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BE819177R - Oxazolo- et thiazolopyridines - Google Patents

Oxazolo- et thiazolopyridines

Info

Publication number
BE819177R
BE819177R BE147896A BE147896A BE819177R BE 819177 R BE819177 R BE 819177R BE 147896 A BE147896 A BE 147896A BE 147896 A BE147896 A BE 147896A BE 819177 R BE819177 R BE 819177R
Authority
BE
Belgium
Prior art keywords
thiazolopyridines
oxazolo
Prior art date
Application number
BE147896A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AR248527A priority Critical patent/AR208500A1/es
Priority to FI1657/73A priority patent/FI57417C/fi
Priority to DK284973A priority patent/DK152050C/da
Priority to SE7307412A priority patent/SE401675B/xx
Priority to NLAANVRAGE7307582,A priority patent/NL184836C/xx
Priority to AU56511/73A priority patent/AU472528B2/en
Priority to ZA00733760A priority patent/ZA733760B/xx
Priority to CA173,275A priority patent/CA1019741A/en
Priority to CH831173A priority patent/CH591494A5/xx
Priority to AT508673A priority patent/AT333277B/de
Priority to GB2763273A priority patent/GB1421619A/en
Priority to CS7300004243A priority patent/CS178889B2/cs
Priority to DD171559A priority patent/DD105237A5/xx
Priority to DE2330109A priority patent/DE2330109A1/de
Priority to LU67786A priority patent/LU67786A1/xx
Priority to BE132231A priority patent/BE800868A/fr
Priority to FR7321443A priority patent/FR2187356B1/fr
Priority to JP48066453A priority patent/JPS5943475B2/ja
Priority to BE147896A priority patent/BE819177R/fr
Application filed filed Critical
Application granted granted Critical
Publication of BE819177R publication Critical patent/BE819177R/fr
Priority to AT462875A priority patent/AT346327B/de
Priority to AU82335/75A priority patent/AU8233575A/en
Priority to CH925075A priority patent/CH605971A5/de
Priority to DK357175A priority patent/DK138456B/da
Priority to SE7604385A priority patent/SE432767B/xx
Priority to FI800611A priority patent/FI58921C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
BE147896A 1972-06-14 1974-08-26 Oxazolo- et thiazolopyridines BE819177R (fr)

Priority Applications (25)

Application Number Priority Date Filing Date Title
AR248527A AR208500A1 (es) 1972-06-14 1973-03-12 Procedimiento para la preparacion de derivados de oxazolo(4,5-b)-piridinas
FI1657/73A FI57417C (fi) 1972-06-14 1973-05-22 Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-substituerad-oxazolo-(4,5-b)-pyridiner
DK284973A DK152050C (da) 1972-06-14 1973-05-24 Analogifremgangsmaade til fremstilling af oxazolopyridiner
SE7307412A SE401675B (sv) 1972-06-14 1973-05-25 Sett att framstella 1,3-oxazolo/4,5-b/pyridinderivat
NLAANVRAGE7307582,A NL184836C (nl) 1972-06-14 1973-05-30 Werkwijze voor het bereiden van anti-inflammatoir werkzame farmaceutische preparaten, alsmede werkwijze ter bereiding van anti-inflammatoir werkzame oxazolopyridinen.
AU56511/73A AU472528B2 (en) 1972-06-14 1973-06-04 Oxazolo and thiazolopyridines
ZA00733760A ZA733760B (en) 1972-06-14 1973-06-04 Oxazolo- and thiazolopyridines
CA173,275A CA1019741A (en) 1972-06-14 1973-06-05 Oxazolo- and thiazolopyridines
CH831173A CH591494A5 (fr) 1972-06-14 1973-06-07
AT508673A AT333277B (de) 1972-06-14 1973-06-08 Verfahren zur herstellung von neuen oxazolpyridinen und deren n-oxiden und quaternaren pyridiniumsalzen
GB2763273A GB1421619A (en) 1972-06-14 1973-06-11 Oxazolopyridines and thiazolopyridines
DD171559A DD105237A5 (fr) 1972-06-14 1973-06-12
CS7300004243A CS178889B2 (en) 1972-06-14 1973-06-12 Method for preparation of oxazolopyridines and derivatives thereof
LU67786A LU67786A1 (fr) 1972-06-14 1973-06-13
BE132231A BE800868A (fr) 1972-06-14 1973-06-13 Oxazolo- et thiazolopyridines
FR7321443A FR2187356B1 (fr) 1972-06-14 1973-06-13
DE2330109A DE2330109A1 (de) 1972-06-14 1973-06-13 Oxazol- und thiazolpyridine
JP48066453A JPS5943475B2 (ja) 1972-06-14 1973-06-14 オキサゾロ−及びチアゾロピリジン
BE147896A BE819177R (fr) 1972-06-14 1974-08-26 Oxazolo- et thiazolopyridines
AT462875A AT346327B (de) 1972-06-14 1975-06-17 Verfahren zur herstellung von neuen oxazolpyridinen
AU82335/75A AU8233575A (en) 1972-06-14 1975-06-20 Oxazolo%4,5,-6<pyridines
CH925075A CH605971A5 (en) 1972-06-14 1975-07-15 2-(Substd phenyl) oxazolo (4,5-b) pyridines
DK357175A DK138456B (da) 1972-06-14 1975-08-06 Analogifremgangsmåde til fremstilling af oxazolo(4,5-b)pyridiner.
SE7604385A SE432767B (sv) 1972-06-14 1976-04-14 Forfarande for framstellning av oxazolo-(5,4-b)-pyridiner
FI800611A FI58921C (fi) 1972-06-14 1980-02-28 Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-substituerade-oxazolo-(5,4-b)-pyridiner

