BG105803A - Epotylon derivatives, method for their production and pharmaceutical use thereof - Google Patents
Epotylon derivatives, method for their production and pharmaceutical use thereofInfo
- Publication number
- BG105803A BG105803A BG105803A BG10580301A BG105803A BG 105803 A BG105803 A BG 105803A BG 105803 A BG105803 A BG 105803A BG 10580301 A BG10580301 A BG 10580301A BG 105803 A BG105803 A BG 105803A
- Authority
- BG
- Bulgaria
- Prior art keywords
- methyl
- pyridyl
- oxazolyl
- thiazolyl
- atom
- Prior art date
Links
- -1 2-methyl-4-thiazolyl Chemical group 0.000 abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 5
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 2
- 125000003258 trimethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])[*:1] 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1999107480 DE19907480A1 (de) | 1999-02-11 | 1999-02-11 | Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| DE19954229A DE19954229A1 (de) | 1999-11-04 | 1999-11-04 | Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| PCT/EP2000/001104 WO2000047584A2 (de) | 1999-02-11 | 2000-02-11 | Epothilon-derivate, verfahren zu deren herstellung und ihre pharmazeutische verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG105803A true BG105803A (en) | 2002-03-29 |
Family
ID=26051977
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG105803A BG105803A (en) | 1999-02-11 | 2001-08-09 | Epotylon derivatives, method for their production and pharmaceutical use thereof |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7001916B1 (es) |
| EP (1) | EP1161430A2 (es) |
| JP (1) | JP2002536450A (es) |
| KR (1) | KR20010094763A (es) |
| CN (1) | CN1340053A (es) |
| AU (1) | AU4101800A (es) |
| BG (1) | BG105803A (es) |
| BR (1) | BR0008206A (es) |
| CA (1) | CA2360952A1 (es) |
| CZ (1) | CZ20012886A3 (es) |
| EA (1) | EA200100833A1 (es) |
| EE (1) | EE200100422A (es) |
| HK (1) | HK1044946A1 (es) |
| HU (1) | HUP0105330A2 (es) |
| IL (1) | IL144370A0 (es) |
| MX (1) | MXPA01008148A (es) |
| NO (1) | NO20013900L (es) |
| PL (1) | PL350190A1 (es) |
| SK (1) | SK11452001A3 (es) |
| WO (1) | WO2000047584A2 (es) |
| YU (1) | YU57601A (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69734362T2 (de) | 1996-12-03 | 2006-07-20 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6660758B1 (en) * | 1996-12-13 | 2003-12-09 | The Scripps Research Institute | Epothilone analogs |
| US7125893B1 (en) * | 1999-04-30 | 2006-10-24 | Schering Ag | 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations |
| CA2439268C (en) * | 2001-02-27 | 2010-01-19 | Novartis Ag | Combination comprising a signal transduction inhibitor and an epothilone derivative |
| WO2003018002A2 (en) * | 2001-08-23 | 2003-03-06 | Novartis Ag | Cyclopropyl and cyclobutyl epothilone analogs |
| AU2003218110A1 (en) | 2002-03-12 | 2003-09-29 | Bristol-Myers Squibb Company | C3-cyano epothilone derivatives |
| AU2003242646A1 (en) * | 2002-06-10 | 2003-12-22 | Novartis Ag | Combinations comprising epothilones and pharmaceutical uses thereof |
| RU2379032C9 (ru) * | 2002-06-10 | 2010-03-27 | Новартис Аг | Комбинации, включающие эпотилоны, и их фармацевтическое применение |
| RU2338741C2 (ru) * | 2002-07-31 | 2008-11-20 | Мершан Корпорейшн | Новые физиологически активные вещества |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| EP1589011A1 (en) * | 2004-04-22 | 2005-10-26 | Schering Aktiengesellschaft | Novel chiral heptyne derivates for the preparation of epothilones and processes for their preparation |
| EP2634252B1 (en) | 2005-02-11 | 2018-12-19 | University of Southern California | Method of expressing proteins with disulfide bridges |
| WO2007130501A2 (en) * | 2006-05-01 | 2007-11-15 | University Of Southern California | Combination therapy for treatment of cancer |
| US20100113128A1 (en) * | 2008-11-05 | 2010-05-06 | Snow Richard N | Methods and apparatus for determining a reel strip position |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| US20100125146A1 (en) * | 2008-11-19 | 2010-05-20 | Johnson Matthey Public Limited Company | Method for making pharmaceutical compounds |
| US20110300150A1 (en) | 2010-05-18 | 2011-12-08 | Scott Eliasof | Compositions and methods for treatment of autoimmune and other disease |
| CN108430996A (zh) * | 2015-10-16 | 2018-08-21 | 威廉马歇莱思大学 | 埃博霉素类似物、合成方法、治疗方法及其药物缀合物 |
| WO2017096559A1 (en) * | 2015-12-09 | 2017-06-15 | Rhodia Operations | Production of xylene derivatives |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| US5469145A (en) | 1992-05-29 | 1995-11-21 | Johnson; Lonnie | Wet diaper detector |
