BE771964A - Procede pour la preparation de derives du benzo-cyclohepta-thiophene - Google Patents

Procede pour la preparation de derives du benzo-cyclohepta-thiophene

Info

Publication number: BE771964A
Authority: BE; Belgium
Prior art keywords: cyclohepta; benzo; preparation; thiophene derivatives; thiophene
Prior art date: 1970-03-11

Application number

BE771964A

Other languages

English (en)

Inventor

J P Bourquin

G Schwarb

E Waldvogel

Original Assignee

Sandoz Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1970-03-11

Filing date

1971-08-30

Publication date

1972-02-29

1970-03-11 Priority claimed from CH359870A external-priority patent/CH533639A/de

1970-09-24 Priority claimed from CH1412070A external-priority patent/CH537404A/de

1971-08-30 Application filed by Sandoz Sa filed Critical Sandoz Sa

1972-02-29 Publication of BE771964A publication Critical patent/BE771964A/fr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Compounds Containing Sulfur Atoms (AREA)

BE771964A 1970-03-11 1971-08-30 Procede pour la preparation de derives du benzo-cyclohepta-thiophene BE771964A (fr)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
CH359870A CH533639A (de)	1970-03-11	1970-03-11	Verfahren zur Herstellung neuer Benzo(4,5)cyclohepta(1,2-b)-thiophen-Derivate
CH1159370A CH531000A (de)	1970-03-11	1970-07-31	Verfahren zur Herstellung neuer Benzocycloheptathiophene
CH1412070A CH537404A (de)	1970-09-24	1970-09-24	Verfahren zur Herstellung neuer Thiophenderivate
CH163271		1971-02-04

Publications (1)

Publication Number	Publication Date
BE771964A true BE771964A (fr)	1972-02-29

Family

ID=27428249

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BE764019A BE764019A (fr)	1970-03-11	1971-03-09	Nouveaux derives du benzo-cyclohepta-thiophene et leur preparation
BE771964A BE771964A (fr)	1970-03-11	1971-08-30	Procede pour la preparation de derives du benzo-cyclohepta-thiophene

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BE764019A BE764019A (fr)	1970-03-11	1971-03-09	Nouveaux derives du benzo-cyclohepta-thiophene et leur preparation

Country Status (12)

