BE866117A - Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament - Google Patents

Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament

Info

Publication number: BE866117A
Authority: BE; Belgium
Prior art keywords: intermediaries; somatostatin; approved; preparation; medicinal product
Prior art date: 1977-04-21

Application number

BE1008847A

Other languages

English (en)

French (fr)

Inventor

J E Shields

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-04-21

Filing date

1978-04-19

Publication date

1978-10-19

1978-04-19 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

1978-10-19 Publication of BE866117A publication Critical patent/BE866117A/xx

Links

102000005157 Somatostatin Human genes 0.000 title 1
108010056088 Somatostatin Proteins 0.000 title 1
229940126601 medicinal product Drugs 0.000 title 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 title 1
229960000553 somatostatin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/28—Bound to a nonpeptide drug, nonpeptide label, nonpeptide carrier, or a nonpeptide resin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biophysics (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Steroid Compounds (AREA)

BE1008847A 1977-04-21 1978-04-19 Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament BE866117A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US05/789,472 US4100117A (en)	1977-04-21	1977-04-21	Somatostatin analogs and intermediates thereto

Publications (1)

Publication Number	Publication Date
BE866117A true BE866117A (fr)	1978-10-19

Family

ID=25147748

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE1008847A BE866117A (fr)	1977-04-21	1978-04-19	Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament

Country Status (31)

Country	Link
US (1)	US4100117A (xx)
JP (1)	JPS53132588A (xx)
AR (1)	AR221699A1 (xx)
AT (1)	AT361142B (xx)
AU (1)	AU519275B2 (xx)
BE (1)	BE866117A (xx)
BG (1)	BG28703A3 (xx)
CA (2)	CA1102315A (xx)
CH (1)	CH634039A5 (xx)
CS (1)	CS202096B2 (xx)
DD (1)	DD135900A5 (xx)
DE (1)	DE2816854A1 (xx)
DK (1)	DK174278A (xx)
ES (2)	ES469005A1 (xx)
FI (1)	FI64576C (xx)
FR (1)	FR2387941A1 (xx)
GB (1)	GB1596328A (xx)
GR (1)	GR68945B (xx)
HU (1)	HU177435B (xx)
IE (1)	IE46868B1 (xx)
IL (1)	IL54533A (xx)
IT (1)	IT1094462B (xx)
NL (1)	NL7804218A (xx)
NZ (1)	NZ187009A (xx)
PL (2)	PL115827B1 (xx)
PT (1)	PT67913B (xx)
RO (2)	RO76054A (xx)
SE (1)	SE7804397L (xx)
SU (2)	SU730295A3 (xx)
YU (1)	YU91578A (xx)
ZA (1)	ZA782247B (xx)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4202802A (en) *	1978-10-02	1980-05-13	Eli Lilly And Company	Peptides related to somatostatin
US4199500A (en) *	1978-11-20	1980-04-22	Eli Lilly And Company	Peptides related to somatostatin
US4199501A (en) *	1978-11-20	1980-04-22	Eli Lilly And Company	Peptides related to somatostatin
US4428942A (en)	1982-05-17	1984-01-31	The Salk Institute For Biological Studies	Analogs of somatostatin
GB8423431D0 (en) *	1984-09-17	1984-10-24	Sandoz Ltd	Organic compounds
SE8702550D0 (sv) *	1987-06-18	1987-06-18	Anders Grubb	Cysteinproteashemmare
NZ240214A (en)	1990-10-16	1993-02-25	Takeda Chemical Industries Ltd	Polymer compositions comprising a polylactic acid and a copolymer of glycolic acid and a hydroxycarboxylic acid; use as carrier for prolonged release pharmaceutical compositions of water soluble drugs
ATE161716T1 (de)	1992-08-07	1998-01-15	Takeda Chemical Industries Ltd	Herstellung von mikrokapseln, die wasserlösliche arzneimittel enthalten
CA2143044C (en) *	1994-02-21	2005-04-12	Yasutaka Igari	Matrix for sustained-release preparation
US6117455A (en)	1994-09-30	2000-09-12	Takeda Chemical Industries, Ltd.	Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
CA2192782C (en)	1995-12-15	2008-10-14	Nobuyuki Takechi	Production of microspheres
CN1095681C (zh) *	1996-06-20	2002-12-11	久光制药株式会社	一种用于离子电渗疗法的装置结构
US6309633B1 (en)	1999-06-19	2001-10-30	Nobex Corporation	Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
US7169889B1 (en)	1999-06-19	2007-01-30	Biocon Limited	Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
DE60136958D1 (de)	2000-12-01	2009-01-22	Takeda Pharmaceutical	Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz
US7060675B2 (en) *	2001-02-15	2006-06-13	Nobex Corporation	Methods of treating diabetes mellitus
US6867183B2 (en) *	2001-02-15	2005-03-15	Nobex Corporation	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US6713452B2 (en) *	2001-06-04	2004-03-30	Nobex Corporation	Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828305B2 (en) *	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7713932B2 (en) *	2001-06-04	2010-05-11	Biocon Limited	Calcitonin drug-oligomer conjugates, and uses thereof
US6835802B2 (en) *	2001-06-04	2004-12-28	Nobex Corporation	Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
US6858580B2 (en) *	2001-06-04	2005-02-22	Nobex Corporation	Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6828297B2 (en)	2001-06-04	2004-12-07	Nobex Corporation	Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US7166571B2 (en) *	2001-09-07	2007-01-23	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7312192B2 (en) *	2001-09-07	2007-12-25	Biocon Limited	Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US6913903B2 (en) *	2001-09-07	2005-07-05	Nobex Corporation	Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
US7196059B2 (en)	2001-09-07	2007-03-27	Biocon Limited	Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
US7601688B2 (en) *	2002-06-13	2009-10-13	Biocon Limited	Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
US7872095B2 (en)	2004-07-19	2011-01-18	Biocon Limited	Insulin-oligomer conjugates, formulations and uses thereof
CN101939023B (zh)	2007-10-16	2016-08-03	百康有限公司	可经口给药的固体药物组合物及其方法
US20150157619A1 (en)	2012-07-10	2015-06-11	Takeda Pharmaceutical Company Limited	Pharmaceutical preparation for injection

