BG106127A - 13-метил еритромицинови производни - Google Patents

13-метил еритромицинови производни Download PDF

Info

Publication number: BG106127A
Authority: BG; Bulgaria
Prior art keywords: alkyl; independently selected; substituents; optionally substituted; formula
Prior art date: 1999-05-24

Application number

BG106127A

Other languages

Bulgarian (bg)

English (en)

Inventor

John Dirlam

Takushi Kaneko

Hamish Mcarthur

Wei-Guo Su

Yong-Jin Wu

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-24

Filing date

2001-11-21

Publication date

2002-05-31

2001-11-21 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2002-05-31 Publication of BG106127A publication Critical patent/BG106127A/bg

Links

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229940002612 prodrug Drugs 0.000 claims abstract description 24
239000012453 solvate Substances 0.000 claims abstract description 10
-1 N 3i CN Chemical group 0.000 claims description 146
125000001424 substituent group Chemical group 0.000 claims description 90
125000000217 alkyl group Chemical group 0.000 claims description 58
229910052799 carbon Inorganic materials 0.000 claims description 56
125000004432 carbon atom Chemical group C* 0.000 claims description 49
229910052739 hydrogen Inorganic materials 0.000 claims description 48
208000015181 infectious disease Diseases 0.000 claims description 35
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 30
125000003342 alkenyl group Chemical group 0.000 claims description 29
125000004429 atom Chemical group 0.000 claims description 29
125000000304 alkynyl group Chemical group 0.000 claims description 28
125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 24
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125000003118 aryl group Chemical group 0.000 claims description 21
125000000623 heterocyclic group Chemical group 0.000 claims description 20
229910052731 fluorine Inorganic materials 0.000 claims description 18
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 17
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125000004122 cyclic group Chemical group 0.000 claims description 15
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229910052757 nitrogen Inorganic materials 0.000 claims description 14
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IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 11
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
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Genetics & Genomics (AREA)
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Communicable Diseases (AREA)
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BG106127A 1999-05-24 2001-11-21 13-метил еритромицинови производни BG106127A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US13546899P	1999-05-24	1999-05-24
PCT/IB2000/000502 WO2000071557A1 (en)	1999-05-24	2000-04-25	13-methyl-erythromycin derivatives

Publications (1)

Publication Number	Publication Date
BG106127A true BG106127A (bg)	2002-05-31

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ID=22468240

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG106127A BG106127A (bg)	1999-05-24	2001-11-21	13-метил еритромицинови производни

Country Status (32)

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US (2)	US20030100518A1 (es)
EP (1)	EP1180110A1 (es)
JP (1)	JP2003500414A (es)
KR (1)	KR20020016799A (es)
CN (1)	CN1351608A (es)
AP (1)	AP2001002302A0 (es)
AR (1)	AR020032A1 (es)
AU (1)	AU3832100A (es)
BG (1)	BG106127A (es)
BR (1)	BR0010938A (es)
CA (1)	CA2373117C (es)
CZ (1)	CZ20013733A3 (es)
DZ (1)	DZ3045A1 (es)
EA (1)	EA200100983A1 (es)
EE (1)	EE200100613A (es)
HK (1)	HK1045523A1 (es)
HR (1)	HRP20010866A2 (es)
HU (1)	HUP0201516A3 (es)
IL (1)	IL145739A0 (es)
IS (1)	IS6128A (es)
MA (1)	MA26740A1 (es)
NO (1)	NO20015172L (es)
OA (1)	OA11945A (es)
PA (1)	PA8495101A1 (es)
PE (1)	PE20010171A1 (es)
PL (1)	PL352720A1 (es)
SK (1)	SK15162001A3 (es)
TN (1)	TNSN00108A1 (es)
TR (1)	TR200103395T2 (es)
UY (1)	UY26161A1 (es)
WO (1)	WO2000071557A1 (es)
ZA (1)	ZA200109595B (es)

