCSA-N 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- VLCQZHSMCYCDJL-UHFFFAOYSA-N tribenuron methyl Chemical compound COC(=O)C1=CC=CC=C1S(=O)(=O)NC(=O)N(C)C1=NC(C)=NC(OC)=N1 VLCQZHSMCYCDJL-UHFFFAOYSA-N 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/002—Details of inhalators; Constructional features thereof with air flow regulating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
- A61M15/0035—Piercing means
- A61M15/0036—Piercing means hollow piercing means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0051—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a tape, e.g. strips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0083—Timers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0093—Inhalators mechanically breath-triggered without arming or cocking, e.g. acting directly on the delivery valve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0091—Inhalators mechanically breath-triggered
- A61M15/0096—Hindering inhalation before activation of the dispenser
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
- A61M16/049—Mouthpieces
- A61M16/0493—Mouthpieces with means for protecting the tube from damage caused by the patient's teeth, e.g. bite block
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
- A61M16/049—Mouthpieces
- A61M16/0495—Mouthpieces with tongue depressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/08—Bellows; Connecting tubes ; Water traps; Patient circuits
- A61M16/0866—Passive resistors therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
- A61M16/206—Capsule valves, e.g. mushroom, membrane valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Otolaryngology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14179399P | 1999-06-30 | 1999-06-30 | |
| US19806000P | 2000-04-18 | 2000-04-18 | |
| PCT/US2000/018084 WO2001000263A2 (en) | 1999-06-30 | 2000-06-29 | Systems and methods for aerosolizing pharmaceutical formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG106218A true BG106218A (bg) | 2002-07-31 |
Family
ID=26839451
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG106218A BG106218A (bg) | 1999-06-30 | 2001-12-13 | Устройства и методи за образуване на аерозолни фармацевтични форми за приложение |
Country Status (42)
| Country | Link |
|---|---|
| US (2) | US6606992B1 (no) |
| EP (1) | EP1212111B1 (no) |
| JP (2) | JP2003503117A (no) |
| KR (2) | KR20080081376A (no) |
| CN (1) | CN1217713C (no) |
| AP (1) | AP1611A (no) |
| AT (1) | ATE474615T1 (no) |
| AU (1) | AU771926B2 (no) |
| BG (1) | BG106218A (no) |
| BR (1) | BR0012013A (no) |
| CA (1) | CA2377625C (no) |
| CO (1) | CO5280133A1 (no) |
| CZ (1) | CZ20014723A3 (no) |
| DE (1) | DE60044719D1 (no) |
| DZ (1) | DZ3169A1 (no) |
| EA (1) | EA003153B1 (no) |
| EE (1) | EE04631B1 (no) |
| ES (1) | ES2347410T3 (no) |
| GE (1) | GEP20043258B (no) |
| HK (1) | HK1047408A1 (no) |
| HR (1) | HRP20010936A2 (no) |
| HU (1) | HU225182B1 (no) |
| IL (2) | IL147303A0 (no) |
| IS (1) | IS6197A (no) |
| LT (1) | LT4943B (no) |
| LV (1) | LV12804B (no) |
| MA (1) | MA26800A1 (no) |
| MX (1) | MXPA01012789A (no) |
| MY (1) | MY125534A (no) |
| NO (1) | NO20016277L (no) |
| NZ (1) | NZ516098A (no) |
| PA (1) | PA8497901A1 (no) |
| PE (1) | PE20010356A1 (no) |
| PL (1) | PL205905B1 (no) |
| PT (1) | PT1212111E (no) |
| RS (1) | RS50349B (no) |
| SG (1) | SG135936A1 (no) |
| TN (1) | TNSN00148A1 (no) |
| TR (3) | TR200202522T2 (no) |
| TW (1) | TW470655B (no) |
| UY (1) | UY26232A1 (no) |
| WO (1) | WO2001000263A2 (no) |
Families Citing this family (187)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5823179A (en) | 1996-02-13 | 1998-10-20 | 1263152 Ontario Inc. | Nebulizer apparatus and method |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
| US7464706B2 (en) * | 1999-07-23 | 2008-12-16 | Mannkind Corporation | Unit dose cartridge and dry powder inhaler |
| US7305986B1 (en) | 1999-07-23 | 2007-12-11 | Mannkind Corporation | Unit dose capsules for use in a dry powder inhaler |
| US20010035184A1 (en) | 1999-12-17 | 2001-11-01 | Carlos Schuler | Systems and methods for treating packaged powders |
| US20010029947A1 (en) * | 1999-12-17 | 2001-10-18 | Steve Paboojian | Receptacles to facilitate the extraction of powders |
| CA2406185C (en) | 2000-04-11 | 2011-03-15 | Trudell Medical International | Aerosol delivery apparatus with positive expiratory pressure capacity |
| US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| US6668827B2 (en) | 2000-05-16 | 2003-12-30 | Nektar Therapeutics | Systems devices and methods for opening receptacles having a powder to be fluidized |
| GB0024793D0 (en) * | 2000-10-10 | 2000-11-22 | Innovata Biomed Ltd | Diaphragm |
| US6782887B2 (en) * | 2001-01-12 | 2004-08-31 | Becton, Dickinson And Company | Medicament respiratory delivery device and cartridge |
| US6443152B1 (en) * | 2001-01-12 | 2002-09-03 | Becton Dickinson And Company | Medicament respiratory delivery device |
| US6722364B2 (en) * | 2001-01-12 | 2004-04-20 | Becton, Dickinson And Company | Medicament inhalation delivery devices and methods for using the same |
| ES2375333T3 (es) | 2001-03-20 | 2012-02-28 | Trudell Medical International | Aparato nebulizador. |
| US7905230B2 (en) * | 2001-05-09 | 2011-03-15 | Novartis Ag | Metered dose inhaler with lockout |
| US6550493B2 (en) | 2001-06-13 | 2003-04-22 | Baxter International Inc. | Vacuum demand valve |