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2608336A1 (de) *	1975-03-11	1976-09-30	Sandoz Ag	Neue organische verbindungen, ihre herstellung und verwendung
US4372884A (en) *	1975-08-06	1983-02-08	The Salk Institute For Biological Studies	Pharmaceutically active peptides

1977
- 1977-04-21 US US05/789,472 patent/US4100117A/en not_active Expired - Lifetime
1978
- 1978-04-17 GB GB14916/78A patent/GB1596328A/en not_active Expired
- 1978-04-18 RO RO7893835A patent/RO76054A/ro unknown
- 1978-04-18 FI FI781184A patent/FI64576C/fi not_active IP Right Cessation
- 1978-04-18 NZ NZ187009A patent/NZ187009A/xx unknown
- 1978-04-18 AR AR271820A patent/AR221699A1/es active
- 1978-04-18 JP JP4621378A patent/JPS53132588A/ja active Pending
- 1978-04-18 PT PT67913A patent/PT67913B/pt unknown
- 1978-04-18 SE SE7804397A patent/SE7804397L/xx unknown
- 1978-04-18 IL IL54533A patent/IL54533A/xx unknown
- 1978-04-18 RO RO78102194A patent/RO81079A/ro unknown
- 1978-04-18 YU YU00915/78A patent/YU91578A/xx unknown
- 1978-04-18 DE DE19782816854 patent/DE2816854A1/de not_active Withdrawn
- 1978-04-19 AU AU35253/78A patent/AU519275B2/en not_active Expired
- 1978-04-19 FR FR7811580A patent/FR2387941A1/fr active Granted
- 1978-04-19 IE IE765/78A patent/IE46868B1/en unknown
- 1978-04-19 GR GR56030A patent/GR68945B/el unknown
- 1978-04-19 ZA ZA00782247A patent/ZA782247B/xx unknown
- 1978-04-19 CA CA301,500A patent/CA1102315A/en not_active Expired
- 1978-04-19 BE BE1008847A patent/BE866117A/xx not_active IP Right Cessation
- 1978-04-20 NL NL7804218A patent/NL7804218A/xx not_active Application Discontinuation
- 1978-04-20 ES ES469005A patent/ES469005A1/es not_active Expired
- 1978-04-20 HU HU78EI790A patent/HU177435B/hu unknown
- 1978-04-20 SU SU782607708A patent/SU730295A3/ru active
- 1978-04-20 CH CH425778A patent/CH634039A5/de not_active IP Right Cessation
- 1978-04-20 AT AT282878A patent/AT361142B/de not_active IP Right Cessation
- 1978-04-20 IT IT22552/78A patent/IT1094462B/it active
- 1978-04-20 DK DK174278A patent/DK174278A/da active IP Right Grant
- 1978-04-21 CS CS782580A patent/CS202096B2/cs unknown
- 1978-04-21 PL PL1978217479A patent/PL115827B1/pl unknown
- 1978-04-21 BG BG039503A patent/BG28703A3/xx unknown
- 1978-04-21 PL PL1978206280A patent/PL114533B1/pl unknown
- 1978-04-21 DD DD78204957A patent/DD135900A5/xx unknown
1979
- 1979-01-05 SU SU792705047A patent/SU904519A3/ru active
- 1979-01-16 ES ES476901A patent/ES476901A1/es not_active Expired
1980
- 1980-12-08 CA CA366,345A patent/CA1113928A/en not_active Expired