Country	Link
US (4)	US3682930A (fr)
AT (2)	AT319238B (fr)
BE (2)	BE764019A (fr)
CA (2)	CA960673A (fr)
CH (1)	CH531000A (fr)
DE (2)	DE2111071C3 (fr)
FR (2)	FR2085695B1 (fr)
GB (4)	GB1355537A (fr)
LU (2)	LU62757A1 (fr)
NL (2)	NL167431C (fr)
OA (2)	OA03692A (fr)
SE (2)	SE368954B (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH531000A (de) *	1970-03-11	1972-11-30	Sandoz Ag	Verfahren zur Herstellung neuer Benzocycloheptathiophene
US3960894A (en) *	1972-01-24	1976-06-01	Sandoz Ltd.	9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones
BE794377A (fr) *	1972-01-24	1973-07-23	Sandoz Sa	Nouveaux derives du benzo-cyclohepta-thiophene
US4072756A (en) *	1973-05-17	1978-02-07	Sandoz Ltd.	Tricyclo piperidino ketones and soporific compositions thereof
CA1041100A (fr) *	1973-10-04	1978-10-24	Herbert G. Johnson	Acide pyridine-diyldioxamique
CH580621A5 (fr) *	1973-10-08	1976-10-15	Sandoz Ag
US4073915A (en) *	1975-05-20	1978-02-14	Sandoz Ltd.	Treating asthma
FI761607A7 (fr) *	1975-06-16	1976-12-17	Sandoz Ag
US4128549A (en) *	1976-02-27	1978-12-05	Sandoz Ltd.	Precursors of 4-(1-alkyl-4-piperidylidene-4H-benzo[4,5]cyclohepta-[1,2-b]thiophen-10(9H)-ones
US4282233B1 (en) *	1980-06-19	2000-09-05	Schering Corp	Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
DE3045135A1 (de) *	1980-11-29	1982-06-09	Sandoz-Patent-GmbH, 7850 Lörrach	Pharmazeutische kompositionen enthaltende bioabbaubare polymere
HU202753B (en) *	1986-06-21	1991-04-29	Sandoz Ag	Process for producing retard pharmaceutical compositions containing cetotiphene
US5438062A (en) *	1986-10-31	1995-08-01	Schering Corporation	Benzo(5,6)cycloheptapyridines, compositions and methods of use
US5089496A (en) *	1986-10-31	1992-02-18	Schering Corporation	Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
DZ1460A1 (fr) *	1989-11-22	2004-09-13	Sod Conseils Rech Applic	Nouveaux dérivés du sélénophèn ainsi que leur procédé de préparation.
CA2038417A1 (fr) *	1990-04-11	1991-10-12	Yasuo Ito	Composes de piperidine, methode de preparation de ces composes, et une composition pharmaceutique qui en contient.
WO1992006981A1 (fr) *	1990-10-10	1992-04-30	Schering Corporation	Imidazobenzazepines substituees et imidazopyridazepines
US5891460A (en) *	1995-06-07	1999-04-06	University Of Southern California University Park Campus	Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof
WO1998056381A1 (fr) *	1997-06-09	1998-12-17	Bridge Pharma, Inc.	Composes a combinaison d'activites antihistaminique et stabilisatrice des membranes cellulaires de mastocytes, utilises a des fins ophtalmiques
US6221897B1 (en) *	1998-06-10	2001-04-24	Aventis Pharma Deutschland Gmbh	Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use
CN1391475A (zh) *	1999-09-13	2003-01-15	布里奇药品有限公司	酮替芬的旋光异构体及其治疗学上的活性代谢产物
AU5139800A (en) *	1999-12-01	2001-06-12	Klein Pharmaceuticals	Topical administration of ketotifen
US20030212078A1 (en) *	2001-05-17	2003-11-13	Klein Gerald L.	Topical administration of pharmacological compositions for non-systemic treatment of pruritus
WO2004064845A1 (fr) *	2003-01-14	2004-08-05	Gilead Sciences, Inc.	Compositions et methodes destinees a une therapie de combinaison antivirale
CN100381439C (zh) *	2005-04-05	2008-04-16	浙江华海药业股份有限公司	9,10-二溴-9,10-二氢-4-H苯并[4,5]环庚烯并[1,2-b]噻吩-4-酮的制备方法
TWI471145B (zh)	2005-06-13	2015-02-01	Bristol Myers Squibb & Gilead Sciences Llc	單一式藥學劑量型
TWI375560B (en) *	2005-06-13	2012-11-01	Gilead Sciences Inc	Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
WO2008153761A1 (fr) *	2007-05-23	2008-12-18	Mastcell Pharmaceuticals, Inc.	Méthodes
JP5096500B2 (ja)	2008-01-30	2012-12-12	日本臓器製薬株式会社	ピペリジン誘導体
WO2009142772A2 (fr)	2008-05-23	2009-11-26	Mastcell Pharmaceuticals, Inc.	Méthodes et traitement d’allergies et inflammations associées à des pathologies gastro-intestinales
TWI457341B (zh) *	2008-08-01	2014-10-21	Nippon Zoki Pharmaceutical Co	胺基亞丙基衍生物
JP5606440B2 (ja) *	2009-07-28	2014-10-15	日本臓器製薬株式会社	チアベンゾアズレンプロピオン酸誘導体の製造法
BR112014010228B1 (pt)	2011-10-28	2020-09-29	Lumena Pharmaceuticals Llc	Uso de inibidores de reciclagem de ácido biliar para o tratamento de hipercolemia e doença hepática colestática
JP6217938B2 (ja)	2011-10-28	2017-10-25	ルメナファーマシューティカルズエルエルシー	小児の胆汁うっ滞性肝疾患の処置のための胆汁酸再循環阻害剤
US8557846B1 (en)	2012-10-23	2013-10-15	Bridge Pharma, Inc.	Medicinal treatment of dermal diseases in dogs
US8778971B2 (en)	2012-10-23	2014-07-15	Bridge Pharma, Inc.	Medicinal treatment of dermal diseases in companion animals
US20140120121A1 (en)	2012-10-30	2014-05-01	Bridge Pharma, Inc.	Medicinal treatment of atopic inflammatory diseases
US20150272941A1 (en)	2012-10-30	2015-10-01	Bridge Pharma, Inc.	Medicinal treatment of chronic pulmonary inflammatory diseases with norketotifen
US9138431B2 (en)	2013-08-06	2015-09-22	Bridge Pharma, Inc.	Methods of treatment of histamine H-4 receptor-related pruritus
US9345697B2 (en)	2013-08-06	2016-05-24	Bridge Pharma, Inc.	Methods of treatment of non-histaminic pruritus
US9439895B2 (en)	2013-08-06	2016-09-13	Bridge Pharma, Inc.	Methods of treating pruritic conditions mediated through non-histaminergic mechanisms in diabetic patients
CA2988564C (fr)	2015-06-11	2021-10-05	Bridge Pharma, Inc.	Procedes de traitement du prurit non histaminique chez des mammiferes
MX2018011699A (es)	2018-09-26	2019-07-24	Federico Amezcua Amezcua	Composicion farmaceutica sinergica de un antagonista de los receptores de leucotrienos y un agonista inverso de la histamina h1.
US10959992B2 (en)	2019-02-22	2021-03-30	Bridge Pharma Inc.	Methods of treatment of asthma and COPD