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26289872A 1972-06-14 1972-06-14
BE147896A BE819177R (fr) 1972-06-14 1974-08-26 Oxazolo- et thiazolopyridines

Publications (1)

Publication Number Publication Date
BE819177R true BE819177R (fr) 1975-02-26

Family

ID=25648082

Family Applications (2)

Application Number Title Priority Date Filing Date
BE132231A BE800868A (fr) 1972-06-14 1973-06-13 Oxazolo- et thiazolopyridines
BE147896A BE819177R (fr) 1972-06-14 1974-08-26 Oxazolo- et thiazolopyridines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BE132231A BE800868A (fr) 1972-06-14 1973-06-13 Oxazolo- et thiazolopyridines

Country Status (17)

Country Link
JP (1) JPS5943475B2 (fr)
AR (1) AR208500A1 (fr)
AT (1) AT333277B (fr)
AU (1) AU472528B2 (fr)
BE (2) BE800868A (fr)
CA (1) CA1019741A (fr)
CS (1) CS178889B2 (fr)
DD (1) DD105237A5 (fr)
DE (1) DE2330109A1 (fr)
DK (1) DK152050C (fr)
FI (1) FI57417C (fr)
FR (1) FR2187356B1 (fr)
GB (1) GB1421619A (fr)
LU (1) LU67786A1 (fr)
NL (1) NL184836C (fr)
SE (2) SE401675B (fr)
ZA (1) ZA733760B (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2527321A1 (de) * 1975-06-19 1976-12-23 Merck & Co Inc Oxazol eckige klammer auf 4,5-b eckige klammer zu pyridine
JPS527992A (en) * 1975-07-04 1977-01-21 Merck & Co Inc Oxazolo *4*55b* pyridines
NL187021C (nl) * 1975-07-15 1991-05-01 Merck & Co Inc Werkwijze ter bereiding van een farmaceutisch preparaat met anti-inflammatoire werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte anti-inflammatoir werkzame 2-fenyl-oxazolo-(4,5-b)pyridinederivaten.
US4011326A (en) * 1975-07-29 1977-03-08 Merck & Co., Inc. 2-Substituted oxazolo[4,5-b]pyridine anti-inflammatory agents
US4753673A (en) * 1977-07-22 1988-06-28 The Dow Chemical Company Trifluoromethyl pyridinyloxyphenoxy and pyridinylthiophenoxy propanoic acids and propanols and derivatives thereof and methods of herbicidal use
EP0001473B1 (fr) * 1977-08-12 1988-07-27 Imperial Chemical Industries Plc Acides halogénométhyl-pyridyloxy-phénoxy-alcanecarboxyliques herbicides et dérivés; procédés pour contrôler la croissance de plantes indésirées
JPS5461182A (en) * 1977-10-20 1979-05-17 Ishihara Sangyo Kaisha Ltd 2-phenoxy-5-trifluoromethylpyridine compounds
JPS5461183A (en) * 1977-10-21 1979-05-17 Ishihara Sangyo Kaisha Ltd 2-substituted-5-trifluoromethyl pyridine compounds
DE2967674D1 (en) * 1978-02-15 1988-03-10 Ici Plc Herbicidal derivatives of 2-(4(2-pyridyloxy)phenoxy)propane, processes for preparing them, and herbicidal compositions containing them
JPS55130840U (fr) * 1979-03-12 1980-09-16
JPS55124763A (en) * 1979-03-19 1980-09-26 Ishihara Sangyo Kaisha Ltd 5-trifluoromethyl-2-pyridone derivative
GB8333514D0 (en) * 1983-12-16 1984-01-25 Erba Farmitalia Tetrahydrothiazolo(5 4-c)pyridine derivatives
FR2652085A1 (fr) * 1989-09-20 1991-03-22 Science Organisation Nouveau procede de synthese de derives d'oxazolopyridines.
EP0937075B1 (fr) * 1996-11-11 2003-12-17 ALTANA Pharma AG Nouvelles Imidazo- et Oxazolopyridines comme inhibiteurs de la Phosphodiesterase.
WO1999062908A2 (fr) * 1998-06-04 1999-12-09 Abbott Laboratories Composes anti-inflammatoires inhibant l'adhesion cellulaire