Also Published As

Publication number	Publication date
IT7822552A0 (it)	1978-04-20
FI64576C (fi)	1983-12-12
AT361142B (de)	1981-02-25
US4100117A (en)	1978-07-11
FI64576B (fi)	1983-08-31
ZA782247B (en)	1979-12-27
CA1102315A (en)	1981-06-02
NL7804218A (nl)	1978-10-24
SE7804397L (sv)	1978-10-22
PL206280A1 (xx)	1980-01-02
PL115827B1 (en)	1981-05-30
ATA282878A (de)	1980-07-15
IL54533A0 (en)	1978-07-31
NZ187009A (en)	1981-04-24
AU519275B2 (en)	1981-11-19
ES469005A1 (es)	1979-09-01
FR2387941B1 (xx)	1983-06-10
RO81079B (ro)	1983-05-30
IT1094462B (it)	1985-08-02
HU177435B (en)	1981-10-28
AU3525378A (en)	1979-10-25
YU91578A (en)	1983-01-21
CS202096B2 (en)	1980-12-31
ES476901A1 (es)	1979-10-16
PL114533B1 (en)	1981-02-28
RO81079A (ro)	1983-06-01
BG28703A3 (bg)	1980-06-16
RO76054A (ro)	1981-08-17
IL54533A (en)	1982-11-30
DK174278A (da)	1978-10-22
PT67913B (en)	1979-11-14
FR2387941A1 (fr)	1978-11-17
PT67913A (en)	1978-05-01
IE46868B1 (en)	1983-10-19
IE780765L (en)	1978-10-21
GB1596328A (en)	1981-08-26
DD135900A5 (de)	1979-06-06
JPS53132588A (en)	1978-11-18
SU730295A3 (ru)	1980-04-25
CA1113928A (en)	1981-12-08
AR221699A1 (es)	1981-03-13
DE2816854A1 (de)	1978-11-02
CH634039A5 (de)	1983-01-14
GR68945B (xx)	1982-03-29
FI781184A7 (fi)	1978-10-22
SU904519A3 (ru)	1982-02-07

Publication	Publication Date	Title
BE866117A (fr)	1978-10-19	Homologue de la somatostatine, ses intermediaires de preparation et son utilisation comme medicament
DE2861692D1 (en)	1982-04-29	Insecticidal and acaricidal agents containing chroman derivatives, their preparation and their use, as well as chroman derivatives and their preparation
DE2962051D1 (en)	1982-03-11	Benzimidazoles, their preparation and pharmaceutical compositions containing them
IL54560A0 (en)	1978-07-31	Novel cyclohexane derivatives, their preparation and their use as heribicides
BE879918A (fr)	1980-05-08	Distributeur de medicament
DE2860574D1 (en)	1981-04-23	Substituted phenoxybenzyloxycarbonyl derivatives, their preparation and their use as insecticides and acaricides
JPS5359293A (en)	1978-05-27	Medical respirator
DE2967559D1 (en)	1986-02-13	Agricultural sulfonamides, and preparation and use thereof
IL55643A0 (en)	1978-12-17	Novel cyclopeptides,their preparation and pharmaceutical compositions containing
BE881351A (fr)	1980-05-16	Preparation medicale
IL56405A0 (en)	1979-03-12	Novel substituted n-pehnyl-n'-(2-chloro-6-fluoro-benzoyl)-ureas, their preparation and their use as insecticides
FR2511003B1 (fr)	1986-12-05	Alacaloides ergopeptidiques, leur preparation et leur utilisation comme medicaments
AU520017B2 (en)	1982-01-07	Fowl cholera vaccine
IT1111290B (it)	1986-01-13	Dispositivo per la respirazione artificiale di pazienti
DE2860270D1 (en)	1981-02-05	Novel derivatives of substituted 2-benzoyl-4-chloro-glycinanilides, their preparation and their use as medicines.
LU79356A1 (fr)	1978-11-27	Preparation d'interphenylene 8-aza-9-dioxathia-11,12-secoprostaglandines utiles comme medicaments
DE2960024D1 (en)	1981-01-22	Substituted diphenylmethyl-imidazoles, their preparation and medicaments containing them
DE2860410D1 (en)	1981-02-26	2-piperazinotetraline derivatives, their preparation and their use as medicines
BE865404A (fr)	1978-09-29	3-amino-6,7-dialcoxy-1h-1,2,4-benzothiadiazine-1-oxydes 1-substitues et leur utilisation comme medicaments
FR2361345A1 (fr)	1978-03-10	Homologues de somatostatine, sa preparation et son utilisation therapeutique
BE862971A (fr)	1978-07-17	4'-desoxyvincristine et composes apparentes, et leur utilisation comme medicaments
IL57230A0 (en)	1979-09-30	Substituted alkanyl-azolyl oxime-carbamates,their preparation and their use as insecticides,acaricides and nematocides
JPS53107424A (en)	1978-09-19	Antiiinflammatory medical preparation
FR2530634B1 (fr)	1986-11-14	Derives du carbapeneme, leur preparation et leur utilisation comme medicaments
IL65142A0 (en)	1982-05-31	Carbamate derivatives,their preparation and their use as insecticides,miticides and nematodicides

Legal Events

Date	Code	Title	Description
1986-10-31	RE	Patent lapsed	Owner name: ELI LILLY AND CY Effective date: 19860430

Date

Code

Title

Description

1986-10-31

Patent lapsed

Owner name: ELI LILLY AND CY

Effective date: 19860430