| US6554023B2 (en) | 2001-06-13 | 2003-04-29 | Baxter International Inc. | Vacuum demand flow valve |
| ES2431634T3 (es) | 2001-06-20 | 2013-11-27 | Novartis Ag | Dispositivo de administración de aerosol |
| GB2380946A (en) * | 2001-08-31 | 2003-04-23 | Medic Aid Ltd | Nebuliser arrangement |
| DE50106644D1 (de) * | 2001-10-18 | 2005-08-04 | Pari Gmbh | Inhalationstherapievorrichtung |
| WO2003053411A1 (en) | 2001-12-19 | 2003-07-03 | Nektar Therapeutics | Pulmonary delivery of aminoglycosides |
| US8777011B2 (en) * | 2001-12-21 | 2014-07-15 | Novartis Ag | Capsule package with moisture barrier |
| WO2003057564A1 (en) * | 2001-12-21 | 2003-07-17 | Nektar Therapeutics | Apparatus and method for sealing cavities |
| US6994083B2 (en) * | 2001-12-21 | 2006-02-07 | Trudell Medical International | Nebulizer apparatus and method |
| US8116860B2 (en) * | 2002-03-11 | 2012-02-14 | Altea Therapeutics Corporation | Transdermal porator and patch system and method for using same |
| US6863261B2 (en) | 2002-03-12 | 2005-03-08 | Baxter International Inc. | Valve stop |
| ES2425392T3 (es) | 2002-03-20 | 2013-10-15 | Mannkind Corporation | Cartucho para un aparato de inhalación |
| US20030205226A1 (en) | 2002-05-02 | 2003-11-06 | Pre Holding, Inc. | Aerosol medication inhalation system |
| US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| US6904908B2 (en) | 2002-05-21 | 2005-06-14 | Trudell Medical International | Visual indicator for an aerosol medication delivery apparatus and system |
| US7185651B2 (en) * | 2002-06-18 | 2007-03-06 | Nektar Therapeutics | Flow regulator for aerosol drug delivery and methods |
| US6941980B2 (en) * | 2002-06-27 | 2005-09-13 | Nektar Therapeutics | Apparatus and method for filling a receptacle with powder |
| JP2004195191A (ja) * | 2002-10-22 | 2004-07-15 | Akihiko Miyamoto | 呼子付喘息治療薬吸入器 |
| AU2003303036A1 (en) * | 2002-12-13 | 2004-07-09 | Pfizer Products Inc. | Method of decreasing hepatic glucose output in diabetic patients |
| USD499793S1 (en) | 2003-03-17 | 2004-12-14 | Baxter International Inc. | Valve |
| USD507631S1 (en) | 2003-03-17 | 2005-07-19 | Baxter International Inc. | Valve |
| WO2004103445A1 (fr) * | 2003-05-21 | 2004-12-02 | Jean-Marc Aiache | Dispositif d'inhalation de poudre |
| AU2003260166A1 (en) * | 2003-09-16 | 2005-04-06 | Injet Digital Aerosols Limited | Inhaler with air flow regulation |
| AU2006225241B2 (en) * | 2003-09-24 | 2008-07-17 | Tianda Pharmaceuticals (Australia) Pty Limited | Medication Holder |
| AU2004273547B2 (en) * | 2003-09-24 | 2006-07-06 | Tianda Pharmaceuticals (Australia) Pty Ltd | Medication holder |
| WO2005028006A1 (en) * | 2003-09-24 | 2005-03-31 | Medi-Stream Pty Ltd | Medication holder |
| GB2407042B (en) * | 2003-10-17 | 2007-10-24 | Vectura Ltd | Inhaler |
| DE10352277A1 (de) * | 2003-11-08 | 2005-06-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pulverinhalator |
| AU2005209199B2 (en) * | 2004-01-16 | 2008-09-11 | Biodel Inc. | Sublingual drug delivery device |
| US7611709B2 (en) | 2004-05-10 | 2009-11-03 | Boehringer Ingelheim Pharma Gmbh And Co. Kg | 1,4 O-linked saccharose derivatives for stabilization of antibodies or antibody derivatives |
| US7723306B2 (en) | 2004-05-10 | 2010-05-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Spray-dried powder comprising at least one 1,4 O-linked saccharose-derivative and methods for their preparation |
| US7727962B2 (en) | 2004-05-10 | 2010-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder comprising new compositions of oligosaccharides and methods for their preparation |
| BE1015883A3 (fr) * | 2004-06-08 | 2005-10-04 | Occhio | Procede et dispositif de dispersion de poudres seches. |
| JP4695940B2 (ja) * | 2004-08-02 | 2011-06-08 | キヤノン株式会社 | 吸入装置 |
| ES2385934T3 (es) | 2004-08-20 | 2012-08-03 | Mannkind Corporation | Catálisis de la síntesis de dicetopiperazina. |
| HUE025151T2 (en) | 2004-08-23 | 2016-01-28 | Mannkind Corp | Diceto-piperazine salts for drug delivery |
| FR2877925B1 (fr) * | 2004-11-16 | 2008-09-19 | Valois Sas | Dispositif de distribution de produit fluide. |
| GB0427028D0 (en) * | 2004-12-09 | 2005-01-12 | Cambridge Consultants | Dry powder inhalers |
| GB0428169D0 (en) * | 2004-12-23 | 2005-01-26 | 3M Innovative Properties Co | Pressurized inhalation devices |
| FR2881119B1 (fr) * | 2005-01-25 | 2010-07-30 | Valois Sas | Dispositif de distribution de produit fluide. |
| US20070012316A1 (en) * | 2005-07-14 | 2007-01-18 | Joann Truza | Disposable compact rescue inhaler |
| US10244793B2 (en) | 2005-07-19 | 2019-04-02 | Juul Labs, Inc. | Devices for vaporization of a substance |
| US8763605B2 (en) | 2005-07-20 | 2014-07-01 | Manta Devices, Llc | Inhalation device |
| US20070023042A1 (en) * | 2005-07-28 | 2007-02-01 | Lee Lanny R | Demand free air flow inhalator |
| US7799344B2 (en) | 2005-09-14 | 2010-09-21 | Mannkind Corporation | Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents |
| US20090032427A1 (en) * | 2005-09-29 | 2009-02-05 | Nektar Therapeutics | Receptacles and Kits, Such as for Dry Powder Packaging |
| US8039431B2 (en) | 2006-02-22 | 2011-10-18 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
| GB0611656D0 (en) * | 2006-06-13 | 2006-07-19 | Cambridge Consultants | Dry powder inhalers |
| WO2008008021A1 (en) * | 2006-07-14 | 2008-01-17 | Astrazeneca Ab | Inhalation system and delivery device for the administration of a drug in the form of dry powder. |