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE636717A (fr) *	1962-08-31
FR1437412A (fr) *	1963-12-19	1966-05-06	Sandoz Sa	Nouveaux benzo-cyclohepta-thiophènes et leur préparation
US3491103A (en) *	1963-12-19	1970-01-20	Sandoz Ag	Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes
GB1084450A (en) *	1963-12-20	1967-09-20	Sandoz Ltd	Improvements in or relating to 4h-benzo[4,5]cyclohepta-[1,2-b] thiophene derivatives
CH537897A (de) *	1968-03-20	1973-06-15	Hoffmann La Roche	Verfahren zur Herstellung von tricyclischen Verbindungen
US3574199A (en) *	1968-06-28	1971-04-06	Searle & Co	6-(aminoalkyl- and aminoalkylidene)-1,1a,6,10b -tetrahydro-dibenzo(a,e)cyclopropa(c)cycloheptenes
CH531000A (de) *	1970-03-11	1972-11-30	Sandoz Ag	Verfahren zur Herstellung neuer Benzocycloheptathiophene
US3709947A (en) *	1971-07-26	1973-01-09	Searle & Co	6-chloropropylidene-1,1a,6,10b-tetrahydrobenzo(a,e)cyclopropa(c)cycloheptenes

1970
- 1970-07-31 CH CH1159370A patent/CH531000A/de not_active IP Right Cessation
1971
- 1971-03-03 US US120738A patent/US3682930A/en not_active Expired - Lifetime
- 1971-03-08 FR FR7107901A patent/FR2085695B1/fr not_active Expired
- 1971-03-09 OA OA54190A patent/OA03692A/fr unknown
- 1971-03-09 BE BE764019A patent/BE764019A/fr not_active IP Right Cessation
- 1971-03-09 LU LU62757D patent/LU62757A1/xx unknown
- 1971-03-09 DE DE2111071A patent/DE2111071C3/de not_active Expired
- 1971-03-10 CA CA107,340A patent/CA960673A/en not_active Expired
- 1971-03-10 AT AT206471A patent/AT319238B/de not_active IP Right Cessation
- 1971-03-10 SE SE03074/71A patent/SE368954B/xx unknown
- 1971-03-10 NL NL7103174.A patent/NL167431C/xx not_active IP Right Cessation
- 1971-04-19 GB GB2348271*A patent/GB1355537A/en not_active Expired
- 1971-04-19 GB GB2882373A patent/GB1355539A/en not_active Expired
- 1971-06-04 GB GB1894073A patent/GB1355538A/en not_active Expired
- 1971-08-27 NL NLAANVRAGE7111808,A patent/NL171449C/xx not_active IP Right Cessation
- 1971-08-30 BE BE771964A patent/BE771964A/fr unknown
- 1971-08-31 CA CA121,762A patent/CA947767A/en not_active Expired
- 1971-09-02 LU LU63829D patent/LU63829A1/xx unknown
- 1971-09-02 AT AT766471A patent/AT321905B/de not_active IP Right Cessation
- 1971-09-03 FR FR7131866A patent/FR2107917B1/fr not_active Expired
- 1971-09-03 OA OA54351A patent/OA03786A/fr unknown
- 1971-09-03 SE SE7111154A patent/SE378820B/xx unknown
- 1971-09-06 DE DE19712144490 patent/DE2144490A1/de active Pending
- 1971-09-07 US US00178449A patent/US3770728A/en not_active Expired - Lifetime
- 1971-09-21 GB GB4392471A patent/GB1360219A/en not_active Expired
1972
- 1972-08-07 US US00278244A patent/US3749786A/en not_active Expired - Lifetime
- 1972-08-08 US US00278738A patent/US3853915A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FR2085695B1 (fr)	1974-11-15
GB1355538A (en)	1974-06-05
GB1355537A (en)	1974-06-05
LU62757A1 (fr)	1971-10-13
DE2111071C3 (de)	1979-07-12
NL7111808A (fr)	1972-03-28
US3749786A (en)	1973-07-31
US3770728A (en)	1973-11-06
SE368954B (fr)	1974-07-29
CA947767A (en)	1974-05-21
NL167431C (nl)	1981-12-16
OA03786A (fr)	1971-12-24
SE378820B (fr)	1975-09-15
US3853915A (en)	1974-12-10
FR2085695A1 (fr)	1971-12-31
NL171449C (nl)	1983-04-05
BE764019A (fr)	1971-09-09
CA960673A (en)	1975-01-07
AT319238B (de)	1974-12-10
NL7103174A (fr)	1971-09-14
FR2107917A1 (fr)	1972-05-12
AT321905B (de)	1975-04-25
OA03692A (fr)	1971-12-24
DE2111071A1 (de)	1971-09-23
FR2107917B1 (fr)	1975-04-18
DE2144490A1 (de)	1972-03-30
LU63829A1 (fr)	1972-06-27
GB1355539A (en)	1974-06-05
US3682930A (en)	1972-08-08
CH531000A (de)	1972-11-30
DE2111071B2 (de)	1978-11-09
GB1360219A (en)	1974-07-17