| EP1186606B2 (de) | 1995-11-17 | 2011-09-07 | Gesellschaft für Biotechnologische Forschung mbH (GBF) | Epothilon-Derivate, ihre Herstellung und Verwendung |
| US6441025B2 (en) | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
| US5969145A (en) | 1996-08-30 | 1999-10-19 | Novartis Ag | Process for the production of epothilones and intermediate products within the process |
| AU716610B2 (en) | 1996-08-30 | 2000-03-02 | Novartis Ag | Method for producing epothilones, and intermediate products obtained during the production process |
| DE19636343C1 (de) | 1996-08-30 | 1997-10-23 | Schering Ag | Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B |
| US6867305B2 (en) * | 1996-12-03 | 2005-03-15 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| DE69734362T2 (de) | 1996-12-03 | 2006-07-20 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon |
| US6441186B1 (en) * | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| DE19701758A1 (de) | 1997-01-20 | 1998-07-23 | Wessjohann Ludgar A Dr | Epothilone-Synthesebausteine |
| US6605599B1 (en) * | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| AU9340998A (en) * | 1997-08-09 | 1999-03-01 | Schering Aktiengesellschaft | New epothilone derivatives, method for producing same and their pharmaceutical use |
| AU4775299A (en) * | 1998-06-22 | 2000-01-10 | Nicolaou, Kyriacos Costa | Desmethyl epothilones |
| AU6208701A (en) | 2000-03-09 | 2001-09-17 | Schering Aktiengesellschaft | Radioactively labeled epothilone derivatives, method for the production thereof, and their biochemical and pharmaceutical use |
| CA2359267A1 (en) | 2000-10-19 | 2002-04-19 | Manabu Takami | Wavelength selecting module and wavelength selecting apparatus |
| EP1340498A1 (en) * | 2002-03-01 | 2003-09-03 | Schering Aktiengesellschaft | Use of epothilones in the treatment of brain diseases associated with proliferative processes |
| KR20050026033A (ko) * | 2002-07-31 | 2005-03-14 | 쉐링 악티엔게젤샤프트 | 신규 효과기 접합체, 그의 제조 방법 및 그의 약학적 용도 |
| AU2003256417A1 (en) | 2002-08-13 | 2004-02-25 | Kosan Biosciences, Inc. | Transposon-based transformation system |
-
2000
- 2000-02-11 AU AU41018/00A patent/AU4101800A/en not_active Abandoned
- 2000-02-11 JP JP2000598504A patent/JP2002536450A/ja active Pending
- 2000-02-11 EP EP00920433A patent/EP1161430A2/de not_active Withdrawn
- 2000-02-11 MX MXPA01008148A patent/MXPA01008148A/es unknown
- 2000-02-11 EA EA200100833A patent/EA200100833A1/ru unknown
- 2000-02-11 IL IL14437000A patent/IL144370A0/xx unknown
- 2000-02-11 CN CN00803717A patent/CN1340053A/zh active Pending
- 2000-02-11 PL PL00350190A patent/PL350190A1/xx not_active Application Discontinuation
- 2000-02-11 KR KR1020017010109A patent/KR20010094763A/ko not_active Withdrawn
- 2000-02-11 BR BR0008206-6A patent/BR0008206A/pt not_active IP Right Cessation
- 2000-02-11 EE EEP200100422A patent/EE200100422A/xx unknown
- 2000-02-11 WO PCT/EP2000/001104 patent/WO2000047584A2/de not_active Ceased
- 2000-02-11 HK HK02106492.8A patent/HK1044946A1/zh unknown
- 2000-02-11 YU YU57601A patent/YU57601A/sh unknown
- 2000-02-11 HU HU0105330A patent/HUP0105330A2/hu unknown
- 2000-02-11 SK SK1145-2001A patent/SK11452001A3/sk unknown
- 2000-02-11 CA CA002360952A patent/CA2360952A1/en not_active Abandoned
- 2000-02-11 US US09/913,163 patent/US7001916B1/en not_active Expired - Fee Related
- 2000-02-11 CZ CZ20012886A patent/CZ20012886A3/cs unknown
-
2001
- 2001-08-09 BG BG105803A patent/BG105803A/xx unknown
- 2001-08-10 NO NO20013900A patent/NO20013900L/no not_active Application Discontinuation
-
2005
- 2005-07-27 US US11/189,787 patent/US20060040990A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20012886A3 (cs) | 2001-11-14 |
| YU57601A (sh) | 2005-06-10 |
| NO20013900D0 (no) | 2001-08-10 |
| SK11452001A3 (sk) | 2002-04-04 |
| NO20013900L (no) | 2001-10-11 |
| KR20010094763A (ko) | 2001-11-01 |
| HK1044946A1 (zh) | 2002-11-08 |
| EP1161430A2 (de) | 2001-12-12 |
| EA200100833A1 (ru) | 2002-02-28 |
| PL350190A1 (en) | 2002-11-18 |
| EE200100422A (et) | 2002-12-16 |
| BR0008206A (pt) | 2002-02-19 |
| MXPA01008148A (es) | 2003-07-21 |
| CA2360952A1 (en) | 2000-08-17 |
| HUP0105330A2 (hu) | 2002-05-29 |
| IL144370A0 (en) | 2002-05-23 |
| CN1340053A (zh) | 2002-03-13 |
| WO2000047584A2 (de) | 2000-08-17 |
| US7001916B1 (en) | 2006-02-21 |
| AU4101800A (en) | 2000-08-29 |
| US20060040990A1 (en) | 2006-02-23 |
| JP2002536450A (ja) | 2002-10-29 |
| WO2000047584A3 (de) | 2000-12-28 |
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