[go: up one dir, main page]

AU7661594A - Bis(amidinobenzimidazolyl)alkanes as antiviral agents - Google Patents

Bis(amidinobenzimidazolyl)alkanes as antiviral agents

Info

Publication number
AU7661594A
AU7661594A AU76615/94A AU7661594A AU7661594A AU 7661594 A AU7661594 A AU 7661594A AU 76615/94 A AU76615/94 A AU 76615/94A AU 7661594 A AU7661594 A AU 7661594A AU 7661594 A AU7661594 A AU 7661594A
Authority
AU
Australia
Prior art keywords
amidinobenzimidazolyl
alkanes
bis
antiviral agents
antiviral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU76615/94A
Inventor
Darryl Gene Cleary
Michael Cory
Paula Ann Sherman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Services ULC
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of AU7661594A publication Critical patent/AU7661594A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/20—Two benzimidazolyl-2 radicals linked together directly or via a hydrocarbon or substituted hydrocarbon radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU76615/94A 1993-09-22 1994-09-21 Bis(amidinobenzimidazolyl)alkanes as antiviral agents Abandoned AU7661594A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12546693A 1993-09-22 1993-09-22
US125466 1993-09-22
US23291594A 1994-04-25 1994-04-25
US232915 1994-04-25
PCT/GB1994/002051 WO1995008540A1 (en) 1993-09-22 1994-09-21 Bis(amidinobenzimidazolyl)alkanes as antiviral agents

Publications (1)

Publication Number Publication Date
AU7661594A true AU7661594A (en) 1995-04-10

Family

ID=26823613

Family Applications (1)

Application Number Title Priority Date Filing Date
AU76615/94A Abandoned AU7661594A (en) 1993-09-22 1994-09-21 Bis(amidinobenzimidazolyl)alkanes as antiviral agents

Country Status (6)

Country Link
EP (1) EP0720603A1 (en)
JP (1) JPH09506335A (en)
AU (1) AU7661594A (en)
HU (1) HUT71345A (en)
IL (1) IL111011A0 (en)
WO (1) WO1995008540A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6815461B1 (en) * 1994-01-20 2004-11-09 The University Of North Carolina At Chapel Hill Method of inhibiting retroviral integrase
US6562854B2 (en) 1994-12-14 2003-05-13 Axys Pharmaceuticals, Inc. Compositions comprising a substituted benzimidazole useful for treating immunomediated inflammatory disorders
US6255091B1 (en) 1995-04-28 2001-07-03 Axys Pharmaceuticals, Inc. Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
US5723495A (en) * 1995-11-16 1998-03-03 The University Of North Carolina At Chapel Hill Benzamidoxime prodrugs as antipneumocystic agents
DE69814049T2 (en) 1997-02-25 2004-02-19 The Government of the United States of America, as represented by the Secretary National Institute of Health, Office of Technology Transfer SUBSTITUTED BENZIMIDAZOLES AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS
US5935982A (en) * 1997-02-28 1999-08-10 The University Of North Carolina At Chapel Hill Methods of treating retroviral infection and compounds useful therefor
EE04055B1 (en) * 1997-04-07 2003-06-16 Axys Pharmaceuticals, Inc. Compounds and compositions for the treatment of diseases associated with serine protease activity, in particular tryptase activity, and their use
US5886191A (en) * 1997-08-18 1999-03-23 Dupont Pharmaceuticals Company Amidinoindoles, amidinoazoles, and analogs thereof
US6150379A (en) * 1997-11-26 2000-11-21 Axys Pharmaceuticals, Inc. Compounds and compositions as anticoagulants
WO1999026933A1 (en) * 1997-11-26 1999-06-03 Axys Pharmaceuticals, Inc. Substituted amidinoaryl derivatives and their use as anticoagulants
ID28266A (en) 1998-04-10 2001-05-10 Japan Tobacco Inc AMIDIN COMPOUNDS
GT199900167A (en) * 1998-10-01 2001-03-21 NEW BIS-BENZIMIDAZOLES.
CA2375843A1 (en) * 1999-06-04 2000-12-14 Qi Zhao Compositions and methods for inhibiting cell death
DE60032022T2 (en) * 1999-12-20 2007-05-16 The University Of North Carolina At Chapel Hill DIAMIDINE COMPOUNDS AS DNA NON-BILATIN BINDER
IT1317925B1 (en) * 2000-11-03 2003-07-15 Sigma Tau Ind Farmaceuti BIS-HETEROCYCLES WITH ANTI-TUMOR AND CHEMOSENSITIZING ACTIVITY.
WO2009043902A1 (en) * 2007-10-05 2009-04-09 Universite De Mons Hainaut Bisbenzimidazoles as antimalarial agents
CA2871547C (en) 2012-05-25 2021-05-25 Janssen R&D Ireland Uracyl spirooxetane nucleosides
EP3421482A1 (en) 2012-12-21 2019-01-02 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4324794A (en) * 1980-08-26 1982-04-13 Research Triangle Institute Inhibition of respiratory syncytial virus-induced cell fusion by amidino compounds
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor

Also Published As

Publication number Publication date
IL111011A0 (en) 1994-11-28
HU9501811D0 (en) 1995-08-28
WO1995008540A1 (en) 1995-03-30
HUT71345A (en) 1995-11-28
EP0720603A1 (en) 1996-07-10
JPH09506335A (en) 1997-06-24

Similar Documents

Publication Publication Date Title
AU1317795A (en) Machine-tool
AU6733994A (en) Chondroprotective agents
AU7207094A (en) Wrist brace
AU7661594A (en) Bis(amidinobenzimidazolyl)alkanes as antiviral agents
AU1272295A (en) Proinsulin-like compounds
AU7855191A (en) 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents
AU5976394A (en) Oxidising agents
AU7623991A (en) Antiviral agents
AU4479189A (en) Antiviral agents
AU8612491A (en) Antiviral compounds
AU5261093A (en) Aminoalkylphenyl compounds
AU6571594A (en) Thioindole pyperidinyl derivatives used as antalgics
AU6135896A (en) Antiviral agents
AU6544294A (en) Polystyrene-dissolving agent
AU8334691A (en) Antiviral agent
AU675568B2 (en) Antitumor agent
AU7843394A (en) Antiviral compounds
AU7863994A (en) Antiviral drug
AU7507591A (en) Antiviral compounds
AU1699992A (en) Dibenzothiazepinthione as antiviral agents
AU6734094A (en) Chondroprotective agents
AU4290993A (en) Michellamines useful as antiviral agents
AU4167293A (en) Heterocyclyl-phenoxyalkyl-piperidinylpyridazines as antiviral agents
AU4347596A (en) Thienoxazinone derivatives useful as antiviral agents
AU8858191A (en) Worktable