| WO2008051471A2 (en) * | 2006-10-19 | 2008-05-02 | Haroutunian Greg G | Flow modification device |
| US9155849B2 (en) | 2006-10-19 | 2015-10-13 | G Greg Haroutunian | Flow modification device |
| MX2009004349A (es) * | 2006-10-25 | 2009-07-22 | Novartis Ag | Aparato de dispersion de polvo, metodo para hacer y usar el aparato, y componentes que se pueden usar en el aparato y otros dispositivos. |
| CA2675030C (en) * | 2007-01-09 | 2015-06-09 | Mystic Pharmaceuticals, Inc. | Intranasal cartridge devices |
| WO2008101992A1 (en) * | 2007-02-21 | 2008-08-28 | Novo Nordisk A/S | Aerosol generating device with air flow control |
| WO2008101991A1 (en) * | 2007-02-21 | 2008-08-28 | Novo Nordisk A/S | Breath actuation mechanism for an aerosol generating device |
| US20080257358A1 (en) * | 2007-04-23 | 2008-10-23 | Goodhealth, Llc | Passive Treatment Device |
| US8683995B2 (en) | 2007-05-16 | 2014-04-01 | Mystic Pharmaceuticals, Inc. | Dose dispensing containers |
| US9248076B2 (en) | 2007-05-16 | 2016-02-02 | Mystic Pharmaceuticals, Inc. | Dose dispensing containers |
| JP5352583B2 (ja) | 2007-05-16 | 2013-11-27 | ミスティック ファーマシューティカルズ, インコーポレイテッド | 単位用量投薬用の連結容器 |
| US11224704B2 (en) | 2007-07-06 | 2022-01-18 | Manta Devices, Llc | Dose delivery device for inhalation |
| CN101795723B (zh) * | 2007-07-06 | 2013-06-19 | 蒙塔设备有限公司 | 用于存储和输送药物的吸入装置 |
| ES2398921T3 (es) * | 2007-08-02 | 2013-03-22 | Activaero Gmbh | Dispositivo y sistema para dirigir partículas aerosolizadas a un área específica de los pulmones |
| US7963089B2 (en) * | 2007-09-14 | 2011-06-21 | Mystic Pharmaceuticals, Inc. | Deep draw container forming method |
| CN101835508A (zh) * | 2007-10-25 | 2010-09-15 | 诺瓦提斯公司 | 单位剂量药物包装的粉末调节 |
| DE102007056263A1 (de) | 2007-11-22 | 2009-05-28 | Siegfried Generics International Ag | Dosiervorrichtung zur Inhalierung einer pulverförmigen Substanz |
| CA2709071C (en) | 2007-12-14 | 2016-11-15 | Labogroup S.A.S. | Delivering aerosolizable food products |
| GB0802028D0 (en) | 2008-02-05 | 2008-03-12 | Dunne Stephen T | Powder inhaler flow regulator |
| US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
| DK2293833T3 (en) | 2008-06-13 | 2016-05-23 | Mannkind Corp | DRY POWDER INHALER AND MEDICINAL ADMINISTRATION SYSTEM |
| JP5479465B2 (ja) | 2008-06-20 | 2014-04-23 | マンカインド コーポレイション | 吸入努力をリアルタイムにプロファイルする対話式機器および方法 |
| WO2010011329A2 (en) * | 2008-07-23 | 2010-01-28 | Map Pharmaceuticals, Inc. | The delivery of powdered drug via inhalation |
| TWI494123B (zh) | 2008-08-11 | 2015-08-01 | Mannkind Corp | 超快起作用胰島素之用途 |
| US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
| CA2754595C (en) | 2009-03-11 | 2017-06-27 | Mannkind Corporation | Apparatus, system and method for measuring resistance of an inhaler |
| US8551528B2 (en) | 2009-06-12 | 2013-10-08 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
| US8495998B2 (en) | 2009-06-17 | 2013-07-30 | British American Tobacco (Investments) Limited | Inhaler |
| EP2283887B1 (de) * | 2009-08-06 | 2012-07-04 | Activaero GmbH | Vorrichtung zur Flussbegrenzung bei niedrigen Differenzdrücken |
| US9016147B2 (en) | 2009-11-03 | 2015-04-28 | Mannkind Corporation | Apparatus and method for simulating inhalation efforts |
| EP2506905B1 (en) | 2009-12-04 | 2017-07-05 | Koninklijke Philips N.V. | Apparatus comprising adjustable stepped mouthpiece for aerosol drug delivery |
| US8974771B2 (en) * | 2010-03-09 | 2015-03-10 | Penn-Century, Inc. | Apparatus and method for aerosol delivery to the lungs or other locations of the body |
| US9044256B2 (en) * | 2010-05-19 | 2015-06-02 | Board Of Regents, The University Of Texas System | Medical devices, apparatuses, systems, and methods |
| IL223742A (en) | 2010-06-21 | 2016-06-30 | Mannkind Corp | A dry powder inhaler and preparation for it |
| US8689439B2 (en) | 2010-08-06 | 2014-04-08 | Abbott Laboratories | Method for forming a tube for use with a pump delivery system |
| US9757528B2 (en) | 2010-08-23 | 2017-09-12 | Darren Rubin | Nebulizer having different negative pressure threshold settings |
| CA2808836C (en) | 2010-08-23 | 2020-05-12 | Darren Rubin | Systems and methods of aerosol delivery with airflow regulation |
| US8377000B2 (en) | 2010-10-01 | 2013-02-19 | Abbott Laboratories | Enteral feeding apparatus having a feeding set |
| US8377001B2 (en) | 2010-10-01 | 2013-02-19 | Abbott Laboratories | Feeding set for a peristaltic pump system |
| CN102553038B (zh) * | 2010-12-17 | 2014-07-02 | 陈庆堂 | 药粉吸嘴放置盒 |
| WO2012085919A2 (en) | 2010-12-22 | 2012-06-28 | Exonoid Medical Devices Ltd. | Method and system for drug delivery |
| MY180552A (en) | 2011-04-01 | 2020-12-02 | Mannkind Corp | Blister package for pharmaceutical cartridges |
| WO2012168780A2 (en) * | 2011-06-06 | 2012-12-13 | Trudell Medical International | Oscillating positive expiratory pressure device |
| WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
| EP2776053A1 (en) | 2011-10-24 | 2014-09-17 | MannKind Corporation | Methods and compositions for treating pain |
| CA2859684C (en) * | 2011-11-18 | 2020-02-11 | Colin Dunlop | A method and apparatus for facilitating delivery of anaesthetic |
| ES2924032T3 (es) | 2011-12-16 | 2022-10-04 | Novartis Ag | Aparato de aerosolización de polvo pasivo |
| US9364622B2 (en) | 2012-04-20 | 2016-06-14 | Fsc Laboratories, Inc. | Inhalation devices and systems and methods including the same |
