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AU8457298A - 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine D4 receptor - Google Patents

2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine D4 receptor

Info

Publication number
AU8457298A
AU8457298A AU84572/98A AU8457298A AU8457298A AU 8457298 A AU8457298 A AU 8457298A AU 84572/98 A AU84572/98 A AU 84572/98A AU 8457298 A AU8457298 A AU 8457298A AU 8457298 A AU8457298 A AU 8457298A
Authority
AU
Australia
Prior art keywords
piperazin
dopamine
ylmethyl
heteroaryl
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU84572/98A
Other languages
English (en)
Inventor
Anton Franz Josef Fliri
Mark Jerome Majchrzak
Hans Rollema
Patricia Ann Seymour
Stevin Howard Zorn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of AU8457298A publication Critical patent/AU8457298A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
AU84572/98A 1997-08-15 1998-08-05 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine D4 receptor Abandoned AU8457298A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5576497P 1997-08-15 1997-08-15
US60055764 1997-08-15
PCT/IB1998/001198 WO1999009025A2 (fr) 1997-08-15 1998-08-05 Derives de 2-(4-aryl- ou heteroaryl-piperazin-1-ylmethyl)-1h-indole

Publications (1)

Publication Number Publication Date
AU8457298A true AU8457298A (en) 1999-03-08

Family

ID=22000003

Family Applications (1)

Application Number Title Priority Date Filing Date
AU84572/98A Abandoned AU8457298A (en) 1997-08-15 1998-08-05 2-(4-aryl or heteroaryl-piperazin-1-ylmethyl)-1H-indole derivatives interacting with the dopamine D4 receptor

Country Status (30)

Country Link
EP (1) EP1003739A2 (fr)
JP (1) JP2002536291A (fr)
KR (1) KR20010022507A (fr)
CN (1) CN1265660A (fr)
AP (1) AP9801321A0 (fr)
AR (1) AR017019A1 (fr)
AU (1) AU8457298A (fr)
BG (1) BG104069A (fr)
BR (1) BR9811557A (fr)
CA (1) CA2297486C (fr)
CO (1) CO4960656A1 (fr)
DZ (1) DZ2583A1 (fr)
EA (1) EA200000023A1 (fr)
HR (1) HRP980441A2 (fr)
HU (1) HUP0003425A3 (fr)
ID (1) ID23803A (fr)
IL (1) IL133960A0 (fr)
IS (1) IS5336A (fr)
MA (1) MA24632A1 (fr)
NO (1) NO20000722L (fr)
OA (1) OA11286A (fr)
PA (1) PA8457001A1 (fr)
PE (1) PE106299A1 (fr)
PL (1) PL338947A1 (fr)
SK (1) SK1352000A3 (fr)
TN (1) TNSN98151A1 (fr)
TR (1) TR200000414T2 (fr)
UY (1) UY25144A1 (fr)
WO (1) WO1999009025A2 (fr)
ZA (1) ZA987304B (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK285198B6 (sk) * 1997-10-27 2006-08-03 Neurosearch A/S Homopiperazínový derivát, farmaceutická kompozícia obsahujúca tento derivát a jeho použitie
EP0953567A3 (fr) 1998-04-29 2003-04-02 Pfizer Products Inc. Dérivés de piperazin-, piperidine- et tetrahydropyridine bicyclique substitués, leur préparation et leur utilisation comme agents a activité dopaminergique (recepteur D4 de la dopamine) centrale
DK1246817T3 (da) * 1999-12-30 2004-10-18 Lundbeck & Co As H 4-Phenyl-1-piperazinyl, -piperidinyl og - tetrahydropyridyl derivater
GB0017952D0 (en) * 2000-07-22 2000-09-13 Univ Manchester Treatment of dyskinesia
EP1177792A3 (fr) 2000-07-27 2002-10-23 Pfizer Products Inc. Ligands dopamine d4 destines au traitement des troubles associees a la cherche de la nouveaute
AU2002336273A1 (en) 2001-03-09 2002-09-24 Ortho-Mcneil Pharmaceutical, Inc. Heterocyclic compounds and their use as histamine h4 ligands.
MXPA05002575A (es) 2002-09-06 2005-09-08 Johnson & Johnson Compuestos heterociclicos.
WO2004108671A1 (fr) * 2003-06-06 2004-12-16 Suven Life Sciences Limited Indoles substitues dotes d'une affinite pour le recepteur de la serotonine, leur procede de fabrication et compositions pharmaceutiques les contenant
WO2005095338A1 (fr) 2004-03-30 2005-10-13 Takeda Pharmaceutical Company Limited Dérivés de l’acide alkoxyphénylpropanoïque
US7572805B2 (en) 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
US7618980B2 (en) 2004-07-14 2009-11-17 Bristol-Myers Squibb Company Pyrrolo(oxo)quinolines as 5HT ligands
JO2769B1 (en) * 2005-10-26 2014-03-15 جانسين فارماسوتيكا ان. في Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor
JO2642B1 (en) 2006-12-08 2012-06-17 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
JO2849B1 (en) * 2007-02-13 2015-03-15 جانسين فارماسوتيكا ان. في Dopamine 2 receptor antagonists are rapidly hydrolyzed
CA2682671C (fr) 2007-04-23 2015-11-17 Janssen Pharmaceutica N.V. Thia(dia)zoles en tant qu'antagonistes du recepteur de la dopamine a dissociation rapide
KR20100016620A (ko) 2007-04-23 2010-02-12 얀센 파마슈티카 엔.브이. 속해리성 도파민 2 수용체 길항제로서의 4-알콕시피리다진 유도체
EP2310374B1 (fr) 2008-07-03 2012-10-31 Janssen Pharmaceutica N.V. 6-(1-pipérazinyl)-pyridazines substituées comme antagonistes du récepteur 5-ht6
US8895562B2 (en) 2008-07-31 2014-11-25 Janssen Pharmaceutica Nv Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists
EP3686196B1 (fr) * 2017-09-20 2024-06-12 Hangzhou Innogate Pharma Co., Ltd. Composé polycyclique agissant en tant qu'inhibiteur de l'ido et/ou en tant qu'inhibiteur double de l'ido-hdac
WO2021216665A1 (fr) * 2020-04-22 2021-10-28 Anima Biotech Inc. Inhibiteurs de traduction de collagène 1 et leurs procédés d'utilisation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (fr) * 1959-09-25 1900-01-01
DE69217224T2 (de) * 1991-07-03 1997-06-05 Pharmacia & Upjohn Co., Kalamazoo, Mich. Substituierte indole als anti-aids pharmaceutische zubereitungen
JPH05255089A (ja) * 1991-12-18 1993-10-05 Sanwa Kagaku Kenkyusho Co Ltd 抗ウイルス剤
CA2146018A1 (fr) * 1992-10-23 1994-05-11 Paul David Leeson Ligands de sous-types de recepteurs dopaminergiques
AU6215594A (en) * 1993-03-18 1994-10-11 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
GB9305644D0 (en) * 1993-03-18 1993-05-05 Merck Sharp & Dohme Therapeutic agents
AU6435594A (en) * 1993-04-15 1994-11-08 Merck Sharp & Dohme Limited Indole derivatives as dopamine d4 antagonists
DE4414113A1 (de) * 1994-04-22 1995-10-26 Merck Patent Gmbh 3-Indolylpiperidine
TW406075B (en) * 1994-12-13 2000-09-21 Upjohn Co Alkyl substituted piperidinyl and piperazinyl anti-AIDS compounds
ZA968661B (en) * 1995-11-17 1998-04-14 Upjohn Co Oxazolidinone antibacterial agent with tricyclic substituents.
TW504510B (en) * 1996-05-10 2002-10-01 Janssen Pharmaceutica Nv 2,4-diaminopyrimidine derivatives

