[go: up one dir, main page]

BE904662A - Derive antipsychotique du benzisothiazole s-oxyde. - Google Patents

Derive antipsychotique du benzisothiazole s-oxyde.

Info

Publication number
BE904662A
BE904662A BE0/216581A BE216581A BE904662A BE 904662 A BE904662 A BE 904662A BE 0/216581 A BE0/216581 A BE 0/216581A BE 216581 A BE216581 A BE 216581A BE 904662 A BE904662 A BE 904662A
Authority
BE
Belgium
Prior art keywords
antipsychotic
benzisothiazole
derivative
oxide
compound
Prior art date
Application number
BE0/216581A
Other languages
English (en)
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of BE904662A publication Critical patent/BE904662A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procédé de préparation d'un composé de formule (1) ou de ses sels d'addition d'acides pharmaceutiquement acceptables, qui consiste à faire réagir un composé de formule (2) avec un mélange d'acides minéraux à une température inférieure à environ 5 degrés C et, si on le souhaite, à en former le sel pharmaceutiquement acceptable par réaction du produit final basique avec un acide organique ou minéral choisi, pour obtenir un agent antipsychotique présentant moins d'effets secondaires genants.
BE0/216581A 1985-04-24 1986-04-23 Derive antipsychotique du benzisothiazole s-oxyde. BE904662A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/726,449 US4656173A (en) 1985-04-24 1985-04-24 Antipsychotic benzisothiazole S-oxide compound

Publications (1)

Publication Number Publication Date
BE904662A true BE904662A (fr) 1986-10-23

Family

ID=24918649

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216581A BE904662A (fr) 1985-04-24 1986-04-23 Derive antipsychotique du benzisothiazole s-oxyde.

Country Status (26)

Country Link
US (1) US4656173A (fr)
JP (1) JPH0764842B2 (fr)
KR (1) KR900000372B1 (fr)
CN (1) CN1017528B (fr)
AT (1) AT394719B (fr)
AU (1) AU592787B2 (fr)
BE (1) BE904662A (fr)
CA (1) CA1247102A (fr)
CH (1) CH666034A5 (fr)
DE (1) DE3613739C2 (fr)
DK (1) DK187686A (fr)
EG (1) EG18002A (fr)
ES (1) ES8708228A1 (fr)
FI (1) FI84604C (fr)
FR (1) FR2581064B1 (fr)
GB (1) GB2174393B (fr)
GR (1) GR861063B (fr)
HU (1) HU195654B (fr)
IE (1) IE59182B1 (fr)
IT (1) IT1208600B (fr)
LU (1) LU86405A1 (fr)
MY (1) MY102041A (fr)
NL (1) NL8601043A (fr)
PT (1) PT82450B (fr)
SE (1) SE462163B (fr)
ZA (1) ZA861531B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4780466A (en) * 1988-03-17 1988-10-25 Hoechst-Roussel Pharmaceuticals, Inc. Arylpiperazinylalkoxy derivatives of cyclic imides
EP0350145A3 (fr) * 1988-04-28 1990-07-04 Yamanouchi Pharmaceutical Co. Ltd. Derivés de Pyridylthiazolidine carboxamide et intermédiaires et leur production
WO1990002552A1 (fr) * 1988-09-16 1990-03-22 Pfizer Inc. Imides bicycliques polynucleaires de 4-[4-(3-benzisothiazolyl)-1-piperazinyl]butyle a usage antipsychotique
US4956368A (en) * 1989-07-24 1990-09-11 Bristol-Myers Company Metabolites and prodrug formulations of 8-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione
US4968792A (en) * 1989-09-25 1990-11-06 American Home Products Corporation Psychotropic benzisothiazole derivatives
US5162321A (en) * 1989-12-20 1992-11-10 Adir Et Compagnie 1-naphthyl piperazines useful as 5-HT1A receptor ligands
JP2800953B2 (ja) * 1990-07-06 1998-09-21 住友製薬株式会社 新規なイミド誘導体
HK1215170A1 (zh) 2012-11-14 2016-08-19 The Johns Hopkins University 治療精神分裂症的方法和組合物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
US3976776A (en) * 1972-12-06 1976-08-24 Mead Johnson & Company Tranquilizer process employing N-(heteroarcyclic)piperazinylalkylazaspiroalkanediones
CH582699A5 (fr) * 1973-03-26 1976-12-15 Sandoz Ag
AT342057B (de) * 1974-04-25 1978-03-10 Thomae Gmbh Dr K Verfahren zur herstellung von neuen 3-piperazino-isochinolinen und deren salzen
FI753625A7 (fr) * 1975-01-06 1976-07-07 Spofa Vereinigte Pharma Werke
JPS51144735A (en) * 1975-06-06 1976-12-13 Nippon Nohyaku Co Ltd A remedy for hepatic failure
US4411901A (en) * 1981-12-23 1983-10-25 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4452799A (en) * 1981-12-23 1984-06-05 Mead Johnson & Company Benzisothiazole and benzisoxazole piperazine derivatives
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Also Published As