| DE102012103482A1 (de) * | 2012-04-20 | 2013-10-24 | Alfred Von Schuckmann | Vorrichtung zum Inhalieren pulverförmiger Substanzen |
| CN104470569B (zh) * | 2012-06-28 | 2018-04-27 | 美国政府(由卫生和人类服务部的部长所代表) | 用于疫苗和其它治疗试剂的鼻干粉递送系统 |
| SG11201500218VA (en) | 2012-07-12 | 2015-03-30 | Mannkind Corp | Dry powder drug delivery systems and methods |
| US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
| AU2014228415B2 (en) | 2013-03-15 | 2018-08-09 | Mannkind Corporation | Microcrystalline diketopiperazine compositions and methods |
| MX394255B (es) | 2013-07-18 | 2025-03-24 | Mannkind Corp | Composiciones farmaceuticas en polvo seco estables al calor y metodos |
| EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
| US10076139B2 (en) | 2013-12-23 | 2018-09-18 | Juul Labs, Inc. | Vaporizer apparatus |
| GB2558805B8 (en) | 2013-12-23 | 2018-12-19 | Juul Labs Uk Holdco Ltd | Vaporization device systems and methods |
| US10159282B2 (en) | 2013-12-23 | 2018-12-25 | Juul Labs, Inc. | Cartridge for use with a vaporizer device |
| US20160366947A1 (en) | 2013-12-23 | 2016-12-22 | James Monsees | Vaporizer apparatus |
| USD842536S1 (en) | 2016-07-28 | 2019-03-05 | Juul Labs, Inc. | Vaporizer cartridge |
| US10058129B2 (en) | 2013-12-23 | 2018-08-28 | Juul Labs, Inc. | Vaporization device systems and methods |
| US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
| US11147936B2 (en) | 2014-05-02 | 2021-10-19 | Manta Devices, Llc | Dose delivery device with cover connected to dose chamber seal |
| EP3954417A1 (en) | 2014-06-30 | 2022-02-16 | Syqe Medical Ltd. | Method and device for vaporization and inhalation of isolated substances |
| RU2691615C2 (ru) | 2014-06-30 | 2019-06-14 | Сике Медикал Лтд. | Ингалятор с регулированием потока |
| US11298477B2 (en) | 2014-06-30 | 2022-04-12 | Syqe Medical Ltd. | Methods, devices and systems for pulmonary delivery of active agents |
| CA3199049A1 (en) * | 2014-06-30 | 2016-01-07 | Syqe Medical Ltd. | Flow regulating inhaler device |
| AU2015283593B2 (en) | 2014-06-30 | 2019-08-22 | Syqe Medical Ltd. | Drug dose cartridge for an inhaler device |
| CA160775S (en) | 2014-08-11 | 2015-09-29 | Ploom Inc | Electronic vaporization device with cartridge |
| US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
| RU2741417C2 (ru) * | 2015-04-15 | 2021-01-26 | Филип Моррис Продактс С.А. | Порошковый ингалятор, обеспечивающий два сопротивления потоку на вдохе |
| MX2018001194A (es) | 2015-07-29 | 2018-04-24 | Innovative Therapies Inc | Monitoreo de presion de dispositivo de terapia de herida y sistema de control. |
| MX395190B (es) * | 2015-11-06 | 2025-03-25 | Boehringer Ingelheim Int | Sistema con nebulizador y recipiente. |
| WO2017095220A1 (en) * | 2015-12-04 | 2017-06-08 | Medspray Bv | Fluidic sprayer |
| US10857317B2 (en) | 2015-12-04 | 2020-12-08 | Trudell Medical International | Huff cough simulation device |
| EA202092986A3 (ru) * | 2015-12-18 | 2021-11-30 | Джт Интернэшнл С.А. | Персональное испарительное устройство |
| EP3393564B1 (en) * | 2015-12-21 | 2021-09-15 | Kindeva Drug Delivery L.P. | Flow governors for use in medicinal inhalers |
| JP2019503829A (ja) * | 2015-12-21 | 2019-02-14 | スリーエム イノベイティブ プロパティズ カンパニー | 医療用吸入器で使用するための流れ調整器アセンブリ |
| WO2017112400A1 (en) | 2015-12-21 | 2017-06-29 | 3M Innovative Properties Company | Medicinal inhalers |
| EP3851102B1 (en) | 2016-01-06 | 2025-04-16 | Syqe Medical Ltd. | Low dose therapeutic treatment |
| USD858869S1 (en) | 2016-02-08 | 2019-09-03 | Juul Labs, Inc. | Vaporizer cartridge |
| USD861975S1 (en) | 2016-02-08 | 2019-10-01 | Juul Labs, Inc. | Vaporizer device with cartridges |
| SG11201806801VA (en) | 2016-02-11 | 2018-09-27 | Juul Labs Inc | Securely attaching cartridges for vaporizer devices |
| EP3871717B1 (en) | 2016-05-19 | 2023-11-08 | Trudell Medical International | Smart valved holding chamber |
| USD849996S1 (en) | 2016-06-16 | 2019-05-28 | Pax Labs, Inc. | Vaporizer cartridge |
| USD851830S1 (en) | 2016-06-23 | 2019-06-18 | Pax Labs, Inc. | Combined vaporizer tamp and pick tool |
| USD836541S1 (en) | 2016-06-23 | 2018-12-25 | Pax Labs, Inc. | Charging device |
| ES2988939T3 (es) | 2016-07-08 | 2024-11-22 | Trudell Medical Int Inc | Dispositivo de presión espiratoria positiva oscilante inteligente |
| US10786638B2 (en) | 2016-07-08 | 2020-09-29 | Trudell Medical International | Nebulizer apparatus and method |
| GB2556331A (en) | 2016-09-14 | 2018-05-30 | British American Tobacco Investments Ltd | A container |
| GB201615601D0 (en) * | 2016-09-14 | 2016-10-26 | British American Tobacco Investments Ltd | Receptacle section |
| GB201615603D0 (en) | 2016-09-14 | 2016-10-26 | British American Tobacco Investments Ltd | Receptacle section |
| GB201615602D0 (en) * | 2016-09-14 | 2016-10-26 | British American Tobacco Investments Ltd | Receptacle Section |
| GB201615608D0 (en) | 2016-09-14 | 2016-10-26 | British American Tobacco Investments Ltd | A container |
| CA3046132A1 (en) * | 2016-12-06 | 2018-06-14 | Heath Rainbow | Inhaler housing |
| WO2018104805A1 (en) | 2016-12-09 | 2018-06-14 | Trudell Medical International | Smart nebulizer |
| GB201700136D0 (en) | 2017-01-05 | 2017-02-22 | British American Tobacco Investments Ltd | Aerosol generating device and article |
| GB201700620D0 (en) | 2017-01-13 | 2017-03-01 | British American Tobacco Investments Ltd | Aerosol generating device and article |
| US20200368312A1 (en) | 2017-05-22 | 2020-11-26 | Insmed Incorporated | Glycopeptide derivative compounds and uses thereof |