Also Published As

Publication number Publication date
HUP0003425A2 (hu) 2001-10-28
JP2002536291A (ja) 2002-10-29
EA200000023A1 (ru) 2000-08-28
CO4960656A1 (es) 2000-09-25
SK1352000A3 (en) 2000-08-14
IL133960A0 (en) 2001-04-30
TNSN98151A1 (fr) 2005-03-15
UY25144A1 (es) 2000-12-29
ID23803A (id) 2000-05-11
HRP980441A2 (en) 1999-04-30
AR017019A1 (es) 2001-08-22
ZA987304B (en) 2000-02-14
BG104069A (en) 2001-05-31
PE106299A1 (es) 1999-11-02
CA2297486A1 (fr) 1999-02-25
PL338947A1 (en) 2000-12-04
TR200000414T2 (tr) 2000-08-21
BR9811557A (pt) 2000-08-22
AP9801321A0 (en) 2000-02-14
IS5336A (is) 2000-01-11
CA2297486C (fr) 2005-05-03
PA8457001A1 (es) 2000-09-29
CN1265660A (zh) 2000-09-06
NO20000722D0 (no) 2000-02-14
DZ2583A1 (fr) 2003-02-22
WO1999009025A2 (fr) 1999-02-25
HUP0003425A3 (en) 2002-02-28
WO1999009025A3 (fr) 1999-04-15
MA24632A1 (fr) 1999-04-01
KR20010022507A (ko) 2001-03-15
EP1003739A2 (fr) 2000-05-31
OA11286A (en) 2003-10-22
NO20000722L (no) 2000-02-14

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Legal Events

Date Code Title Description
MK5 Application lapsed section 142(2)(e) - patent request and compl. specification not accepted