BG105855A - 2-aminopyridines containing fused ring substituents - Google Patents
2-aminopyridines containing fused ring substituentsInfo
- Publication number
- BG105855A BG105855A BG105855A BG10585501A BG105855A BG 105855 A BG105855 A BG 105855A BG 105855 A BG105855 A BG 105855A BG 10585501 A BG10585501 A BG 10585501A BG 105855 A BG105855 A BG 105855A
- Authority
- BG
- Bulgaria
- Prior art keywords
- group
- alkyl
- ring
- aryl
- aralkyl
- Prior art date
Links
- 150000003930 2-aminopyridines Chemical class 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 2
- 125000004429 atom Chemical group 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- -1 nitro, cyano, amino Chemical group 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12159799P | 1999-02-25 | 1999-02-25 | |
| PCT/IB2000/000109 WO2000050400A1 (en) | 1999-02-25 | 2000-02-02 | 2-aminopyridines containing fused ring substituents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG105855A true BG105855A (en) | 2002-04-30 |
Family
ID=22397690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG105855A BG105855A (en) | 1999-02-25 | 2001-08-30 | 2-aminopyridines containing fused ring substituents |
Country Status (44)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) * | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| AP2001002251A0 (en) * | 1999-02-25 | 2001-09-30 | Pfizer Prod Inc | 2-aminopyridines containing fused ring substituents. |
| EP1268427A1 (en) | 2000-03-31 | 2003-01-02 | Cocensys, Inc. | Aminopyridines and their use as anticonvulsants and sodium channel blockers |
| US20040092741A1 (en) * | 2002-11-08 | 2004-05-13 | Pfizer Inc | Substituted pyridines via boronic acid coupling |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| JP4903385B2 (ja) * | 2002-12-06 | 2012-03-28 | パーデュー・リサーチ・ファウンデーション | 損傷した哺乳類神経組織を治療するためのピリジン類 |
| US20050192321A1 (en) * | 2003-09-15 | 2005-09-01 | Meythaler Jay M. | Treatment of neuropathy with rapid release aminopyridine |
| US9120750B2 (en) | 2013-03-07 | 2015-09-01 | Northwestern University | 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors |
| US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| WO2016073623A2 (en) | 2014-11-04 | 2016-05-12 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
| US12213973B2 (en) | 2021-10-18 | 2025-02-04 | Northwestern University | Bacterial nitric oxide synthase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4515696A (en) * | 1994-12-12 | 1996-07-03 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| JPH101435A (ja) * | 1995-09-14 | 1998-01-06 | Nippon Kayaku Co Ltd | 2−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤 |
| EA002270B1 (ru) * | 1996-03-29 | 2002-02-28 | Пфайзер Инк. | Производные 6-фенилпиридил-2-амина |
| HN1997000027A (es) | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| TR199901917T2 (xx) * | 1997-02-10 | 1999-12-21 | Pfizer Products Inc. | 2-Amino-6-(2-ikame edilmi�-4-fenoksi)-ikame edilmi� piridinler |
| HN1998000118A (es) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
| HN1998000125A (es) * | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
| AU765851B2 (en) * | 1998-06-03 | 2003-10-02 | Pfizer Products Inc. | 2-aminopyridines containing fused ring substituents as nitric oxide synthase inhibitors |
| AP2001002251A0 (en) * | 1999-02-25 | 2001-09-30 | Pfizer Prod Inc | 2-aminopyridines containing fused ring substituents. |
-
2000
- 2000-02-02 AP APAP/P/2001/002251A patent/AP2001002251A0/en unknown
- 2000-02-02 JP JP2000600983A patent/JP3825636B2/ja not_active Expired - Fee Related
- 2000-02-02 EE EEP200100454A patent/EE200100454A/xx unknown
- 2000-02-02 KR KR1020017010899A patent/KR20010114213A/ko not_active Ceased
- 2000-02-02 CN CN00804126A patent/CN1341099A/zh active Pending
- 2000-02-02 NZ NZ512912A patent/NZ512912A/en unknown
- 2000-02-02 MX MXPA01008671A patent/MXPA01008671A/es active IP Right Grant
- 2000-02-02 CZ CZ20013036A patent/CZ20013036A3/cs unknown
- 2000-02-02 PT PT00901285T patent/PT1155000E/pt unknown
- 2000-02-02 PL PL00350219A patent/PL350219A1/xx not_active Application Discontinuation
- 2000-02-02 BR BR0008569-3A patent/BR0008569A/pt not_active IP Right Cessation
- 2000-02-02 OA OA1200100224A patent/OA11841A/en unknown
- 2000-02-02 AU AU21243/00A patent/AU767593B2/en not_active Ceased
- 2000-02-02 CA CA002364719A patent/CA2364719C/en not_active Expired - Fee Related
- 2000-02-02 HU HU0200163A patent/HUP0200163A3/hu unknown
- 2000-02-02 ES ES00901285T patent/ES2200813T3/es not_active Expired - Lifetime
- 2000-02-02 HR HR20010597A patent/HRP20010597A2/hr not_active Application Discontinuation
- 2000-02-02 DK DK00901285T patent/DK1155000T3/da active
- 2000-02-02 DE DE60003893T patent/DE60003893T2/de not_active Expired - Fee Related
- 2000-02-02 TR TR2001/02481T patent/TR200102481T2/xx unknown
- 2000-02-02 WO PCT/IB2000/000109 patent/WO2000050400A1/en not_active Ceased
- 2000-02-02 IL IL14430800A patent/IL144308A0/xx unknown
- 2000-02-02 ID IDW00200101819A patent/ID29892A/id unknown
- 2000-02-02 EP EP00901285A patent/EP1155000B1/en not_active Expired - Lifetime
- 2000-02-02 SK SK1202-2001A patent/SK12022001A3/sk unknown
- 2000-02-02 YU YU58301A patent/YU58301A/sh unknown
- 2000-02-02 EA EA200100816A patent/EA003941B1/ru not_active IP Right Cessation
- 2000-02-02 AT AT00901285T patent/ATE245143T1/de not_active IP Right Cessation
- 2000-02-03 HN HN2000000016A patent/HN2000000016A/es unknown
- 2000-02-15 US US09/504,989 patent/US6211208B1/en not_active Expired - Fee Related
- 2000-02-17 PA PA20008490901A patent/PA8490901A1/es unknown
- 2000-02-23 AR ARP000100767A patent/AR018979A1/es unknown
- 2000-02-23 DZ DZ000036A patent/DZ3017A1/xx active
- 2000-02-23 MA MA25912A patent/MA26721A1/fr unknown
- 2000-02-23 CO CO00012733A patent/CO5160241A1/es unknown
- 2000-02-23 PE PE2000000146A patent/PE20001482A1/es not_active Application Discontinuation
- 2000-02-23 TN TNTNSN00034A patent/TNSN00034A1/fr unknown
- 2000-02-24 SV SV2000000026A patent/SV2002000026A/es not_active Application Discontinuation
- 2000-02-24 GT GT200000021A patent/GT200000021A/es unknown
-
2001
- 2001-02-08 US US09/779,318 patent/US6372768B2/en not_active Expired - Fee Related
- 2001-07-13 IS IS6005A patent/IS6005A/is unknown
- 2001-08-08 CR CR6438A patent/CR6438A/es unknown
- 2001-08-23 ZA ZA200106974A patent/ZA200106974B/en unknown
- 2001-08-23 NO NO20014095A patent/NO20014095L/no not_active Application Discontinuation
- 2001-08-30 BG BG105855A patent/BG105855A/xx unknown
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