| USD887632S1 (en) | 2017-09-14 | 2020-06-16 | Pax Labs, Inc. | Vaporizer cartridge |
| GB201720338D0 (en) | 2017-12-06 | 2018-01-17 | British American Tobacco Investments Ltd | Component for an aerosol-generating apparatus |
| AU2019205865B2 (en) | 2018-01-04 | 2024-11-28 | Trudell Medical International Inc. | Smart oscillating positive expiratory pressure device |
| CN108635643B (zh) * | 2018-06-04 | 2025-01-10 | 润生药业有限公司 | 一种干粉吸入装置 |
| CN109224216B (zh) * | 2018-10-23 | 2021-04-13 | 济南市儿童医院 | 用于呼吸系统的理疗仪 |
| GB2579364B (en) * | 2018-11-29 | 2021-08-18 | Kapitex Healthcare Ltd | An improved speaking valve |
| GB2591064B (en) * | 2018-11-29 | 2021-12-22 | Kapitex Healthcare Ltd | An improved speaking valve |
| UA129289C2 (uk) * | 2018-12-07 | 2025-03-12 | Філіп Морріс Продактс С.А. | Система, що генерує аерозоль, та спосіб генерування аерозолю |
| USD903192S1 (en) | 2019-02-21 | 2020-11-24 | Juul Labs, Inc. | Vaporizer accessory |
| WO2020243107A1 (en) * | 2019-05-24 | 2020-12-03 | Stamford Devices Ltd. | Design of aerosol system and interface to deliver clinically and economically feasible inhaled dose with neonatal cpap device |
| CN110338465B (zh) * | 2019-07-16 | 2024-10-15 | 深圳麦克韦尔科技有限公司 | 换气阀及电子雾化装置 |
| JP7692895B2 (ja) | 2019-08-27 | 2025-06-16 | トゥルーデル メディカル インターナショナル インコーポレイテッド | 振動型呼気陽圧器具 |
| USD943160S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer device |
| USD943159S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Component for a vaporizer cartridge |
| USD943161S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer device |
| USD943158S1 (en) | 2019-11-14 | 2022-02-08 | Juul Labs, Inc. | Vaporizer cartridge |
| USD917093S1 (en) * | 2020-01-15 | 2021-04-20 | 2334271 Ontario Ltd. | Capsule for use in a vaporizer device |
| FR3115996A1 (fr) * | 2020-11-06 | 2022-05-13 | Nemera La Verpilliere | Système d’assistance à la distribution de produit |
| EP4301440B1 (en) * | 2021-03-03 | 2024-11-06 | Philip Morris Products S.A. | Holder for inhaler article with inhalation volume estimator |
| US20250089790A1 (en) * | 2021-07-21 | 2025-03-20 | Jt International Sa | Vapour Generating Device |
| CN113559371A (zh) * | 2021-09-03 | 2021-10-29 | 深圳乐普智能医疗器械有限公司 | 雾化杯 |
Family Cites Families (139)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2587215A (en) | 1949-04-27 | 1952-02-26 | Frank P Priestly | Inhalator |
| US3788310A (en) | 1970-03-25 | 1974-01-29 | Westinghouse Electric Corp | Flow control apparatus |
| NO134730L (no) * | 1971-07-19 | 1900-01-01 | ||
| GB1392945A (en) | 1972-08-23 | 1975-05-07 | Fisons Ltd | Inhalation device |
| US4086918A (en) | 1976-02-11 | 1978-05-02 | Chesebrough-Pond's Inc. | Inhalation device |
| US4170228A (en) | 1976-11-05 | 1979-10-09 | C. R. Bard, Inc. | Variable flow incentive spirometer |
| US4106503A (en) | 1977-03-11 | 1978-08-15 | Richard R. Rosenthal | Metering system for stimulating bronchial spasm |
| GB1598053A (en) | 1978-01-31 | 1981-09-16 | Fisons Ltd | Pocket inhaler |
| US4176617A (en) * | 1978-03-23 | 1979-12-04 | Pilipski M | Low pressure alarm |
| US4274404A (en) | 1979-04-13 | 1981-06-23 | American Safety Flight Systems, Inc. | Oxygen supply system controlled by user exhalation |
| IT1116047B (it) | 1979-04-27 | 1986-02-10 | Sigma Tau Ind Farmaceuti | Dispositivo per la rapida inalazione di farmaci in polvere da parte di persone sofferenti di asma |
| US4284083A (en) | 1979-05-29 | 1981-08-18 | Lester Victor E | Inhalation incentive device |
| US4259951A (en) | 1979-07-30 | 1981-04-07 | Chesebrough-Pond's Inc. | Dual valve for respiratory device |
| DE3023648A1 (de) | 1980-06-24 | 1982-01-21 | Jaeger, Erich, 8700 Würzburg | Einrichtung zur untersuchung der atemwege auf reizstoff-ueberempfindlichkeit |
| US4391283A (en) | 1981-03-24 | 1983-07-05 | Whitman Medical Corporation | Incentive spirometer |
| US4484577A (en) | 1981-07-23 | 1984-11-27 | Key Pharmaceuticals, Inc. | Drug delivery method and inhalation device therefor |
| US4442856A (en) | 1981-08-18 | 1984-04-17 | Puritan-Bennett | Oxygen regulator and alarm system for an anesthesia machine |
| US4533137A (en) | 1982-01-19 | 1985-08-06 | Healthscan Inc. | Pulmonary training method |
| US4444202A (en) | 1982-03-31 | 1984-04-24 | Howard Rubin | Breathing exerciser |
| ES286422Y (es) | 1982-10-08 | 1986-09-16 | Glaxo Group Limited | Dispositivo para administrar medicamentos a pacientes |
| US4778054A (en) | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
| US4495944A (en) | 1983-02-07 | 1985-01-29 | Trutek Research, Inc. | Inhalation therapy apparatus |
| US4534343A (en) * | 1984-01-27 | 1985-08-13 | Trutek Research, Inc. | Metered dose inhaler |
| NZ209900A (en) | 1984-10-16 | 1989-08-29 | Univ Auckland | Automatic inhaler |
| US4592348A (en) | 1984-12-17 | 1986-06-03 | Waters Iv William C | Aerosol inhaler |
| SE8603252L (sv) | 1985-07-30 | 1987-01-31 | Glaxo Group Ltd | Anordning for att tillfora lekemedel till patienter |
| SE453566B (sv) | 1986-03-07 | 1988-02-15 | Draco Ab | Anordning vid pulverinhalatorer |
| US4926852B1 (en) | 1986-06-23 | 1995-05-23 | Univ Johns Hopkins | Medication delivery system phase one |
| ES2051371T3 (es) | 1988-10-04 | 1994-06-16 | Univ Johns Hopkins | Inhalador de aerosoles. |
| US5033655A (en) | 1989-02-15 | 1991-07-23 | Liquid Molding Systems Inc. | Dispensing package for fluid products and the like |
