AU6296898A - Acarbose (acb) cluster from (actinoplanes) sp. se 50/110 - Google Patents

Acarbose (acb) cluster from (actinoplanes) sp. se 50/110

Info

Publication number: AU6296898A
Authority: AU; Australia
Prior art keywords: actinoplanes; acb; acarbose; cluster
Prior art date: 1997-02-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

AU62968/98A

Other languages

English (en)

Inventor

Heiner Apeler

Anneliese Crueger

Paz Marta Diaz-Guardamino Uribe

Jurgen Distler

Klaus Goeke

Martin Jarling

Hermann Pape

Wolfgang Piepersberg

Werner Schroder

Ansgar Stratmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-28

Filing date

1998-02-16

Publication date

1998-09-18

1998-02-16 Application filed by Bayer AG filed Critical Bayer AG

1998-09-18 Publication of AU6296898A publication Critical patent/AU6296898A/en

Status Abandoned legal-status Critical Current

Links

XUFXOAAUWZOOIT-SXARVLRPSA-N (2R,3R,4R,5S,6R)-5-[[(2R,3R,4R,5S,6R)-5-[[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-1-cyclohex-2-enyl]amino]-2-oxanyl]oxy]-3,4-dihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-6-(hydroxymethyl)oxane-2,3,4-triol Chemical compound O([C@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)O[C@H]1O[C@@H]([C@H]([C@H](O)[C@H]1O)N[C@@H]1[C@@H]([C@@H](O)[C@H](O)C(CO)=C1)O)C)[C@@H]1[C@@H](CO)O[C@@H](O)[C@H](O)[C@H]1O XUFXOAAUWZOOIT-SXARVLRPSA-N 0.000 title 1
241000187844 Actinoplanes Species 0.000 title 1
229960002632 acarbose Drugs 0.000 title 1
XUFXOAAUWZOOIT-UHFFFAOYSA-N acarviostatin I01 Natural products OC1C(O)C(NC2C(C(O)C(O)C(CO)=C2)O)C(C)OC1OC(C(C1O)O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O XUFXOAAUWZOOIT-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Enzymes And Modification Thereof (AREA)
Saccharide Compounds (AREA)

AU62968/98A 1997-02-28 1998-02-16 Acarbose (acb) cluster from (actinoplanes) sp. se 50/110 Abandoned AU6296898A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE19708127		1997-02-28
DE19708127A DE19708127A1 (de)	1997-02-28	1997-02-28	Acarbose acb-Cluster: Isolierung von weiteren Genen der Acarbose Biosynthese und des Acarbose-Stoffwechsels aus Actinoplanes sp. SE 50/110 sowie deren Verwendung
PCT/EP1998/000862 WO1998038313A1 (de)	1997-02-28	1998-02-16	Acarbose acb-cluster aus $i(actinoplanes) sp. se 50/110

Publications (1)

Publication Number	Publication Date
AU6296898A true AU6296898A (en)	1998-09-18

Family

ID=7821816

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AU62968/98A Abandoned AU6296898A (en)	1997-02-28	1998-02-16	Acarbose (acb) cluster from (actinoplanes) sp. se 50/110

Country Status (15)

Country	Link
EP (1)	EP0968294A1 (no)
KR (1)	KR20000075777A (no)
CN (1)	CN1249001A (no)
AU (1)	AU6296898A (no)
BG (1)	BG103672A (no)
BR (1)	BR9807640A (no)
CA (1)	CA2282735A1 (no)
CZ (1)	CZ9903054A3 (no)
DE (1)	DE19708127A1 (no)
HU (1)	HUP0000889A2 (no)
IL (1)	IL131433A0 (no)
NO (1)	NO994164L (no)
PL (1)	PL335369A1 (no)
WO (1)	WO1998038313A1 (no)
ZA (1)	ZA981659B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0796915A3 (de) *	1996-03-22	1999-04-14	Bayer Ag	Verfahren zur Herstellung sowie zur Verwendung von Acarviosyl-Transferase bei der Umwandlung von Acarbose-Homologen in Acarbose, zur Herstellung von Acarbose-Homologen
TW201217533A (en) *	2010-08-04	2012-05-01	Bayer Pharma AG	Genomics of actinoplanes utahensis
CN106167814B (zh) *	2016-08-31	2019-08-09	河北华荣制药有限公司	一种提高阿卡波糖发酵单位的方法
CN106566796B (zh) *	2016-10-28	2020-11-10	上海交通大学	阿卡波糖生产菌Actinoplanes spp.的遗传操作体系
WO2021073900A1 (en) *	2019-10-16	2021-04-22	Bayer Aktiengesellschaft	Methods for the improved formation of acarbose
CN112592878B (zh) *	2020-12-25	2022-08-26	上海交通大学	增强正调控蛋白基因表达以提高阿卡波糖发酵水平的方法
CN113444670A (zh) *	2021-07-28	2021-09-28	山东鲁抗医药股份有限公司	一种高活性阿卡波糖产生菌的筛选方法和培养方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19507214A1 (de) *	1995-03-02	1996-10-31	Bayer Ag	Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihre Verwendung
DE19622783A1 (de) *	1996-06-07	1997-12-11	Hoechst Ag	Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung

1997
- 1997-02-28 DE DE19708127A patent/DE19708127A1/de not_active Withdrawn
1998
- 1998-02-16 PL PL98335369A patent/PL335369A1/xx unknown
- 1998-02-16 HU HU0000889A patent/HUP0000889A2/hu unknown
- 1998-02-16 KR KR1019997007849A patent/KR20000075777A/ko not_active Withdrawn
- 1998-02-16 CZ CZ993054A patent/CZ9903054A3/cs unknown
- 1998-02-16 EP EP98906953A patent/EP0968294A1/de not_active Withdrawn
- 1998-02-16 CA CA002282735A patent/CA2282735A1/en not_active Abandoned
- 1998-02-16 AU AU62968/98A patent/AU6296898A/en not_active Abandoned
- 1998-02-16 BR BR9807640A patent/BR9807640A/pt not_active Application Discontinuation
- 1998-02-16 CN CN98802927A patent/CN1249001A/zh active Pending
- 1998-02-16 IL IL13143398A patent/IL131433A0/xx unknown
- 1998-02-16 WO PCT/EP1998/000862 patent/WO1998038313A1/de not_active Ceased
- 1998-02-27 ZA ZA981659A patent/ZA981659B/xx unknown
1999
- 1999-08-20 BG BG103672A patent/BG103672A/xx unknown
- 1999-08-27 NO NO994164A patent/NO994164L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0000889A2 (en)	2000-07-28
DE19708127A1 (de)	1998-09-03
BG103672A (en)	2000-05-31
CA2282735A1 (en)	1998-09-03
BR9807640A (pt)	2000-03-21
CN1249001A (zh)	2000-03-29
CZ9903054A3 (cs)	1999-11-17
WO1998038313A1 (de)	1998-09-03
IL131433A0 (en)	2001-01-28
PL335369A1 (en)	2000-04-25
NO994164D0 (no)	1999-08-27
ZA981659B (en)	1998-09-10
NO994164L (no)	1999-08-27
EP0968294A1 (de)	2000-01-05
KR20000075777A (ko)	2000-12-26

Publication	Publication Date	Title
ZA9610070B (en)	1998-05-29	Cyclosporin compositions.
AU3222099A (en)	1999-10-25	Interactive telephony system
AU1441797A (en)	1997-08-20	(2-dimethylphenoxy-1-methylethyl) ethylamine
AU7203496A (en)	1997-04-28	Novel peptides
AU4522699A (en)	2000-01-17	Spring units
AU7711998A (en)	1999-01-04	Low modulus elastomer
AU2038197A (en)	1997-10-22	Call routing
AU8344198A (en)	1999-01-19	Telecommunication system
AU6123196A (en)	1997-01-09	N-aryl-1,2,4-triazolin-5-ones
AU4281999A (en)	1999-12-30	Peptide
AU4427296A (en)	1996-08-07	Novel peptide
AU2753797A (en)	1998-01-15	Suction service valve
AU8484798A (en)	1999-02-10	Sublancin lantibiotic produced by (bacillus subtilis) 168
AU9495698A (en)	1999-04-05	Non-blocking filter
AU6296898A (en)	1998-09-18	Acarbose (acb) cluster from (actinoplanes) sp. se 50/110
AUPO712097A0 (en)	1997-06-26	Vacuum deposition system
ZA965538B (en)	1997-12-29	Somatostatin peptides.
AU9495498A (en)	1999-04-05	Telephony testing system
AU6659998A (en)	1998-09-18	Tazarotene-induced gene 3 (tig3)
AU4218896A (en)	1996-08-08	Service interactions
AU1851797A (en)	1997-08-22	Cyclic peptide antifungal agents
AU1999999A (en)	1999-07-19	Contryphan peptides
AUPP086797A0 (en)	1998-01-08	Gaming system
AU7223796A (en)	1997-05-07	Cluster analysis
AU3930399A (en)	1999-12-06	Cyclosporin preparations

Legal Events

Date	Code	Title	Description
2001-11-15	MK5	Application lapsed section 142(2)(e) - patent request and compl. specification not accepted