Publication number Publication date
JPH0764842B2 (ja) 1995-07-12
KR860008174A (ko) 1986-11-12
FI84604C (fi) 1991-12-27
CN1017528B (zh) 1992-07-22
HU195654B (en) 1988-06-28
DK187686A (da) 1986-10-25
GB2174393A (en) 1986-11-05
AU592787B2 (en) 1990-01-25
LU86405A1 (fr) 1986-11-05
US4656173A (en) 1987-04-07
SE8601883D0 (sv) 1986-04-23
GB8609932D0 (en) 1986-05-29
CA1247102A (fr) 1988-12-20
FI861668L (fi) 1986-10-25
GB2174393B (en) 1989-02-01
SE8601883L (sv) 1986-10-25
DE3613739A1 (de) 1986-11-20
FI861668A0 (fi) 1986-04-21
CN86102742A (zh) 1987-02-04
EG18002A (en) 1991-08-30
AT394719B (de) 1992-06-10
DK187686D0 (da) 1986-04-23
MY102041A (en) 1992-02-29
IE59182B1 (en) 1994-01-26
ES8708228A1 (es) 1987-10-01
KR900000372B1 (ko) 1990-01-25
FI84604B (fi) 1991-09-13
NL8601043A (nl) 1986-11-17
ATA110486A (de) 1991-11-15
JPS61251683A (ja) 1986-11-08
SE462163B (sv) 1990-05-14
ES554284A0 (es) 1987-10-01
GR861063B (en) 1986-09-01
CH666034A5 (de) 1988-06-30
AU5612186A (en) 1986-10-30
FR2581064A1 (fr) 1986-10-31
DE3613739C2 (de) 1993-12-09
ZA861531B (en) 1986-10-29
HUT42088A (en) 1987-06-29
PT82450A (en) 1986-05-01
IT1208600B (it) 1989-07-10
PT82450B (pt) 1988-11-30
IT8620187A0 (it) 1986-04-23
IE861083L (en) 1986-10-24
FR2581064B1 (fr) 1988-09-16

Similar Documents

Publication Publication Date Title
US5212204A (en) Antihypertensive compositions and use thereof
EP0274453A3 (fr) Nouveaux composés à activité d'inhibiteurs de collagénase, procédé pour les préparer et compositions pharmaceutiques contenant ces composés
HUT37780A (en) Process for producing n-/4-piperidyl/-substituted bicyclic condensed 2-imidazolyl-amine derivatives and pharmaceutical compositions containing them as active agents
DE3562374D1 (en) Compound having antibronchopneumopathic activity, process for its preparation and pharmaceutical compositions containing it
AR240830A2 (es) Procedimiento para preparar derivados de acidos naftiridin quinolin-y benzoxazincarboxilicos.
SE9000282L (sv) 6-brom-5-hydroxi-4-dimetylaminometyl-1-metyl-2-fenyltiometylindol-3-karbonsyra etylester-hydroklorid i monohydratform, foerfarande foer framstaellning av densamma och paa hydrokloriden i monohydratform baserat laekemedelspreparat med antivirusverkan interferoninducerande och immunomodulerande verkan
BE904662A (fr) Derive antipsychotique du benzisothiazole s-oxyde.
CZ282036B6 (cs) Nové 3-cykloalkylpropanamidy, jejich tautomerní formy a jejich soli, způsob jejich přípravy a použití jako léčiv a kompozice tyto 3-cykloalkyl propanamidy obsahující
EP0870761B1 (fr) Dérivés de thiocolchicine ayant une activité antiinfammatoire et relaxante des muscles
DK0430201T3 (fr)
Barton et al. The invention of new radical chain reactions: part XIII. Generation and reactivity of perfluoroalkyl radicals from thiohydroxamic esters
GR3026186T3 (en) Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
HUT46895A (en) Process for production of new 5-lipoxigenase bicyclic compounds with inhibiation effect
FI900365A0 (fi) Menetelmä terapeuttisesti käyttökelpoisten 3-fenyyli-5,6-dihydrobents/C/akridiini-7-karboksyylihappojohdannnaisten valmistamiseksi
EP0059108B1 (fr) Dérivés d'acide dihydroxibenzoique
KR880007556A (ko) 새로운 안트라시클린 유도체와 이의 제조 방법
BE905409A (fr) Procede de preparation de n-sulfamyl-3-(2-guanidino-thiazol-4-yl-methylthio)-propionamidine.
ZA842423B (en) Compounds with antiinflammatory activity,process for preparation thereof and pharmaceutical compositions therefrom
US4125711A (en) Process for preparing auranofin
EP0204172B1 (fr) Dérivés de phénylpyrazine, leurs procédés de préparation, composition pharmaceutique at utilisation
CH634075A5 (en) Process for the preparation of hydrated imidazothiazole and thiazolopyrimidine derivatives having an anti-inflammatory activity
ATE19781T1 (de) Androstenen enthaltenden pharmazeutische zusammensetzungen.
EP0371837A3 (fr) Procédé de synthèse spécifique de nouveaux esters d'acides dithiocarbamiques par substitution de sites hydroxylés sur des molécules mono- ou polyhydroxylées produits obtenus for ce procédé et leurs applications
FR2415641A1 (fr) Amino-3-cardenolides, procede pour leur preparation, et medicaments les contenant
FR2396761A1 (fr) Procede de preparation du r,s-2,3,5,6-tetrahydro-6-phenyl-imidazo (2,1-b)-thiazole et de ses sels d'addition d'acide pharmaceutiquement acceptables, mettant en oeuvre un alkylxanthogenate ou du thiophene

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BRISTOL-MYERS CY

Effective date: 20000430