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2000
- 2000-04-25 CA CA002373117A patent/CA2373117C/en not_active Expired - Fee Related
- 2000-04-25 EP EP00917230A patent/EP1180110A1/en not_active Withdrawn
- 2000-04-25 AP APAP/P/2001/002302A patent/AP2001002302A0/en unknown
- 2000-04-25 CZ CZ20013733A patent/CZ20013733A3/cs unknown
- 2000-04-25 KR KR1020017015049A patent/KR20020016799A/ko not_active Ceased
- 2000-04-25 HU HU0201516A patent/HUP0201516A3/hu unknown
- 2000-04-25 EE EEP200100613A patent/EE200100613A/xx unknown
- 2000-04-25 HR HR20010866A patent/HRP20010866A2/hr not_active Application Discontinuation
- 2000-04-25 CN CN00807992A patent/CN1351608A/zh active Pending
- 2000-04-25 BR BR0010938-0A patent/BR0010938A/pt not_active IP Right Cessation
- 2000-04-25 WO PCT/IB2000/000502 patent/WO2000071557A1/en not_active Ceased
- 2000-04-25 IL IL14573900A patent/IL145739A0/xx unknown
- 2000-04-25 AU AU38321/00A patent/AU3832100A/en not_active Abandoned
- 2000-04-25 OA OA1200100303A patent/OA11945A/en unknown
- 2000-04-25 JP JP2000619813A patent/JP2003500414A/ja active Pending
- 2000-04-25 PL PL00352720A patent/PL352720A1/xx not_active Application Discontinuation
- 2000-04-25 TR TR2001/03395T patent/TR200103395T2/xx unknown
- 2000-04-25 HK HK02107035.0A patent/HK1045523A1/zh unknown
- 2000-04-25 SK SK1516-2001A patent/SK15162001A3/sk unknown
- 2000-04-25 EA EA200100983A patent/EA200100983A1/ru unknown
- 2000-05-05 PA PA20008495101A patent/PA8495101A1/es unknown
- 2000-05-22 AR ARP000102485A patent/AR020032A1/es not_active Application Discontinuation
- 2000-05-23 DZ DZ000088A patent/DZ3045A1/xx active
- 2000-05-23 PE PE2000000491A patent/PE20010171A1/es not_active Application Discontinuation
- 2000-05-23 TN TNTNSN00108A patent/TNSN00108A1/fr unknown
- 2000-05-24 UY UY26161A patent/UY26161A1/es not_active Application Discontinuation
- 2000-05-24 MA MA25990A patent/MA26740A1/fr unknown
- 2000-05-24 US US09/577,901 patent/US20030100518A1/en not_active Abandoned
2001
- 2001-10-23 NO NO20015172A patent/NO20015172L/no not_active Application Discontinuation
- 2001-10-26 IS IS6128A patent/IS6128A/is unknown
- 2001-11-21 BG BG106127A patent/BG106127A/bg unknown
- 2001-11-21 ZA ZA200109595A patent/ZA200109595B/xx unknown
2003
- 2003-05-19 US US10/441,347 patent/US6777543B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HRP20010866A2 (en)	2003-06-30
BR0010938A (pt)	2002-03-19
PE20010171A1 (es)	2001-02-10
DZ3045A1 (fr)	2004-03-27
EE200100613A (et)	2003-02-17
CN1351608A (zh)	2002-05-29
PA8495101A1 (es)	2002-08-26
OA11945A (en)	2006-04-13
EA200100983A1 (ru)	2002-10-31
US6777543B2 (en)	2004-08-17
HUP0201516A2 (en)	2002-08-28
AR020032A1 (es)	2002-03-27
NO20015172D0 (no)	2001-10-23
US20030100518A1 (en)	2003-05-29
HUP0201516A3 (en)	2003-03-28
TNSN00108A1 (fr)	2002-05-30
CZ20013733A3 (cs)	2002-11-13
CA2373117C (en)	2006-02-28
HK1045523A1 (zh)	2002-11-29
AP2001002302A0 (en)	2001-10-25
JP2003500414A (ja)	2003-01-07
PL352720A1 (en)	2003-09-08
AU3832100A (en)	2000-12-12
US20030229031A1 (en)	2003-12-11
NO20015172L (no)	2002-01-23
IS6128A (is)	2001-10-26
UY26161A1 (es)	2000-12-29
TR200103395T2 (tr)	2002-04-22
KR20020016799A (ko)	2002-03-06
ZA200109595B (en)	2003-05-28
WO2000071557A1 (en)	2000-11-30
EP1180110A1 (en)	2002-02-20
IL145739A0 (en)	2002-07-25
MA26740A1 (fr)	2004-12-20
CA2373117A1 (en)	2000-11-30
SK15162001A3 (sk)	2003-02-04

Publication	Publication Date	Title
US6777543B2 (en)	2004-08-17	13-methyl erythromycin derivatives
US6472371B1 (en)	2002-10-29	Macrolides
US6270768B1 (en)	2001-08-07	Azalides and methods of making same
US6437151B2 (en)	2002-08-20	Erythromycins and process for their preparation
US6825171B2 (en)	2004-11-30	Erythromycin derivatives
EP1131331B1 (en)	2004-03-03	13-membered azalides and their use as antibiotic agents
EP0952157B1 (en)	2003-06-18	9A, 11B-Dehydro derivatives of 9-oxime-3-keto-6-0-methylerythromycin
MXPA01010817A (es)	2002-06-05	Derivados de 13-metil eritromicina
MXPA00006604A (es)	2001-06-26	Nuevos macrolidos
MXPA00001110A (es)	2001-06-26	Nuevos azalidos y metodos para prepararlos