Publication	Publication Date	Title
BE771964A (fr)	1972-02-29	Procede pour la preparation de derives du benzo-cyclohepta-thiophene
RO64573A (fr)	1979-08-15	Procede pour la preparation des derives du piperydine
RO64454A (fr)	1979-07-15	Procede pour la preparation des phenylimidazolyle-alkylalcanyles derives
RO72460A (fr)	1982-10-26	Procede pour la preparation des derives de n-phosphomethylglycines
RO66268A (fr)	1978-12-15	Procede pour la preparation des derives du 1-phenoxy-3-aminopropan-2-ole
BE776530A (fr)	1972-06-12	Procede pour la preparation de 5-vinylnorbornene-2
RO62392A (fr)	1978-03-15	Procede pour la preparation des derives du thiopyrimidine
BE761028A (fr)	1971-06-30	Procede pour la preparation de derives de polyeniques
RO63049A (fr)	1978-07-15	Procede pour la preparation des derives du 2-nitro-5-imidazolaldehyde
BE772049A (fr)	1972-03-01	Procede pour la preparation de 4-oxocapronitrile
RO62662A (fr)	1978-05-15	Procede pour la preparation des derives du oxindol
BE772818A (fr)	1972-03-20	Procede pour la preparation de derives de
RO63006A (fr)	1978-05-15	Procede pour la preparation des derives du 2-hydrazinobenzthiazole
BE766238A (fr)	1971-10-25	Procede pour la preparation de piperidyl-steroides
RO66910A (fr)	1980-04-15	Procede pour la preparation des derives du tropane-3-ole
RO76964A (fr)	1981-08-30	Procede pour la preparation des derives de neriifoline
RO65263A (fr)	1983-07-07	Procede pour la preparation des derives de 6-aza-3h-benzodiazepines
RO62337A (fr)	1977-10-15	Procede pour la preparation des derives de 22-fluor-digoxine
RO70586A (fr)	1981-07-30	Procede pour la preparation des derives benzodiazepiniques
BE774676A (fr)	1972-05-02	Procede pour la preparation de derives de phenylalanine
BE765270A (fr)	1971-10-05	Procede pour la preparation de derives de beta- aminoethylsulfonium
BE801225A (fr)	1973-10-15	Procede pour la preparation de derives de tricyclohe xyletain
RO68363A (fr)	1981-09-24	Procede pour la preparation des derives de thyrisine
BE773443A (fr)	1972-04-04	Procede pour la preparation de 1-chloro-3-methyl-2-
BE744703A (fr)	1970-07-22	Procede pour la preparation de derives de