| US4991745A (en) | 1989-04-25 | 1991-02-12 | Liquid Molding Systems, Inc. | Dispensing valve with trampoline-like construction |
| WO1990013327A1 (en) | 1989-04-28 | 1990-11-15 | Riker Laboratories, Inc. | Dry powder inhalation device |
| US4955371A (en) | 1989-05-08 | 1990-09-11 | Transtech Scientific, Inc. | Disposable inhalation activated, aerosol device for pulmonary medicine |
| GB8919131D0 (en) | 1989-08-23 | 1989-10-04 | Riker Laboratories Inc | Inhaler |
| US5201308A (en) | 1990-02-14 | 1993-04-13 | Newhouse Michael T | Powder inhaler |
| SG45171A1 (en) * | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
| US5042467A (en) * | 1990-03-28 | 1991-08-27 | Trudell Medical | Medication inhaler with fitting having a sonic signalling device |
| DE4027391A1 (de) | 1990-08-30 | 1992-03-12 | Boehringer Ingelheim Kg | Treibgasfreies inhalationsgeraet |
| CA2090495A1 (en) * | 1990-08-31 | 1992-03-01 | Constantinos Sioutas | Aerosol actuator providing increased respirable fraction |
| DE4029183A1 (de) | 1990-09-14 | 1992-03-19 | Dieter Kuhn | Durchflussregler |
| GB9021433D0 (en) | 1990-10-02 | 1990-11-14 | Atomic Energy Authority Uk | Power inhaler |
| FR2667509B1 (fr) | 1990-10-04 | 1995-08-25 | Valois | Inhalateur a poudre, dispositif de conditionnement de microdoses de poudre sous forme de bandes adaptees a etre utilisees dans un inhalateur a poudre, et procede de fabrication de ces bandes. |
| US5042472A (en) | 1990-10-15 | 1991-08-27 | Merck & Co., Inc. | Powder inhaler device |
| GB9024760D0 (en) | 1990-11-14 | 1991-01-02 | Riker Laboratories Inc | Inhalation device and medicament carrier |
| GB9026025D0 (en) | 1990-11-29 | 1991-01-16 | Boehringer Ingelheim Kg | Inhalation device |
| GB9026191D0 (en) | 1990-12-01 | 1991-01-16 | Harris Pharma Ltd | Breath actuated dispensing device |
| US5040527A (en) | 1990-12-18 | 1991-08-20 | Healthscan Products Inc. | Metered dose inhalation unit with slide means |
| US5186164A (en) * | 1991-03-15 | 1993-02-16 | Puthalath Raghuprasad | Mist inhaler |
| AU651882B2 (en) | 1991-05-14 | 1994-08-04 | Visiomed Group Limited | Aerosol inhalation device |
| US6055980A (en) | 1991-05-20 | 2000-05-02 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| ES2141108T3 (es) | 1991-07-02 | 2000-03-16 | Inhale Inc | Metodo y dispositivo para proporcionar medicamentos en aerosol. |
| US5337740A (en) | 1991-08-01 | 1994-08-16 | New England Pharmaceuticals, Inc. | Inhalation devices |
| US5161524A (en) | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
| US6119688A (en) | 1991-08-26 | 2000-09-19 | 3M Innovative Properties Company | Powder dispenser |
| AU2513092A (en) * | 1991-08-26 | 1993-03-16 | Minnesota Mining And Manufacturing Company | Powder dispenser |
| US5167506A (en) | 1991-10-24 | 1992-12-01 | Minnesota Mining And Manufacturing Company | Inhalation device training system |
| US5213236A (en) | 1991-12-06 | 1993-05-25 | Liquid Molding Systems, Inc. | Dispensing valve for packaging |
| US5409144A (en) | 1991-12-06 | 1995-04-25 | Liquid Molding Systems Inc. | Dispensing valve for packaging |
| DE4211475A1 (de) | 1991-12-14 | 1993-06-17 | Asta Medica Ag | Pulverinhalator |
| US5320094A (en) | 1992-01-10 | 1994-06-14 | The Johns Hopkins University | Method of administering insulin |
| EP0558879B1 (en) | 1992-03-04 | 1997-05-14 | Astra Aktiebolag | Disposable inhaler |
| US5639441A (en) | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
| US5785049A (en) | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US5284133A (en) | 1992-07-23 | 1994-02-08 | Armstrong Pharmaceuticals, Inc. | Inhalation device with a dose-timer, an actuator mechanism, and patient compliance monitoring means |
| US5333106A (en) | 1992-10-09 | 1994-07-26 | Circadian, Inc. | Apparatus and visual display method for training in the power use of aerosol pharmaceutical inhalers |
| DE4239402A1 (de) | 1992-11-24 | 1994-05-26 | Bayer Ag | Pulverinhalator |
| WO1994016756A1 (en) | 1993-01-29 | 1994-08-04 | Miris Medical Corporation | Intrapulmonary delivery of hormones |
| US6012450A (en) * | 1993-01-29 | 2000-01-11 | Aradigm Corporation | Intrapulmonary delivery of hematopoietic drug |
| US5743250A (en) | 1993-01-29 | 1998-04-28 | Aradigm Corporation | Insulin delivery enhanced by coached breathing |
| US5888477A (en) | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
| US5873358A (en) | 1993-01-29 | 1999-02-23 | Aradigm Corporation | Method of maintaining a diabetic patient's blood glucose level in a desired range |
| US5672581A (en) | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
| US5558085A (en) | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
| US5364838A (en) | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
| FR2701399B1 (fr) | 1993-02-16 | 1995-03-31 | Valois | Dispositif portatif de pulvérisation à actionnement déclenché par l'inhalation. |
| DE69413528T2 (de) | 1993-04-06 | 1999-05-06 | Minnesota Mining And Mfg. Co., Saint Paul, Minn. | Vorrichtung zum deagglomerieren für trockenpulverinhalatoren |
| US5497763A (en) * | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
| US5533502A (en) * | 1993-05-28 | 1996-07-09 | Vortran Medical Technology, Inc. | Powder inhaler with aerosolization occurring within each individual powder receptacle |
| WO1995005208A1 (en) | 1993-08-18 | 1995-02-23 | Fisons Plc | Inhalator with breath flow regulation |
