BG104506A - Производни на хидроксамови киселини като инхибитори на матриксни металопротеази - Google Patents

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Publication number

BG104506A

BG104506A BG104506A BG10450600A BG104506A BG 104506 A BG104506 A BG 104506A BG 104506 A BG104506 A BG 104506A BG 10450600 A BG10450600 A BG 10450600A BG 104506 A BG104506 A BG 104506A

Authority

BG

Bulgaria

Prior art keywords

preparation

brs

title compound

mmol

compound

Prior art date

1997-12-05

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• 150000001875 compounds Chemical class 0.000 claims abstract description 390
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• 239000001257 hydrogen Substances 0.000 claims abstract description 41
• 150000003839 salts Chemical class 0.000 claims abstract description 40
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• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 5
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 4
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• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 4
• 241000282412 Homo Species 0.000 claims description 4
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• 230000003213 activating effect Effects 0.000 claims description 4
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 4
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 4
• 239000003085 diluting agent Substances 0.000 claims description 4
• BWOKVQMLEBMZFQ-UHFFFAOYSA-N 2-[[4-[4-(3-ethoxyphenyl)-3-methylphenyl]-3,6-dihydro-2h-pyridin-1-yl]sulfonyl]-n-hydroxy-2-methylpropanamide Chemical compound CCOC1=CC=CC(C=2C(=CC(=CC=2)C=2CCN(CC=2)S(=O)(=O)C(C)(C)C(=O)NO)C)=C1 BWOKVQMLEBMZFQ-UHFFFAOYSA-N 0.000 claims description 3
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 3
• 125000003762 3,4-dimethoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C(OC([H])([H])[H])C([H])=C1* 0.000 claims description 3
• 239000007821 HATU Substances 0.000 claims description 3
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• 125000004122 cyclic group Chemical group 0.000 claims description 3
• 125000002541 furyl group Chemical group 0.000 claims description 3
• 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 3
• 125000001041 indolyl group Chemical group 0.000 claims description 3
• VDBNYAPERZTOOF-UHFFFAOYSA-N isoquinolin-1(2H)-one Chemical compound C1=CC=C2C(=O)NC=CC2=C1 VDBNYAPERZTOOF-UHFFFAOYSA-N 0.000 claims description 3
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