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
HK1045306A1 (zh) * 1999-06-03 2002-11-22 Abbott Laboratories 抑制细胞黏附的抗炎化合物
AU2002216649A1 (en) * 2000-10-31 2002-05-15 Lynn Bonham Benzoxazole lpaat- beta inhibitors and uses thereof
CA2617557A1 (fr) 2005-08-04 2007-02-15 Sirtris Pharmaceuticals, Inc. Derives de benzimidazole en tant que modulateur du sirtuin
US8093401B2 (en) 2005-08-04 2012-01-10 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US7855289B2 (en) 2005-08-04 2010-12-21 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
US8088928B2 (en) 2005-08-04 2012-01-03 Sirtris Pharmaceuticals, Inc. Sirtuin modulating compounds
CL2008001822A1 (es) 2007-06-20 2009-03-13 Sirtris Pharmaceuticals Inc Compuestos derivados de tiazolo[5,4-b]piridina; composicion farmaceutica que comprende a dichos compuestos; y uso del compuesto en el tratamiento de la resistencia a la insulina, sindrome metabolico, diabetes, entre otras.
AU2009285584B2 (en) * 2008-08-29 2015-04-02 Treventis Corporation Butyrylcholinesterase ligands as diagnostic tools and treatment for deseases of the nervous system
EP2376502B1 (fr) 2008-12-19 2015-06-17 GlaxoSmithKline LLC Composés thiazolopyridines de modulation des sirtuines
AR078463A1 (es) * 2009-09-30 2011-11-09 Sumitomo Chemical Co Composicion y metodo para controlar plagas de artropodos
WO2012035039A1 (fr) 2010-09-15 2012-03-22 F. Hoffmann-La Roche Ag Composés d'azabenzothiazole, compositions et procédés d'utilisation
BR112013016022B1 (pt) 2010-12-24 2019-05-07 Sumitomo Chemical Company, Limited Composto heterocíclico fundido e uso do mesmo para controle de peste.
WO2015200650A1 (fr) * 2014-06-25 2015-12-30 Epizyme, Inc. Composés hétéroaryles bicycliques fusionnés en 6,5 ou benzènes substitués
TR201815071T4 (tr) 2014-12-02 2018-11-21 Bayer Cropscience Ag Zararlılarla mücadele maddesi olarak bisiklik bileşikler.
US10399966B2 (en) 2016-01-21 2019-09-03 University Of Washington Compounds for treatment of trypanosomes and neurological pathogens and uses thereof
EP3483148B1 (fr) 2016-07-07 2023-08-23 Hodogaya Chemical Co., Ltd. Composé à structure cyclique de benzazole et élément électroluminescent organique

Also Published As

Publication number Publication date
AT333277B (de) 1976-11-10
NL184836C (nl) 1989-11-16
NL184836B (nl) 1989-06-16
ATA508673A (de) 1976-03-15
AU5651173A (en) 1974-12-05
BE800868A (fr) 1973-12-13
DK152050B (da) 1988-01-25
FI57417C (fi) 1980-08-11
FR2187356A1 (fr) 1974-01-18
LU67786A1 (fr) 1973-08-16
AR208500A1 (es) 1977-02-15
DD105237A5 (fr) 1974-04-12
GB1421619A (en) 1976-01-21
CS178889B2 (en) 1977-10-31
JPS5943475B2 (ja) 1984-10-22
DE2330109A1 (de) 1974-01-03
FR2187356B1 (fr) 1977-01-28
SE401675B (sv) 1978-05-22
SE432767B (sv) 1984-04-16
FI57417B (fi) 1980-04-30
CA1019741A (en) 1977-10-25
NL7307582A (fr) 1973-12-18
JPS4961195A (fr) 1974-06-13
SE7604385L (sv) 1976-04-14
ZA733760B (en) 1975-01-29
DK152050C (da) 1988-07-18
AU472528B2 (en) 1976-05-27

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: MERCK + CO. INC.

Effective date: 19920630