| US5655520A (en) * | 1993-08-23 | 1997-08-12 | Howe; Harvey James | Flexible valve for administering constant flow rates of medicine from a nebulizer |
| US5692498A (en) * | 1993-11-09 | 1997-12-02 | Cprx, Inc. | CPR device having valve for increasing the duration and magnitude of negative intrathoracic pressures |
| US6062219A (en) * | 1993-11-09 | 2000-05-16 | Cprx Llc | Apparatus and methods for assisting cardiopulmonary resuscitation |
| CN1133470C (zh) | 1993-12-18 | 2004-01-07 | 默克专利股份有限公司 | 粉末吸入器 |
| GB9326574D0 (en) | 1993-12-31 | 1994-03-02 | King S College London | Dry power inhalers |
| US6102036A (en) | 1994-04-12 | 2000-08-15 | Smoke-Stop | Breath activated inhaler |
| US5483954A (en) | 1994-06-10 | 1996-01-16 | Mecikalski; Mark B. | Inhaler and medicated package |
| US5509404A (en) | 1994-07-11 | 1996-04-23 | Aradigm Corporation | Intrapulmonary drug delivery within therapeutically relevant inspiratory flow/volume values |
| US5653223A (en) * | 1994-09-08 | 1997-08-05 | Pruitt; Michael D. | Accurately controlled portable nebulizer |
| JP3706136B2 (ja) | 1994-09-21 | 2005-10-12 | ネクター セラピューティクス | 乾燥粉末薬剤の分散装置及び方法 |
| US5993421A (en) | 1994-12-02 | 1999-11-30 | Science Incorporated | Medicament dispenser |
| SE9404439D0 (sv) | 1994-12-21 | 1994-12-21 | Astra Ab | Inhalation device |
| US5522380A (en) * | 1995-01-18 | 1996-06-04 | Dwork; Paul | Metered dose medication adaptor with improved incentive spirometer |
| ES2145421T3 (es) | 1995-01-23 | 2000-07-01 | Direct Haler A S | Inhalador. |
| US5901703A (en) * | 1995-02-06 | 1999-05-11 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
| US5513630A (en) | 1995-03-08 | 1996-05-07 | Century; Theodore J. | Powder dispenser |
| US5586550A (en) | 1995-08-31 | 1996-12-24 | Fluid Propulsion Technologies, Inc. | Apparatus and methods for the delivery of therapeutic liquids to the respiratory system |
| US5921237A (en) | 1995-04-24 | 1999-07-13 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| US5622166A (en) * | 1995-04-24 | 1997-04-22 | Dura Pharmaceuticals, Inc. | Dry powder inhaler delivery system |
| US5654007A (en) | 1995-06-07 | 1997-08-05 | Inhale Therapeutic Systems | Methods and system for processing dispersible fine powders |
| US5826571A (en) | 1995-06-08 | 1998-10-27 | Innovative Devices, Llc | Device for use with metered dose inhalers (MDIS) |
| GB9513218D0 (en) * | 1995-06-29 | 1995-09-06 | Fisons Plc | Inhalation device and method |
| DE19523516C1 (de) * | 1995-06-30 | 1996-10-31 | Asta Medica Ag | Inhalator zum Verabreichen von Medikamenten aus Blisterpackungen |
| US5692496A (en) | 1995-08-02 | 1997-12-02 | Innovative Devices, Llc | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| US5823183A (en) | 1995-08-02 | 1998-10-20 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| US5988163A (en) | 1995-08-02 | 1999-11-23 | Innovative Devices | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of delivery of medicament |
| US6209538B1 (en) * | 1995-08-02 | 2001-04-03 | Robert A. Casper | Dry powder medicament inhalator having an inhalation-activated flow diverting means for triggering delivery of medicament |
| FR2738152B1 (fr) * | 1995-09-04 | 1998-01-23 | Tebro | Dispositif de pre-dosage de produit pulverulent pour un distributeur de produit |
| US5738087A (en) * | 1995-09-21 | 1998-04-14 | King; Russell W. | Aerosol medication delivery system |
| ATE209939T1 (de) * | 1996-01-03 | 2001-12-15 | Glaxo Group Ltd | Inhalator |
| US5694920A (en) * | 1996-01-25 | 1997-12-09 | Abrams; Andrew L. | Inhalation device |
| US6026809A (en) * | 1996-01-25 | 2000-02-22 | Microdose Technologies, Inc. | Inhalation device |
| US5699789A (en) | 1996-03-11 | 1997-12-23 | Hendricks; Mark R. | Dry powder inhaler |
| JP3328132B2 (ja) * | 1996-03-21 | 2002-09-24 | 株式会社ユニシアジェックス | 吸入式投薬器 |
| DE19613185A1 (de) * | 1996-04-02 | 1997-10-09 | Pfeiffer Erich Gmbh & Co Kg | Dosiereinrichtung für strömungsfähige Medien wie Pulver/Luft-Dispersionen |
| US5875776A (en) | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
| US5826633A (en) | 1996-04-26 | 1998-10-27 | Inhale Therapeutic Systems | Powder filling systems, apparatus and methods |
| GB2312848B (en) | 1996-04-26 | 1999-11-17 | Bespak Plc | Controlled flow inhalers |
| HUP9901575A3 (en) | 1996-04-29 | 1999-11-29 | Dura Pharmaceuticals Inc San D | Methods of dry powder inhalation |
| US5706830A (en) * | 1996-05-06 | 1998-01-13 | South Alabama Medical Science Foundation | Liquid ventilator system and use thereof |
| US5813401A (en) | 1996-10-15 | 1998-09-29 | Radcliff; Janet H. | Nebulizer automatic control valve |
| US5906202A (en) * | 1996-11-21 | 1999-05-25 | Aradigm Corporation | Device and method for directing aerosolized mist to a specific area of the respiratory tract |
| SE9700422D0 (sv) | 1997-02-07 | 1997-02-07 | Astra Ab | Single dose inhaler II |
| US6006747A (en) | 1997-03-20 | 1999-12-28 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| DE19734022C2 (de) * | 1997-08-06 | 2000-06-21 | Pari Gmbh | Inhalationstherapiegerät mit einem Ventil zur Begrenzung des Inspirationsflusses |
| CA2212430A1 (en) | 1997-08-07 | 1999-02-07 | George Volgyesi | Inhalation device |
| US6044841A (en) * | 1997-08-29 | 2000-04-04 | 1263152 Ontario Inc. | Breath actuated nebulizer with valve assembly having a relief piston |
| US5855202A (en) | 1997-10-08 | 1999-01-05 | Andrade; Joseph R. | Aerosol holding chamber for a metered-dose inhaler |
