PE20001482A1 - 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado - Google Patents
2-aminopiridinas que contienen sustituyentes de tipo anillo condensadoInfo
- Publication number
- PE20001482A1 PE20001482A1 PE2000000146A PE0001462000A PE20001482A1 PE 20001482 A1 PE20001482 A1 PE 20001482A1 PE 2000000146 A PE2000000146 A PE 2000000146A PE 0001462000 A PE0001462000 A PE 0001462000A PE 20001482 A1 PE20001482 A1 PE 20001482A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- naphthalen
- pyridin
- ilamine
- etoxy
- Prior art date
Links
- 150000003930 2-aminopyridines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000008299 Nitric Oxide Synthase Human genes 0.000 abstract 1
- 108010021487 Nitric Oxide Synthase Proteins 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- -1 PHENYL RING Chemical group 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 208000013200 Stress disease Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 208000020431 spinal cord injury Diseases 0.000 abstract 1
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Communicable Diseases (AREA)
- Child & Adolescent Psychology (AREA)
Abstract
SE REFIERE A 2-AMINOPIRIDINAS DE FORMULA I, DONDE: A Y B SON H, O JUNTOS FORMAN UN ANILLO CONDENSADO AL ANILLO DE FENILO CON 5-7 MIEMBROS CON 1-2 N, O, S, LOS MIEMBROS ADYACENTES DE DOS ANILLOS ADYACENTES NO SON HETEROATOMOS; X ES O, UN ENLACE; Y ES ALQUILO C1-C6; R1 ES H, ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON NR2R3; R2 Y R3 SON H, ALQUILO, ARILO, ARALQUILO, TETRAHIDRONAFTALENO O JUNTO CON N FORMAN UN HETEROCICLO, ANILLO CICLICO, BICICLICO, 6-AMINO-3-AZABICICLO[3.1.0]HEX-3-ILO SUSTITUIDO CON NR4R5; R4 Y R5 SON H, ALQUILO C1-C6, FENILO, NAFTILO, ALQUILO C1-C6-CO, CHO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS 1-[4-(6-AMINO-PIRIDIN-2-IL)-NAFTALEN-1-ILOXIMETIL]-CICLOHEXANOL, 6-[4-(2-(2-DIMETILAMINOETOXI)-ETOXI-NAFTALEN-1-IL]-PIRIDIN-2-ILAMINA, 6-[4-(2-HIDROXI-ETOXI)-5,6,7,8-TETRAHIDRO-NAFTALEN-1-IL]-PIRIDIN-2-ILAMINA, 6-[4-(2-(2-DIETILAMINOETOXI)ETOXI)NAFTALEN-1-IL]-PIRIDIN-2-ILAMINA. EL COMPUESTO I INHIBE LA ACTIVIDAD DE LA OXIDO NITRICO SINTASA NOS Y PUEDE SER UTIL PARA EL TRATAMIENTO DE TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL, TRASTORNOS INFLAMATORIOS, CHOQUE SEPTICO, OBESIDAD, LESION AGUDA DE LA MEDULA ESPINAL, TRASTORNOS DE LA ANSIEDAD, TRASTORNOS POR ESTRESS, CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12159799P | 1999-02-25 | 1999-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001482A1 true PE20001482A1 (es) | 2001-01-03 |
Family
ID=22397690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2000000146A PE20001482A1 (es) | 1999-02-25 | 2000-02-23 | 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado |
Country Status (44)
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) * | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| NZ512912A (en) * | 1999-02-25 | 2003-07-25 | Pfizer Prod Inc | 2-aminopyridine derivatives having a fused ring substituent are useful for inhibiting the activity of a nitric oxide synthase |
| US6335354B2 (en) | 2000-03-31 | 2002-01-01 | Cocensys Inc. | Aminopyridines and methods of using thereof |
| US20040092741A1 (en) * | 2002-11-08 | 2004-05-13 | Pfizer Inc | Substituted pyridines via boronic acid coupling |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| AU2003298034B2 (en) * | 2002-12-06 | 2011-04-21 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| US20050192321A1 (en) * | 2003-09-15 | 2005-09-01 | Meythaler Jay M. | Treatment of neuropathy with rapid release aminopyridine |
| WO2014138460A1 (en) | 2013-03-07 | 2014-09-12 | Northwestern University | 2-aminopyridine-based selective neuronal nitric oxide synthase inhibitors |
| US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| EP3215497A4 (en) | 2014-11-04 | 2018-11-07 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
| US12213973B2 (en) | 2021-10-18 | 2025-02-04 | Northwestern University | Bacterial nitric oxide synthase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996018616A1 (en) * | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| JPH101435A (ja) * | 1995-09-14 | 1998-01-06 | Nippon Kayaku Co Ltd | ２−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤 |
| ES2214604T3 (es) * | 1996-03-29 | 2004-09-16 | Pfizer Inc. | Derivados de la 6-fenilpiridil-2-amina. |
| HN1997000027A (es) | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| BR9811093A (pt) * | 1997-02-10 | 2000-07-18 | Pfizer Prod Inc | Piridinas substituìdas com 2-amino-6-(4-fenóxi 2-substituìdo) |
| HN1998000118A (es) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
| HN1998000125A (es) * | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
| HUP0102236A3 (en) * | 1998-06-03 | 2003-01-28 | Pfizer Prod Inc | 2-aminopyridines containing fused ring substituents as nitric oxide synthase inhibitors and pharmaceutical compositions containing them and their use |
| NZ512912A (en) * | 1999-02-25 | 2003-07-25 | Pfizer Prod Inc | 2-aminopyridine derivatives having a fused ring substituent are useful for inhibiting the activity of a nitric oxide synthase |
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2000
- 2000-02-02 NZ NZ512912A patent/NZ512912A/en unknown
- 2000-02-02 IL IL14430800A patent/IL144308A0/xx unknown
- 2000-02-02 BR BR0008569-3A patent/BR0008569A/pt not_active IP Right Cessation
- 2000-02-02 AP APAP/P/2001/002251A patent/AP2001002251A0/en unknown
- 2000-02-02 TR TR2001/02481T patent/TR200102481T2/xx unknown
- 2000-02-02 CZ CZ20013036A patent/CZ20013036A3/cs unknown
- 2000-02-02 YU YU58301A patent/YU58301A/sh unknown
- 2000-02-02 PT PT00901285T patent/PT1155000E/pt unknown
- 2000-02-02 SK SK1202-2001A patent/SK12022001A3/sk unknown
- 2000-02-02 AU AU21243/00A patent/AU767593B2/en not_active Ceased
- 2000-02-02 EE EEP200100454A patent/EE200100454A/xx unknown
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- 2000-02-02 CN CN00804126A patent/CN1341099A/zh active Pending
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