| US6237591B1 (en) * | 1998-11-02 | 2001-05-29 | Dura Pharmaceuticals, Inc. | Turbine dry powder inhaler |
| US6116238A (en) * | 1997-12-02 | 2000-09-12 | Dura Pharmaceuticals, Inc. | Dry powder inhaler |
| US6076523A (en) | 1998-01-15 | 2000-06-20 | Nellcor Puritan Bennett | Oxygen blending in a piston ventilator |
| JP4462761B2 (ja) * | 1998-03-10 | 2010-05-12 | バルワー エス.アー. | 格納容器に格納された液体製品を投与する装置、及び格納容器の充填方法 |
| AP1342A (en) | 1998-03-16 | 2004-12-15 | Nektar Therapeutics | Aerosolized active agent delivery. |
| US6142146A (en) | 1998-06-12 | 2000-11-07 | Microdose Technologies, Inc. | Inhalation device |
| US6234169B1 (en) * | 1998-08-14 | 2001-05-22 | Arthur Slutsky | Inhaler |
| UA73924C2 (en) * | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
| US6223744B1 (en) * | 1999-03-16 | 2001-05-01 | Multi-Vet Ltd. | Wearable aerosol delivery apparatus |
| US6527011B1 (en) * | 2000-05-18 | 2003-03-04 | Robert F. Mantz | Flexible retainer ring for duck bill valve |
| US6408847B1 (en) * | 2000-08-29 | 2002-06-25 | Marshall L. Nuckols | Rebreather system that supplies fresh make-up gas according to a user's respiratory minute volume |
| US8949406B2 (en) | 2008-08-14 | 2015-02-03 | International Business Machines Corporation | Method and system for communication between a client system and a server system |
-
2000
- 2000-05-30 US US09/583,312 patent/US6606992B1/en not_active Expired - Lifetime
- 2000-06-20 MY MYPI20002769A patent/MY125534A/en unknown
- 2000-06-27 PE PE2000000649A patent/PE20010356A1/es not_active Application Discontinuation
- 2000-06-29 AP APAP/P/2001/002366A patent/AP1611A/en active
- 2000-06-29 TR TR2002/02522T patent/TR200202522T2/xx unknown
- 2000-06-29 HK HK02108960.7A patent/HK1047408A1/zh unknown
- 2000-06-29 EP EP00945039A patent/EP1212111B1/en not_active Expired - Lifetime
- 2000-06-29 DE DE60044719T patent/DE60044719D1/de not_active Expired - Lifetime
- 2000-06-29 CO CO00048974A patent/CO5280133A1/es not_active Application Discontinuation
- 2000-06-29 CA CA2377625A patent/CA2377625C/en not_active Expired - Fee Related
- 2000-06-29 CN CN00809747XA patent/CN1217713C/zh not_active Expired - Fee Related
- 2000-06-29 AU AU59035/00A patent/AU771926B2/en not_active Ceased
- 2000-06-29 HU HU0201726A patent/HU225182B1/hu not_active IP Right Cessation
- 2000-06-29 KR KR1020087021159A patent/KR20080081376A/ko not_active Ceased
- 2000-06-29 JP JP2001505970A patent/JP2003503117A/ja active Pending
- 2000-06-29 CZ CZ20014723A patent/CZ20014723A3/cs unknown
- 2000-06-29 AT AT00945039T patent/ATE474615T1/de active
- 2000-06-29 IL IL14730300A patent/IL147303A0/xx unknown
- 2000-06-29 DZ DZ003169A patent/DZ3169A1/xx active
- 2000-06-29 PL PL352903A patent/PL205905B1/pl not_active IP Right Cessation
- 2000-06-29 BR BR0012013-8A patent/BR0012013A/pt not_active Application Discontinuation
- 2000-06-29 NZ NZ516098A patent/NZ516098A/en unknown
- 2000-06-29 RS YUP-898/01A patent/RS50349B/sr unknown
- 2000-06-29 KR KR1020017016829A patent/KR100885713B1/ko not_active Expired - Fee Related
- 2000-06-29 MX MXPA01012789A patent/MXPA01012789A/es active IP Right Grant
- 2000-06-29 GE GEAP20006303A patent/GEP20043258B/en unknown
- 2000-06-29 TR TR2002/02521T patent/TR200202521T2/xx unknown
- 2000-06-29 ES ES00945039T patent/ES2347410T3/es not_active Expired - Lifetime
- 2000-06-29 WO PCT/US2000/018084 patent/WO2001000263A2/en not_active Ceased
- 2000-06-29 HR HR20010936A patent/HRP20010936A2/hr not_active Application Discontinuation
- 2000-06-29 EA EA200101252A patent/EA003153B1/ru not_active IP Right Cessation
- 2000-06-29 TR TR2001/03800T patent/TR200103800T2/xx unknown
- 2000-06-29 SG SG200307890-4A patent/SG135936A1/en unknown
- 2000-06-29 EE EEP200100714A patent/EE04631B1/xx not_active IP Right Cessation
- 2000-06-29 PT PT00945039T patent/PT1212111E/pt unknown
- 2000-06-30 UY UY26232A patent/UY26232A1/es not_active Application Discontinuation
- 2000-06-30 TN TNTNSN00148A patent/TNSN00148A1/fr unknown
- 2000-06-30 PA PA20008497901A patent/PA8497901A1/es unknown
- 2000-08-01 TW TW089112866A patent/TW470655B/zh not_active IP Right Cessation
-
2001
- 2001-12-13 BG BG106218A patent/BG106218A/bg unknown
- 2001-12-13 IS IS6197A patent/IS6197A/is unknown
- 2001-12-20 NO NO20016277A patent/NO20016277L/no not_active Application Discontinuation
- 2001-12-21 MA MA26449A patent/MA26800A1/fr unknown
- 2001-12-25 IL IL147303A patent/IL147303A/en not_active IP Right Cessation
-
2002
- 2002-01-22 LV LVP-02-09A patent/LV12804B/xx unknown
- 2002-01-23 LT LT2002008A patent/LT4943B/lt not_active IP Right Cessation
-
2003
- 2003-06-19 US US10/601,127 patent/US20050016533A1/en not_active Abandoned
-
2006
- 2006-08-23 JP JP2006227120A patent/JP4607834B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG106218A (bg) | Устройства и методи за образуване на аерозолни фармацевтични форми за приложение | |
| US10099019B2 (en) | Nasal delivery device | |
| US7591264B2 (en) | Device for swallowing powder granular or granulated substances | |
| JP2002502673A (ja) | 所定用量吸入ポンプ | |
| JP2000005310A (ja) | 肺への薬の吸入投与のための装置 | |
| WO2008101992A1 (en) | Aerosol generating device with air flow control | |
| UA68442C2 (en) | Method for aerosolizing pharmaceutical formulation (variants) and system for aerosolizing (variants) | |
| AU2003203590B2 (en) | Inhalation Therapy Assembly And Method | |
| HK1047714B (en) | Systems and methods for aerosolizing pharmaceutical formulations |